TWAS hub - MAPK3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1260	0.0330	2.3e-12	0.112	0.098	0.109	0.104	0.105	1.6e-13	6.2e-12	3.8e-13	1.3e-12	8.8e-13
2	GTEx	Brain Frontal Cortex BA9	0.2383	0.0950	1.2e-03	0.088	NA	0.125	NA	0.109	2.5e-03	NA	3.5e-04	NA	8.4e-04
3	GTEx	Cells EBV-transformed lymphocytes	0.2270	0.0750	4.0e-06	0.117	NA	0.079	NA	0.066	1.3e-04	NA	1.5e-03	NA	3.4e-03
4	GTEx	Cells Transformed fibroblasts	0.1210	0.0440	2.6e-06	0.048	NA	0.009	NA	0.043	1.7e-04	NA	6.2e-02	NA	3.7e-04
5	GTEx	Nerve Tibial	0.1458	0.0458	2.7e-06	0.023	NA	0.086	NA	0.057	8.4e-03	NA	1.1e-06	NA	6.5e-05
6	GTEx	Small Intestine Terminal Ileum	0.1700	0.0840	2.8e-03	0.009	NA	0.015	NA	0.036	2.0e-01	NA	1.5e-01	NA	5.4e-02
7	GTEx	Whole Blood	0.0950	0.0320	4.8e-07	0.051	NA	0.092	NA	0.042	1.5e-05	NA	7.8e-09	NA	8.7e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.1213	0.0302	0.0e+00	0.122	0.161	0.163	0.160	0.160	1.9e-15	4.0e-20	1.8e-20	4.7e-20	4.3e-20
9	YFS	Blood	0.3758	0.0429	0.0e+00	0.288	0.299	0.333	0.299	0.329	1.6e-95	1.2e-99	4.7e-113	1.4e-99	1.2e-111
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0350	0.0220	7.8e-03	0.024	0.042	0.024	NA	0.036	1.6e-02	2.0e-03	1.5e-02	NA	3.9e-03
11	TCGA	Lung Squamous Cell Carcinoma	0.0285	0.0198	5.1e-03	0.014	0.013	0.016	NA	0.014	8.5e-03	1.0e-02	5.5e-03	NA	9.4e-03
12	TCGA	Prostate Adenocarcinoma	0.0729	0.0293	5.1e-12	0.091	0.103	0.110	NA	0.112	8.5e-10	7.2e-11	1.6e-11	NA	8.9e-12
13	TCGA	Testicular Germ Cell Tumors	0.1310	0.0780	1.6e-03	0.107	0.056	0.080	NA	0.083	1.3e-04	4.9e-03	9.2e-04	NA	7.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Waist circumference	27.2	99.6	158.8	-9.2	-7.3	-12.1	-12.4	-5.3	-12.6	-10.3	-9.9	-10.2	-8.7	-10.5	-9.2	-9.5
Blood Red Count	26.8	258.7	361.0	14.8	15.7	17.2	15.3	17.8	12.6	14.3	16.8	15.5	19.0	15.8	17.1	16.2
Weight	26.7	131.4	190.4	-10.3	-8.9	-13.7	-13.8	-6.8	-13.6	-11.6	-11.1	-11.6	-10.4	-12.7	-11.1	-11.3
Arm fat mass (left)	26.3	107.8	156.2	-9.6	-8.6	-12.5	-12.4	-7.0	-11.8	-10.3	-10.4	-10.5	-9.7	-10.8	-10.0	-10.1
Arm fat mass (right)	25.6	105.5	153.8	-9.6	-8.1	-12.4	-12.4	-6.7	-11.8	-10.2	-10.3	-10.4	-9.4	-10.7	-9.9	-10.1
Leg fat-free mass (right)	25.4	135.6	187.7	-10.3	-9.1	-13.7	-13.3	-7.0	-13.4	-12.1	-11.3	-11.9	-10.9	-13.4	-11.6	-11.5
Leg predicted mass (right)	25.1	134.0	185.0	-10.3	-9.0	-13.6	-13.2	-7.0	-13.3	-12.1	-11.3	-11.8	-10.8	-13.3	-11.5	-11.5
Basal metabolic rate	24.9	137.8	198.8	-10.4	-9.1	-13.9	-14.1	-6.7	-13.8	-12.4	-11.4	-11.9	-10.5	-13.5	-11.2	-11.4
Leg predicted mass (left)	24.5	129.5	179.6	-10.1	-8.8	-13.4	-13.2	-6.9	-13.2	-12.1	-11.1	-11.6	-10.5	-13.0	-11.1	-11.1
Leg fat-free mass (left)	24.4	129.1	176.9	-10.1	-8.8	-13.3	-13.2	-6.9	-13.2	-12.0	-11.1	-11.6	-10.5	-13.0	-11.1	-11.1
Hip circumference	24.2	104.4	151.3	-9.2	-8.9	-12.1	-12.3	-6.8	-11.8	-10.1	-10.1	-10.1	-9.6	-10.8	-9.8	-9.8
Body mass index (BMI)	24.1	102.9	148.9	-9.8	-7.8	-12.2	-11.9	-6.9	-11.1	-10.0	-10.1	-10.5	-9.7	-10.2	-10.2	-10.2
Arm predicted mass (left)	22.7	115.5	176.9	-9.5	-8.2	-12.8	-13.3	-5.7	-12.8	-11.6	-10.4	-10.8	-9.2	-12.5	-10.0	-10.4
Whole body water mass	22.6	129.1	185.0	-10.1	-8.5	-13.4	-13.6	-6.2	-13.4	-12.2	-11.0	-11.5	-10.0	-13.3	-10.9	-11.1
Arm fat-free mass (left)	22.4	113.8	174.2	-9.5	-8.0	-12.7	-13.2	-5.7	-12.7	-11.7	-10.3	-10.8	-9.1	-12.3	-9.9	-10.2
Impedance of leg (right)	22.0	106.4	144.0	10.0	7.1	12.0	10.8	7.0	10.6	10.5	10.2	10.9	10.7	11.0	11.2	10.8
Number of incorrect matches in round	22.0	36.6	46.2	6.2	4.8	6.8	6.5	5.0	6.0	5.8	6.5	6.2	6.3	6.3	6.0	6.0
Whole body fat-free mass	22.0	125.5	179.6	-9.9	-8.4	-13.2	-13.4	-6.2	-13.3	-12.0	-10.9	-11.3	-9.9	-13.1	-10.7	-10.9
Arm fat-free mass (right)	21.2	108.7	158.8	-9.3	-8.1	-12.3	-12.6	-5.6	-12.3	-11.4	-10.0	-10.6	-9.0	-12.0	-9.9	-10.1
Arm predicted mass (right)	21.0	107.3	158.8	-9.2	-8.1	-12.2	-12.6	-5.4	-12.3	-11.2	-9.9	-10.5	-8.9	-12.0	-9.8	-10.1
BMI	20.8	120.5	171.6	-9.0	-7.8	-13.1	-12.6	-7.3	-12.3	-10.7	-10.8	-11.0	-10.7	-11.9	-11.9	-11.8
Leg fat mass (left)	19.7	76.9	116.6	-8.1	-7.0	-10.7	-10.8	-5.6	-10.0	-8.6	-8.7	-9.0	-7.9	-9.1	-8.4	-8.7
Whole body fat mass	19.5	81.4	123.2	-8.2	-7.3	-10.9	-11.1	-5.8	-10.7	-9.0	-8.9	-9.1	-8.1	-9.4	-8.6	-8.8
Impedance of leg (left)	19.4	94.4	127.7	9.6	6.5	11.3	10.3	6.8	10.1	10.2	9.8	10.1	10.0	10.2	10.4	9.9
Trunk fat-free mass	18.7	107.4	161.3	-9.1	-7.6	-12.3	-12.7	-5.2	-12.6	-11.2	-10.0	-10.3	-8.9	-12.4	-9.7	-10.0
Trunk predicted mass	18.7	106.7	158.8	-9.0	-7.5	-12.2	-12.6	-5.2	-12.6	-11.2	-10.0	-10.3	-8.9	-12.4	-9.7	-9.9
Impedance of whole body	18.7	95.4	132.2	9.8	6.4	11.5	11.0	6.3	10.1	10.3	9.6	10.3	9.5	10.4	10.2	10.1
Leg fat mass (right)	18.0	69.9	108.2	-7.8	-6.7	-10.1	-10.4	-5.4	-9.7	-8.3	-8.3	-8.6	-7.5	-8.7	-7.9	-8.1
Trunk fat mass	16.5	70.7	108.2	-7.5	-7.0	-10.2	-10.4	-5.2	-10.1	-8.3	-8.3	-8.4	-7.5	-8.9	-7.9	-8.1
Arm fat percentage (left)	15.8	63.0	92.5	-7.3	-6.7	-9.6	-9.4	-5.7	-9.1	-7.4	-8.0	-8.1	-7.7	-7.8	-7.8	-7.7
Arm fat percentage (right)	15.6	61.4	91.6	-7.2	-6.3	-9.6	-9.5	-5.4	-9.1	-7.4	-7.9	-7.9	-7.5	-7.8	-7.6	-7.6
Impedance of arm (right)	12.7	59.2	83.5	8.0	5.2	9.1	8.9	4.7	7.6	8.3	7.5	8.3	7.2	8.0	7.9	8.0
Impedance of arm (left)	12.5	57.8	86.1	7.8	4.5	9.1	9.3	4.2	8.1	8.3	7.4	8.1	6.7	8.1	7.6	7.8
Qualifications: NVQ or HND or HNC or equivalent	10.6	12.8	19.3	-3.6	-1.9	-4.1	-3.9	-2.5	-3.5	-3.1	-3.0	-3.7	-3.3	-4.4	-4.2	-4.3
Bipolar Disorder or Schizophrenia	10.3	25.0	44.4	4.8	2.8	6.0	6.6	3.1	6.0	6.7	4.9	4.9	3.9	4.8	4.2	4.4
Age when periods started (menarche)	10.3	24.8	37.2	4.9	1.7	6.0	6.1	3.2	5.8	5.1	5.8	5.4	4.5	5.3	4.2	4.7
Comparative body size at age 10	10.0	27.6	43.7	-5.1	-3.1	-6.3	-5.4	-4.0	-4.9	-4.1	-5.3	-5.8	-5.9	-4.8	-6.6	-5.9
Body fat percentage	9.7	38.4	61.0	-5.5	-5.4	-7.7	-7.8	-4.3	-7.4	-5.8	-6.2	-6.2	-5.6	-6.0	-5.9	-5.9
Wheeze or whistling in the chest in last year	9.4	16.8	21.9	-4.1	-3.5	-4.7	-4.1	-4.4	-3.3	-3.4	-3.9	-4.2	-4.3	-4.1	-4.5	-4.6
Diabetes (father)	9.0	11.1	16.9	-3.3	-3.5	-3.6	-3.5	-1.9	-4.0	-3.4	-3.5	-2.8	-2.8	-4.1	-2.6	-3.6
Trunk fat percentage	8.7	35.0	54.8	-5.2	-5.5	-7.3	-7.4	-4.1	-7.1	-5.5	-6.0	-5.7	-5.3	-5.8	-5.5	-5.6
Leg fat percentage (left)	8.6	31.1	53.1	-5.3	-4.6	-7.0	-7.3	-3.7	-6.4	-5.0	-5.6	-5.8	-4.9	-5.2	-5.2	-5.5
Alcohol intake versus 10 years previously	8.3	12.4	18.2	-3.0	-2.3	-4.2	-4.2	-1.9	-3.9	-3.6	-3.5	-3.8	-2.9	-4.3	-3.5	-3.8
Schizophrenia (2014)	8.1	17.9	32.4	4.0	3.0	5.0	5.7	2.8	5.3	5.2	4.2	4.2	3.5	4.2	3.3	3.6
Tense / ‘highly strung’	8.1	13.4	26.0	2.9	5.1	4.2	4.8	3.1	3.9	3.2	3.4	3.2	3.2	4.0	2.7	3.0
Neck or shoulder pain in last month	8.1	11.6	20.3	-2.6	-2.6	-3.5	-3.4	-2.6	-3.2	-3.2	-3.0	-4.0	-3.4	-4.5	-3.7	-3.9
Schizophrenia (2018)	8.0	16.7	29.4	3.7	3.0	4.7	5.4	2.4	4.9	5.1	3.7	4.0	3.6	4.2	3.5	3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	7.8	10.1	12.5	3.0	3.5	3.1	3.4	3.1	3.5	3.2	2.4	3.1	3.1	3.4	3.0	3.2
Nervous feelings	7.5	14.0	35.8	2.2	4.4	4.0	5.3	1.6	6.0	2.8	3.3	3.1	3.1	4.8	2.7	2.7
Comparative height size at age 10	7.1	39.2	62.4	-5.4	-5.2	-7.3	-7.7	-3.8	-7.4	-6.6	-6.6	-5.7	-5.0	-7.9	-5.5	-6.0
Number of children fathered	7.0	7.9	11.3	-2.9	-1.1	-2.9	-2.6	-3.1	-2.3	-3.0	-2.0	-3.2	-2.9	-3.2	-3.2	-3.4
Blood Eosinophil Count	6.6	51.0	98.0	4.4	6.2	7.6	7.8	5.0	7.2	5.6	5.1	7.9	7.5	9.9	8.1	8.3
Medication: Bendroflumethiazide	6.5	9.9	19.3	-2.6	-1.4	-3.5	-3.5	-0.4	-4.4	-3.1	-2.0	-4.1	-2.8	-3.8	-3.7	-3.2
Leg fat percentage (right)	6.4	23.3	43.5	-4.6	-4.1	-6.0	-6.6	-3.3	-5.7	-4.4	-4.9	-4.9	-4.1	-4.3	-4.3	-4.5
Alcohol intake frequency.	6.2	14.4	33.9	-2.0	-1.6	-4.6	-4.9	-0.5	-5.8	-2.5	-3.1	-4.2	-2.8	-5.1	-4.2	-4.1
Suffer from ‘nerves’	6.1	9.6	25.5	1.9	5.0	2.9	3.0	2.5	4.1	2.0	2.8	2.4	3.1	4.0	2.5	2.6
Eye problems/disorders: Cataract	5.9	6.8	9.4	2.7	1.0	2.7	2.5	1.7	2.5	2.5	3.1	3.0	2.9	2.8	2.9	2.8
Body Mass Index (BMI) (2010)	5.7	7.8	11.3	-2.3	-2.4	-3.3	-2.9	-1.5	-2.9	-2.4	-2.5	-3.0	-3.1	-3.4	-3.1	-3.0
Hand grip strength (left)	5.6	14.8	23.0	-2.4	-3.4	-3.9	-4.3	-1.9	-4.7	-4.1	-3.2	-4.7	-3.8	-4.8	-4.0	-3.7
Mouth/teeth dental problems: Dentures	5.5	9.3	14.7	-3.3	-2.0	-3.6	-3.8	-1.6	-3.7	-3.0	-3.3	-3.6	-2.6	-2.7	-2.6	-2.8
Medication: Ibuprofen (e.g. Nurofen)	5.4	6.8	11.2	-2.0	-1.5	-3.3	-3.3	-1.5	-3.0	-2.7	-3.0	-2.6	-2.4	-2.6	-2.6	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.3	11.3	18.7	3.1	3.1	3.9	4.3	2.8	3.8	2.7	3.3	3.0	3.2	3.6	3.3	3.3
Primary Biliary Cirrhosis	5.2	7.4	13.0	-3.2	-1.8	-2.9	-2.2	-2.2	-1.2	-2.3	-2.6	-3.6	-2.9	-2.6	-3.5	-3.5
Bipolar Disorder (2018)	5.1	8.1	16.7	2.9	0.8	3.6	3.6	1.4	3.4	4.1	3.3	2.9	1.9	2.4	2.4	2.4
Fed-up feelings	4.9	8.8	12.6	-3.3	-1.8	-3.6	-3.5	-1.8	-2.7	-3.2	-2.9	-3.5	-2.7	-2.8	-3.2	-3.0
Relative age voice broke	4.9	7.5	12.2	3.0	2.5	2.5	2.2	2.4	2.6	1.5	2.9	2.2	3.3	3.2	3.2	3.5
Worry (Nagel 2018)	4.8	10.1	24.2	1.2	4.6	3.4	4.5	1.5	4.9	2.5	2.6	2.7	2.1	4.3	1.7	2.3
Asthma (self-reported)	4.8	9.6	17.1	-2.9	-3.5	-3.2	-2.9	-4.1	-1.6	-2.6	-3.1	-2.9	-3.7	-2.5	-3.3	-3.2
Ulcerative Colitis	4.7	6.8	14.5	-3.3	-1.3	-2.6	-1.6	-2.5	-0.8	-1.8	-2.1	-2.9	-3.0	-2.7	-3.8	-3.7
Heel T-Score	4.5	36.1	50.8	6.4	5.9	7.1	6.8	4.2	6.4	5.5	6.7	5.4	6.2	5.4	5.9	5.6
Lung FEV1/FVC ratio	4.3	21.7	35.6	3.5	5.6	4.7	4.5	6.0	4.2	3.5	4.4	4.7	5.7	4.5	4.5	4.0
Chronotype (morning person)	4.2	9.6	14.1	-2.8	-1.8	-3.3	-3.3	-2.4	-3.4	-3.1	-2.4	-3.2	-3.1	-3.8	-3.5	-3.5
Frequency of tenseness / restlessness in last 2 weeks	4.2	6.5	16.0	1.5	4.0	2.5	2.6	1.9	3.0	1.5	2.1	2.5	2.8	2.9	2.4	2.4
Long-standing illness, disability or infirmity	4.2	6.5	11.5	-3.2	-2.0	-2.5	-1.8	-2.2	-1.2	-1.0	-2.9	-2.6	-3.2	-2.5	-3.4	-3.3
Basal cell carcinoma (self-reported)	4.1	4.9	12.5	1.9	-0.1	2.4	1.5	1.6	1.1	2.0	1.9	2.5	2.5	2.2	3.5	3.2
Asthma	4.0	8.0	14.6	-2.6	-3.3	-2.9	-2.7	-3.8	-1.4	-2.5	-2.9	-2.7	-3.3	-2.4	-2.9	-2.8
Supplements: Vitamin C	4.0	4.7	10.1	2.7	1.1	2.2	2.2	2.1	1.1	3.2	1.8	2.6	2.1	1.4	2.3	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.0	4.6	7.2	-2.6	-1.5	-2.2	-1.2	-2.3	-1.3	-2.1	-2.3	-2.3	-2.5	-1.6	-2.7	-2.7
Relative age of first facial hair	3.8	7.7	11.2	3.3	2.4	2.7	3.0	1.8	2.9	2.2	2.9	2.4	2.6	3.4	2.8	3.3
Ever unenthusiastic/disinterested for a whole week	3.8	4.6	8.1	1.3	2.2	2.2	2.7	1.5	2.8	2.8	2.3	2.1	1.9	2.5	1.4	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	8.1	2.2	2.8	2.3	2.4	2.2	2.7	2.4	2.3	2.3	2.4	2.8	1.9	2.4
Respiratory disease	3.7	8.3	17.2	-2.4	-3.5	-2.8	-2.3	-4.2	-1.8	-1.5	-3.1	-2.5	-3.9	-2.0	-3.2	-2.9
Hand grip strength (right)	3.7	9.9	18.1	-1.9	-3.1	-3.0	-3.6	-1.3	-4.1	-3.3	-2.3	-3.9	-2.7	-4.2	-3.0	-2.9
High blood pressure (mother)	3.6	5.1	9.4	-2.0	-1.2	-2.0	-2.4	-0.9	-3.1	-2.7	-1.6	-2.7	-2.0	-3.0	-2.2	-2.3
Mouth/teeth dental problems	3.6	5.6	9.3	2.3	1.0	2.8	2.6	1.7	2.5	2.7	2.0	3.1	2.0	2.5	2.4	2.5
Illnesses of father: High blood pressure	3.6	4.5	7.3	-2.0	-2.0	-2.2	-2.5	-2.2	-1.2	-2.2	-1.2	-2.6	-1.7	-2.5	-1.9	-2.7
Maternal smoking around birth	3.4	4.9	10.4	-2.3	-1.9	-2.5	-1.9	-1.6	-0.5	-3.2	-2.0	-2.7	-1.6	-2.4	-2.3	-2.6
Happiness	3.4	4.1	5.6	2.4	2.1	2.1	2.3	1.8	1.7	2.3	2.2	2.1	2.2	1.4	1.8	1.6
Medication: Ventolin 100micrograms inhaler	3.4	4.4	9.3	-2.5	-2.2	-2.2	-1.2	-3.0	-0.3	-1.8	-2.3	-1.4	-2.9	-0.9	-2.6	-1.9
Rheumatoid Arthritis	3.3	4.6	9.0	-2.2	-1.8	-2.2	-1.6	-0.6	-1.3	-2.0	-2.0	-3.0	-2.3	-2.6	-2.5	-2.6
Time employed in main current job	3.2	3.7	5.9	2.3	2.4	2.3	1.8	1.4	1.3	1.9	2.3	1.3	1.9	1.7	2.0	1.9
Depressed Affect (Nagel 2018)	3.1	6.5	11.4	-3.3	-0.8	-2.9	-2.2	-2.3	-1.5	-3.0	-2.3	-2.9	-2.5	-1.9	-3.4	-2.8
Ulcerative Colitis (UC)	3.1	5.9	13.8	-3.0	-1.2	-2.3	-1.3	-2.5	-0.6	-1.3	-2.1	-3.1	-2.6	-2.1	-3.7	-3.4
Ever had hysterectomy (womb removed)	3.0	3.4	7.2	0.9	2.7	2.1	1.5	2.2	1.8	1.4	1.9	1.2	2.4	1.8	1.9	1.3
Qualifications: College or University degree	3.0	9.6	17.7	2.9	0.3	3.4	3.4	0.8	3.2	3.2	2.5	4.2	2.3	3.7	3.6	4.0
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	6.3	1.8	2.4	2.0	1.4	1.2	0.9	1.9	1.8	2.1	2.0	2.4	2.5	2.4
Leg pain on walking	2.8	3.5	6.5	-1.6	-1.7	-2.3	-1.6	-0.9	-1.2	-1.5	-1.7	-2.1	-1.7	-2.5	-2.2	-2.5
Medication: Aspirin	2.8	3.6	7.7	1.7	2.1	1.6	0.8	2.5	0.8	1.7	1.9	1.9	2.8	1.8	2.3	1.7
Blood White Count	2.7	20.0	41.2	3.1	3.8	4.0	4.9	5.5	3.5	1.0	3.6	4.5	5.7	4.3	6.4	5.2
Medication: Ibuprofen	2.7	3.3	5.4	-1.3	-1.4	-2.3	-2.2	-0.4	-1.7	-1.7	-2.1	-2.1	-1.8	-1.8	-1.9	-1.9
Family relationship satisfaction	2.7	3.4	6.3	2.3	1.4	1.8	1.7	1.3	1.0	2.1	1.6	2.5	2.3	1.0	2.1	1.9
Heart disease (mother)	2.6	3.2	6.4	-2.1	-0.8	-1.6	-1.2	-1.2	-0.8	-1.7	-1.3	-2.5	-2.0	-1.9	-2.5	-2.5
Height	2.5	48.4	116.6	-3.5	-4.9	-7.8	-8.9	-1.1	-10.8	-7.5	-5.5	-6.5	-4.8	-10.5	-5.8	-6.3
High blood pressure	2.5	6.9	18.6	-1.8	-0.7	-2.7	-3.4	0.3	-4.3	-3.2	-1.3	-3.5	-1.4	-3.0	-2.4	-2.6
Ever taken oral contraceptive pill	2.5	2.8	7.3	-1.8	-0.7	-1.6	-1.5	-0.5	-1.1	-1.3	-1.6	-2.0	-1.5	-2.7	-1.8	-2.4
Diabetes (mother)	2.4	3.0	10.8	-0.5	-0.2	-1.8	-2.2	0.1	-3.3	-1.5	-0.7	-1.9	-1.0	-2.3	-1.8	-2.0
Average weekly fortified wine intake	2.4	2.8	6.0	1.8	0.0	2.1	2.4	0.1	2.1	1.5	1.9	2.0	1.0	1.9	1.1	1.5
Standing height	2.4	23.4	58.4	-2.8	-4.0	-5.4	-6.4	-1.2	-7.6	-5.4	-4.2	-4.2	-3.1	-7.2	-3.4	-3.9
Birth weight of first child	2.4	4.4	6.8	-2.0	-2.3	-2.4	-2.1	-2.0	-1.4	-2.0	-1.8	-2.1	-2.5	-1.9	-2.6	-2.0
Medication: Aspirin	2.4	3.1	6.6	1.7	2.0	1.4	0.7	2.5	0.7	1.8	1.8	1.8	2.6	1.5	2.0	1.5
Eye problems/disorders: Glaucoma	2.4	2.9	6.2	-1.3	-2.2	-2.0	-2.0	-1.4	-1.9	-0.7	-2.5	-1.6	-1.6	-1.7	-1.0	-1.4
Medication: Blood pressure	2.4	4.5	11.8	-1.7	-0.2	-2.2	-2.2	0.3	-3.4	-2.4	-1.6	-2.8	-1.8	-2.1	-2.3	-2.1
Alzheimer’s Disease (including proxy)	2.3	3.3	10.3	-0.3	1.9	2.4	3.2	0.1	3.1	0.9	1.7	1.0	0.6	2.2	1.2	1.4
Type 2 Diabetes (T2D) (2018)	2.3	4.2	9.5	-1.7	-1.3	-2.0	-2.3	0.4	-3.1	-1.4	-1.4	-2.2	-1.1	-3.1	-2.1	-2.7
Blood clot in the leg (DVT)	2.3	2.9	5.6	1.5	2.4	1.6	1.2	1.0	0.7	1.7	1.4	1.8	1.6	2.2	2.1	2.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	5.2	1.9	1.3	2.0	1.9	1.5	1.8	1.7	2.3	1.6	1.7	1.1	1.3	1.2
Hair/balding pattern: Pattern 3	2.2	3.3	4.4	2.0	1.3	2.0	1.8	2.0	1.7	1.9	1.7	1.7	1.5	2.1	1.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	8.1	-2.0	-2.5	-2.2	-2.7	-2.3	-2.9	-2.2	-1.7	-1.4	-1.9	-2.3	-1.5	-1.4
Ever depressed for a whole week	2.2	2.7	5.4	0.9	1.5	1.6	1.8	1.2	2.3	1.5	1.7	1.7	1.6	2.2	1.4	1.2
Supplements: Calcium	2.2	2.5	6.7	2.0	0.6	1.6	1.5	1.1	1.2	2.6	1.4	1.7	1.6	1.1	1.5	1.6
Medication: Seretide 50 evohaler	2.1	2.4	5.0	-1.4	-1.9	-1.6	-0.8	-0.8	-0.8	-0.9	-1.9	-1.2	-1.5	-1.9	-2.0	-2.2
High cholesterol (Self-reported)	2.1	3.8	7.2	2.3	2.1	1.9	0.8	2.1	0.6	1.1	2.4	1.4	2.7	2.3	2.3	2.1
Taking other prescription medications	2.0	3.1	5.9	-2.1	-1.0	-2.1	-1.4	-1.9	-0.7	-1.7	-1.6	-1.7	-1.9	-1.1	-2.4	-2.3
Number of live births	2.0	2.8	7.1	1.6	1.3	1.6	2.1	0.9	2.7	1.9	1.4	1.3	1.6	1.8	1.4	1.3
Qualifications: A levels/AS levels or equivalent	2.0	4.4	9.3	2.3	0.4	2.2	1.8	1.0	1.7	2.1	1.9	3.0	1.9	2.5	2.4	2.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.0	-1.5	-2.8	-1.5	-1.6	-1.6	-0.1	-0.5	-2.0	-1.3	-1.6	-1.6	-0.7	-1.1
Commuting to job workplace: Cycle	2.0	2.5	5.6	2.4	2.0	2.0	1.3	2.1	0.3	1.2	1.4	1.2	1.4	0.8	1.5	1.6
Vascular/heart problems diagnosed by doctor	2.0	5.4	13.6	1.6	0.6	2.4	3.2	-0.6	3.7	2.6	1.1	3.3	1.1	2.8	2.1	2.2
Supplements: Glucosamine	1.9	2.5	4.3	-1.3	-1.2	-1.9	-2.1	-1.6	-1.6	-1.9	-1.4	-1.5	-1.3	-1.9	-1.4	-1.6
Hearing difficulty/problems with background noise	1.9	3.1	5.6	1.8	1.7	2.2	1.1	1.3	1.0	1.8	1.5	2.1	2.4	1.7	2.0	1.8
Hypertension (Self-reported)	1.9	5.2	16.6	-1.2	-0.1	-2.2	-3.0	0.8	-4.1	-2.9	-0.8	-3.0	-1.0	-2.7	-2.0	-2.1
Illnesses of father: None of the above (group 1)	1.9	2.3	6.4	1.2	0.9	1.7	2.5	1.6	1.7	1.7	1.1	1.2	0.6	1.9	0.8	1.9
Birth weight	1.8	4.0	5.8	-1.9	-1.3	-2.3	-1.9	-2.4	-1.2	-2.4	-1.4	-2.4	-2.4	-2.0	-2.1	-1.8
Crohns Disease (2012)	1.7	2.7	8.9	1.4	3.0	1.6	1.2	0.1	2.0	1.3	1.9	1.6	1.5	1.8	1.3	1.2
LDL Cholesterol	1.7	2.8	4.6	1.3	1.3	1.7	2.1	1.0	1.6	2.0	1.2	2.1	1.6	2.1	1.5	1.5
Medication for pain relief, constipation, heartburn	1.7	3.0	5.8	1.8	0.1	2.4	2.2	1.1	1.7	1.7	1.7	1.9	1.2	1.2	2.0	2.1
Had major operations	1.7	2.0	4.8	1.9	1.3	1.2	0.3	2.2	0.0	1.0	1.6	1.2	1.8	0.8	1.6	1.7
Knee pain experienced in last month	1.7	2.6	7.2	-1.9	-0.5	-1.6	-0.6	-2.2	-0.6	-1.0	-1.2	-1.7	-2.1	-0.9	-2.7	-2.2
Medication: Gliclazide	1.7	1.9	6.3	-0.3	-1.9	-1.2	-1.0	-0.7	-1.0	-1.0	-0.7	-1.6	-0.8	-2.5	-1.3	-2.0
Alzheimer’s Disease (in mother)	1.6	1.9	7.3	0.3	1.1	1.7	2.4	0.7	2.7	0.5	1.7	0.7	0.9	1.2	0.8	0.8
Hypothyroidism (self reported)	1.6	3.7	8.3	1.7	1.1	1.9	1.3	1.5	1.4	1.9	2.2	1.7	2.6	1.5	2.9	2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	7.5	2.7	2.6	2.2	2.5	1.9	1.8	1.2	2.1	1.5	1.9	0.6	1.6	1.4
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.2	0.8	2.0	1.6	1.2	2.0	1.0	1.2	1.4	0.8	1.7	0.9	1.7	0.8
Worrier / anxious feelings	1.6	3.0	9.1	-0.0	2.6	1.8	3.0	-0.3	3.0	0.6	1.3	1.3	0.7	2.5	0.3	0.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.5	-1.1	-0.1	-1.2	-1.0	-0.7	-1.9	-1.7	-0.7	-1.9	-1.2	-1.9	-1.4	-1.7
Glaucoma (self-reported)	1.6	1.8	2.8	-0.6	-1.7	-1.5	-1.5	-1.5	-1.5	-0.7	-1.6	-1.4	-1.2	-1.7	-0.8	-1.1
Medication: Blood pressure	1.6	2.7	7.8	-1.1	0.5	-1.6	-2.2	1.1	-2.8	-1.6	-0.7	-2.2	-0.3	-2.3	-1.2	-1.6
Mean Putamen Volume	1.5	1.8	3.1	-1.7	-1.1	-1.6	-1.4	-0.6	-1.2	-1.4	-1.8	-1.6	-1.0	-0.9	-1.0	-1.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.8	-2.2	-0.5	-1.2	-0.6	-0.7	-0.3	-1.0	-1.1	-1.6	-1.2	-1.2	-1.6	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.3	8.6	2.9	1.8	2.1	2.2	1.4	1.6	1.2	2.3	1.3	1.9	0.5	1.8	1.5
Illnesses of mother	1.5	1.9	3.6	1.5	0.8	1.3	1.6	0.6	1.5	1.5	0.9	1.9	1.2	1.7	1.2	1.4
Number of treatments/medications taken	1.4	2.6	5.6	-1.5	-0.5	-2.0	-1.7	0.4	-1.0	-1.0	-1.2	-2.4	-1.0	-2.0	-2.1	-2.4
Forced vital capacity (FVC)	1.4	5.2	12.5	-1.6	-1.8	-2.4	-2.3	-1.2	-2.8	-2.7	-1.9	-2.5	-2.3	-3.5	-1.8	-1.9
Medication: Simvastatin	1.4	2.1	5.5	1.5	1.5	1.2	0.8	2.3	0.5	1.0	1.8	1.0	2.1	1.5	1.3	1.1
Pulse rate	1.4	2.4	4.2	1.5	-0.2	1.8	2.0	2.0	1.4	1.9	1.7	1.4	1.5	1.1	1.5	1.2
Age at last live birth	1.4	2.1	3.7	1.9	1.7	1.4	1.0	1.8	0.1	1.5	1.3	1.5	1.3	1.2	1.4	1.7
Myopia	1.4	2.1	4.9	1.6	-0.4	1.1	0.4	-0.2	0.7	1.2	1.7	2.1	1.4	1.8	1.8	2.2
Prostate Cancer	1.3	1.8	4.9	1.5	1.4	1.7	1.6	2.2	0.3	1.4	1.6	0.7	1.4	0.4	0.9	1.0
Medication: Cholesterol lowering	1.3	2.0	5.2	1.4	1.3	1.2	0.4	2.2	1.2	1.1	1.4	1.0	2.3	1.1	1.6	1.1
Medication: Paracetamol	1.3	2.2	4.8	-1.2	0.1	-1.9	-1.4	-0.7	-1.1	-1.2	-1.0	-2.1	-1.6	-1.4	-2.2	-1.9
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.6	1.8	1.2	1.4	1.0	1.3	1.1	1.5	1.5	1.7	2.1	1.6	2.1	1.6
Mean time to correctly identify matches	1.3	2.6	6.1	1.3	2.5	1.6	2.2	0.7	1.3	1.6	1.5	1.7	0.9	2.0	0.9	1.5
Friendships satisfaction	1.3	1.6	3.5	1.9	1.8	1.2	1.6	0.8	0.3	1.5	1.2	1.2	0.9	0.7	0.8	1.4
Average weekly champagne plus white wine intake	1.3	1.8	4.6	1.5	1.8	1.6	1.5	0.8	2.2	0.8	1.6	1.2	0.8	1.0	1.1	1.1
Mother’s age at death	1.3	1.6	3.1	1.8	0.9	1.3	1.1	1.2	-0.9	1.6	1.0	1.7	1.2	0.7	1.1	1.2
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.9	2.0	1.5	1.0	0.6	0.9	0.5	1.0	1.4	1.1	1.1	0.9	1.2	1.6
Crohns Disease (2017)	1.2	2.6	10.3	1.2	3.2	1.6	1.0	0.4	1.8	1.5	1.8	1.1	1.7	1.4	1.6	1.2
Medication for hormone replacement therapy	1.2	1.3	3.7	1.3	1.9	0.9	0.7	1.0	1.3	1.2	1.0	1.0	1.4	0.8	1.2	0.9
Medication: Metformin	1.2	1.7	3.8	-0.8	-1.2	-1.6	-1.9	-0.1	-1.6	-0.8	-1.2	-1.5	-0.6	-1.8	-1.1	-1.6
Exposure to tobacco smoke at home	1.2	1.4	2.6	-1.4	-0.3	-1.3	-1.6	-1.3	-1.6	-1.1	-1.1	-0.9	-1.5	-0.7	-1.0	-0.5
Emphysema/chronic bronchitis	1.2	1.4	4.6	-2.1	-0.8	-1.1	-0.7	-1.4	-1.0	-1.2	-1.5	-1.1	-1.1	-0.4	-0.9	-0.8
Loneliness, isolation	1.2	1.7	3.9	-1.5	0.7	-1.8	-2.0	-0.5	-1.9	-1.3	-1.7	-0.9	-1.0	-0.7	-0.9	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.2	1.3	1.1	1.1	1.4	1.8	0.9	2.0	0.9	1.2	0.9	0.4	0.1	0.1
Neuroticism (2016)	1.1	1.6	9.8	1.0	3.1	0.9	0.7	-0.2	0.6	0.2	1.5	0.8	1.2	1.6	0.5	0.9
Smoking Status	1.1	2.7	5.3	-1.4	0.1	-1.7	-1.6	-0.5	-1.3	-2.3	-1.5	-2.1	-1.5	-1.7	-2.1	-2.0
Medication: Co-codamol	1.1	1.3	2.7	-0.9	-0.6	-1.0	-0.9	-0.0	-1.4	-0.6	-1.0	-1.6	-1.4	-1.3	-1.4	-1.4
Alcohol usually taken with meals	1.1	1.7	4.2	-1.1	-1.9	-1.2	-0.8	-2.1	-1.5	-0.5	-1.4	-0.8	-2.0	-0.9	-0.9	-0.5
Medication: Ramipril	1.1	1.5	5.7	-0.4	-0.1	-0.8	-1.8	1.6	-2.4	-0.8	-0.6	-1.3	-0.4	-1.7	-0.7	-0.8
Loud music exposure frequency	1.1	1.1	4.9	-1.2	-0.3	-0.8	0.2	-2.2	0.8	-1.2	-1.0	-0.9	-1.2	-0.3	-1.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	1.8	1.1	0.9	1.2	0.9	0.8	1.3	1.2	1.3	0.9	1.1	1.0	1.4	1.2
Cardiovascular Disease	1.0	3.2	11.5	-1.2	-0.3	-1.6	-2.5	1.0	-3.4	-2.3	-0.5	-2.5	-0.5	-2.1	-1.3	-1.2
Serious illness, injury or assault to yourself	1.0	1.2	5.9	-0.2	-0.2	-1.0	-0.9	0.7	-1.8	-0.8	-0.2	-1.2	-0.3	-2.4	-0.8	-1.1
Past tobacco smoking	1.0	1.8	3.9	1.3	-1.1	1.5	1.3	0.4	1.1	2.0	1.2	1.7	0.8	1.4	1.4	1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.3	0.5	0.6	1.2	1.3	0.9	1.3	-0.3	0.5	1.5	1.4	1.8	1.3	1.4
Length of working week for main job	1.0	1.1	2.7	-1.0	-0.9	-1.0	-0.6	-0.6	-0.9	-0.4	-1.1	-1.2	-1.0	-1.6	-1.3	-1.2
Eye problems/disorders: None of the above	1.0	1.2	3.6	-1.2	0.8	-0.7	-0.2	-0.0	0.3	-1.5	-0.7	-1.9	-0.9	-0.8	-1.7	-1.4
Medication: Omeprazole	1.0	1.2	3.3	-1.8	-0.3	-1.0	-0.5	-1.4	0.4	-0.5	-1.1	-1.2	-0.8	-0.6	-1.3	-1.8
Mood swings	1.0	1.9	6.1	-1.5	-0.1	-1.3	-0.3	-1.6	-0.2	-1.3	-0.7	-1.5	-1.7	-0.6	-2.5	-2.0
Diabetes diagnosed by doctor	1.0	1.7	4.4	-0.7	-0.8	-1.4	-1.5	0.5	-1.4	-0.9	-0.7	-1.4	-0.4	-2.1	-1.4	-2.0
Miserableness	1.0	1.8	5.2	-0.9	0.4	-1.7	-1.9	-0.4	-1.3	-2.3	-0.8	-1.6	-0.7	-1.2	-1.4	-1.0
Guilty feelings	1.0	1.5	4.0	-0.7	1.6	-1.3	-1.5	0.2	-2.0	-1.1	-1.0	-1.3	-0.5	-1.1	-1.2	-1.2
Medication: Lisinopril	1.0	1.3	3.6	-0.4	-0.1	-0.8	-0.8	0.7	-1.9	-1.9	-0.0	-1.3	-0.6	-1.7	-1.2	-1.0
HbA1C	0.9	1.0	4.3	-1.1	-2.1	-0.9	-1.3	-1.3	-0.9	-0.6	-1.0	-0.7	-0.8	-0.5	0.0	-0.4
Angina	0.9	1.2	3.0	-0.9	0.9	-1.0	-1.4	0.0	-0.7	-1.1	-0.4	-1.7	-0.3	-1.7	-1.0	-1.6
Current tobacco smoking	0.9	1.4	2.4	-0.8	-0.7	-1.2	-1.3	0.2	-1.5	-1.6	-0.6	-1.5	-0.8	-1.5	-1.4	-1.3
Chronic bronchitis/emphysema (father)	0.9	1.1	3.5	-1.4	-0.1	-1.3	-1.1	-1.9	-0.4	-1.1	-1.2	-0.6	-0.7	-0.1	-1.0	-1.0
Pain all over the body in last month	0.9	0.9	2.2	-0.4	0.8	-1.0	-1.5	0.8	-1.2	-1.1	-0.7	-1.1	0.1	-1.3	-0.7	-0.9
Diabetes (self-reported)	0.9	1.3	3.4	-0.7	-0.8	-1.3	-1.3	0.6	-1.3	-0.6	-1.0	-1.3	-0.2	-1.8	-1.0	-1.8
Shortness of breath walking on level ground	0.9	1.1	2.8	-1.5	0.3	-1.2	-0.4	-0.9	-0.6	0.1	-1.3	-0.7	-1.5	-0.4	-1.7	-1.5
Breast cancer (self-reported)	0.9	1.1	4.8	-1.4	-2.2	-1.0	-0.8	-1.1	-0.3	-0.6	-1.3	-0.8	-0.9	-0.9	-0.6	-0.6
Wears glasses or contact lenses	0.9	1.0	2.0	-1.0	-0.0	-1.1	-0.7	-0.4	-0.6	-1.0	-0.5	-1.2	-1.2	-1.4	-1.4	-1.4
Cholesterol lowering medication	0.9	1.3	2.9	1.3	1.0	0.9	0.6	1.7	-0.2	1.2	1.7	0.6	1.5	1.2	1.0	1.1
Lupus	0.8	1.2	5.5	-1.3	-2.3	-0.8	-0.1	-2.0	1.0	-0.5	-0.7	0.1	-0.6	0.1	-0.6	-0.7
Medication: Levothyroxine sodium	0.8	1.4	4.0	1.3	0.6	0.7	-0.1	0.5	-0.1	0.8	1.2	1.5	1.8	1.2	2.0	1.4
Qualifications: None of the above	0.8	1.7	5.6	-1.9	0.4	-1.4	-0.7	-0.6	-0.5	-2.4	-1.3	-1.7	-0.4	-0.9	-1.2	-1.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	-1.5	0.2	-0.9	-0.6	-0.7	0.7	-1.5	-1.0	-1.2	-0.6	0.1	-1.1	-1.1
Qualifications: nursing, teaching	0.8	1.2	3.1	1.8	0.1	1.2	1.3	0.7	0.2	1.2	1.6	1.6	0.7	0.5	0.8	1.0
Commuting to job workplace: Walk	0.8	0.8	1.9	1.3	0.3	0.8	0.9	-0.2	0.6	0.3	1.1	0.9	1.0	0.8	1.4	1.4
Major Depression (MDD)	0.7	0.9	3.8	0.4	0.7	1.4	1.9	0.3	0.0	1.8	0.6	1.1	0.0	0.0	0.0	0.0
Triglycerides	0.7	1.1	2.9	-0.7	-0.6	-1.1	-1.2	0.4	-1.2	-1.6	-0.4	-1.7	-0.5	-1.2	-0.8	-1.0
Allergy or Eczema	0.7	1.9	3.8	0.6	-1.3	1.5	1.4	-1.2	1.5	0.9	0.6	1.9	0.3	1.8	1.7	1.9
Fluid intelligence score	0.7	1.5	4.7	-1.2	-1.7	-0.9	-0.7	-2.2	-0.5	-1.2	-1.0	-1.0	-1.7	-0.5	-1.0	-0.8
Health satisfaction	0.7	0.9	4.5	0.9	2.1	0.5	-0.1	1.5	-0.8	1.2	0.7	0.2	0.8	-0.3	0.5	0.1
Angina (self-reported)	0.7	1.0	2.8	-0.7	0.9	-0.8	-1.2	0.1	-0.7	-0.9	-0.2	-1.4	-0.2	-1.7	-0.9	-1.5
Smoking status: Previous	0.7	1.1	2.9	-1.2	0.9	-1.1	-1.1	-0.9	-0.3	-1.7	-1.1	-1.3	-0.6	-0.8	-0.8	-1.1
Smoking status: Current	0.7	1.1	2.4	-0.5	-0.5	-1.0	-1.1	0.6	-1.4	-1.5	-0.3	-1.3	-0.6	-1.5	-1.2	-1.2
Number of operations (self-reported)	0.7	1.0	2.2	-1.1	-0.4	-1.1	-1.5	-0.2	-1.0	-0.9	-0.9	-1.4	-0.5	-0.9	-0.9	-1.2
Alzheimer’s Disease (in father)	0.6	0.7	2.1	-0.2	1.4	1.2	1.4	0.2	0.9	0.8	0.2	0.1	-0.3	1.1	0.4	0.5
Sensitivity / hurt feelings	0.6	1.0	4.0	0.5	2.0	0.8	0.6	0.5	1.3	0.4	1.1	0.6	1.2	1.1	0.8	0.9
Systolic blood pressure, automated reading	0.6	1.8	5.0	-0.0	0.7	-1.7	-2.2	1.0	-2.0	-2.0	-0.3	-1.9	0.3	-1.5	-0.4	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-1.0	-0.8	-1.1	-1.6	-0.3	-0.9	-0.8	-0.8	-1.2	-0.5	-1.0	-0.3	-0.5
Multivitamins +/- minerals	0.6	0.8	4.1	0.9	-0.0	-0.7	-1.5	1.1	-1.2	-0.3	0.0	-0.2	0.4	-2.0	-0.1	-0.0
Noisy workplace	0.6	0.7	2.2	-1.1	0.0	-0.8	-0.3	-0.5	0.2	-0.5	-0.4	-0.9	-0.7	-1.2	-1.3	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	5.2	-0.4	-1.6	-0.2	0.7	-2.3	0.7	0.0	-1.0	0.4	-1.6	0.5	-0.5	-0.0
Exposure to tobacco smoke outside home	0.6	0.8	2.2	0.5	0.9	1.1	0.7	1.0	1.3	1.5	1.1	0.3	1.2	-0.1	0.5	-0.1
Ever had bowel cancer screening	0.6	0.7	4.8	0.2	2.2	0.6	0.4	0.5	0.3	0.2	1.1	0.4	0.9	0.7	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.5	-1.0	0.3	-0.8	-0.0	-1.1	-0.0	-1.4	-0.4	-0.9	-0.9	-0.9	-1.6	-1.3
Medication: Atorvastatin	0.6	0.8	1.9	0.4	0.2	1.0	0.2	1.4	1.1	0.5	1.2	0.3	1.4	0.4	1.2	0.7
Irritability	0.6	1.0	3.0	-0.7	1.5	-0.8	-0.3	0.4	-0.8	-1.7	-0.3	-0.9	-0.7	-0.8	-1.6	-1.2
Risk taking	0.6	0.9	2.4	-0.6	-1.4	-1.1	-0.9	-0.3	-0.4	0.3	-1.5	-0.7	-1.3	-1.2	-0.8	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	4.5	-0.7	-2.1	-1.0	-0.8	-0.6	0.1	-0.9	-0.6	-0.4	-0.3	-0.7	-0.4	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	-1.3	-0.2	-0.6	0.1	-1.1	0.8	-0.6	-0.6	-1.0	-0.5	-0.2	-1.3	-1.4
Neuroticism (Nagel 2018)	0.5	1.2	3.4	-1.9	1.7	-0.3	0.6	-1.0	1.5	-0.8	-0.5	-0.8	-0.7	0.5	-1.5	-1.0
Fasting Glucose	0.5	0.6	2.5	0.7	0.8	0.6	0.9	0.5	1.6	0.6	0.2	0.9	0.5	1.0	0.5	0.7
Waist Hip Ratio (WHR)	0.5	2.0	10.0	-0.6	1.4	-1.1	-1.5	2.2	-3.2	-1.6	-0.6	-0.9	0.9	-1.2	0.7	-0.1
Lung FVC	0.5	2.6	6.1	1.2	1.4	1.8	2.5	0.6	2.2	0.5	1.7	1.2	0.9	1.6	1.9	2.1
Neuroticism	0.5	1.2	3.5	-1.8	1.9	-0.6	0.1	-0.8	0.3	-1.5	-0.6	-1.1	-1.0	0.4	-1.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.5	-1.1	1.9	-0.9	-1.1	0.0	-0.9	-1.1	-0.6	-0.0	0.1	0.3	-0.1	-0.2
Had menopause	0.5	0.7	1.2	0.7	0.6	0.7	0.2	0.9	-0.1	1.1	0.5	1.0	1.0	0.9	1.1	1.0
Had other major operations	0.5	0.6	1.4	-0.8	-0.7	-0.8	-0.6	-1.2	-0.3	-0.3	-0.3	-1.0	-0.8	-0.9	-0.8	-1.0
Lung cancer (father)	0.5	0.6	1.5	-1.1	-0.3	-1.0	-0.4	-0.6	-0.5	0.2	-0.9	-0.6	-1.1	-0.2	-1.2	-0.9
Number of full brothers	0.5	0.6	2.2	1.2	0.2	0.2	0.0	1.5	-0.2	0.8	1.0	0.6	1.1	0.1	0.8	0.6
Pulse rate, automated reading	0.5	1.8	3.6	1.9	-1.1	1.5	1.4	1.6	0.5	1.6	1.3	1.5	1.2	0.7	1.1	1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.8	-0.6	-0.7	-1.1	-1.3	-0.1	-1.2	-1.1	-0.3	-0.7	-0.3	-0.7	-0.0	-0.5
Average weekly red wine intake	0.5	0.7	2.2	1.1	-0.0	1.0	0.7	-0.0	0.1	0.2	0.7	1.1	0.8	0.7	1.5	1.2
Medication for cholesterol	0.5	0.7	2.8	-0.6	-1.7	0.3	0.6	-1.5	1.5	0.5	-0.5	0.8	-0.4	0.1	0.1	-0.0
Back pain experienced in last month	0.5	0.7	2.0	-1.4	-0.7	-0.9	-0.6	-1.2	-0.6	-0.8	-0.9	-0.5	-0.8	-0.1	-1.0	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.3	-0.5	-0.5	-0.4	-0.5	-0.6	-0.6	-0.2	-0.7	-0.9	-1.4	-1.2	-1.4
Osteoarthritis (self-reported)	0.5	0.6	1.3	-1.0	-1.1	-0.5	-0.3	-0.9	-0.4	-0.9	-0.7	-1.2	-0.7	-0.9	-0.5	-0.7
Diastolic blood pressure, automated reading	0.5	1.5	3.8	0.6	-1.1	-1.3	-1.9	1.6	-1.9	-1.3	0.1	-1.2	0.5	-1.7	-0.1	-0.2
Alcohol drinker status: Previous	0.5	0.5	2.2	-0.5	0.0	-0.7	-1.4	0.1	-1.5	-1.0	-0.4	-0.6	0.3	-0.7	0.0	-0.2
Depression (Nagel 2018)	0.4	0.6	2.4	-0.3	1.6	0.3	0.6	-0.2	0.9	0.5	0.4	1.2	0.5	1.1	-0.0	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.9	-0.9	-1.1	-1.1	-1.2	-1.7	-1.3	-0.9	-1.4	-0.9	-1.3	-0.6	-0.7	-0.4
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	-1.2	1.2	-0.5	-0.2	-1.5	0.9	0.2	-0.2	-1.4	-0.6	-0.4	-1.4	-1.5
Reaction Time	0.4	0.7	1.9	0.6	1.4	0.7	1.2	-0.5	0.5	0.4	0.8	0.7	-0.0	1.3	0.2	0.9
Systolic Blood Pressure	0.4	2.2	7.2	0.5	1.0	-0.7	-2.1	2.4	-2.7	-1.4	0.7	-1.6	0.9	-1.9	0.5	0.1
Vitamin and mineral supplements	0.4	0.5	1.5	-1.0	-0.1	-0.1	0.4	-1.2	0.4	-0.8	-0.9	-0.3	-0.8	1.2	-0.3	-0.1
Pack years adult smoking proportion	0.4	0.6	3.5	-1.1	-1.9	-0.8	-0.6	-0.4	-0.6	0.3	-0.9	-0.2	-0.5	0.1	-0.5	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	6.4	-0.4	-2.5	0.0	0.1	-1.7	0.4	-0.0	-0.8	0.8	-0.8	0.4	0.5	0.6
Allergy	0.4	0.9	5.0	0.4	2.2	0.2	0.2	1.9	-0.5	0.2	0.9	-0.2	1.0	-0.2	-0.0	-0.1
Neuroticism score	0.4	0.8	6.6	-0.8	2.6	-0.3	-0.0	-0.2	0.2	-1.1	-0.1	-0.6	-0.2	0.6	-1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	4.3	-0.3	2.1	0.2	-0.1	1.4	-0.3	-0.5	0.2	-0.4	0.8	-0.1	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.2	-0.3	-0.6	-1.1	-0.8	-0.0	-1.7	-1.5	-0.9	-1.1	-1.0	-2.3	-0.8	-0.8
Prospective memory result	0.4	0.5	1.9	0.6	1.4	0.3	0.8	1.2	0.0	0.8	-0.0	0.5	0.7	0.5	0.5	0.3
Pulse wave reflection index	0.4	0.5	1.7	0.2	1.0	-0.6	-0.4	-0.0	-0.9	-1.3	-0.2	-0.7	-0.5	-0.8	-0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.2	1.2	0.2	1.1	0.9	0.3	0.5	1.0	1.5	0.8	0.3	0.3	0.2	0.4
Gout (self-reported)	0.4	0.6	1.7	-1.3	-0.5	-1.2	-0.6	-0.6	-0.0	-1.0	-1.0	-0.4	-0.4	0.0	-0.5	-0.9
Medication: Amlodipine	0.4	0.6	2.2	0.8	1.5	0.3	-0.2	1.2	-0.6	-0.3	1.2	-0.3	0.9	-0.2	0.3	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.5	4.8	-0.6	-1.2	-1.3	-1.0	-0.5	-1.4	-1.5	-1.2	-1.1	-1.5	-2.2	-0.7	-0.6
Migraine (self-reported)	0.4	0.5	2.2	-0.4	0.4	0.6	0.7	-0.6	0.9	0.7	0.0	0.6	0.0	1.5	0.4	0.8
Number of full sisters	0.4	0.5	1.7	-0.7	-0.5	-0.8	-1.3	-1.0	-0.4	-0.7	-0.5	-0.7	-0.0	-0.7	-0.2	-0.8
Overall health rating	0.4	0.8	2.1	-1.3	-0.4	-1.1	-1.0	0.1	-0.9	-0.3	-0.7	-0.9	-0.2	-0.9	-1.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.5	-0.3	0.6	0.7	1.0	-0.6	1.0	0.2	0.3	0.7	0.4	1.6	-0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	-1.0	0.5	-0.0	0.3	0.2	1.5	1.1	0.1	0.3	0.7	0.7	-0.1	-0.8
Hearing aid user	0.4	0.5	2.5	-0.8	-0.1	-1.0	-1.6	-0.1	-0.8	-0.7	-0.7	-0.4	-0.3	0.5	-0.2	-0.2
Ever smoked	0.4	0.6	2.7	0.1	1.6	-0.3	-0.4	1.1	-1.2	-0.5	-0.2	-0.6	-0.3	-1.0	-0.7	-0.5
Pain experienced in last month	0.4	0.7	1.4	0.7	-0.6	0.4	0.3	1.2	0.8	1.1	0.2	1.0	0.9	0.6	1.2	0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.0	-0.7	-0.5	-0.8	-0.8	-1.7	-0.8	-0.8	-0.9	-0.8	-1.2	-0.3	-0.9	-0.6
Age at First Birth	0.3	0.4	1.3	1.1	0.4	0.7	0.7	-0.6	0.7	0.4	0.2	1.0	0.8	0.2	0.6	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.5	-1.1	0.5	-0.5	-0.3	-0.8	0.3	-1.1	-0.8	0.2	-0.3	1.2	-0.1	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.4	0.8	-0.7	-0.9	-0.1	-0.2	-0.7	-0.9	-0.5	0.3	-0.5	0.2	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	0.2	0.4	0.4	0.6	1.0	0.3	0.7	0.5	0.9	0.8	0.5	0.6	0.3
Supplements: Zinc	0.3	0.3	1.1	-0.1	-1.0	-0.3	0.0	-0.2	-0.1	0.6	-0.3	0.0	-0.4	-0.9	-0.5	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.1	0.1	-1.0	0.4	0.1	-0.1	0.7	1.4	0.1	-0.1	-0.1	-0.0	0.1	-0.0
Stomach or abdominal pain in last month	0.3	0.3	2.2	-0.7	1.5	0.7	0.3	0.4	0.4	0.1	0.1	-0.1	0.5	0.6	0.5	0.1
Sitting height	0.3	2.1	7.8	0.8	0.3	-0.8	-2.0	2.2	-2.8	-1.3	-0.1	0.6	1.6	-2.0	1.0	0.1
Falls in the last year	0.3	0.4	1.1	0.3	-1.1	0.0	-1.0	-0.1	-0.2	0.8	-0.1	-0.2	0.8	-0.9	0.9	-0.0
Pulse wave Arterial Stiffness index	0.3	0.4	2.5	0.3	0.8	-0.2	-0.2	1.6	-0.8	-0.5	0.4	-0.4	0.6	-0.4	0.1	0.1
Breastfed as a baby	0.3	0.4	1.3	0.5	-0.6	0.7	0.3	-0.2	0.3	1.0	0.5	1.1	0.4	0.5	0.9	0.7
Peak expiratory flow (PEF)	0.3	0.8	3.2	1.8	0.6	0.7	0.3	1.1	-0.9	0.5	1.3	0.2	0.8	-1.0	0.6	0.5
Pulse wave peak to peak time	0.3	0.4	2.5	-0.4	-1.1	-0.1	-0.2	-1.6	0.2	0.1	-0.6	0.2	-0.7	0.0	-0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.7	-0.2	-0.8	-0.6	-0.6	-0.3	0.0	-0.5	-0.6	-0.8	-0.9	-0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	0.3	0.3	0.4	-0.2	0.7	0.3	0.7	0.3	0.9	1.1	0.7	0.9	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	2.3	0.1	-0.2	-0.3	-1.0	-0.5	-1.5	0.1	-0.4	-0.0	-0.4	-0.4	-0.1	0.0
Mineral and other dietary supplements	0.3	0.4	2.4	-0.2	0.6	0.4	1.5	0.5	0.8	0.5	0.1	0.3	-0.2	0.7	-0.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.8	0.8	0.3	0.0	-1.3	0.0	-0.5	0.3	0.2	0.6	0.8	0.0	1.0	0.8
Medication: Paracetamol	0.3	0.4	1.7	-0.2	0.7	-0.6	-0.3	0.5	-0.2	0.1	0.1	-1.0	-0.6	-0.6	-1.3	-0.9
Average weekly beer plus cider intake	0.3	0.4	1.6	-0.5	0.7	0.1	0.1	-0.1	1.1	-0.9	-0.1	-0.0	1.3	0.3	0.6	-0.4
Unable to work because of sickness or disability	0.3	0.3	1.1	-0.6	-0.4	-0.3	-0.3	0.4	-0.0	-0.0	-0.6	-1.1	-0.7	-0.8	-0.7	-0.8
Pack years of smoking	0.3	0.4	2.1	-0.9	-1.5	-0.6	-0.4	-0.2	-0.4	0.6	-0.8	0.1	-0.3	0.4	-0.2	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	1.6	-0.2	1.3	-0.1	0.2	-0.4	-0.1	0.1	-0.7	0.4	-0.2	0.9	-0.4	0.2
Breast Cancer	0.2	0.6	1.0	-0.5	-0.3	-0.7	-0.8	-0.7	-0.3	-1.0	-0.7	-1.0	-0.5	-1.0	-0.7	-1.0
Blood Platelet Count	0.2	2.8	8.5	1.2	0.9	1.3	1.7	-0.3	0.9	1.4	1.4	2.4	1.2	2.9	1.7	2.4
Tanning	0.2	1.9	6.9	-0.1	-1.0	1.7	1.7	0.4	2.6	1.6	1.1	0.7	0.8	1.8	0.8	1.4
Average weekly spirits intake	0.2	0.2	0.8	-0.2	-0.7	0.3	-0.3	0.2	0.2	-0.4	0.9	0.2	0.7	-0.0	0.7	0.5
Severe depression (siblings)	0.2	0.2	0.9	0.0	-0.3	-0.1	-0.2	-0.3	-0.4	-0.1	0.1	-0.8	-0.0	-1.0	-0.6	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.2	0.3	-0.4	-0.9	0.5	-0.7	-0.6	-0.0	-0.4	0.6	-0.8	0.2	-0.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	0.5	0.3	0.5	0.7	-0.0	0.9	0.6	0.4	0.5	0.1	0.2	0.3	0.7
Heart attack	0.2	0.2	0.5	0.3	-0.1	0.4	0.0	0.7	-0.6	-0.1	0.4	0.3	0.7	-0.3	0.7	0.2
Illnesses of siblings	0.2	0.3	1.2	0.4	0.4	0.4	0.5	-0.5	1.1	0.2	-0.0	0.7	0.0	0.6	0.4	0.7
Depression (self-reported)	0.2	0.2	1.3	-0.0	0.7	-0.1	0.5	-0.0	0.6	0.1	-0.3	0.7	0.0	1.1	-0.2	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.8	-0.7	-0.3	-0.4	-0.4	-0.3	-0.5	0.0	-0.2	-0.4	-0.7	-0.7	-1.3	-1.2
Headache pain in last month	0.2	0.3	1.3	-0.0	1.1	0.1	-0.1	-0.9	-0.4	-0.3	-0.1	-0.4	-0.4	0.8	0.1	0.7
High blood pressure (siblings)	0.2	0.2	0.6	0.6	0.5	0.4	0.1	0.7	-0.4	0.2	0.7	-0.6	0.6	-0.1	0.3	0.1
Worry too long after embarrassment	0.2	0.3	0.9	-0.2	0.9	0.7	0.3	0.0	0.8	0.3	0.4	0.5	0.7	0.8	0.4	0.2
Chest pain or discomfort	0.2	0.3	1.2	0.4	0.9	0.3	-0.3	1.1	0.3	0.8	0.7	0.1	0.8	-0.5	0.4	0.0
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.2	0.7	-0.3	-0.8	0.8	-0.7	-0.4	-0.1	-0.2	0.4	-0.6	-0.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	0.6	0.8	0.5	0.3	0.8	-0.1	0.6	0.3	0.5	0.6	-0.5	0.2	0.1
Financial situation satisfaction	0.2	0.2	0.6	-0.8	0.3	-0.8	-0.6	-0.1	-0.6	0.1	-0.6	0.2	-0.0	-0.3	-0.1	-0.2
Alcohol drinker status: Never	0.2	0.3	0.7	0.2	0.1	-0.6	-0.5	-0.4	-0.8	-0.1	-0.3	-0.8	-0.4	-0.8	-0.4	-0.4
Age started oral contraceptive pill	0.2	0.2	0.9	-0.1	-0.3	0.2	0.6	-1.0	0.0	0.2	-0.1	0.5	-0.3	0.8	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.5	0.1	0.5	0.1	0.8	-0.6	0.1	0.5	0.4	0.9	-0.2	0.9	0.4
Heart disease (siblings)	0.2	0.3	0.9	-0.3	0.5	-0.3	-0.9	0.3	-0.7	-0.9	0.3	-0.2	0.8	-0.3	0.4	-0.0
Ovarian Cancer	0.1	0.1	0.4	0.3	0.5	0.1	0.5	-0.3	0.6	0.2	-0.1	0.2	0.0	0.3	-0.1	0.0
HDL Cholesterol	0.1	0.1	0.7	-0.0	0.1	0.1	0.8	-0.5	0.9	0.0	0.1	0.3	0.0	0.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	-0.9	0.5	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.4	0.7	0.5	-0.4	-0.1	0.0	0.8	0.2	0.6	0.5	0.6	0.3	0.5
Medication: Atenolol	0.1	0.2	0.6	-0.2	0.4	-0.3	-0.6	0.4	-0.7	-0.1	-0.1	-0.8	0.2	-0.4	0.2	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.7	0.1	-0.6	-0.6	-0.9	0.1	-0.1	-0.2	0.0	0.1	-0.0	-0.6	0.0	0.0
Father’s age at death	0.1	0.2	1.1	0.2	1.0	-0.1	0.5	-0.0	0.6	0.1	0.1	0.7	0.3	0.2	0.2	0.3
Medication: Lansoprazole	0.1	0.1	0.4	-0.3	0.1	-0.4	-0.1	-0.6	0.2	-0.3	-0.5	-0.3	-0.5	0.4	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	1.0	0.5	0.6	0.9	1.0	0.3	0.1	0.4	0.8	0.5	-0.3	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	0.4	0.2	0.3	-0.1	-0.1	0.0	-0.1	0.6	-0.0	0.5	-0.3	0.7	0.5
Age at first live birth	0.1	0.2	0.9	0.6	-0.9	0.5	0.2	0.4	-0.6	0.3	0.1	0.3	-0.1	-0.3	0.4	0.6
Medication: Allopurinol	0.1	0.2	0.6	-0.8	0.1	-0.6	-0.0	0.1	0.1	-0.2	-0.7	-0.1	-0.2	0.2	-0.5	-0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.7	-0.8	-0.2	-0.2	-0.2	-0.9	-0.2	0.1	-0.5	0.2	-0.5	-0.0	-0.3	-0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.5	-0.4	0.7	0.2	-0.2	0.5	-0.0	-0.0	0.4	-0.3	0.5	0.3	0.2	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.6	-0.1	0.3	0.1	0.5	-0.1	0.2	0.4	-0.1	0.4	-0.0	0.4	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.2	1.0	-0.2	-1.0	-0.0	0.2	-0.3	-0.3	0.4	0.3	0.1	-0.1	-0.6	-0.2	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	1.1	-1.1	0.4	0.1	0.5	-0.1	-0.4	-0.6	-0.1	-0.3	-0.4	0.3	-0.0	-0.0

Hub : Genes

MAPK3

Models

Trait associations