Best TWAS P=4.63e-13 · Best GWAS P=1.58e-12 conditioned to 0.52
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | COL21A1 | 0.17 | 0.11 | lasso | 5 | 0.12 | 2.7e-10 | 7.0 | -6.9 | 6.5e-12 | -0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | COL21A1 | 0.17 | 0.05 | lasso | 8 | 0.03 | 9.3e-03 | 5.7 | -5.8 | 6.3e-09 | -0.87 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Nerve Tibial | COL21A1 | 0.26 | 0.11 | lasso | 10 | 0.15 | 9.7e-11 | 7.1 | -7.2 | 4.6e-13 | -0.95 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | COL21A1 | 0.11 | 0.07 | lasso | 14 | 0.05 | 7.7e-05 | 4.8 | -5.3 | 1.1e-07 | -0.50 | 0.57 | 0.34 | FALSE |
| 5 | GTEx | Thyroid | COL21A1 | 0.12 | 0.08 | lasso | 3 | 0.10 | 8.0e-08 | 5.6 | -6.7 | 2.4e-11 | -0.92 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | COL21A1 | 0.12 | 0.10 | blup | 243 | 0.10 | 7.0e-09 | 6.6 | -6.2 | 7.6e-10 | -0.83 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | COL21A1 | 0.22 | 0.34 | lasso | 7 | 0.33 | 8.9e-71 | 7.1 | -7.1 | 9.7e-13 | -0.99 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COL21A1 | 0.41 | 0.55 | lasso | 5 | 0.55 | 2.7e-74 | 7.1 | -7.1 | 1.6e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | COL21A1 | 0.09 | 0.01 | blup | 245 | 0.02 | 1.5e-02 | 7.1 | -5.8 | 6.0e-09 | -0.82 | 0.00 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | COL21A1 | 0.18 | 0.09 | blup | 240 | 0.13 | 7.1e-07 | 7.1 | -7.0 | 3.5e-12 | -0.90 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | COL21A1 | 0.08 | 0.08 | lasso | 2 | 0.05 | 4.1e-03 | 6.3 | -6.5 | 7.0e-11 | -0.91 | 0.02 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | COL21A1 | 0.39 | 0.39 | lasso | 3 | 0.37 | 1.5e-15 | 7.1 | -7.0 | 2.5e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | COL21A1 | 0.15 | 0.14 | enet | 20 | 0.12 | 1.1e-12 | 7.1 | -6.0 | 1.7e-09 | -0.92 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | COL21A1 | 0.32 | 0.31 | lasso | 5 | 0.29 | 2.2e-08 | 7.1 | -7.0 | 3.1e-12 | -0.99 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | COL21A1 | 0.12 | 0.03 | blup | 243 | 0.09 | 7.9e-07 | 7.1 | -5.3 | 1.0e-07 | -0.79 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | COL21A1 | 0.29 | 0.40 | lasso | 8 | 0.40 | 7.3e-41 | 7.1 | -7.1 | 1.1e-12 | -1.00 | 0.00 | 1.00 | FALSE |