[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr6:78,880,271-80,486,611

Best TWAS P=3.06e-16 · Best GWAS P=1.7e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	IRAK1BP1	0.12	0.10	lasso	4	0.15	2.7e-12	7.9	7.4	1.3e-13	0.90	0.04	0.96	FALSE
2	GTEx	Adipose Visceral Omentum	IRAK1BP1	0.17	0.16	enet	20	0.19	2.5e-10	7.9	7.6	3.5e-14	0.97	0.03	0.97	FALSE
3	GTEx	Adrenal Gland	IRAK1BP1	0.33	0.40	enet	31	0.40	1.5e-15	7.9	8.2	3.1e-16	0.97	0.03	0.97	TRUE
4	GTEx	Artery Aorta	IRAK1BP1	0.17	0.15	lasso	1	0.11	1.6e-06	7.9	7.9	3.4e-15	1.00	0.03	0.97	FALSE
5	GTEx	Artery Coronary	IRAK1BP1	0.11	-0.01	lasso	3	0.01	1.8e-01	7.9	7.5	9.2e-14	0.85	0.04	0.83	FALSE
6	GTEx	Artery Coronary	PHIP	0.17	0.02	lasso	5	0.02	8.5e-02	4.6	6.7	2.7e-11	0.71	0.11	0.63	FALSE
7	GTEx	Artery Tibial	IRAK1BP1	0.11	0.15	lasso	4	0.16	1.4e-12	7.9	7.7	1.8e-14	0.98	0.03	0.97	FALSE
8	GTEx	Brain Caudate basal ganglia	IRAK1BP1	0.11	0.12	enet	7	0.09	1.3e-03	-6.5	5.9	3.3e-09	0.91	0.04	0.80	FALSE
9	GTEx	Brain Cerebellar Hemisphere	IRAK1BP1	0.21	0.13	enet	26	0.12	4.4e-04	-5.8	6.3	2.8e-10	0.85	0.04	0.95	FALSE
10	GTEx	Brain Hypothalamus	IRAK1BP1	0.21	0.16	enet	28	0.18	4.4e-05	-6.0	6.1	1.2e-09	0.85	0.05	0.91	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	IRAK1BP1	0.11	0.08	lasso	10	0.07	6.0e-03	7.8	-8.0	8.8e-16	-0.97	0.04	0.87	FALSE
12	GTEx	Breast Mammary Tissue	IRAK1BP1	0.09	0.07	enet	10	0.07	1.1e-04	7.9	7.9	2.6e-15	0.88	0.04	0.94	FALSE
13	GTEx	Breast Mammary Tissue (Male)	IRAK1BP1	0.10	0.00	enet	2	0.00	3.9e-01	-6.0	6.0	1.9e-09	0.73	0.05	0.29	FALSE
14	GTEx	Cells Transformed fibroblasts	IRAK1BP1	0.25	0.35	enet	30	0.36	3.5e-28	7.9	7.6	2.8e-14	0.95	0.03	0.97	FALSE
15	GTEx	Colon Sigmoid	IRAK1BP1	0.19	0.20	lasso	2	0.17	1.0e-06	7.9	7.9	3.4e-15	1.00	0.03	0.97	FALSE
16	GTEx	Colon Transverse	IRAK1BP1	0.11	0.18	lasso	2	0.16	4.0e-08	-5.8	5.8	6.1e-09	0.81	0.11	0.89	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	IRAK1BP1	0.18	0.18	enet	34	0.18	4.7e-07	7.9	7.5	9.1e-14	0.97	0.03	0.97	FALSE
18	GTEx	Esophagus Mucosa	IRAK1BP1	0.16	0.13	lasso	4	0.13	4.2e-09	-4.9	5.5	4.2e-08	0.75	0.95	0.05	FALSE
19	GTEx	Esophagus Muscularis	IRAK1BP1	0.17	0.22	lasso	4	0.22	1.6e-13	7.9	7.6	4.0e-14	0.98	0.03	0.97	FALSE
20	GTEx	Esophagus Muscularis	PHIP	0.08	0.04	enet	15	0.02	3.6e-02	7.9	6.9	3.7e-12	0.88	0.04	0.93	FALSE
21	GTEx	Heart Atrial Appendage	IRAK1BP1	0.15	0.14	lasso	2	0.12	4.6e-06	7.9	7.6	3.0e-14	0.98	0.03	0.96	FALSE
22	GTEx	Heart Left Ventricle	IRAK1BP1	0.17	0.20	lasso	5	0.20	8.7e-11	7.8	7.8	4.4e-15	1.00	0.03	0.97	FALSE
23	GTEx	Liver	IRAK1BP1	0.16	0.01	enet	22	0.06	9.3e-03	7.9	5.8	5.6e-09	0.86	0.05	0.74	FALSE
24	GTEx	Lung	IRAK1BP1	0.14	0.18	lasso	5	0.17	3.9e-13	7.9	8.0	1.4e-15	0.99	0.03	0.97	FALSE
25	GTEx	Muscle Skeletal	IRAK1BP1	0.10	0.11	lasso	2	0.10	1.3e-09	7.9	8.0	1.2e-15	1.00	0.03	0.97	FALSE
26	GTEx	Nerve Tibial	IRAK1BP1	0.12	0.16	lasso	6	0.14	8.8e-10	-5.8	7.0	3.4e-12	0.93	0.04	0.96	FALSE
27	GTEx	Ovary	IRAK1BP1	0.13	0.15	lasso	2	0.06	1.2e-02	7.8	7.8	4.2e-15	1.00	0.04	0.90	FALSE
28	GTEx	Pancreas	IRAK1BP1	0.24	0.23	lasso	8	0.25	6.1e-11	7.9	7.7	1.5e-14	0.96	0.03	0.97	FALSE
29	GTEx	Prostate	IRAK1BP1	0.15	0.08	enet	7	0.09	2.4e-03	7.9	7.5	9.0e-14	0.92	0.05	0.87	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	IRAK1BP1	0.10	0.09	lasso	4	0.08	3.3e-05	-4.8	5.6	2.3e-08	0.76	0.69	0.26	FALSE
31	GTEx	Skin Sun Exposed Lower leg	IRAK1BP1	0.17	0.18	lasso	4	0.18	2.0e-14	-5.8	5.9	2.9e-09	0.81	0.97	0.03	FALSE
32	GTEx	Spleen	IRAK1BP1	0.20	0.16	enet	6	0.12	5.3e-04	-5.8	5.8	7.0e-09	0.75	0.09	0.67	FALSE
33	GTEx	Stomach	IRAK1BP1	0.18	0.14	enet	32	0.14	2.6e-07	7.9	7.3	2.2e-13	0.95	0.03	0.97	FALSE
34	GTEx	Testis	IRAK1BP1	0.39	0.56	lasso	11	0.58	7.7e-31	7.9	7.9	3.6e-15	1.00	0.03	0.97	FALSE
35	GTEx	Thyroid	IRAK1BP1	0.09	0.12	lasso	9	0.11	5.2e-09	7.9	8.1	6.8e-16	0.99	0.03	0.97	FALSE
36	METSIM	Adipose	IRAK1BP1	0.15	0.17	lasso	6	0.16	1.1e-23	-5.8	5.7	9.0e-09	0.81	1.00	0.00	FALSE
37	YFS	Blood	PHIP	0.05	0.07	lasso	5	0.08	1.8e-24	-5.8	6.0	2.4e-09	0.80	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	IRAK1BP1	0.03	0.03	lasso	4	0.02	1.2e-03	-5.8	6.2	6.5e-10	0.85	0.03	0.76	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	PHIP	0.11	0.08	blup	75	0.07	2.6e-07	7.9	6.4	1.1e-10	0.90	0.02	0.98	FALSE