Best TWAS P=1.06e-10 · Best GWAS P=1.24e-10 conditioned to 0.174
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SGIP1 | 0.21 | 0.08 | lasso | 8 | 0.11 | 1.1e-06 | -5.0 | 5.5 | 3.3e-08 | -0.79 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Brain Cortex | TCTEX1D1 | 0.27 | 0.23 | lasso | 7 | 0.26 | 8.7e-08 | 3.9 | -5.2 | 2.4e-07 | 0.53 | 0.48 | 0.27 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | TCTEX1D1 | 0.20 | 0.00 | lasso | 6 | 0.04 | 4.1e-02 | -5.9 | -6.3 | 2.4e-10 | 0.66 | 0.09 | 0.55 | FALSE |
| 4 | GTEx | Colon Transverse | SGIP1 | 0.19 | 0.01 | enet | 25 | 0.04 | 5.0e-03 | 1.7 | 6.1 | 1.4e-09 | -0.63 | 0.04 | 0.91 | FALSE |
| 5 | GTEx | Heart Left Ventricle | SGIP1 | 0.24 | 0.26 | lasso | 7 | 0.28 | 3.1e-15 | 5.1 | 5.6 | 1.7e-08 | -0.56 | 0.80 | 0.20 | FALSE |
| 6 | GTEx | Muscle Skeletal | SGIP1 | 0.07 | 0.04 | enet | 15 | 0.02 | 3.1e-03 | 4.4 | 5.2 | 2.6e-07 | -0.51 | 0.61 | 0.29 | FALSE |
| 7 | GTEx | Nerve Tibial | SGIP1 | 0.18 | 0.06 | lasso | 3 | 0.07 | 1.4e-05 | 5.6 | 5.9 | 4.5e-09 | -0.58 | 0.22 | 0.75 | FALSE |
| 8 | GTEx | Testis | SGIP1 | 0.28 | 0.22 | lasso | 8 | 0.21 | 1.3e-09 | -5.5 | 6.5 | 1.1e-10 | -0.91 | 0.01 | 0.99 | TRUE |