Best TWAS P=3.42e-14 · Best GWAS P=5.94e-12 conditioned to 0.216
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | ARL14EP | 0.38 | 0.31 | enet | 34 | 0.32 | 4.1e-11 | 6.9 | -5.4 | 6.5e-08 | -0.80 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Spleen | ARL14EP | 0.34 | 0.19 | enet | 24 | 0.30 | 1.7e-08 | 6.9 | -7.6 | 3.4e-14 | -0.81 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Stomach | ARL14EP | 0.10 | 0.07 | lasso | 3 | 0.04 | 4.0e-03 | -5.7 | -5.7 | 1.2e-08 | -0.43 | 0.57 | 0.18 | FALSE |
| 4 | GTEx | Whole Blood | ARL14EP | 0.07 | 0.05 | lasso | 2 | 0.05 | 3.3e-05 | 6.4 | -6.5 | 7.6e-11 | -0.90 | 0.01 | 0.99 | FALSE |
| 5 | NTR | Blood | C11orf46 | 0.02 | 0.01 | blup | 400 | 0.01 | 3.8e-05 | 6.4 | -6.9 | 4.3e-12 | -0.76 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C11orf46 | 0.05 | 0.05 | lasso | 5 | 0.06 | 6.2e-12 | 6.6 | -6.6 | 4.4e-11 | -0.90 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf46 | 0.12 | 0.08 | blup | 34 | 0.07 | 5.7e-05 | -3.7 | -5.3 | 1.2e-07 | -0.79 | 0.03 | 0.78 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | C11orf46 | 0.17 | 0.07 | blup | 34 | 0.11 | 2.5e-04 | 4.0 | -5.2 | 1.7e-07 | -0.82 | 0.00 | 0.90 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf46 | 0.06 | 0.06 | lasso | 2 | 0.05 | 5.5e-06 | 6.9 | -6.8 | 9.2e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf46 | 0.36 | 0.27 | lasso | 5 | 0.30 | 8.3e-34 | 6.9 | -6.6 | 3.9e-11 | -0.97 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C11orf46 | 0.13 | 0.12 | lasso | 3 | 0.11 | 8.9e-07 | 6.9 | -6.9 | 6.1e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C11orf46 | 0.12 | 0.07 | blup | 34 | 0.07 | 4.4e-04 | 6.9 | -6.0 | 1.5e-09 | -0.84 | 0.00 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | C11orf46 | 0.09 | 0.11 | lasso | 4 | 0.10 | 1.2e-11 | 6.9 | -6.9 | 4.3e-12 | -0.99 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C11orf46 | 0.22 | 0.22 | lasso | 3 | 0.20 | 1.1e-08 | 6.9 | -6.9 | 4.4e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf46 | 0.09 | 0.07 | lasso | 2 | 0.06 | 2.4e-07 | 6.9 | -6.9 | 5.9e-12 | -1.00 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C11orf46 | 0.11 | 0.05 | enet | 7 | 0.09 | 3.4e-07 | 6.6 | -5.3 | 1.3e-07 | -0.87 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf46 | 0.12 | 0.06 | blup | 34 | 0.10 | 1.4e-09 | 6.9 | -5.9 | 3.1e-09 | -0.83 | 0.00 | 1.00 | FALSE |