Best TWAS P=7.14e-51 · Best GWAS P=5.78e-71 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | POC1B | 0.12 | 0.08 | lasso | 9 | 0.09 | 1.7e-07 | -8.77 | 8.1 | 4.4e-16 | -0.58 | 0.96 | 0.03 | FALSE |
| 2 | GTEx | Adrenal Gland | RP11-981P6.1 | 0.33 | 0.29 | lasso | 3 | 0.19 | 2.2e-07 | -8.77 | -9.8 | 9.8e-23 | 0.54 | 0.99 | 0.00 | TRUE |
| 3 | GTEx | Artery Aorta | POC1B | 0.12 | 0.07 | lasso | 5 | 0.04 | 3.9e-03 | -8.74 | 6.3 | 3.9e-10 | -0.53 | 0.22 | 0.14 | FALSE |
| 4 | GTEx | Artery Tibial | ATP2B1 | 0.08 | 0.01 | enet | 10 | 0.03 | 3.5e-03 | -17.77 | -15.0 | 7.1e-51 | 0.87 | 0.01 | 0.97 | TRUE |
| 5 | GTEx | Artery Tibial | RP11-981P6.1 | 0.07 | 0.06 | lasso | 1 | 0.03 | 1.3e-03 | -8.55 | -8.6 | 1.2e-17 | 0.57 | 0.60 | 0.02 | FALSE |
| 6 | GTEx | Brain Cerebellum | RP11-981P6.1 | 0.47 | 0.27 | enet | 41 | 0.21 | 7.1e-07 | 0.81 | -6.2 | 6.7e-10 | 0.46 | 0.75 | 0.16 | FALSE |
| 7 | GTEx | Colon Sigmoid | RP11-981P6.1 | 0.19 | 0.12 | lasso | 4 | 0.11 | 9.7e-05 | -8.77 | -8.4 | 4.9e-17 | 0.58 | 0.31 | 0.11 | FALSE |
| 8 | GTEx | Colon Transverse | RP11-981P6.1 | 0.14 | 0.05 | enet | 26 | 0.05 | 1.9e-03 | -8.83 | -6.8 | 8.3e-12 | 0.50 | 0.25 | 0.39 | TRUE |
| 9 | GTEx | Esophagus Muscularis | RP11-981P6.1 | 0.18 | 0.10 | lasso | 3 | 0.06 | 2.9e-04 | -8.75 | -8.6 | 1.2e-17 | 0.59 | 0.82 | 0.11 | TRUE |
| 10 | GTEx | Lung | RP11-981P6.1 | 0.08 | 0.01 | lasso | 3 | 0.01 | 3.9e-02 | -8.77 | -10.6 | 2.8e-26 | 0.61 | 0.23 | 0.32 | TRUE |
| 11 | GTEx | Nerve Tibial | POC1B | 0.30 | 0.18 | lasso | 6 | 0.22 | 1.0e-15 | 6.02 | 8.6 | 1.3e-17 | -0.44 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Prostate | POC1B | 0.25 | 0.00 | enet | 37 | 0.01 | 1.6e-01 | -14.95 | 8.2 | 3.0e-16 | -0.50 | 0.02 | 0.64 | FALSE |
| 13 | GTEx | Spleen | RP11-981P6.1 | 0.28 | 0.18 | lasso | 13 | 0.14 | 2.1e-04 | -8.55 | -9.1 | 7.6e-20 | 0.61 | 0.19 | 0.57 | FALSE |
| 14 | GTEx | Thyroid | RP11-981P6.1 | 0.24 | 0.25 | lasso | 5 | 0.26 | 3.9e-20 | -8.75 | -9.7 | 3.5e-22 | 0.64 | 1.00 | 0.00 | FALSE |
| 15 | METSIM | Adipose | POC1B | 0.07 | 0.03 | bslmm | 381 | 0.03 | 5.2e-05 | -8.83 | 10.6 | 4.5e-26 | -0.56 | 0.90 | 0.03 | TRUE |
| 16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC338758 | 0.14 | 0.00 | enet | 6 | 0.01 | 6.2e-02 | 3.98 | -10.2 | 1.4e-24 | 0.32 | 0.01 | 0.07 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GALNT4 | 0.05 | 0.05 | lasso | 2 | 0.04 | 8.7e-06 | 6.03 | 6.3 | 2.6e-10 | -0.24 | 0.84 | 0.01 | TRUE |