Best TWAS P=6.93e-11 · Best GWAS P=4.39e-08 conditioned to 0.65
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | WDR66 | 0.25 | 0.14 | lasso | 5 | 0.17 | 2.1e-06 | 5.09 | 5.5 | 2.9e-08 | -0.08 | 0.03 | 0.94 | FALSE |
| 2 | GTEx | Artery Tibial | WDR66 | 0.16 | 0.12 | lasso | 1 | 0.11 | 7.3e-09 | 5.15 | 5.2 | 2.7e-07 | -0.07 | 0.06 | 0.94 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | WDR66 | 0.28 | 0.05 | lasso | 8 | 0.04 | 3.6e-02 | 5.07 | 5.7 | 9.8e-09 | -0.04 | 0.05 | 0.48 | FALSE |
| 4 | GTEx | Brain Cerebellum | WDR66 | 0.28 | 0.31 | lasso | 8 | 0.31 | 7.6e-10 | 5.09 | 5.2 | 1.6e-07 | -0.07 | 0.08 | 0.92 | FALSE |
| 5 | GTEx | Esophagus Mucosa | SIRT4 | 0.21 | 0.09 | enet | 19 | 0.08 | 8.7e-06 | 5.06 | 5.4 | 7.1e-08 | 0.84 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Lung | KDM2B | 0.10 | 0.06 | lasso | 3 | 0.05 | 1.4e-04 | -5.28 | 5.3 | 1.3e-07 | -0.09 | 0.04 | 0.95 | TRUE |
| 7 | GTEx | Muscle Skeletal | RSRC2 | 0.06 | 0.03 | enet | 7 | 0.04 | 9.6e-05 | 5.06 | 5.2 | 1.9e-07 | 0.08 | 0.00 | 0.97 | TRUE |
| 8 | GTEx | Muscle Skeletal | WDR66 | 0.06 | 0.03 | lasso | 2 | 0.02 | 3.4e-03 | 5.09 | 5.1 | 2.7e-07 | -0.06 | 0.08 | 0.76 | FALSE |
| 9 | GTEx | Pancreas | RP11-347I19.8 | 0.12 | 0.00 | enet | 13 | 0.00 | 2.9e-01 | -0.79 | 5.4 | 8.0e-08 | -0.03 | 0.05 | 0.45 | FALSE |
| 10 | GTEx | Stomach | SIRT4 | 0.14 | 0.14 | enet | 8 | 0.09 | 3.1e-05 | 5.06 | 5.3 | 1.3e-07 | 1.00 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SIRT4 | 0.07 | 0.01 | blup | 37 | 0.05 | 3.2e-05 | 5.06 | 5.3 | 1.1e-07 | 0.85 | 0.01 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIRT4 | 0.06 | 0.06 | lasso | 4 | 0.05 | 2.8e-11 | 5.10 | 5.2 | 2.5e-07 | 1.00 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIRT4 | 0.09 | 0.00 | enet | 6 | 0.03 | 9.0e-03 | 5.10 | 6.5 | 6.9e-11 | 0.86 | 0.00 | 0.70 | TRUE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | WDR66 | 0.32 | 0.14 | blup | 81 | 0.11 | 3.4e-04 | -4.31 | 5.8 | 7.0e-09 | -0.05 | 0.15 | 0.72 | TRUE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIRT4 | 0.03 | 0.02 | enet | 12 | 0.02 | 3.6e-03 | 5.10 | 5.5 | 4.9e-08 | 0.92 | 0.00 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIRT4 | 0.17 | 0.17 | enet | 4 | 0.18 | 8.5e-19 | 5.10 | 5.5 | 3.8e-08 | 0.97 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SIRT4 | 0.10 | 0.06 | blup | 37 | 0.08 | 1.3e-06 | 5.04 | 5.7 | 9.6e-09 | 0.91 | 0.00 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMD9 | 0.09 | 0.10 | lasso | 4 | 0.10 | 7.4e-10 | 5.41 | -5.5 | 3.9e-08 | 0.08 | 0.01 | 0.99 | FALSE |