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chr15:62,636,766-64,123,980

Best TWAS P=9.59e-12 · Best GWAS P=1.62e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LACTB	0.12	0.14	lasso	2	0.14	1.2e-16	-5.6	-5.5	4.9e-08	-0.54	0.69	0.31	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TPM1	0.07	0.01	bslmm	523	0.02	3.3e-03	6.6	5.6	2.5e-08	0.64	0.02	0.94	FALSE
3	GTEx	Adipose Subcutaneous	LACTB	0.11	0.10	enet	11	0.07	2.3e-06	-5.6	-5.4	8.6e-08	-0.61	0.63	0.36	FALSE
4	GTEx	Adipose Subcutaneous	TPM1	0.19	0.13	enet	17	0.11	3.1e-09	5.0	6.0	2.5e-09	0.65	0.75	0.25	FALSE
5	GTEx	Adipose Subcutaneous	RP11-244F12.3	0.16	0.12	lasso	5	0.10	6.5e-09	6.2	6.2	4.9e-10	0.77	0.06	0.94	FALSE
6	GTEx	Adipose Subcutaneous	RP11-244F12.2	0.14	0.10	lasso	3	0.09	1.3e-07	5.2	5.3	1.1e-07	0.59	0.92	0.08	FALSE
7	GTEx	Adipose Visceral Omentum	LACTB	0.16	0.11	lasso	3	0.09	2.7e-05	-5.6	-5.4	7.1e-08	-0.61	0.39	0.50	FALSE
8	GTEx	Adipose Visceral Omentum	RP11-244F12.3	0.15	0.00	lasso	5	0.00	2.2e-01	6.2	6.2	5.7e-10	0.78	0.03	0.84	FALSE
9	GTEx	Artery Aorta	TPM1	0.25	0.10	lasso	11	0.13	9.6e-08	6.1	6.1	1.2e-09	0.75	0.09	0.91	FALSE
10	GTEx	Artery Aorta	RP11-244F12.2	0.20	0.06	lasso	9	0.04	1.9e-03	5.1	5.8	5.7e-09	0.67	0.16	0.75	FALSE
11	GTEx	Artery Coronary	TPM1	0.32	0.09	lasso	6	0.03	2.6e-02	6.1	5.9	3.7e-09	0.70	0.08	0.82	FALSE
12	GTEx	Artery Tibial	TPM1	0.22	0.18	lasso	4	0.21	2.3e-16	6.2	6.4	1.3e-10	0.71	0.07	0.93	FALSE
13	GTEx	Artery Tibial	RP11-244F12.2	0.15	0.11	lasso	4	0.14	7.2e-11	5.3	5.6	1.8e-08	0.55	0.71	0.29	FALSE
14	GTEx	Brain Caudate basal ganglia	TPM1	0.35	0.18	lasso	3	0.15	3.5e-05	6.1	5.4	7.3e-08	0.73	0.06	0.72	FALSE
15	GTEx	Brain Caudate basal ganglia	RP11-244F12.2	0.47	0.27	lasso	8	0.30	2.5e-09	6.1	6.2	7.4e-10	0.79	0.07	0.92	FALSE
16	GTEx	Brain Cerebellum	RP11-244F12.2	0.48	0.23	lasso	13	0.40	8.2e-13	-2.3	5.2	1.6e-07	0.38	0.21	0.50	FALSE
17	GTEx	Brain Frontal Cortex BA9	RP11-244F12.2	0.22	0.11	lasso	6	0.11	8.8e-04	5.8	6.1	9.6e-10	0.84	0.03	0.92	FALSE
18	GTEx	Brain Hippocampus	TPM1	0.34	0.10	lasso	5	0.17	1.0e-04	6.1	5.6	1.8e-08	0.77	0.04	0.74	FALSE
19	GTEx	Brain Hippocampus	RP11-244F12.2	0.36	0.39	lasso	6	0.36	2.4e-09	6.1	6.0	1.7e-09	0.77	0.08	0.91	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	TPM1	0.37	0.22	lasso	8	0.01	1.4e-01	5.1	5.4	8.0e-08	0.50	0.18	0.26	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	RP11-244F12.2	0.33	0.24	enet	22	0.15	7.2e-05	5.1	6.1	8.5e-10	0.67	0.14	0.62	FALSE
22	GTEx	Esophagus Muscularis	LACTB	0.12	0.05	lasso	9	0.06	1.3e-04	-5.7	-6.5	8.1e-11	-0.74	0.18	0.78	FALSE
23	GTEx	Esophagus Muscularis	TPM1	0.14	0.05	enet	33	0.08	1.2e-05	6.2	5.8	7.1e-09	0.61	0.08	0.90	FALSE
24	GTEx	Heart Atrial Appendage	LACTB	0.17	0.05	lasso	5	0.08	2.2e-04	-5.6	-5.4	7.6e-08	-0.65	0.36	0.60	FALSE
25	GTEx	Heart Left Ventricle	LACTB	0.09	0.01	enet	12	0.02	2.0e-02	-5.6	-6.1	1.2e-09	-0.61	0.11	0.58	FALSE
26	GTEx	Lung	LACTB	0.10	0.09	lasso	4	0.08	9.2e-07	-5.6	-6.1	1.2e-09	-0.66	0.65	0.34	FALSE
27	GTEx	Lung	TPM1	0.09	0.03	lasso	5	0.03	1.6e-03	6.1	5.5	3.8e-08	0.75	0.06	0.89	FALSE
28	GTEx	Muscle Skeletal	RP11-244F12.3	0.17	0.02	lasso	5	0.01	1.4e-02	5.2	6.1	1.4e-09	0.65	0.29	0.55	FALSE
29	GTEx	Muscle Skeletal	RP11-244F12.2	0.05	0.00	enet	18	0.01	7.5e-02	5.1	5.8	5.3e-09	0.64	0.10	0.72	FALSE
30	GTEx	Nerve Tibial	TPM1	0.14	0.04	lasso	9	0.04	9.8e-04	6.2	6.2	5.4e-10	0.77	0.08	0.91	FALSE
31	GTEx	Nerve Tibial	RP11-244F12.2	0.16	0.00	lasso	8	0.02	9.9e-03	6.2	6.2	4.6e-10	0.78	0.08	0.89	FALSE
32	GTEx	Skin Sun Exposed Lower leg	TPM1	0.08	0.08	lasso	5	0.07	2.4e-06	6.6	6.8	1.4e-11	0.97	0.01	0.99	FALSE
33	GTEx	Skin Sun Exposed Lower leg	RP11-244F12.3	0.06	0.06	lasso	3	0.04	5.8e-04	6.7	6.8	9.6e-12	1.00	0.00	0.99	TRUE
34	GTEx	Skin Sun Exposed Lower leg	RP11-244F12.2	0.06	0.06	lasso	3	0.08	4.0e-07	6.6	6.7	3.0e-11	0.88	0.02	0.98	FALSE
35	GTEx	Thyroid	LACTB	0.10	0.03	lasso	4	0.02	1.0e-02	-5.7	-5.6	2.0e-08	-0.62	0.49	0.19	FALSE
36	METSIM	Adipose	LACTB	0.17	0.20	lasso	4	0.20	1.3e-28	-5.6	-5.6	1.8e-08	-0.59	0.70	0.30	FALSE
37	YFS	Blood	LACTB	0.07	0.06	lasso	6	0.09	1.0e-26	-5.6	-6.6	3.9e-11	-0.77	0.24	0.76	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	LACTB	0.25	0.04	enet	12	0.19	1.9e-06	6.6	-6.7	2.5e-11	-0.82	0.00	0.98	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LACTB	0.04	0.01	blup	52	0.02	2.5e-03	4.5	-6.1	1.4e-09	-0.67	0.24	0.41	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	LACTB	0.16	0.20	enet	8	0.21	2.5e-23	-5.7	-5.9	3.0e-09	-0.64	0.61	0.39	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	LACTB	0.04	0.07	lasso	5	0.06	8.2e-08	-5.7	-6.4	1.8e-10	-0.74	0.40	0.59	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	TPM1	0.05	0.04	blup	80	0.05	1.3e-06	5.2	-6.5	9.1e-11	-0.65	0.77	0.19	FALSE