Best TWAS P=8.56e-10 · Best GWAS P=1.71e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | FAM96B | 0.08 | 0.09 | lasso | 4 | 0.09 | 1.1e-06 | 6.0 | -5.7 | 1.0e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CES2 | 0.20 | 0.18 | lasso | 6 | 0.20 | 1.1e-13 | 6.0 | -6.1 | 8.9e-10 | -0.98 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Esophagus Mucosa | RP11-361L15.4 | 0.18 | 0.17 | lasso | 5 | 0.20 | 2.5e-13 | 6.0 | -6.1 | 8.6e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Lung | RP11-403P17.5 | 0.17 | 0.05 | enet | 26 | 0.07 | 2.9e-06 | 6.0 | 5.8 | 6.2e-09 | 0.75 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CDH16 | 0.02 | 0.01 | blup | 37 | 0.01 | 3.4e-02 | 4.9 | -5.4 | 5.6e-08 | -0.77 | 0.02 | 0.65 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CES2 | 0.03 | 0.01 | blup | 30 | 0.01 | 8.2e-03 | 4.6 | -5.2 | 1.9e-07 | -0.69 | 0.02 | 0.46 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC79 | 0.11 | 0.03 | blup | 46 | 0.03 | 7.5e-04 | 5.7 | -5.5 | 4.0e-08 | -0.91 | 0.00 | 0.94 | FALSE |