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chr16:69,062,879-72,569,466

Best TWAS P=7.88e-11 · Best GWAS P=8.59e-15 conditioned to 2.17e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IL34	0.02	0.02	blup	149	0.01	4.1e-02	4.8	5.1	2.7e-07	0.15	0.02	0.67	FALSE
2	GTEx	Adipose Subcutaneous	CMTR2	0.16	0.05	lasso	5	0.02	4.1e-03	5.1	5.3	1.1e-07	0.22	0.04	0.90	TRUE
3	GTEx	Adrenal Gland	RP11-296I10.6	0.13	0.09	enet	18	0.04	1.4e-02	-3.7	-5.3	1.4e-07	-0.12	0.22	0.16	FALSE
4	GTEx	Artery Aorta	SF3B3	0.05	0.01	enet	9	0.01	6.4e-02	4.7	5.2	2.2e-07	0.12	0.04	0.65	FALSE
5	GTEx	Breast Mammary Tissue (Female)	PDXDC2P	0.44	0.14	enet	16	0.16	1.9e-05	-4.4	-5.2	2.0e-07	-0.07	0.21	0.43	FALSE
6	GTEx	Cells Transformed fibroblasts	VAC14-AS1	0.06	0.00	enet	11	0.01	3.2e-02	-4.9	5.3	1.1e-07	0.14	0.07	0.68	FALSE
7	GTEx	Colon Transverse	PDXDC2P	0.52	0.28	enet	24	0.33	2.7e-16	4.2	-5.7	1.4e-08	-0.12	0.44	0.50	FALSE
8	GTEx	Esophagus Mucosa	PDXDC2P	0.39	0.22	lasso	6	0.23	1.6e-15	-5.4	-6.0	1.6e-09	-0.07	0.00	1.00	TRUE
9	GTEx	Nerve Tibial	CTD-2033A16.3	0.13	0.04	enet	16	0.07	1.7e-05	-4.0	5.3	1.1e-07	0.22	0.06	0.85	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	PDXDC2P	0.36	0.22	enet	24	0.24	4.1e-13	4.2	-5.3	1.1e-07	-0.13	0.49	0.45	FALSE
11	GTEx	Stomach	RP11-296I10.6	0.24	0.15	enet	14	0.16	4.5e-08	-3.7	-5.3	1.0e-07	-0.10	0.80	0.09	FALSE
12	GTEx	Testis	PDXDC2P	0.62	0.50	enet	15	0.57	6.8e-30	-5.4	-5.6	2.6e-08	-0.08	0.00	1.00	FALSE
13	GTEx	Thyroid	PDXDC2P	0.41	0.27	lasso	10	0.30	5.0e-23	4.1	-5.6	2.2e-08	-0.08	0.61	0.32	FALSE
14	GTEx	Uterus	PHLPP2	0.25	0.02	lasso	11	0.04	6.6e-02	4.0	-5.4	5.8e-08	-0.25	0.07	0.20	FALSE
15	GTEx	Whole Blood	PDXDC2P	0.16	0.05	lasso	3	0.07	9.0e-07	-5.2	-5.9	3.8e-09	-0.07	0.01	0.99	FALSE
16	METSIM	Adipose	PHLPP2	0.07	0.03	lasso	5	0.06	1.7e-09	-4.4	-5.8	8.4e-09	-0.21	1.00	0.00	FALSE
17	YFS	Blood	ATXN1L	0.02	0.02	blup	413	0.02	6.5e-07	-4.5	-6.5	7.9e-11	-0.38	0.98	0.01	TRUE
18	YFS	Blood	PHLPP2	0.04	0.03	bslmm	459	0.05	5.5e-16	4.4	-5.3	1.1e-07	-0.24	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	COG4	0.12	0.00	enet	10	0.02	3.9e-02	-2.9	5.2	2.6e-07	0.07	0.00	0.12	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL34	0.04	0.01	blup	47	0.03	2.9e-04	-3.8	-5.8	9.0e-09	-0.14	0.02	0.78	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF23	0.04	0.01	blup	58	0.02	2.7e-03	-4.4	-6.1	1.4e-09	-0.22	0.02	0.26	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLEC18A	0.10	0.02	lasso	2	0.05	1.5e-06	-5.2	-5.1	2.8e-07	-0.05	0.00	0.80	FALSE
23	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	COG4	0.25	-0.01	enet	6	0.05	4.4e-03	-2.9	5.6	2.1e-08	0.08	0.01	0.24	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	COG4	0.08	0.02	enet	9	0.04	3.1e-05	-4.3	5.1	2.8e-07	0.08	0.03	0.92	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	COG4	0.33	0.09	enet	12	0.15	2.5e-04	4.4	5.4	5.7e-08	0.11	0.02	0.67	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	MARVELD3	0.08	0.01	blup	44	0.06	7.1e-07	4.5	-5.3	9.0e-08	-0.25	0.03	0.84	FALSE