Best TWAS P=7.05e-09 · Best GWAS P=2.04e-08 conditioned to 0.254
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Esophagus Mucosa | C17orf75 | 0.11 | 0.10 | lasso | 2 | 0.09 | 1.2e-06 | 5.3 | -5.3 | 1.3e-07 | -0.94 | 0.02 | 0.98 | FALSE |
2 | GTEx | Testis | PSMD11 | 0.42 | 0.38 | lasso | 4 | 0.37 | 1.6e-17 | 5.5 | -5.4 | 7.4e-08 | -0.98 | 0.02 | 0.98 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf75 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.5e-04 | 5.3 | -5.2 | 1.5e-07 | -0.98 | 0.00 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C17orf75 | 0.07 | 0.07 | blup | 24 | 0.06 | 4.3e-04 | 5.3 | -5.3 | 9.8e-08 | -0.90 | 0.01 | 0.89 | FALSE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf75 | 0.08 | 0.04 | blup | 24 | 0.06 | 3.1e-07 | 5.3 | -5.3 | 1.0e-07 | -0.82 | 0.00 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C17orf75 | 0.17 | 0.16 | lasso | 3 | 0.16 | 1.3e-17 | 5.3 | -5.4 | 8.4e-08 | -0.98 | 0.00 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf75 | 0.03 | 0.03 | blup | 24 | 0.03 | 3.2e-04 | 5.3 | -5.4 | 6.1e-08 | -0.93 | 0.00 | 0.93 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | C17orf75 | 0.06 | 0.05 | blup | 24 | 0.05 | 2.8e-06 | 5.4 | -5.8 | 7.1e-09 | -0.87 | 0.00 | 0.99 | TRUE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C17orf75 | 0.06 | 0.04 | blup | 24 | 0.04 | 1.1e-03 | 5.4 | -5.4 | 7.9e-08 | -0.94 | 0.00 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C17orf75 | 0.15 | 0.10 | blup | 24 | 0.11 | 3.0e-05 | 5.3 | -5.3 | 1.2e-07 | -0.91 | 0.00 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf75 | 0.21 | 0.20 | enet | 12 | 0.22 | 1.1e-20 | 5.3 | -5.3 | 1.1e-07 | -0.94 | 0.00 | 1.00 | FALSE |