Best TWAS P=2.62e-16 · Best GWAS P=2.03e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PLEKHJ1 | 0.14 | 0.09 | lasso | 2 | 0.06 | 3.3e-05 | 8.2 | 8.2 | 2.6e-16 | 1.00 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | KLF16 | 0.19 | 0.07 | enet | 13 | 0.08 | 8.8e-07 | -3.7 | 5.3 | 8.6e-08 | 0.26 | 0.79 | 0.04 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | AMH | 0.34 | 0.11 | lasso | 6 | 0.16 | 2.1e-06 | 8.2 | -7.0 | 2.6e-12 | -0.91 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | DOT1L | 0.12 | 0.03 | lasso | 5 | 0.05 | 6.3e-04 | 3.0 | 6.5 | 7.0e-11 | 0.67 | 0.03 | 0.94 | FALSE |
| 5 | GTEx | Esophagus Muscularis | ATP8B3 | 0.33 | 0.23 | enet | 31 | 0.25 | 2.1e-15 | -5.1 | -5.5 | 4.7e-08 | -0.11 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -5.2 | -5.1 | 3.1e-07 | -0.10 | 0.59 | 0.04 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | DOT1L | 0.08 | 0.06 | lasso | 5 | 0.07 | 8.0e-09 | 7.3 | 7.8 | 8.7e-15 | 0.89 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AMH | 0.10 | 0.05 | blup | 35 | 0.04 | 1.2e-02 | 7.3 | -5.1 | 2.9e-07 | -0.69 | 0.06 | 0.64 | FALSE |