Best TWAS P=8.01e-12 · Best GWAS P=6.08e-12 conditioned to 0.0338
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DDX11L2 | 0.28 | 0.18 | enet | 18 | 0.21 | 2.0e-25 | 4.3 | 5.3 | 1.4e-07 | -0.61 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RABL2A | 0.18 | 0.14 | lasso | 9 | 0.18 | 1.5e-14 | -5.0 | -6.2 | 4.3e-10 | 0.64 | 0.69 | 0.31 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RABL2A | 0.11 | 0.00 | lasso | 4 | 0.02 | 4.0e-02 | -6.6 | -6.8 | 8.0e-12 | 0.83 | 0.01 | 0.86 | TRUE |
| 4 | GTEx | Brain Cerebellum | RPL23AP7 | 0.52 | 0.30 | lasso | 13 | 0.34 | 7.7e-11 | 4.3 | 5.5 | 3.4e-08 | -0.61 | 0.67 | 0.28 | FALSE |
| 5 | GTEx | Nerve Tibial | RABL2A | 0.23 | 0.18 | enet | 14 | 0.19 | 1.6e-13 | -5.0 | -5.8 | 9.1e-09 | 0.57 | 0.91 | 0.09 | FALSE |
| 6 | GTEx | Ovary | DDX11L2 | 0.23 | 0.27 | enet | 13 | 0.28 | 1.6e-07 | 4.3 | 5.2 | 2.3e-07 | -0.53 | 0.38 | 0.35 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RABL2A | 0.10 | 0.05 | enet | 12 | 0.05 | 3.4e-05 | -5.0 | -5.9 | 3.0e-09 | 0.53 | 0.81 | 0.12 | FALSE |
| 8 | METSIM | Adipose | RABL2A | 0.05 | 0.04 | enet | 17 | 0.03 | 1.3e-05 | 4.4 | -5.2 | 2.7e-07 | 0.53 | 0.84 | 0.13 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DDX11L2 | 0.08 | 0.04 | enet | 4 | 0.06 | 5.0e-06 | -6.6 | 5.9 | 2.9e-09 | -0.77 | 0.00 | 0.95 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DDX11L2 | 0.14 | 0.05 | lasso | 2 | 0.13 | 1.1e-14 | -6.6 | 6.2 | 7.3e-10 | -0.74 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DDX11L2 | 0.19 | 0.03 | enet | 3 | 0.11 | 5.5e-07 | -6.6 | 6.2 | 4.4e-10 | -0.73 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DDX11L2 | 0.20 | 0.08 | lasso | 4 | 0.13 | 1.3e-14 | -6.6 | 6.2 | 5.9e-10 | -0.75 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | DDX11L2 | 0.14 | 0.08 | lasso | 3 | 0.11 | 6.2e-13 | -6.6 | 6.3 | 2.9e-10 | -0.81 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DDX11L2 | 0.12 | 0.11 | enet | 5 | 0.13 | 3.1e-14 | -6.6 | 6.2 | 4.0e-10 | -0.85 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DDX11L2 | 0.14 | 0.03 | enet | 5 | 0.13 | 4.8e-09 | -1.5 | 5.3 | 1.2e-07 | -0.62 | 0.00 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DDX11L2 | 0.15 | 0.03 | blup | 5 | 0.11 | 3.4e-08 | -1.5 | 5.6 | 2.5e-08 | -0.64 | 0.01 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX11L2 | 0.15 | 0.02 | enet | 4 | 0.12 | 1.0e-11 | -6.6 | 5.9 | 3.4e-09 | -0.69 | 0.00 | 1.00 | FALSE |