Best TWAS P=3.79e-09 · Best GWAS P=4.15e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | TMEM87B | 0.12 | 0.08 | lasso | 9 | 0.07 | 5.5e-06 | -5.9 | -5.9 | 3.8e-09 | 0.96 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Colon Sigmoid | MERTK | 0.47 | 0.07 | lasso | 10 | 0.20 | 1.9e-07 | -2.6 | -5.3 | 1.3e-07 | 0.40 | 0.11 | 0.84 | FALSE |
| 3 | GTEx | Muscle Skeletal | TMEM87B | 0.04 | 0.01 | enet | 9 | 0.01 | 5.3e-02 | 5.3 | 5.5 | 3.4e-08 | -0.47 | 0.11 | 0.68 | FALSE |
| 4 | GTEx | Nerve Tibial | TMEM87B | 0.14 | 0.04 | enet | 13 | 0.07 | 1.3e-05 | 4.5 | 5.2 | 1.6e-07 | -0.46 | 0.38 | 0.61 | FALSE |
| 5 | GTEx | Thyroid | TMEM87B | 0.09 | 0.00 | lasso | 5 | 0.01 | 1.1e-01 | 5.1 | 5.8 | 5.3e-09 | -0.52 | 0.06 | 0.51 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM87B | 0.03 | 0.04 | lasso | 1 | 0.03 | 8.0e-05 | 5.3 | -5.3 | 1.3e-07 | 0.42 | 0.06 | 0.90 | FALSE |