Best TWAS P=1.92e-13 · Best GWAS P=1.69e-27 conditioned to 5.72e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | ACTRT3 | 0.09 | 0.01 | enet | 19 | 0.03 | 3.9e-03 | -2.7 | -7.3 | 1.9e-13 | -0.11 | 0.11 | 0.04 | TRUE |
| 2 | GTEx | Testis | MYNN | 0.12 | 0.13 | lasso | 5 | 0.13 | 1.8e-06 | -5.0 | -5.2 | 1.8e-07 | -0.01 | 0.86 | 0.02 | FALSE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ARPM1 | 0.04 | 0.02 | blup | 27 | 0.02 | 3.4e-03 | -6.0 | 5.4 | 7.8e-08 | 0.02 | 0.01 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARPM1 | 0.02 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -6.0 | 6.0 | 2.7e-09 | 0.02 | 0.01 | 0.97 | FALSE |