Best TWAS P=9.45e-12 · Best GWAS P=4.74e-09 conditioned to 0.566
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | YEATS2-AS1 | 0.08 | 0.02 | lasso | 10 | 0.01 | 3.3e-02 | 5.1 | -5.3 | 1.0e-07 | 0.83 | 0.04 | 0.92 | FALSE |
| 2 | GTEx | Artery Tibial | MAP6D1 | 0.13 | 0.07 | enet | 15 | 0.07 | 5.1e-06 | -5.7 | 6.2 | 4.4e-10 | -0.91 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | YEATS2-AS1 | 0.20 | 0.05 | lasso | 3 | 0.02 | 1.1e-01 | -2.0 | -5.2 | 2.1e-07 | 0.73 | 0.06 | 0.61 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MAP6D1 | 0.20 | 0.03 | lasso | 6 | 0.06 | 1.0e-02 | -5.8 | 5.5 | 3.0e-08 | -0.86 | 0.04 | 0.84 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | YEATS2-AS1 | 0.20 | 0.16 | lasso | 5 | 0.16 | 6.2e-05 | -5.7 | -5.2 | 1.6e-07 | 0.87 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Brain Cerebellum | YEATS2-AS1 | 0.48 | 0.48 | lasso | 10 | 0.47 | 8.0e-16 | -5.9 | -5.8 | 7.3e-09 | 1.00 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | MAP6D1 | 0.09 | 0.03 | lasso | 6 | 0.03 | 2.0e-03 | -5.5 | -5.3 | 1.3e-07 | 0.80 | 0.04 | 0.95 | FALSE |
| 8 | GTEx | Esophagus Mucosa | MAP6D1 | 0.08 | 0.07 | lasso | 11 | 0.07 | 3.4e-05 | -5.8 | -5.8 | 6.9e-09 | 1.00 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Esophagus Mucosa | YEATS2-AS1 | 0.09 | 0.02 | enet | 25 | 0.06 | 1.4e-04 | -5.8 | -6.0 | 2.1e-09 | 0.75 | 0.03 | 0.96 | FALSE |
| 10 | GTEx | Muscle Skeletal | YEATS2-AS1 | 0.07 | 0.08 | lasso | 7 | 0.06 | 1.6e-06 | -5.9 | -5.8 | 4.8e-09 | 1.00 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Nerve Tibial | YEATS2-AS1 | 0.08 | 0.07 | lasso | 4 | 0.04 | 5.3e-04 | -5.9 | -5.8 | 6.1e-09 | 1.00 | 0.02 | 0.97 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | YEATS2-AS1 | 0.21 | 0.21 | enet | 18 | 0.21 | 1.2e-11 | -5.8 | -5.2 | 2.1e-07 | 0.97 | 0.02 | 0.98 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | MAP6D1 | 0.07 | 0.02 | lasso | 5 | 0.03 | 2.7e-03 | -5.8 | -6.8 | 9.5e-12 | 0.90 | 0.03 | 0.93 | TRUE |
| 14 | GTEx | Skin Sun Exposed Lower leg | YEATS2-AS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.8e-13 | -5.8 | -5.8 | 5.0e-09 | 0.98 | 0.02 | 0.98 | FALSE |
| 15 | GTEx | Whole Blood | ABCC5 | 0.10 | 0.08 | lasso | 4 | 0.08 | 9.9e-08 | -5.3 | 5.4 | 6.9e-08 | -0.31 | 0.32 | 0.68 | FALSE |
| 16 | YFS | Blood | ABCC5 | 0.25 | 0.37 | enet | 48 | 0.42 | 8.9e-154 | -5.3 | 5.3 | 9.6e-08 | -0.36 | 0.22 | 0.78 | FALSE |
| 17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MAP6D1 | 0.07 | 0.06 | blup | 55 | 0.06 | 9.4e-04 | -5.7 | -5.7 | 1.2e-08 | 0.98 | 0.02 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MAP6D1 | 0.04 | 0.01 | blup | 55 | 0.04 | 4.0e-05 | -4.2 | -5.6 | 1.9e-08 | 0.88 | 0.03 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAP6D1 | 0.03 | 0.04 | enet | 17 | 0.05 | 1.8e-06 | -5.7 | -6.0 | 2.0e-09 | 0.92 | 0.02 | 0.98 | FALSE |