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chr4:55,517,005-57,110,821

Best TWAS P=2.3e-15 · Best GWAS P=6.75e-11 conditioned to 0.961

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TMEM165	0.09	0.01	lasso	3	0.03	1.6e-03	-6.1	6.5	5.6e-11	0.32	0.09	0.90	FALSE
2	GTEx	Adipose Visceral Omentum	TMEM165	0.14	0.04	enet	20	0.06	3.3e-04	3.1	5.6	1.9e-08	0.43	0.05	0.60	FALSE
3	GTEx	Artery Aorta	SRD5A3	0.34	0.05	lasso	12	0.23	1.0e-12	-6.2	-7.0	2.6e-12	-0.56	0.03	0.97	FALSE
4	GTEx	Artery Aorta	TMEM165	0.10	0.00	lasso	3	0.00	7.5e-01	-6.2	7.4	1.5e-13	0.60	0.04	0.58	FALSE
5	GTEx	Artery Coronary	SRD5A3	0.49	-0.01	enet	29	0.16	6.3e-06	-2.7	-5.3	9.9e-08	-0.43	0.07	0.65	FALSE
6	GTEx	Artery Coronary	SRD5A3-AS1	0.28	0.00	enet	15	0.03	3.5e-02	2.4	-6.4	1.2e-10	-0.68	0.04	0.71	FALSE
7	GTEx	Artery Tibial	TMEM165	0.07	0.02	lasso	5	0.01	3.2e-02	4.9	6.3	3.3e-10	0.49	0.16	0.63	FALSE
8	GTEx	Artery Tibial	SRD5A3-AS1	0.19	0.05	enet	26	0.10	2.4e-08	-6.2	-5.5	3.9e-08	-0.20	0.07	0.93	FALSE
9	GTEx	Brain Cerebellum	SRD5A3-AS1	0.36	0.06	enet	38	0.20	1.9e-06	-6.0	-5.2	1.7e-07	-0.28	0.11	0.75	FALSE
10	GTEx	Brain Cortex	TMEM165	0.31	0.08	lasso	6	0.04	2.2e-02	-5.3	5.4	5.8e-08	0.30	0.07	0.50	FALSE
11	GTEx	Breast Mammary Tissue	TMEM165	0.10	0.12	lasso	5	0.12	6.4e-07	-5.3	5.2	2.2e-07	0.17	0.12	0.85	FALSE
12	GTEx	Breast Mammary Tissue (Male)	TMEM165	0.18	0.11	lasso	10	0.11	1.4e-03	-5.3	5.3	1.2e-07	0.20	0.07	0.55	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SRD5A3	0.19	0.06	enet	21	0.13	5.9e-05	-5.3	-6.0	1.5e-09	-0.32	0.06	0.84	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	CLOCK	0.21	0.06	lasso	3	0.04	1.5e-02	5.2	-6.2	5.9e-10	-0.70	0.05	0.71	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	SRD5A3-AS1	0.21	0.09	lasso	3	0.20	4.3e-07	-5.3	-5.7	1.3e-08	-0.18	0.06	0.90	FALSE
16	GTEx	Cells Transformed fibroblasts	SRD5A3	0.39	0.22	enet	51	0.36	2.9e-28	-6.0	-6.4	1.7e-10	-0.38	0.08	0.92	FALSE
17	GTEx	Cells Transformed fibroblasts	SRD5A3-AS1	0.36	0.19	enet	52	0.30	1.2e-22	-6.0	-5.9	4.0e-09	-0.33	0.07	0.93	FALSE
18	GTEx	Colon Sigmoid	SRD5A3	0.34	0.18	enet	30	0.31	1.5e-11	-6.0	-6.2	7.5e-10	-0.35	0.08	0.91	FALSE
19	GTEx	Colon Sigmoid	SRD5A3-AS1	0.16	0.14	enet	18	0.13	2.9e-05	-6.1	-7.1	1.1e-12	-0.47	0.06	0.85	FALSE
20	GTEx	Esophagus Mucosa	SRD5A3	0.20	0.12	enet	24	0.18	2.5e-12	-6.0	-5.2	1.5e-07	-0.17	0.06	0.94	FALSE
21	GTEx	Esophagus Mucosa	CLOCK	0.12	0.11	enet	22	0.09	9.3e-07	-6.0	-7.1	1.2e-12	-0.35	0.07	0.93	FALSE
22	GTEx	Esophagus Mucosa	SRD5A3-AS1	0.18	0.12	enet	26	0.17	1.1e-11	-6.0	-5.3	1.3e-07	-0.18	0.07	0.93	FALSE
23	GTEx	Esophagus Muscularis	TMEM165	0.07	0.04	lasso	2	0.02	1.7e-02	6.4	6.2	4.4e-10	0.65	0.05	0.87	FALSE
24	GTEx	Lung	SRD5A3	0.35	0.13	enet	32	0.27	1.1e-20	-6.1	-5.6	1.7e-08	-0.26	0.07	0.93	FALSE
25	GTEx	Lung	TMEM165	0.09	0.01	lasso	6	0.01	3.4e-02	-6.5	6.9	4.1e-12	0.43	0.03	0.87	FALSE
26	GTEx	Lung	SRD5A3-AS1	0.19	0.07	enet	26	0.14	8.6e-11	-5.3	-6.1	9.8e-10	-0.33	0.09	0.91	FALSE
27	GTEx	Muscle Skeletal	SRD5A3-AS1	0.20	0.13	enet	25	0.20	1.4e-19	-6.0	-6.9	4.8e-12	-0.42	0.06	0.94	FALSE
28	GTEx	Nerve Tibial	TMEM165	0.18	0.22	enet	29	0.27	1.6e-19	-4.2	5.2	1.5e-07	0.22	0.15	0.85	FALSE
29	GTEx	Nerve Tibial	CLOCK	0.14	0.06	lasso	4	0.10	1.6e-07	-6.2	-7.8	8.8e-15	-0.55	0.03	0.97	FALSE
30	GTEx	Prostate	SRD5A3	0.39	0.04	enet	27	0.28	9.6e-08	-6.0	-6.6	4.3e-11	-0.25	0.09	0.79	TRUE
31	GTEx	Prostate	SRD5A3-AS1	0.32	0.14	enet	41	0.22	3.1e-06	-6.0	-6.0	1.8e-09	-0.36	0.08	0.68	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	SRD5A3	0.43	0.06	enet	61	0.30	1.1e-16	-3.5	-5.3	1.4e-07	-0.25	0.09	0.90	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	CLOCK	0.08	0.08	lasso	5	0.05	1.4e-03	-6.1	-6.1	1.1e-09	-0.24	0.06	0.87	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CLOCK	0.07	0.05	lasso	5	0.07	3.5e-06	5.1	-6.7	2.4e-11	-0.54	0.08	0.91	FALSE
35	GTEx	Small Intestine Terminal Ileum	SRD5A3	0.38	0.28	lasso	4	0.25	2.2e-06	-5.3	-5.4	7.5e-08	-0.17	0.11	0.48	FALSE
36	GTEx	Small Intestine Terminal Ileum	SRD5A3-AS1	0.40	0.32	lasso	3	0.28	4.5e-07	-5.3	-5.4	7.6e-08	-0.18	0.13	0.53	FALSE
37	GTEx	Spleen	TMEM165	0.17	0.13	enet	10	0.11	7.7e-04	-5.3	5.8	8.8e-09	0.20	0.07	0.49	FALSE
38	GTEx	Stomach	SRD5A3-AS1	0.16	0.11	lasso	11	0.12	1.8e-06	-6.0	-5.3	1.1e-07	-0.09	0.12	0.88	FALSE
39	GTEx	Testis	SRD5A3-AS1	0.21	0.09	enet	16	0.09	6.6e-05	6.1	-5.9	3.5e-09	-0.60	0.08	0.86	FALSE
40	GTEx	Thyroid	TMEM165	0.10	0.03	lasso	5	0.03	1.9e-03	-6.5	6.7	2.2e-11	0.44	0.02	0.97	FALSE
41	GTEx	Thyroid	SRD5A3-AS1	0.32	0.14	enet	56	0.21	1.1e-15	-4.2	-5.3	1.1e-07	-0.24	0.16	0.84	FALSE
42	GTEx	Whole Blood	SRD5A3	0.37	0.19	enet	57	0.30	1.3e-27	-6.0	-6.1	8.9e-10	-0.29	0.09	0.91	FALSE
43	GTEx	Whole Blood	SRD5A3-AS1	0.33	0.17	lasso	9	0.21	4.1e-19	-6.0	-6.5	1.1e-10	-0.24	0.09	0.91	FALSE
44	METSIM	Adipose	TMEM165	0.07	0.07	enet	12	0.07	1.1e-10	-6.1	6.1	8.2e-10	0.23	0.07	0.93	FALSE
45	NTR	Blood	CLOCK	0.02	0.01	lasso	2	0.01	5.4e-05	-5.3	-6.2	4.9e-10	-0.29	0.03	0.96	FALSE
46	NTR	Blood	SRD5A3	0.10	0.04	bslmm	407	0.08	2.3e-24	-6.0	-5.5	3.9e-08	-0.36	0.10	0.90	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM165	0.02	0.04	lasso	3	0.03	1.0e-07	-6.1	6.0	2.6e-09	0.26	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRD5A3	0.09	0.08	lasso	4	0.09	2.7e-05	-6.0	-5.4	8.1e-08	-0.08	0.02	0.67	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM165	0.06	0.07	enet	11	0.06	2.1e-04	-6.1	5.3	1.4e-07	0.11	0.04	0.85	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	SRD5A3	0.22	0.14	blup	44	0.12	1.9e-04	-5.3	-6.2	6.1e-10	-0.06	0.02	0.86	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRD5A3	0.04	0.03	blup	44	0.03	1.1e-04	-6.1	-6.0	2.6e-09	-0.22	0.02	0.96	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLOCK	0.02	0.02	enet	5	0.02	1.9e-03	-4.3	-6.4	1.7e-10	-0.13	0.05	0.69	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRD5A3	0.21	0.14	lasso	4	0.14	2.6e-15	-6.0	-6.0	1.8e-09	-0.17	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRD5A3	0.14	0.07	blup	44	0.08	3.4e-09	-6.0	-6.6	4.6e-11	-0.34	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM165	0.19	0.16	lasso	4	0.17	2.1e-18	-6.1	5.5	3.1e-08	0.15	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	SRD5A3	0.04	0.03	lasso	4	0.02	1.0e-03	-6.0	-6.0	1.8e-09	-0.21	0.02	0.92	FALSE
57	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CLOCK	0.62	0.07	enet	9	0.11	1.2e-07	5.0	-5.3	1.2e-07	-0.55	0.12	0.34	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRD5A3	0.12	0.07	lasso	2	0.06	4.2e-05	-6.0	-6.5	6.5e-11	-0.24	0.02	0.87	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRD5A3	0.26	0.12	lasso	6	0.10	7.0e-05	-6.0	-5.5	3.7e-08	-0.19	0.03	0.93	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRD5A3	0.19	0.07	blup	44	0.11	5.5e-12	-6.0	-7.2	7.7e-13	-0.43	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	TMEM165	0.40	0.05	enet	19	0.12	9.4e-04	6.4	7.4	1.4e-13	0.58	0.01	0.57	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRD5A3	0.15	0.01	enet	12	0.06	2.5e-04	-6.0	-6.2	5.7e-10	-0.21	0.02	0.70	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	PDCL2	0.07	0.03	blup	50	0.02	5.4e-03	6.4	7.9	2.3e-15	0.88	0.00	0.98	TRUE
64	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM165	0.12	0.08	enet	12	0.08	2.1e-08	-6.1	5.4	5.6e-08	0.22	0.03	0.97	FALSE