Best TWAS P=1.4e-09 · Best GWAS P=8.8e-08 conditioned to 0.985
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MAP1B | 0.21 | 0.19 | lasso | 4 | 0.19 | 2.1e-15 | 5.3 | 5.5 | 3.5e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | MAP1B | 0.23 | 0.20 | enet | 16 | 0.22 | 3.6e-12 | 4.7 | 5.5 | 3.7e-08 | 0.86 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Artery Tibial | MAP1B | 0.47 | 0.46 | lasso | 4 | 0.47 | 4.2e-41 | 4.7 | 5.1 | 2.8e-07 | 0.83 | 0.07 | 0.92 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | MAP1B | 0.28 | 0.10 | lasso | 5 | 0.14 | 1.5e-04 | 5.3 | 6.1 | 1.4e-09 | 0.88 | 0.01 | 0.96 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | MAP1B | 0.23 | 0.23 | lasso | 5 | 0.25 | 9.7e-19 | 4.7 | 5.2 | 2.6e-07 | 0.92 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MAP1B | 0.08 | 0.07 | lasso | 2 | 0.06 | 1.6e-05 | 4.7 | 5.2 | 1.6e-07 | 0.82 | 0.06 | 0.90 | FALSE |
| 7 | METSIM | Adipose | MAP1B | 0.03 | 0.00 | blup | 463 | 0.01 | 2.6e-02 | 4.7 | 5.4 | 5.3e-08 | 0.47 | 0.04 | 0.63 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP1B | 0.06 | 0.02 | blup | 104 | 0.04 | 3.1e-05 | 4.7 | 5.5 | 3.2e-08 | 0.82 | 0.00 | 0.98 | FALSE |