Best TWAS P=1.57e-10 · Best GWAS P=3.4e-11 conditioned to 0.00474
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PCCB | 0.09 | 0.19 | lasso | 7 | 0.18 | 1.2e-21 | -6.1 | -6.0 | 1.5e-09 | -0.68 | 0.05 | 0.95 | FALSE |
2 | GTEx | Adrenal Gland | PCCB | 0.17 | 0.09 | lasso | 6 | 0.10 | 2.1e-04 | -5.9 | -5.7 | 1.3e-08 | -0.70 | 0.11 | 0.78 | FALSE |
3 | GTEx | Artery Coronary | RP11-85F14.5 | 0.15 | 0.01 | lasso | 4 | 0.00 | 2.3e-01 | -5.2 | -5.8 | 8.7e-09 | -0.66 | 0.04 | 0.75 | FALSE |
4 | GTEx | Artery Tibial | PCCB | 0.05 | 0.02 | lasso | 5 | 0.02 | 1.7e-02 | -5.6 | -5.5 | 5.1e-08 | -0.72 | 0.07 | 0.90 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | PCCB | 0.11 | 0.01 | enet | 9 | 0.01 | 1.7e-01 | 4.7 | -5.5 | 3.2e-08 | -0.74 | 0.06 | 0.55 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PCCB | 0.10 | 0.09 | lasso | 3 | 0.07 | 5.0e-06 | -5.7 | -5.7 | 1.2e-08 | -0.68 | 0.17 | 0.83 | FALSE |
7 | GTEx | Colon Transverse | PCCB | 0.07 | 0.06 | lasso | 3 | 0.04 | 7.7e-03 | -5.5 | -5.4 | 6.3e-08 | -0.69 | 0.13 | 0.68 | FALSE |
8 | GTEx | Esophagus Mucosa | PCCB | 0.10 | 0.12 | lasso | 3 | 0.11 | 4.8e-08 | -5.8 | -5.5 | 5.0e-08 | -0.66 | 0.08 | 0.92 | FALSE |
9 | GTEx | Heart Left Ventricle | PCCB | 0.08 | 0.05 | enet | 7 | 0.01 | 7.2e-02 | -5.6 | -5.5 | 4.2e-08 | -0.69 | 0.11 | 0.86 | FALSE |
10 | GTEx | Muscle Skeletal | PCCB | 0.09 | 0.09 | enet | 13 | 0.11 | 1.2e-10 | -5.4 | -5.9 | 3.4e-09 | -0.68 | 0.10 | 0.90 | FALSE |
11 | GTEx | Testis | PCCB | 0.26 | 0.22 | lasso | 10 | 0.22 | 4.7e-10 | -5.8 | -6.1 | 1.0e-09 | -0.76 | 0.07 | 0.93 | FALSE |
12 | GTEx | Thyroid | PCCB | 0.10 | 0.09 | lasso | 6 | 0.09 | 1.3e-07 | -5.6 | -5.8 | 4.9e-09 | -0.81 | 0.14 | 0.86 | FALSE |
13 | METSIM | Adipose | PCCB | 0.07 | 0.06 | lasso | 12 | 0.06 | 4.1e-09 | -6.2 | -6.4 | 1.6e-10 | -0.74 | 0.04 | 0.96 | TRUE |
14 | ROSMAP | Brain Pre-frontal Cortex | PCCB | 0.10 | 0.07 | lasso | 4 | 0.10 | 4.2e-13 | -5.9 | -5.9 | 3.2e-09 | -0.76 | 0.21 | 0.79 | FALSE |
15 | YFS | Blood | PCCB | 0.13 | 0.20 | lasso | 9 | 0.20 | 1.3e-64 | -5.9 | -5.9 | 4.2e-09 | -0.71 | 0.13 | 0.87 | FALSE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PCCB | 0.05 | 0.03 | blup | 53 | 0.03 | 1.2e-03 | -5.8 | -6.2 | 8.0e-10 | -0.76 | 0.01 | 0.96 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCCB | 0.05 | 0.02 | enet | 12 | 0.04 | 4.0e-09 | -5.3 | -5.5 | 3.5e-08 | -0.66 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Colon Adenocarcinoma | PCCB | 0.11 | 0.03 | blup | 54 | 0.04 | 2.3e-03 | -5.9 | -5.6 | 2.0e-08 | -0.67 | 0.01 | 0.80 | FALSE |
19 | The Cancer Genome Atlas | Esophageal Carcinoma | PCCB | 0.15 | 0.03 | blup | 54 | 0.05 | 9.6e-03 | -5.6 | -5.1 | 2.7e-07 | -0.57 | 0.01 | 0.73 | FALSE |
20 | The Cancer Genome Atlas | Glioblastoma Multiforme | PCCB | 0.10 | 0.03 | blup | 53 | 0.02 | 5.8e-02 | -5.6 | -5.7 | 1.4e-08 | -0.66 | 0.01 | 0.78 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PCCB | 0.05 | 0.05 | blup | 54 | 0.05 | 3.5e-06 | -5.8 | -5.7 | 1.6e-08 | -0.73 | 0.01 | 0.99 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPP2R3A | 0.05 | 0.02 | enet | 8 | 0.02 | 1.1e-03 | -5.6 | -5.3 | 1.3e-07 | -0.52 | 0.07 | 0.24 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PCCB | 0.07 | 0.06 | blup | 53 | 0.06 | 2.1e-04 | -5.0 | -6.1 | 1.4e-09 | -0.76 | 0.01 | 0.96 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCCB | 0.06 | 0.05 | lasso | 2 | 0.03 | 1.2e-04 | -5.9 | -6.0 | 1.8e-09 | -0.74 | 0.00 | 1.00 | FALSE |
25 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCCB | 0.11 | 0.10 | lasso | 3 | 0.10 | 1.3e-11 | -5.9 | -5.8 | 5.7e-09 | -0.70 | 0.00 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Lung Adenocarcinoma | STAG1 | 0.02 | 0.02 | enet | 6 | 0.02 | 3.5e-03 | -5.2 | -5.5 | 3.7e-08 | -0.67 | 0.03 | 0.83 | FALSE |
27 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PCCB | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.4e-11 | -5.6 | -5.5 | 3.3e-08 | -0.66 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | STAG1 | 0.05 | 0.00 | blup | 151 | 0.01 | 2.9e-02 | -6.1 | -5.5 | 4.6e-08 | -0.59 | 0.02 | 0.98 | FALSE |
29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MSL2 | 0.09 | 0.01 | blup | 35 | 0.02 | 8.1e-03 | 4.6 | -5.3 | 1.3e-07 | -0.67 | 0.04 | 0.28 | FALSE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PCCB | 0.12 | 0.07 | enet | 3 | 0.06 | 1.0e-04 | -5.7 | -6.0 | 2.3e-09 | -0.79 | 0.01 | 0.98 | FALSE |
31 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCCB | 0.14 | 0.10 | enet | 6 | 0.10 | 1.0e-06 | -5.9 | -5.7 | 1.6e-08 | -0.69 | 0.00 | 1.00 | FALSE |
32 | The Cancer Genome Atlas | Soft Tissue Sarcoma | STAG1 | 0.06 | 0.06 | lasso | 1 | 0.04 | 2.0e-03 | -6.0 | -6.0 | 1.6e-09 | -0.67 | 0.02 | 0.84 | FALSE |
33 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PCCB | 0.07 | 0.04 | lasso | 1 | 0.02 | 1.1e-02 | -5.8 | -5.8 | 8.0e-09 | -0.70 | 0.01 | 0.96 | FALSE |
34 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCCB | 0.13 | 0.02 | blup | 53 | 0.02 | 4.4e-02 | -2.6 | -5.4 | 8.4e-08 | -0.75 | 0.01 | 0.60 | FALSE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | PCCB | 0.06 | 0.03 | enet | 8 | 0.03 | 2.3e-04 | -5.2 | -5.8 | 9.0e-09 | -0.69 | 0.01 | 0.98 | FALSE |