Hub : Genes

PPP2R3A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0230 1.4e-04 0.020 0.043 0.033 0.045 0.051 1.4e-03 4.8e-06 5.5e-05 3.4e-06 7.7e-07
2 GTEx Adipose Visceral Omentum 0.0800 0.0410 4.5e-03 0.005 NA 0.000 NA -0.003 1.8e-01 NA 3.0e-01 NA 4.8e-01
3 GTEx Artery Tibial 0.0658 0.0319 2.4e-03 0.065 NA 0.017 NA 0.046 7.9e-06 NA 1.5e-02 NA 1.5e-04
4 GTEx Brain Cerebellum 0.2850 0.1040 3.4e-04 -0.010 NA 0.037 NA -0.005 8.4e-01 NA 2.9e-02 NA 4.7e-01
5 GTEx Esophagus Mucosa 0.0620 0.0290 2.1e-03 0.059 NA 0.033 NA 0.041 8.7e-05 NA 2.8e-03 NA 9.1e-04
6 GTEx Stomach 0.0800 0.0360 8.9e-04 0.023 NA 0.031 NA 0.051 2.7e-02 NA 1.2e-02 NA 1.9e-03
7 GTEx Thyroid 0.0970 0.0370 1.4e-05 0.050 NA 0.063 NA 0.051 1.1e-04 NA 1.3e-05 NA 8.9e-05
8 TCGA Colon Adenocarcinoma 0.1350 0.0720 9.6e-04 0.057 0.040 0.034 NA 0.041 3.4e-04 2.2e-03 4.6e-03 NA 2.1e-03
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0493 0.0377 2.9e-03 0.020 0.020 0.023 NA 0.021 2.2e-03 2.5e-03 1.1e-03 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.9 1.5 3.0 -1.6 -0.7 -0.2 -0.3 -1.1 1.5 -1.7 -1.2 1.4
Bipolar Disorder or Schizophrenia 1.8 4.4 9.9 0.6 0.6 3.1 1.4 2.6 -2.2 1.2 2.6 -2.8
Depressed Affect (Nagel 2018) 1.4 3.0 9.7 3.1 0.2 0.4 1.7 0.4 -2.0 1.4 0.5 -2.8
Depression (Nagel 2018) 3.3 4.9 15.6 2.2 1.4 2.0 2.0 1.8 -2.3 1.4 1.8 -3.9
Intelligence (Savage-Jansen 2018) 6.4 19.7 27.8 -4.9 -4.4 -4.6 -3.6 -4.3 5.3 -3.5 -4.3 4.7
Neuroticism (Nagel 2018) 3.2 7.6 26.7 2.9 0.9 2.0 1.9 2.2 -3.1 1.9 2.5 -5.2
Schizophrenia (2018) 6.0 12.4 22.4 2.1 1.3 4.2 2.0 4.3 -4.0 2.9 4.3 -4.7
Schizophrenia vs Biploar Disorder 3.6 4.7 9.6 1.2 1.0 2.1 2.1 2.4 -2.4 2.3 2.3 -3.1
Worry (Nagel 2018) 3.5 7.5 29.1 1.8 1.5 2.1 1.4 2.7 -2.6 1.8 3.0 -5.4
Alzheimer’s Disease (in mother) 0.3 0.4 1.6 -0.1 0.6 -0.5 -1.3 -0.6 0.3 -0.2 -0.6 0.6
Alzheimer’s Disease (in father) 1.0 1.1 6.4 -0.6 2.5 1.0 -0.2 0.7 -0.7 0.1 0.7 0.7
Alzheimer’s Disease (including proxy) 0.4 0.6 4.4 -0.2 2.1 0.0 -0.8 -0.1 -0.4 -0.1 -0.1 0.4
Crohns Disease (2017) 0.5 1.0 2.1 -0.7 -0.7 -0.9 0.8 -1.4 1.4 -0.5 -1.4 0.4
Irritable Bowel Disease (IBD) 0.6 1.4 2.5 -1.1 -1.5 -1.5 -0.1 -1.6 1.4 -0.7 -1.4 -0.0
Ulcerative Colitis (UC) 0.7 1.3 3.0 -0.6 -1.7 -1.7 -0.6 -1.4 0.9 -0.5 -1.2 0.3
Major Depression (MDD) 1.3 1.6 4.2 0.9 -0.3 1.1 0.7 1.0 -1.3 2.0 1.1 -1.9
Reaction Time 1.0 1.9 6.1 1.0 -0.0 1.6 1.4 1.6 -0.8 0.3 1.5 -2.5
Verbal and Numeric Reasoning (VNR) 3.3 7.9 19.1 -4.4 -2.5 -2.7 -2.1 -2.1 3.5 -2.1 -2.1 2.8
Breast Cancer 0.5 1.1 3.3 -0.6 0.1 -1.7 -0.2 -1.0 1.2 -0.5 -1.0 1.8
Ovarian Cancer 1.0 1.3 3.3 -0.1 -0.6 -1.8 0.4 -1.6 0.9 -0.5 -1.5 1.5
Prostate Cancer 0.3 0.4 1.1 -0.6 0.1 -0.7 0.8 -0.4 1.0 0.5 -0.3 0.8
Age at First Birth 0.7 1.1 2.2 -0.4 -1.3 -1.3 -1.5 -1.0 0.4 -1.5 -0.7 -0.6
Bipolar Disorder (2011) 0.4 0.3 0.9 -0.3 -1.0 -0.6 0.6 -0.5 0.5 -0.7 -0.4 0.0
Body Mass Index (BMI) (2010) 3.0 4.1 9.3 3.1 2.1 2.0 1.8 1.9 -2.4 1.7 1.6 -1.0
Coronary Artery Disease (CAD) 1.8 2.1 4.5 1.9 1.0 1.8 2.1 1.0 -1.6 1.2 0.9 -0.8
Crohns Disease (2012) 0.4 0.7 1.8 0.3 -1.3 -0.8 1.3 -0.8 0.8 -0.4 -0.9 0.1
Mean Putamen Volume 0.5 0.6 2.3 -0.2 0.9 -0.7 -1.5 -0.8 0.2 0.0 -0.7 0.5
Fasting Glucose 0.3 0.4 1.0 1.0 1.0 0.8 -0.4 0.3 -0.6 -0.6 0.2 0.1
HbA1C 1.0 1.1 2.5 -1.5 -0.9 -1.2 0.1 -0.9 1.6 -0.6 -0.8 1.2
HDL Cholesterol 2.0 3.3 10.6 -3.3 -1.6 -0.7 -2.0 -0.8 1.6 -2.7 -0.9 -0.8
LDL Cholesterol 1.7 2.7 4.7 0.2 0.5 2.2 1.9 2.0 -1.4 1.5 2.1 -1.9
Lupus 0.5 0.8 1.8 1.3 0.2 1.1 -1.2 0.7 -0.9 -0.4 0.7 -0.7
Neuroticism (2016) 3.6 5.1 19.4 2.3 0.0 2.1 1.1 2.0 -2.0 1.6 2.4 -4.4
Primary Biliary Cirrhosis 0.3 0.4 1.8 0.5 0.4 -0.5 0.4 -0.2 0.5 1.4 -0.2 0.6
Rheumatoid Arthritis 1.2 1.7 10.0 -3.2 -0.9 -0.5 0.3 -0.2 0.4 -1.9 -0.0 -0.5
Schizophrenia (2014) 4.9 10.7 27.9 0.1 0.2 3.9 2.6 3.9 -3.4 2.3 3.9 -5.3
Triglycerides 4.4 7.2 17.2 4.2 2.8 1.8 3.9 1.7 -2.3 3.2 1.9 -0.3
Type 2 Diabetes (T2D) (2012) 1.3 1.5 4.7 1.6 1.3 0.2 1.2 0.7 -0.8 2.2 1.4 -0.1
Ulcerative Colitis 1.2 1.8 4.8 -1.0 -2.2 -1.9 -0.7 -1.4 1.1 -1.0 -1.4 0.6
Blood Eosinophil Count 1.4 11.0 18.1 3.6 3.4 3.2 3.8 3.3 -2.9 4.3 3.2 -1.1
Blood Platelet Count 0.5 5.6 32.4 -1.0 -0.2 -1.4 2.3 -1.1 2.5 -0.5 -1.3 5.7
Blood Red Count 0.1 1.2 4.6 0.8 2.1 -0.1 -1.3 -0.7 -1.4 -0.0 -0.7 0.9
Blood White Count 0.3 2.0 10.6 0.8 1.5 0.9 1.6 0.6 0.6 0.6 0.4 3.3
Heel T-Score 0.1 0.9 4.0 0.8 -0.0 -0.1 2.0 -0.3 0.4 -0.5 -0.7 1.7
BMI 3.8 22.3 40.3 5.2 4.5 4.3 5.2 4.8 -4.5 6.3 4.8 -1.5
Height 5.6 108.0 144.0 -11.4 -12.0 -10.3 -9.7 -10.1 10.7 -11.8 -9.7 7.0
Waist Hip Ratio (WHR) 2.9 13.2 32.7 -2.5 -2.9 -3.5 0.2 -3.5 4.5 -3.6 -3.6 5.7
Systolic Blood Pressure 2.0 10.2 20.1 -2.1 -2.6 -3.0 -2.6 -3.9 2.1 -3.0 -4.1 4.5
Smoking Status 0.5 1.2 2.2 -0.3 -1.1 -1.4 1.3 -1.4 1.0 -0.3 -1.5 0.9
Allergy or Eczema 0.1 0.3 0.8 0.8 -0.9 0.2 0.3 0.0 0.1 -0.7 -0.2 -0.5
Cardiovascular Disease 1.2 3.9 14.3 1.4 1.0 0.4 3.8 -0.5 -1.1 2.2 -0.7 3.3
Hypothyroidism (self reported) 0.4 1.0 3.2 -1.1 -1.8 -0.0 -0.7 -0.0 0.6 -1.3 0.1 -1.2
Respiratory disease 0.7 1.6 7.7 2.8 0.9 0.4 1.5 0.9 -0.6 1.2 1.0 -0.4
Type 2 Diabetes (T2D) (2018) 1.8 3.3 5.3 2.3 1.5 2.0 2.3 1.9 -1.1 2.2 1.5 0.9
Lung FEV1/FVC ratio 1.3 6.6 17.2 -2.6 -1.7 -2.5 -4.2 -2.4 2.7 -2.7 -2.1 1.1
Lung FVC 1.5 7.8 10.9 2.4 3.0 3.3 3.2 2.7 -2.8 3.0 2.6 -1.9
Neuroticism 3.4 8.2 28.5 2.8 0.8 1.8 2.3 2.3 -3.2 2.3 2.7 -5.3
Chronotype (morning person) 0.7 1.6 3.3 0.2 1.0 1.7 1.1 1.2 -1.8 1.8 1.1 -0.2
Hair Pigment 0.3 7.8 13.6 2.8 3.5 2.6 1.5 2.7 -2.9 3.7 2.6 -2.2
Tanning 0.4 4.4 7.5 -2.7 -2.2 -2.0 -2.2 -1.8 2.2 -2.4 -1.9 0.7
Hand grip strength (left) 1.5 4.0 10.4 -1.9 -1.7 -1.8 -3.2 -1.8 1.2 -2.8 -1.8 0.7
Number of treatments/medications taken 1.2 2.2 6.3 2.4 0.7 0.5 2.5 0.7 -1.0 2.1 0.7 0.8
Average weekly spirits intake 2.9 3.6 6.5 1.8 2.5 1.4 1.1 1.8 -1.8 2.6 1.9 -1.7
Sensitivity / hurt feelings 1.8 3.1 10.8 1.2 0.8 1.5 0.1 1.5 -2.3 1.5 1.7 -3.3
Frequency of depressed mood in last 2 weeks 2.1 3.0 11.6 1.6 0.2 1.4 2.1 1.5 -1.1 0.5 1.4 -3.4
Hearing difficulty/problems: Yes 1.7 2.6 7.7 1.2 -1.3 -1.8 0.5 -2.1 0.8 0.5 -2.1 2.8
Relative age of first facial hair 0.9 1.8 3.7 -1.4 -1.9 -1.0 -1.5 -1.1 0.6 -1.5 -1.1 -1.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 3.3 0.9 0.9 1.2 1.8 0.9 -0.5 0.1 0.6 0.8
Ever used hormone-replacement therapy (HRT) 5.8 7.4 17.1 3.7 1.6 2.0 2.8 2.2 -2.9 4.1 2.2 -1.8
Ever had hysterectomy (womb removed) 1.2 1.3 3.8 -0.4 -1.1 -1.9 0.6 -1.4 1.5 0.4 -1.1 1.0
Systolic blood pressure, automated reading 0.3 0.8 2.9 0.0 -0.7 -0.7 1.0 -1.1 -0.3 -0.1 -1.2 1.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 2.7 0.4 -1.6 0.1 -0.2 0.5 0.5 -0.0 0.1 -0.2
Angina 3.5 4.6 10.6 1.8 0.8 2.2 3.3 2.4 -1.3 2.6 2.4 -1.2
Medication for hormone replacement therapy 0.2 0.3 0.7 0.8 0.7 0.2 0.1 0.2 -0.4 0.8 0.3 0.2
Vitamin and mineral supplements 1.5 2.0 5.3 0.3 1.2 2.3 1.0 2.0 -1.5 0.8 1.8 -0.4
Supplements: Zinc 0.4 0.5 0.9 0.4 -0.9 -1.0 0.4 -0.8 0.7 0.8 -0.5 0.2
Medication: Co-codamol 1.7 2.0 5.9 2.4 1.5 0.6 1.7 0.8 -1.4 1.3 1.0 -1.2
Medication: Metformin 5.0 7.0 10.8 3.3 2.2 2.8 1.9 3.0 -2.7 3.3 2.6 -1.5
Diabetes (father) 2.4 3.0 8.4 2.9 2.3 1.4 0.6 1.4 -2.2 1.4 1.2 -0.9
Diabetes (mother) 2.2 2.8 5.6 1.5 1.6 2.2 1.6 2.4 -1.1 1.3 2.1 -0.6
Severe depression (siblings) 0.2 0.2 0.6 0.8 -0.4 -0.0 -0.4 0.2 -0.0 -0.7 0.1 -0.4
Pack years adult smoking proportion 2.5 3.8 15.7 4.0 1.4 1.7 1.9 1.5 -1.4 1.9 1.1 -0.7
Impedance of leg (right) 1.9 9.4 14.6 -3.5 -3.2 -2.8 -3.8 -2.7 3.0 -3.6 -2.6 1.8
Leg fat-free mass (left) 0.1 0.4 1.8 -0.4 -0.7 -0.3 1.3 0.1 0.8 0.1 0.2 0.7
Trunk fat percentage 0.4 1.6 3.5 1.4 0.6 1.2 0.8 1.7 -0.8 1.7 1.9 -0.4
Hand grip strength (right) 1.0 2.8 6.3 -1.8 -1.7 -1.4 -2.5 -1.6 0.9 -1.9 -1.7 1.0
Townsend deprivation index at recruitment 1.5 2.1 6.1 -1.9 -0.1 -0.6 -2.5 -1.3 1.0 -2.0 -1.5 0.6
Current tobacco smoking 0.5 0.7 4.2 1.0 0.3 0.5 2.0 0.2 -0.5 0.9 0.1 -0.4
Average weekly fortified wine intake 0.4 0.5 1.1 -0.7 -0.3 -1.0 -0.4 -0.7 0.9 -1.0 -0.5 0.4
Maternal smoking around birth 1.5 2.2 6.0 -0.0 2.5 1.8 0.6 1.9 -1.3 0.9 1.9 -0.8
Fed-up feelings 3.7 6.8 16.4 3.4 1.0 2.1 2.5 1.8 -3.1 2.4 1.6 -4.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.4 4.6 10.1 1.6 0.9 2.0 2.8 2.0 -2.1 1.9 1.9 -3.2
Relative age voice broke 0.8 1.2 6.0 0.3 -1.0 -0.6 -1.6 -0.6 0.2 0.1 -0.4 -2.4
Taking other prescription medications 0.4 0.6 3.0 1.7 -0.4 0.1 1.3 0.3 -0.0 0.5 0.5 -0.4
Age when periods started (menarche) 0.7 1.7 4.2 0.1 0.9 1.3 0.5 1.8 -1.3 0.8 1.6 -2.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.5 0.0 -0.4 -1.2 0.7 -0.6 0.5 0.6 -0.5 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 3.8 -1.1 -1.4 -1.8 -0.5 -1.5 1.5 -1.1 -1.6 1.9
Tinnitus: Yes, but not now, but have in the past 2.9 3.0 4.7 0.5 2.0 2.2 1.7 2.0 -1.9 1.3 1.9 -1.6
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.2 0.8 1.0 -0.9 0.8 -1.0 0.3 0.7 0.0
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -1.0 -0.3 -0.4 0.8 -0.2 0.7 -0.2 -0.3 0.9
High blood pressure 0.6 1.7 6.6 0.4 0.6 -0.6 2.6 -0.7 0.1 1.0 -0.9 2.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 3.1 0.1 -1.8 -0.1 -1.1 -0.2 0.6 -1.0 -0.3 0.2
Multivitamins +/- minerals 1.5 2.0 4.7 -0.5 -1.7 -2.2 -0.9 -1.8 1.6 -1.0 -1.5 0.3
Stomach or abdominal pain in last month 3.6 4.4 10.7 0.5 0.4 2.4 2.4 2.6 -1.8 1.2 2.5 -3.3
Supplements: Glucosamine 0.6 0.8 4.3 2.1 0.7 -0.4 0.5 -0.5 -0.5 1.2 -0.5 0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.0 -0.6 -1.0 -0.0 -0.7 -0.1 0.7 -1.0 -0.1 0.4
Medication: Atenolol 0.5 0.6 2.8 -0.3 0.6 0.6 1.7 0.8 0.1 1.0 0.8 0.1
Medication: Levothyroxine sodium 0.4 0.6 3.6 -0.8 -0.7 -0.0 -0.4 -0.2 0.6 -1.9 -0.2 -0.1
Sitting height 1.7 11.9 19.3 -3.1 -4.4 -3.8 -1.5 -3.7 3.6 -3.6 -3.6 2.9
Chronic bronchitis/emphysema (father) 0.5 0.6 2.3 1.5 -0.1 0.4 -0.5 0.6 -0.1 1.3 0.7 0.2
High blood pressure (mother) 0.7 1.0 3.3 1.4 0.3 0.4 1.4 0.2 -1.1 1.8 0.1 0.1
Body mass index (BMI) 5.0 21.2 31.6 5.6 4.4 4.3 4.5 4.8 -4.4 5.6 4.8 -2.3
Impedance of leg (left) 1.8 8.8 18.6 -3.2 -3.4 -2.6 -4.3 -2.5 2.6 -3.4 -2.4 1.4
Leg predicted mass (left) 0.1 0.4 2.0 -0.4 -0.6 -0.2 1.4 0.2 0.7 0.2 0.3 0.6
Trunk fat mass 0.2 1.0 1.9 1.3 0.0 0.7 1.0 1.3 -0.4 1.4 1.4 0.0
Waist circumference 1.1 4.0 11.6 2.8 1.5 1.2 3.4 1.6 -0.8 2.5 1.6 1.3
Number of incorrect matches in round 0.4 0.7 3.0 0.8 -0.1 -0.9 -1.1 -0.3 -0.5 0.5 0.1 -1.7
Past tobacco smoking 1.9 3.5 6.0 0.7 1.6 2.4 0.8 2.5 -2.0 1.5 2.5 -1.9
Alcohol usually taken with meals 3.0 4.8 9.9 -1.8 -2.6 -1.9 -1.7 -1.8 2.6 -3.2 -1.8 1.9
Nervous feelings 4.3 8.1 29.4 1.6 1.3 2.9 -0.0 3.1 -2.7 1.4 3.5 -5.4
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 15.3 2.0 0.3 1.5 1.6 1.9 -1.3 1.3 2.0 -3.9
Hearing difficulty/problems with background noise 1.5 2.5 9.7 3.1 0.4 0.3 2.4 0.3 -1.2 2.0 0.3 -0.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 -0.1 -0.6 0.3 0.4 0.8 0.6 -0.3 1.1 -0.8
Had menopause 3.5 4.4 9.6 3.1 1.4 1.8 1.2 1.8 -2.2 2.8 1.8 -2.0
Had other major operations 1.5 1.8 5.8 -1.0 0.4 -1.1 -1.0 -1.0 1.5 -1.8 -1.0 2.4
Forced vital capacity (FVC) 0.5 1.9 7.4 -2.7 -0.7 -0.8 -0.7 -1.0 1.3 -1.8 -1.0 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.2 -1.0 -0.9 -0.7 -0.4 -0.7 0.7 -1.4 -0.9 1.8
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.5 -0.9 -1.8 -1.0 -0.2 -1.0 1.9 -1.2 -1.1 1.1
Qualifications: None of the above 4.1 8.7 14.6 3.3 3.1 3.1 2.3 2.9 -3.0 3.8 2.7 -2.1
Financial difficulties in last 2 years 1.1 1.4 3.8 -0.2 -1.7 -1.0 0.1 -0.8 1.6 -1.9 -1.0 0.9
Mouth/teeth dental problems 4.7 7.3 16.4 -4.1 -2.6 -2.2 -3.5 -1.9 3.0 -2.7 -1.7 1.6
Heart attack 1.5 1.9 6.2 2.0 -1.4 -0.3 2.5 -0.6 -0.5 1.2 -0.7 1.6
Allergy 0.4 0.9 3.4 -1.8 0.6 -1.0 -0.8 -1.0 0.2 -0.7 -0.9 0.5
Pain all over the body in last month 0.6 0.6 1.6 1.3 0.8 -0.1 1.1 -0.1 -1.2 0.8 0.0 0.2
Diabetes (self-reported) 1.4 2.2 6.2 2.5 1.1 1.5 1.4 1.5 -1.1 1.7 1.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.9 -0.2 -0.5 1.4 0.8 1.7 -0.5 -0.4 1.6 -1.2
Medication: Ramipril 0.7 0.9 3.1 0.8 0.2 -0.5 1.6 -0.2 -0.4 1.0 -0.5 1.8
Medication: Simvastatin 1.3 1.9 4.7 2.2 -0.0 0.9 2.2 0.6 -1.2 1.9 0.5 1.2
Fluid intelligence score 2.4 5.0 16.9 -4.1 -1.1 -1.6 -1.9 -1.3 2.4 -1.5 -1.3 3.1
Illnesses of siblings 1.6 2.3 8.1 -1.6 -1.3 -1.0 -2.4 -0.5 1.2 -2.8 -0.0 -0.4
Neuroticism score 2.8 5.8 22.5 2.5 0.3 1.4 1.4 1.8 -2.7 2.2 2.0 -4.7
Weight 0.2 1.2 2.5 1.4 0.3 0.6 1.6 1.2 -0.5 1.5 1.3 0.1
Impedance of arm (right) 6.8 31.7 50.6 -7.1 -5.2 -5.0 -6.4 -5.1 5.9 -6.8 -5.0 3.0
Arm fat percentage (right) 1.5 5.9 8.5 2.9 2.5 2.5 1.7 2.8 -2.1 2.8 2.9 -1.2
Trunk fat-free mass 0.2 1.4 2.6 -0.4 -1.6 -1.5 0.2 -1.1 1.3 -0.8 -1.1 1.5
Hip circumference 1.2 5.3 11.1 3.0 1.8 1.9 2.2 2.5 -1.6 3.3 2.6 -0.6
Time employed in main current job 0.9 1.0 2.2 1.5 0.7 0.9 0.9 0.6 -1.4 1.2 0.5 -0.6
Alcohol intake versus 10 years previously 0.6 0.9 2.6 -0.8 -0.8 -1.1 -0.4 -0.8 1.6 -0.6 -0.9 0.8
Father’s age at death 1.1 1.4 2.6 1.6 0.4 0.9 1.2 1.0 -1.1 1.4 1.1 -1.6
Worrier / anxious feelings 8.4 15.9 28.0 3.2 2.1 4.0 3.7 4.2 -4.5 3.9 4.3 -5.3
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 8.9 3.0 1.6 2.2 2.9 2.1 -2.3 1.6 1.8 -2.9
Falls in the last year 1.4 1.8 6.4 2.5 1.3 0.1 1.9 0.2 -0.0 1.9 0.1 1.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.2 0.7 0.2 -0.6 -1.1 -0.8 0.6 -0.3 -0.9 0.5
Number of live births 4.2 5.9 14.2 2.3 1.5 2.2 3.8 1.9 -2.3 3.3 1.8 -1.9
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 11.6 -3.4 -1.1 -1.2 -1.4 -1.1 1.8 -2.1 -0.9 0.8
Pulse rate 0.3 0.6 2.5 -1.6 -0.9 0.1 -0.5 -0.1 0.5 -0.7 -0.3 1.0
Happiness 0.1 0.2 0.9 0.1 -0.7 0.3 -0.2 0.1 -0.0 0.2 0.0 -0.9
Noisy workplace 2.1 2.6 6.2 1.8 1.0 1.9 2.1 1.1 -1.8 2.5 0.9 0.2
Qualifications: A levels/AS levels or equivalent 1.9 4.3 7.7 -2.8 -1.8 -1.7 -0.2 -2.1 2.4 -2.1 -2.3 2.2
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 4.4 2.0 2.0 1.2 1.1 1.6 -2.1 0.9 1.5 -0.9
Mouth/teeth dental problems: Dentures 7.8 13.1 19.2 4.3 3.1 3.3 3.7 3.1 -4.4 3.9 3.0 -3.5
Asthma 1.1 2.2 7.4 2.7 0.6 0.9 1.6 1.3 -0.9 1.8 1.4 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.7 2.1 0.6 -0.3 2.2 0.2 0.1 1.0 -0.1 1.5
Medication: Cholesterol lowering 1.7 2.6 7.2 2.4 0.2 0.9 2.7 0.9 -1.1 2.0 0.6 1.7
Depression (self-reported) 0.6 0.7 2.6 -0.3 -0.7 -0.7 -1.6 -0.8 0.8 -0.9 -0.9 0.4
Medication: Lansoprazole 1.0 1.1 4.4 2.1 0.1 0.6 1.7 0.9 -0.9 0.4 0.8 -0.4
Prospective memory result 0.5 0.6 1.5 1.2 -0.8 -0.8 -0.7 -0.9 0.3 -0.6 -0.6 0.5
Lung cancer (father) 0.6 0.7 1.8 -1.4 -1.0 -0.7 0.3 -0.6 0.4 -0.9 -0.6 1.0
Illnesses of mother 0.9 1.1 3.0 -1.4 -1.5 -0.5 -0.2 -0.9 0.9 -1.7 -1.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 9.2 -3.0 -0.9 -0.8 -1.6 -0.7 1.9 -2.1 -0.6 0.1
Pulse wave Arterial Stiffness index 4.1 4.8 11.8 0.2 -2.9 -2.3 -0.3 -2.3 1.9 -0.8 -2.7 3.4
Impedance of arm (left) 6.7 31.1 53.3 -7.3 -5.3 -5.2 -5.6 -5.1 6.0 -6.5 -4.9 3.4
Arm fat mass (right) 1.1 4.7 7.7 2.8 1.8 2.0 2.0 2.5 -1.7 2.6 2.5 -0.9
Trunk predicted mass 0.2 1.4 2.7 -0.4 -1.7 -1.6 0.1 -1.1 1.3 -0.8 -1.1 1.5
Standing height 6.1 60.1 79.4 -8.8 -8.8 -7.9 -6.5 -7.4 8.3 -8.9 -7.2 5.0
Length of working week for main job 1.3 1.4 2.1 0.2 1.3 1.4 0.2 1.4 -1.2 1.3 1.4 -1.3
Exposure to tobacco smoke at home 1.5 1.6 5.9 2.4 0.5 0.4 1.8 0.7 -0.8 1.8 0.4 -0.8
Breastfed as a baby 0.5 0.6 1.9 0.8 -0.8 0.2 1.4 0.3 -1.1 0.9 0.2 0.3
Tense / ‘highly strung’ 1.4 2.4 12.4 0.7 0.4 0.8 -0.1 1.1 -1.8 1.3 1.3 -3.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.7 -0.8 -1.1 -0.8 -0.5 -0.5 0.5 -1.3 -0.6 -0.3
Hair/balding pattern: Pattern 4 8.3 20.1 33.2 3.1 4.9 5.8 3.8 5.1 -4.5 4.5 4.8 -3.2
Birth weight of first child 1.5 2.7 5.0 -2.2 -2.1 -1.3 -1.4 -1.8 1.5 -1.3 -1.8 1.0
Peak expiratory flow (PEF) 0.7 1.7 4.4 -2.1 -0.7 -0.8 -1.1 -0.9 1.5 -2.0 -0.9 0.7
Pulse wave reflection index 0.9 1.1 4.2 1.0 0.2 -1.2 0.4 -1.0 -0.0 0.9 -1.2 2.0
Ever highly irritable/argumentative for 2 days 0.5 0.5 2.8 -0.5 0.5 0.7 1.7 0.6 0.5 0.3 0.6 0.2
Loud music exposure frequency 1.5 1.6 2.7 0.5 1.1 1.3 1.3 1.5 -1.0 1.6 1.6 -1.1
Qualifications: O levels/GCSEs or equivalent 1.8 2.8 4.1 -1.5 -1.5 -1.7 -1.7 -1.6 2.0 -2.0 -1.5 1.4
Mouth/teeth dental problems: Bleeding gums 0.7 0.8 3.1 0.2 0.8 -0.5 0.9 -0.8 0.6 -0.6 -1.2 1.8
Blood clot in the leg (DVT) 0.4 0.5 1.7 0.4 0.3 0.7 0.6 0.0 -0.1 1.2 -0.2 1.3
Medication: Paracetamol 0.9 1.4 3.4 1.0 1.8 1.3 1.6 1.0 -0.9 1.1 0.7 0.7
Headache pain in last month 3.5 6.0 12.5 2.9 1.8 2.5 1.8 2.6 -2.2 1.5 2.5 -3.5
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.0 -1.4 -0.1 0.0 -1.5 0.2 0.3 -1.0 0.4 -1.7
Glaucoma (self-reported) 4.2 4.9 7.1 -1.8 -1.9 -2.6 -2.7 -2.5 2.2 -2.6 -2.1 0.8
Gout (self-reported) 0.4 0.5 2.7 0.1 0.2 -0.1 0.8 -0.5 -0.0 -0.2 -0.8 1.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.9 -0.9 -1.5 -0.1 -0.8 -0.3 0.7 -1.7 -0.3 -0.7
Medication: Amlodipine 0.3 0.4 1.1 0.8 0.8 -0.1 0.8 -0.1 -0.4 -0.2 0.0 -1.0
Medication: Ventolin 100micrograms inhaler 2.2 2.9 6.2 1.6 1.0 1.1 2.3 1.5 -1.2 2.5 1.7 -1.6
Birth weight 2.1 4.6 8.9 -3.0 -2.2 -2.3 -1.6 -2.2 1.7 -2.5 -2.2 1.0
Chronic bronchitis/emphysema (mother) 0.9 1.1 1.9 1.0 0.3 0.8 -1.0 1.2 -0.6 1.2 1.4 -1.4
High blood pressure (siblings) 0.6 0.9 2.9 1.1 1.0 1.0 0.8 0.6 -1.0 1.7 0.2 -0.1
Forced vital capacity (FVC), Best measure 0.3 1.1 5.2 -2.3 -0.4 -0.5 -0.5 -0.5 1.2 -1.5 -0.5 0.0
Body fat percentage 1.3 5.1 8.0 2.8 1.8 2.1 1.7 2.7 -2.0 2.8 2.8 -0.9
Leg fat percentage (right) 3.6 12.9 24.8 5.0 3.5 3.3 2.8 3.7 -3.5 4.3 3.7 -1.3
Arm fat-free mass (right) 0.2 0.9 3.2 1.0 -0.1 0.3 1.8 0.8 -0.5 1.3 0.8 0.3
Exposure to tobacco smoke outside home 4.5 6.0 12.9 3.6 2.7 2.1 2.1 2.3 -2.2 3.0 2.2 -1.4
Comparative body size at age 10 0.6 1.6 2.8 0.6 1.3 1.6 1.7 1.6 -1.0 1.2 1.3 0.9
Number of full brothers 1.0 1.2 3.1 0.2 1.6 0.4 1.7 0.4 -1.4 1.7 0.2 -0.3
Worry too long after embarrassment 6.0 10.1 31.7 2.3 1.0 3.0 1.2 3.4 -3.2 2.6 3.8 -5.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 2.2 -0.9 -1.5 -0.7 -0.1 -0.3 0.2 -0.0 -0.3 -0.3
Wheeze or whistling in the chest in last year 1.7 3.1 11.8 3.4 1.3 0.6 2.4 0.6 -1.1 2.6 0.5 0.3
Number of children fathered 0.9 1.0 2.9 1.7 1.0 0.0 1.6 -0.1 -1.2 0.7 0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.0 1.0 -0.8 -0.7 -0.9 -0.2 0.0 0.4 0.1 -1.4
Age at first live birth 0.9 1.5 2.9 -1.6 -1.0 -1.4 -1.1 -1.2 1.3 -1.7 -0.8 0.6
Pulse wave peak to peak time 3.1 3.6 10.0 -0.7 2.5 1.9 -0.0 2.0 -1.5 0.4 2.5 -3.2
Health satisfaction 3.3 4.3 7.9 2.8 0.7 2.1 1.9 2.1 -1.9 2.6 2.0 -1.9
Shortness of breath walking on level ground 0.9 1.0 5.9 2.4 0.5 0.5 0.2 0.6 -0.4 1.1 0.5 -0.9
Qualifications: College or University degree 0.9 2.7 7.4 -2.1 -2.7 -1.2 -0.5 -1.0 1.7 -2.3 -0.9 0.8
Eye problems/disorders: None of the above 0.3 0.3 1.3 -1.1 1.0 0.4 -0.3 -0.0 -0.3 0.5 -0.1 0.2
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.8 1.7 1.4 0.6 1.3 0.6 -0.5 0.8 0.6 -1.1
Emphysema/chronic bronchitis 0.6 0.7 1.3 1.1 -1.1 -0.6 1.1 -0.6 0.7 0.9 -0.5 0.8
Medication for pain relief, constipation, heartburn 1.3 2.2 6.8 -2.6 -1.0 -0.8 -2.3 -0.7 0.5 -1.5 -0.4 -1.7
Neck or shoulder pain in last month 1.4 2.0 4.7 1.8 2.1 1.3 2.2 0.8 -1.3 1.2 0.7 0.0
Medication: Blood pressure 0.4 0.8 1.7 -0.3 -0.3 -1.2 -0.0 -1.1 0.9 -0.1 -1.2 1.3
Angina (self-reported) 4.3 5.7 13.1 2.0 1.1 2.4 3.6 2.7 -1.6 2.9 2.6 -1.4
Migraine (self-reported) 0.7 0.8 2.0 -0.5 -0.5 -0.9 -0.9 -1.0 0.9 -1.4 -0.9 0.8
Medication: Ibuprofen 1.0 1.2 3.1 1.8 1.0 0.0 1.7 0.5 -0.3 1.3 0.2 1.2
Medication: Allopurinol 0.5 0.6 1.0 -0.8 -0.8 -0.9 0.0 -0.9 0.5 -0.8 -1.0 0.9
Medication: Omeprazole 0.4 0.5 1.0 1.0 0.2 0.7 -0.5 0.7 -0.8 0.7 0.9 -0.8
Medication: Seretide 50 evohaler 0.6 0.7 4.1 -0.1 0.1 -0.4 2.0 0.0 0.7 1.0 -0.0 1.0
Mean time to correctly identify matches 0.7 1.3 4.8 1.7 -0.2 0.9 1.2 0.8 -0.6 0.6 0.7 -2.2
Heart disease (mother) 5.2 6.3 11.5 3.4 2.9 2.0 1.8 2.4 -2.7 3.3 2.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.1 0.0 -0.5 -1.4 -0.9 -1.0 0.5 -0.8 -1.2 1.5
Whole body fat mass 0.9 3.6 6.1 2.5 1.2 1.7 1.9 2.2 -1.4 2.4 2.3 -0.4
Leg fat mass (right) 2.4 9.2 14.4 3.8 2.4 2.8 3.1 3.4 -2.6 3.7 3.5 -1.3
Arm predicted mass (right) 0.1 0.6 2.2 0.8 -0.4 0.1 1.5 0.5 -0.3 1.1 0.5 0.4
Pulse rate, automated reading 0.1 0.5 2.0 0.8 -0.2 1.1 0.3 0.3 -0.2 0.1 0.0 1.4
Alcohol intake frequency. 0.8 1.9 4.4 0.7 0.7 2.1 1.2 1.8 -0.7 0.7 1.6 -1.9
Comparative height size at age 10 4.3 23.6 29.1 -5.3 -5.4 -4.9 -4.5 -4.8 5.2 -4.5 -4.7 4.4
Number of full sisters 0.4 0.5 1.5 0.5 -1.2 -0.7 0.5 -0.1 1.1 0.5 -0.3 -0.7
Suffer from ‘nerves’ 0.6 0.9 4.0 -0.5 -1.6 -0.5 -1.0 -0.4 0.4 -0.3 -0.1 -2.0
Overall health rating 2.7 5.8 11.3 3.4 2.5 2.5 2.9 2.3 -2.4 1.8 2.1 -0.7
Chest pain or discomfort 6.9 9.9 20.3 4.0 2.2 2.9 4.5 2.9 -3.4 3.0 2.7 -1.9
Had major operations 1.0 1.1 3.5 -1.4 -0.5 -0.1 1.3 -0.6 1.2 -0.9 -0.7 1.9
Age at last live birth 0.3 0.5 2.0 -1.4 -0.2 -0.0 0.4 0.3 0.2 -0.6 0.5 -1.0
Family relationship satisfaction 1.2 1.5 2.8 -0.9 -1.7 -1.7 0.8 -1.2 1.6 -0.9 -1.2 0.7
Leg pain on walking 1.8 2.3 6.7 2.6 0.6 1.2 0.8 1.1 -1.9 1.7 1.1 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.2 1.5 1.1 -0.0 0.4 0.7 -0.8 1.1 0.5 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.8 -0.0 -0.1 -0.6 -0.3 -0.6 0.2 -1.3 -0.4 0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 1.9 -0.2 -0.1 -0.1 -0.1 -0.3 -0.2 1.4 -0.2 0.2
Medication: Aspirin 1.6 2.1 5.5 2.0 0.2 0.9 2.3 0.4 -0.7 2.2 0.1 1.6
Supplements: Vitamin C 0.6 0.7 2.4 1.5 1.4 -0.8 -0.4 -0.7 -0.3 0.0 -0.6 0.1
Knee pain experienced in last month 1.9 2.9 9.8 2.7 0.5 0.8 3.1 0.9 -1.2 2.1 0.9 -0.7
Hypertension (Self-reported) 0.8 2.1 9.5 0.4 1.2 0.0 3.1 -0.2 -0.5 1.5 -0.4 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.7 0.8 -0.1 0.3 1.3 0.5 0.6 -0.4 0.4 -0.3
Illnesses of father: Heart disease 6.2 8.6 12.6 2.2 3.4 3.4 2.9 3.3 -2.9 3.5 3.0 -0.3
Illnesses of siblings: Diabetes 2.3 2.8 7.7 2.2 1.3 1.1 2.8 0.7 -1.1 2.7 0.4 0.5
Smoking status: Previous 1.4 2.1 3.8 -1.1 -1.3 -1.7 -0.5 -2.0 1.7 -0.8 -1.8 1.6
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.2 12.2 -3.5 -2.0 -2.2 -1.1 -1.8 3.0 -3.0 -1.6 0.7
Whole body fat-free mass 0.1 0.5 1.2 -0.2 -1.1 -0.8 0.8 -0.4 0.9 -0.1 -0.4 1.0
Leg fat-free mass (right) 0.1 0.3 1.0 -0.4 -0.9 -0.3 1.0 0.0 0.8 0.0 0.1 0.6
Arm fat percentage (left) 1.7 6.7 9.9 3.0 2.6 2.5 2.1 2.9 -2.2 3.1 3.0 -1.1
Average weekly red wine intake 2.0 2.9 6.2 -1.0 -2.5 -2.2 -1.6 -2.1 1.4 -1.2 -1.9 0.4
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.6 -1.9 -1.5 -0.5 -0.9 -0.2 1.6 -0.7 -0.1 -0.3
Mood swings 1.0 1.7 5.1 2.3 -1.4 -1.6 1.2 -1.1 -0.1 1.0 -0.9 -1.2
Loneliness, isolation 0.9 1.3 3.2 1.6 -0.2 0.8 1.8 0.7 -1.1 0.5 0.5 -1.6
Long-standing illness, disability or infirmity 2.2 3.3 8.8 2.4 1.5 1.8 3.0 1.7 -0.9 2.0 1.4 -0.9
Ever had bowel cancer screening 1.1 1.3 3.5 0.8 -0.6 1.1 1.1 1.0 -0.8 1.1 1.3 -1.9
Diabetes diagnosed by doctor 2.3 3.8 8.1 2.9 1.2 2.0 1.7 2.3 -1.7 2.4 2.0 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.3 -0.2 -1.4 -1.4 0.8 -1.4 1.4 -0.4 -1.4 1.5
Friendships satisfaction 0.2 0.3 1.0 -0.1 0.6 0.3 1.0 0.2 -0.4 0.8 0.2 0.2
Qualifications: nursing, teaching 0.3 0.5 2.9 -0.1 -0.5 0.2 1.2 -0.0 -0.3 0.0 -0.2 1.7
Commuting to job workplace: Walk 0.6 0.6 2.1 -0.3 -0.6 -0.6 0.3 -0.6 1.0 -0.6 -0.9 1.4
Eye problems/disorders: Cataract 0.7 0.8 4.1 2.0 -0.6 -0.4 1.1 -0.1 0.2 1.2 -0.2 -0.0
Mouth/teeth dental problems: Mouth ulcers 3.4 5.5 9.8 3.1 0.4 1.8 2.7 2.1 -2.5 3.1 2.2 -1.9
Medication for cholesterol 0.3 0.4 1.7 -0.1 -0.4 0.2 -0.8 0.0 0.3 -1.1 -0.0 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.0 -0.3 -1.4 -0.2 -0.3 -0.3 0.9 -1.3 -0.4 0.6
Back pain experienced in last month 2.8 4.0 9.2 2.9 0.7 1.7 3.0 1.6 -1.9 1.9 1.5 -1.8
Mineral and other dietary supplements 0.7 1.0 2.2 -1.3 0.3 1.4 0.9 1.5 -0.4 -0.4 1.3 -0.2
Breast cancer (self-reported) 1.3 1.5 2.9 -0.9 -1.7 -1.7 0.1 -1.5 1.6 -0.6 -1.5 0.5
Asthma (self-reported) 0.9 1.7 7.0 2.6 0.6 0.7 1.5 1.1 -0.6 1.5 1.1 -0.4
Osteoporosis (self-reported) 0.2 0.3 0.9 0.9 -0.4 0.3 0.9 -0.1 -0.5 0.2 -0.4 -0.2
Osteoarthritis (self-reported) 1.0 1.3 2.6 1.6 1.3 0.7 0.5 0.9 -1.5 1.3 1.0 -0.8
Medication: Aspirin 1.8 2.3 7.2 2.2 0.3 0.8 2.7 0.3 -0.5 2.3 0.0 1.7
Medication: Gliclazide 2.0 2.3 4.4 0.3 0.1 1.6 1.3 2.1 -1.4 2.1 1.9 -1.5
Illnesses of father: None of the above (group 1) 1.8 2.3 4.3 -1.4 -2.1 -1.7 -1.0 -1.8 1.0 -1.7 -1.8 -0.2
Smoking status: Current 0.2 0.3 2.2 0.5 0.3 0.1 1.5 -0.1 -0.2 0.4 -0.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.6 -1.2 2.1 1.4 0.5 1.2 -0.6 1.0 1.1 -0.5
Whole body water mass 0.1 0.5 1.3 -0.3 -1.2 -0.8 0.8 -0.4 0.9 -0.2 -0.4 0.9
Leg predicted mass (right) 0.1 0.4 1.0 -0.5 -1.0 -0.3 1.0 0.0 0.8 -0.0 0.1 0.6
Arm fat mass (left) 1.1 4.6 8.1 2.6 1.8 1.9 2.1 2.4 -1.7 2.9 2.5 -0.8
Number of self-reported non-cancer illnesses 0.7 1.1 4.3 2.1 0.9 0.9 1.2 0.7 -1.0 0.7 0.5 0.6
Average weekly champagne plus white wine intake 1.9 2.6 6.0 -2.0 -1.0 -0.9 -1.5 -1.1 1.9 -2.5 -1.1 1.8
Miserableness 2.6 4.4 9.1 2.6 1.1 1.4 2.2 1.5 -2.3 2.4 1.7 -3.0
Guilty feelings 0.7 1.0 4.3 0.9 -0.8 0.1 0.8 0.4 -1.1 0.6 0.7 -2.1
Wears glasses or contact lenses 0.6 0.7 2.6 1.3 -0.5 0.3 0.5 0.4 -1.2 1.6 0.2 -0.3
Ever taken oral contraceptive pill 0.1 0.1 0.5 -0.2 0.1 -0.1 -0.5 -0.2 0.4 -0.1 -0.0 0.7
Hearing aid user 1.2 1.4 3.7 -0.8 -1.5 -1.0 -0.2 -0.8 1.7 0.3 -1.1 1.9
Mother’s age at death 0.7 0.9 2.5 -1.2 -1.3 -0.6 -1.6 -0.8 0.7 -0.2 -0.6 -0.4
Financial situation satisfaction 0.6 0.8 2.5 0.6 -0.1 0.5 0.4 1.2 -0.7 0.4 1.3 -1.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.7 1.3 -0.1 -0.3 -0.5 -0.7 0.1 0.7 -0.7 -0.8
Commuting to job workplace: Public transport 1.8 2.1 4.6 -1.4 -1.7 -1.2 -1.3 -1.1 2.1 -1.4 -1.3 1.4
Eye problems/disorders: Glaucoma 3.8 4.5 9.2 -1.2 -2.0 -2.7 -3.0 -2.4 1.8 -2.4 -2.0 0.7
Medication: Blood pressure 0.4 0.8 3.6 -0.4 0.2 -0.3 1.6 -0.3 0.4 0.8 -0.2 1.9
Pain type(s) experienced in last month: Hip pain 2.4 3.0 6.4 2.3 1.9 2.5 1.0 1.7 -1.8 1.4 1.4 -0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.3 1.5 1.2 0.5 -0.4 0.4 -1.4 1.3 0.5 -0.7
High cholesterol (Self-reported) 2.3 4.1 9.3 3.1 1.2 1.9 1.6 1.6 -2.5 3.0 1.5 0.5
Medication: Bendroflumethiazide 1.0 1.5 4.4 -0.9 -0.9 -1.4 0.5 -1.5 0.6 0.1 -1.5 2.1
Medication: Paracetamol 0.6 0.9 2.1 0.6 1.5 0.9 1.4 0.6 -0.6 0.9 0.4 1.0
Medication: Lisinopril 0.4 0.5 1.8 -1.1 0.1 -0.4 0.5 -0.6 0.7 0.1 -0.7 1.4
Medication: Atorvastatin 2.5 3.0 4.9 1.4 1.0 1.9 1.8 2.2 -1.5 2.2 2.2 -0.8
Illnesses of father: High blood pressure 0.6 0.7 2.3 -1.5 -0.7 -0.8 0.4 -0.8 0.4 -1.0 -0.7 0.8
Alcohol drinker status: Never 5.2 6.2 15.5 0.5 1.6 3.9 2.1 3.2 -2.6 1.8 2.9 -2.2
Ever smoked 4.0 7.0 11.9 -0.8 -2.3 -3.1 -1.4 -3.3 2.8 -2.9 -3.5 2.6
Basal metabolic rate 0.1 0.3 1.1 0.1 -0.8 -0.4 1.0 0.1 0.6 0.2 0.1 0.8
Leg fat percentage (left) 4.1 14.7 30.4 5.5 3.4 3.6 2.5 4.0 -3.9 4.6 4.0 -1.8
Arm fat-free mass (left) 0.2 0.9 1.8 1.3 0.0 0.6 1.2 1.0 -0.7 1.3 1.1 -0.4
Number of operations (self-reported) 0.9 1.3 5.1 0.3 -0.6 -0.9 0.3 -1.0 1.5 -0.6 -1.2 2.3
Average weekly beer plus cider intake 2.1 3.0 7.1 2.7 1.5 1.2 1.1 1.4 -2.0 2.4 1.1 -1.5
Irritability 0.2 0.3 1.6 0.1 -1.3 -0.4 -0.2 -0.2 -0.0 -0.3 -0.2 -0.5
Risk taking 1.7 2.4 11.0 -0.3 -0.4 -1.1 2.4 -0.9 -0.1 0.9 -1.3 3.3
Ever had prostate specific antigen (PSA) test 2.1 2.4 4.5 2.1 0.8 1.0 -0.9 1.5 -1.8 0.8 1.9 -2.1
Fractured/broken bones in last 5 years 0.2 0.3 0.9 0.0 -1.0 -0.3 0.5 0.5 0.1 0.2 0.6 -0.7
Age started oral contraceptive pill 4.1 5.1 8.6 -2.9 -2.0 -2.4 -1.4 -2.5 2.2 -2.6 -2.4 1.4
Diastolic blood pressure, automated reading 0.2 0.7 2.2 -0.5 -0.9 -0.3 0.2 -0.9 0.3 -0.7 -1.2 1.5
Ever depressed for a whole week 1.5 1.8 3.8 -1.0 -1.3 -1.5 -0.6 -1.2 1.9 -1.0 -1.2 1.8
Unable to work because of sickness or disability 0.6 0.7 1.9 -0.5 0.2 -0.3 0.9 -0.9 1.1 0.4 -1.1 1.4
Commuting to job workplace: Cycle 0.8 0.9 3.1 -0.6 1.5 0.5 0.7 1.0 -0.3 1.8 1.0 0.1
Myopia 0.3 0.5 1.2 -1.0 0.2 0.4 0.6 0.6 -0.7 1.1 0.6 -0.6
Vascular/heart problems diagnosed by doctor 0.8 2.2 9.7 -1.1 -0.7 0.1 -3.1 0.3 0.4 -1.7 0.5 -2.3
Cholesterol lowering medication 1.9 2.8 7.7 1.3 1.4 1.6 2.8 1.5 -1.4 2.3 1.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.7 1.3 -0.0 0.4 0.3 0.5 -0.5 0.3 0.6 -0.8
Pain experienced in last month 2.8 4.6 9.3 -3.1 -1.6 -2.2 -2.6 -1.8 2.4 -1.6 -1.8 1.8
Supplements: Calcium 0.7 0.8 3.1 -0.2 -0.1 -0.6 -1.8 -1.1 0.1 -0.8 -1.2 0.2
Basal cell carcinoma (self-reported) 0.2 0.3 1.5 -0.8 -0.4 0.2 -0.2 0.2 -1.2 0.2 0.1 -0.1
Heart attack/myocardial infarction (self-reported) 1.5 1.9 5.8 1.5 -1.5 -0.6 2.4 -0.8 -0.3 1.1 -1.0 1.9
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.6 0.6 0.5 0.9 0.4 0.1 -0.5 1.3 -0.1 1.2
Heart disease (siblings) 2.5 3.0 9.1 0.9 2.0 1.2 2.3 1.3 -1.9 3.0 1.0 0.6
Alcohol drinker status: Previous 0.4 0.4 1.4 0.3 -0.1 1.0 0.8 0.5 -0.7 0.4 0.3 -1.2
Pack years of smoking 2.7 4.0 19.0 4.4 1.3 1.4 1.7 1.2 -1.6 2.4 0.8 -0.4
Impedance of whole body 4.1 20.6 34.5 -5.9 -4.4 -4.0 -5.4 -4.0 4.6 -5.4 -3.8 2.4
Leg fat mass (left) 2.4 9.4 15.6 4.0 2.3 2.9 2.8 3.4 -2.8 3.7 3.5 -1.5
Arm predicted mass (left) 0.2 0.8 1.6 1.3 -0.0 0.4 1.1 1.0 -0.7 1.2 1.1 -0.5