Best TWAS P=1.79e-09 · Best GWAS P=1.97e-08 conditioned to 0.905
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PCNX | 0.17 | 0.21 | lasso | 3 | 0.22 | 1.9e-17 | 4.8 | -5.3 | 1.3e-07 | -0.93 | 0.07 | 0.93 | FALSE |
2 | GTEx | Adipose Visceral Omentum | PCNX | 0.09 | 0.04 | lasso | 2 | 0.03 | 9.9e-03 | 5.6 | -5.6 | 2.3e-08 | -0.90 | 0.01 | 0.96 | FALSE |
3 | GTEx | Artery Aorta | PCNX | 0.26 | 0.32 | enet | 32 | 0.29 | 3.7e-16 | 4.8 | -5.3 | 1.4e-07 | -0.88 | 0.22 | 0.78 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | PCNX | 0.11 | 0.11 | lasso | 3 | 0.07 | 1.3e-02 | 5.6 | -5.6 | 2.4e-08 | -0.95 | 0.03 | 0.70 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | PCNX | 0.14 | 0.06 | enet | 28 | 0.10 | 1.2e-07 | 4.6 | -5.6 | 2.0e-08 | -0.74 | 0.04 | 0.96 | FALSE |
6 | GTEx | Esophagus Mucosa | PCNX | 0.20 | 0.18 | enet | 18 | 0.20 | 2.4e-13 | 5.6 | -5.7 | 9.2e-09 | -0.90 | 0.01 | 0.99 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | PCNX | 0.18 | 0.18 | lasso | 4 | 0.19 | 1.7e-10 | 4.8 | -5.5 | 4.6e-08 | -0.96 | 0.01 | 0.99 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | PCNX | 0.23 | 0.29 | enet | 30 | 0.29 | 2.1e-24 | 4.8 | -5.6 | 1.7e-08 | -0.91 | 0.31 | 0.69 | FALSE |
9 | GTEx | Testis | PCNX | 0.14 | 0.09 | enet | 12 | 0.07 | 3.2e-04 | 4.6 | -5.3 | 1.1e-07 | -0.92 | 0.02 | 0.98 | FALSE |
10 | METSIM | Adipose | PCNX | 0.13 | 0.11 | blup | 440 | 0.11 | 2.5e-16 | 4.5 | -5.1 | 2.8e-07 | -0.81 | 0.47 | 0.53 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCNX | 0.05 | 0.04 | blup | 92 | 0.04 | 4.2e-09 | 5.6 | -5.2 | 2.6e-07 | -0.77 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCNX | 0.06 | 0.06 | blup | 91 | 0.07 | 7.1e-08 | 4.4 | -5.2 | 1.5e-07 | -0.90 | 0.03 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | PCNX | 0.08 | 0.06 | blup | 91 | 0.08 | 8.8e-08 | 5.6 | -6.0 | 1.8e-09 | -0.94 | 0.01 | 0.99 | TRUE |