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chr1:61,510,619-64,021,096

Best TWAS P=3.72e-42 · Best GWAS P=1.23e-42 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATG4C	0.14	0.16	lasso	8	0.16	1.8e-18	5.4	5.5	3.6e-08	-0.34	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	INADL	0.22	0.03	lasso	6	0.05	1.3e-03	-13.4	10.3	1.1e-24	-0.76	0.07	0.54	FALSE
3	GTEx	Artery Aorta	DOCK7	0.14	0.08	lasso	4	0.09	1.2e-05	-13.4	12.9	6.0e-38	-0.92	0.04	0.95	FALSE
4	GTEx	Artery Tibial	DOCK7	0.07	0.07	enet	20	0.07	3.5e-06	-13.5	13.3	1.6e-40	-0.98	0.04	0.96	FALSE
5	GTEx	Brain Cerebellar Hemisphere	ATG4C	0.26	0.08	lasso	11	0.10	1.8e-03	-6.5	-6.3	3.5e-10	0.44	0.30	0.12	FALSE
6	GTEx	Brain Cerebellum	ATG4C	0.23	0.12	lasso	4	0.18	6.4e-06	-6.5	-8.5	1.9e-17	0.57	0.42	0.40	FALSE
7	GTEx	Cells Transformed fibroblasts	DOCK7	0.23	0.21	lasso	5	0.28	4.9e-21	-12.8	12.5	5.7e-36	-0.95	0.11	0.89	FALSE
8	GTEx	Esophagus Mucosa	DOCK7	0.15	0.04	lasso	5	0.02	1.0e-02	-13.4	11.1	1.9e-28	-0.81	0.09	0.79	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	DOCK7	0.17	0.01	lasso	2	0.00	2.5e-01	-13.4	13.5	1.9e-41	-0.99	0.05	0.67	FALSE
10	GTEx	Skin Sun Exposed Lower leg	DOCK7	0.09	0.10	lasso	3	0.10	2.7e-08	-13.4	13.4	4.6e-41	-0.99	0.04	0.96	FALSE
11	GTEx	Spleen	DOCK7	0.28	0.14	enet	33	0.22	2.1e-06	-13.5	10.9	1.1e-27	-0.71	0.08	0.83	FALSE
12	GTEx	Whole Blood	DOCK7	0.06	0.00	lasso	6	0.00	1.6e-01	-12.8	13.0	6.9e-39	-0.98	0.05	0.90	FALSE
13	GTEx	Whole Blood	ATG4C	0.07	0.01	enet	19	0.00	1.7e-01	2.5	5.6	1.7e-08	-0.35	0.06	0.34	FALSE
14	GTEx	Whole Blood	USP1	0.05	0.02	lasso	1	0.02	1.0e-02	-13.6	13.6	3.7e-42	-1.00	0.04	0.92	TRUE
15	NTR	Blood	DOCK7	0.02	0.00	blup	647	0.01	1.5e-03	-13.5	10.9	1.1e-27	-0.83	0.06	0.94	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	DOCK7	0.06	0.06	lasso	6	0.06	3.7e-08	-13.4	-13.2	6.8e-40	0.93	0.04	0.96	FALSE
17	YFS	Blood	DOCK7	0.05	0.04	lasso	8	0.05	1.3e-14	-13.4	13.4	1.1e-40	-0.97	0.04	0.96	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	DOCK7	0.01	0.01	blup	85	0.01	1.1e-03	-13.5	13.4	8.1e-41	-0.99	0.06	0.91	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	DOCK7	0.07	0.06	blup	83	0.06	2.1e-04	-13.4	13.2	9.3e-40	-0.95	0.04	0.94	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DOCK7	0.12	0.05	lasso	8	0.07	9.2e-09	-13.3	12.4	1.6e-35	-0.90	0.05	0.95	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOCK7	0.04	0.01	enet	11	0.04	5.6e-05	-13.5	9.0	2.5e-19	-0.70	0.04	0.92	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DOCK7	0.06	0.07	blup	86	0.07	1.0e-04	-13.5	13.4	5.2e-41	-0.98	0.04	0.96	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	DOCK7	0.04	0.01	enet	3	0.02	3.0e-03	-13.5	13.6	5.3e-42	-0.99	0.05	0.63	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DOCK7	0.08	0.05	enet	29	0.10	7.8e-05	-13.5	12.1	7.5e-34	-0.91	0.04	0.95	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	DOCK7	0.24	0.02	blup	82	0.04	1.7e-05	-11.8	-6.9	4.0e-12	0.52	0.12	0.20	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	DOCK7	0.05	0.03	blup	86	0.02	1.6e-03	-11.8	12.5	4.6e-36	-0.93	0.06	0.89	FALSE