TWAS
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Genes
Traits
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Traits
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Ulcerative Colitis (UC)
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chr2:240,827,284-242,265,313
Best TWAS P=2.61e-16 · Best GWAS P=4.05e-13 conditioned to 0.114
240.8M
241M
241.2M
241.4M
241.6M
241.8M
242M
242.2M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Brain Lower Grade Glioma
GPR35
0.05
0.01
blup
66
0.03
3.9e-04
6.9
8.2
2.6e-16
0.71
0.00
0.89
TRUE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
PP14571
0.05
0.02
enet
13
0.02
5.8e-06
-4.2
-5.4
6.8e-08
-0.07
0.00
0.91
TRUE
2
GTEx
Nerve Tibial
CAPN10
0.25
0.07
lasso
10
0.13
3.1e-09
-7.2
-5.9
3.7e-09
-0.27
0.00
1.00
FALSE
3
GTEx
Stomach
CAPN10
0.20
0.08
lasso
4
0.12
1.5e-06
2.9
-5.1
2.8e-07
-0.22
0.30
0.11
FALSE
1
GTEx
Breast Mammary Tissue (Female)
GPR35
0.27
0.02
enet
17
0.08
2.6e-03
6.9
5.1
3.0e-07
0.60
0.04
0.36
FALSE