TWAS hub - PP14571

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0499	0.0203	3.3e-06	0.015	0.021	0.025	NA	0.021	3.3e-04	2.5e-05	5.8e-06	NA	2.9e-05
2	TCGA	Cervical Squamous Cell Carcinoma	0.0700	0.0380	8.9e-03	0.030	0.038	0.022	NA	0.004	1.2e-02	5.5e-03	2.8e-02	NA	2.0e-01
3	TCGA	Lung Adenocarcinoma	0.0652	0.0333	3.0e-03	0.027	0.039	0.025	NA	0.038	3.6e-04	1.9e-05	5.1e-04	NA	2.5e-05
4	TCGA	Prostate Adenocarcinoma	0.3296	0.0803	1.2e-14	0.096	0.132	0.171	NA	0.070	3.4e-10	1.1e-13	1.5e-17	NA	8.0e-08
5	TCGA	Thyroid Carcinoma	0.2840	0.1060	7.8e-09	0.050	0.095	0.112	NA	0.085	1.2e-05	1.6e-09	5.0e-11	NA	1.2e-08
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.3140	0.1410	6.1e-04	0.104	0.084	0.066	NA	0.110	7.9e-04	2.4e-03	6.6e-03	NA	5.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Ulcerative Colitis (UC)	8.0	15.1	29.2	-5.4	-1.9	-2.1	-3.9	-4.2	-4.6
Alzheimer’s Disease (in mother)	7.9	9.2	15.7	3.2	2.8	1.8	3.0	4.0	3.1
Ulcerative Colitis	7.5	10.9	19.0	-4.4	-2.0	-2.5	-3.6	-3.2	-3.6
Irritable Bowel Disease (IBD)	5.2	12.5	19.7	-4.4	-2.1	-1.8	-3.2	-4.4	-4.2
Alzheimer’s Disease (including proxy)	4.2	6.0	12.6	2.3	2.8	0.7	1.9	3.6	2.6
High blood pressure (siblings)	3.7	5.4	12.4	2.2	3.5	1.5	2.0	1.0	2.8
Serious illness, injury or assault to yourself	3.1	3.8	5.3	-2.0	-2.0	-1.8	-2.0	-2.3	-1.5
Medication: Aspirin	2.9	3.8	9.3	-1.4	-2.6	-0.3	-1.1	-3.1	-1.9
Chronic bronchitis/emphysema (mother)	2.8	3.3	6.6	-1.5	-1.9	-1.9	-1.6	-1.0	-2.6
Medication: Atorvastatin	2.8	3.4	6.2	2.5	1.3	1.6	2.3	1.1	1.9
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	4.8	2.2	1.5	0.9	2.0	1.7	2.1
Medication: Aspirin	2.5	3.3	8.4	-1.4	-2.4	0.0	-0.9	-2.9	-1.6
Miserableness	2.5	4.4	7.7	2.0	2.2	1.8	1.9	1.7	2.8
Age at first live birth	2.4	4.3	7.1	-1.9	-1.9	-1.5	-2.5	-2.7	-1.6
Illnesses of father: None of the above (group 1)	2.4	2.9	5.2	1.6	2.3	0.4	1.7	1.6	2.1
Age at First Birth	2.3	3.4	6.0	-1.6	-1.5	-2.5	-2.1	-1.2	-1.9
HbA1C	2.3	2.5	3.4	-1.2	-1.8	-1.3	-1.7	-1.8	-1.6
Townsend deprivation index at recruitment	2.3	3.2	4.7	2.0	1.8	1.5	1.5	2.2	1.6
Emphysema/chronic bronchitis	2.3	2.6	7.1	1.0	2.7	0.7	1.5	0.7	2.0
Hayfever, allergic rhinitis or eczema	2.2	4.7	11.6	1.9	1.8	1.7	1.4	3.4	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.1	1.8	-0.2	1.9	1.7	2.0	1.3
Age when periods started (menarche)	2.1	5.0	10.0	-2.8	-1.3	-1.2	-2.5	-1.8	-3.2
Medication: Metformin	2.0	2.8	4.7	-1.6	-1.3	-1.5	-2.2	-1.6	-1.7
Medication: Atenolol	2.0	2.5	4.4	-1.7	-2.1	-0.8	-1.5	-1.7	-1.5
Average weekly fortified wine intake	1.9	2.2	3.3	-1.3	-1.4	0.1	-1.8	-1.8	-1.7
Diabetes (self-reported)	1.9	2.9	5.2	-1.8	-1.9	-1.0	-2.3	-1.0	-1.7
Noisy workplace	1.9	2.4	4.3	1.6	2.1	0.2	1.3	1.6	1.8
Diabetes diagnosed by doctor	1.9	3.1	4.9	-1.9	-2.2	-0.9	-2.2	-1.3	-1.7
Average weekly champagne plus white wine intake	1.9	2.7	5.4	-1.6	-0.9	-1.1	-1.6	-1.9	-2.3
Crohns Disease (2012)	1.8	2.9	5.5	-2.3	-1.3	-1.0	-1.7	-1.7	-1.8
Alcohol intake frequency.	1.8	4.3	6.5	1.7	2.5	2.2	2.1	1.3	2.3
Mother’s age at death	1.8	2.2	4.4	-0.6	-1.5	-2.1	-1.6	-1.4	-1.2
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.9	-2.0	-2.4	-0.3	-1.9	-1.0	-2.1
Medication: Allopurinol	1.7	2.3	3.1	-1.6	-1.4	-1.1	-1.7	-1.8	-1.4
Wears glasses or contact lenses	1.7	2.0	4.1	-1.8	-0.8	0.2	-1.7	-2.0	-0.9
Angina	1.6	2.0	3.3	-1.4	-1.6	-0.3	-1.2	-1.8	-1.7
Time employed in main current job	1.6	1.8	3.9	-0.8	-1.1	-1.6	-1.2	-2.0	-1.2
Supplements: Vitamin C	1.6	1.9	3.8	-0.8	-1.5	-0.4	-0.8	-1.9	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	5.1	2.3	0.5	0.8	1.7	1.5	1.8
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.7	-0.2	-1.9	-2.4	-1.1	-0.8	-0.0
Comparative height size at age 10	1.5	8.2	10.8	-3.3	-3.3	1.4	-2.6	-3.1	-3.1
Osteoporosis (self-reported)	1.5	1.8	3.0	0.6	1.7	1.7	1.1	0.8	1.7
Allergy or Eczema	1.4	3.7	7.7	2.2	1.3	1.1	1.4	2.8	2.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.6	-0.6	-1.2	-2.1	-1.4	0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	2.4	1.2	1.3	1.4	1.3	1.5	1.5
Exposure to tobacco smoke at home	1.4	1.6	3.7	-1.2	-0.9	-1.2	-1.9	-0.8	-1.3
Pulse wave reflection index	1.4	1.7	4.8	2.2	0.6	0.4	1.6	1.2	1.1
Angina (self-reported)	1.4	1.8	3.1	-1.3	-1.4	-0.2	-1.1	-1.8	-1.7
Fractured/broken bones in last 5 years	1.4	1.9	6.4	1.0	0.8	-0.0	1.1	2.5	1.4
Lung FEV1/FVC ratio	1.3	6.5	9.9	-2.6	-2.6	-1.4	-3.1	-2.9	-2.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.1	-1.8	-0.8	0.4	-0.9	-1.7	-1.1
Medication: Simvastatin	1.3	2.0	2.7	-0.9	-1.5	-1.6	-1.6	-1.6	-1.1
Impedance of arm (right)	1.3	5.9	23.7	-1.8	-1.0	-4.9	-2.3	-0.1	-1.4
Stomach or abdominal pain in last month	1.2	1.5	3.1	-0.5	-1.5	-1.7	-1.2	-0.9	-1.2
Falls in the last year	1.2	1.6	3.0	-1.3	-0.7	-1.5	-1.7	-0.6	-1.4
Wheeze or whistling in the chest in last year	1.2	2.1	4.0	-2.0	-1.1	-0.6	-1.9	-1.2	-1.5
Mood swings	1.2	2.1	3.5	0.9	1.9	1.1	1.4	1.5	1.7
Qualifications: nursing, teaching	1.2	1.8	3.2	1.7	0.5	0.8	1.4	1.4	1.8
Number of operations (self-reported)	1.2	1.8	5.8	0.9	0.3	2.4	1.1	0.6	1.5
Alcohol drinker status: Previous	1.2	1.4	3.0	-1.1	-0.5	-0.3	-1.7	-1.2	-1.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.6	1.9	0.5	-0.8	1.2	1.2	1.3
Hearing difficulty/problems: Yes	1.1	1.7	3.3	-1.0	-0.6	-1.5	-1.7	-1.8	-0.6
Diabetes (father)	1.1	1.3	4.1	-0.6	-0.7	2.0	0.2	-1.0	-1.4
Sitting height	1.1	8.0	13.2	-3.4	-3.3	0.4	-2.4	-2.6	-3.6
Mouth/teeth dental problems	1.1	1.7	6.7	0.1	1.2	2.6	1.4	0.3	-0.1
Allergy	1.1	2.6	6.1	-1.1	-1.3	-1.8	-1.0	-2.5	-1.6
Illnesses of siblings	1.1	1.5	4.7	-0.1	-2.2	-1.7	-0.4	0.5	-1.0
Alcohol intake versus 10 years previously	1.1	1.7	3.0	1.2	1.4	1.0	1.7	1.0	1.3
Medication: Blood pressure	1.1	2.0	6.8	-0.9	-1.3	-1.0	-1.1	-2.6	-0.8
Hearing aid user	1.1	1.3	2.4	-1.2	-1.1	-1.6	-1.2	-0.9	-0.5
Ever smoked	1.1	2.0	4.3	-1.0	-2.1	-1.6	-1.1	-0.6	-1.6
Cholesterol lowering medication	1.1	1.6	2.5	-0.9	-1.2	-1.1	-1.6	-1.5	-1.0
Crohns Disease (2017)	1.0	2.1	5.9	-1.4	-1.2	-0.5	-0.8	-2.4	-1.6
Ovarian Cancer	1.0	1.4	2.7	-1.3	-0.9	-0.7	-1.1	-1.6	-1.1
Mouth/teeth dental problems: Dentures	1.0	1.7	3.2	-0.8	-1.1	-0.9	-1.8	-1.5	-1.5
Tense / ‘highly strung’	1.0	1.7	2.4	-1.2	-1.5	-1.6	-1.5	-1.2	-0.8
Migraine (self-reported)	1.0	1.3	2.5	-1.6	-0.7	-0.0	-1.5	-0.9	-1.2
Had major operations	1.0	1.2	5.5	0.1	1.2	2.3	0.5	-0.3	0.4
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.9	-1.7	0.4	0.8	-0.8	-1.6	-0.6
Average weekly beer plus cider intake	1.0	1.5	2.5	1.6	0.9	0.0	1.0	1.6	1.5
Rheumatoid Arthritis	0.9	1.2	1.8	1.4	1.0	0.2	1.2	1.2	1.4
Relative age of first facial hair	0.9	1.8	3.7	1.7	0.5	-1.0	1.0	1.3	1.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.5	0.2	0.8	1.9	0.6	1.1	0.7
Heart attack	0.9	1.2	3.9	1.2	-1.0	-2.0	-0.4	-0.5	0.5
Impedance of arm (left)	0.9	4.1	16.6	-1.4	-1.2	-4.1	-1.9	0.2	-1.1
Standing height	0.9	9.4	16.9	-4.1	-2.8	0.3	-2.8	-3.1	-3.7
Birth weight	0.9	1.9	5.8	1.3	2.4	1.4	1.3	0.4	0.6
Comparative body size at age 10	0.9	2.6	8.0	0.6	1.3	2.8	1.8	0.6	1.3
Number of full sisters	0.9	1.1	2.2	1.4	0.8	0.5	1.1	1.5	0.8
Age at last live birth	0.9	1.3	3.5	-1.1	-0.1	-0.6	-1.5	-1.9	-0.5
Ever had bowel cancer screening	0.9	1.1	3.8	-0.8	-0.6	-0.9	-0.9	-1.9	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.3	0.4	1.2	-0.8	0.5	0.4	1.8
Commuting to job workplace: Walk	0.9	1.0	2.0	0.7	0.6	0.8	1.2	1.4	1.1
Vascular/heart problems diagnosed by doctor	0.9	2.5	7.6	0.9	1.4	0.9	1.7	2.7	0.9
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	-1.5	-0.4	-1.2	-1.1	-0.5	-1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	0.0	-1.3	-1.3	-1.2	-0.8	0.2
Medication for hormone replacement therapy	0.8	0.9	1.9	-1.0	-1.0	-0.3	-0.7	-1.4	-1.0
High blood pressure	0.8	2.2	6.0	-1.0	-1.3	-0.8	-1.8	-2.4	-0.9
Nervous feelings	0.8	1.4	2.2	-1.5	-0.9	-0.5	-1.4	-1.3	-1.3
Fluid intelligence score	0.8	1.6	4.3	-0.6	-2.1	-0.7	-1.4	-1.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.0	1.4	0.8	1.4	1.1	1.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.3	1.2	1.8	0.7	1.0	0.9	1.6
Exposure to tobacco smoke outside home	0.8	1.1	3.3	0.8	-0.8	-1.8	-0.2	1.5	0.1
Arm predicted mass (right)	0.8	4.2	14.4	-1.4	-1.6	3.8	-0.3	-2.0	-1.3
Irritability	0.8	1.4	3.3	-1.8	-0.6	-0.4	-1.2	-1.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.4	1.1	-1.1	-1.9	-0.5	-0.6	0.4
Pack years of smoking	0.8	1.2	2.8	-1.0	-0.2	-1.7	-1.3	-0.8	-0.8
Schizophrenia (2018)	0.7	1.4	7.2	0.1	-0.6	-2.7	-0.5	0.6	0.3
Primary Biliary Cirrhosis	0.7	1.0	1.6	-0.8	-1.0	-1.0	-1.3	-1.0	-0.8
Pack years adult smoking proportion	0.7	1.1	3.2	-0.8	-0.3	-1.8	-1.2	-0.5	-0.8
Hand grip strength (right)	0.7	1.8	6.7	0.4	1.2	2.6	1.1	0.8	0.6
Medication: Levothyroxine sodium	0.7	1.2	3.7	0.5	1.9	0.7	0.5	0.8	1.4
Medication: Lansoprazole	0.7	0.8	1.1	-1.0	-0.8	1.0	-0.9	-1.0	-0.7
Arm fat-free mass (right)	0.7	3.6	13.2	-1.1	-1.6	3.6	-0.1	-1.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	-0.4	-0.9	0.5	-0.4	-1.4	-1.3
Hypertension (Self-reported)	0.7	2.1	4.6	-1.2	-1.3	-0.4	-1.8	-2.1	-1.0
Average weekly red wine intake	0.7	1.0	1.9	-1.0	-1.4	-1.2	-0.9	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.3	0.8	0.2	1.8	1.0	1.4	1.2
Medication: Bendroflumethiazide	0.7	1.0	2.1	-1.1	0.2	-1.0	-1.3	-1.4	-0.1
Age started oral contraceptive pill	0.7	0.9	2.1	0.9	0.1	1.3	0.6	1.5	0.6
Myopia	0.7	1.1	2.4	-0.5	-0.9	-1.5	-1.4	-1.0	0.0
Heart disease (siblings)	0.7	0.8	2.5	-1.6	0.4	1.0	-0.9	-0.0	-0.6
Arm predicted mass (left)	0.7	3.7	9.5	-1.5	-1.6	3.1	-0.6	-2.2	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	3.5	0.8	-0.6	-1.9	-0.1	0.4	0.1
Worry (Nagel 2018)	0.6	1.3	2.5	-1.5	-0.9	-0.5	-1.6	-1.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-0.4	-1.9	-0.0	-1.1	-1.9	-0.6
Breast Cancer	0.6	1.3	4.2	0.9	2.1	-0.1	0.9	1.2	0.8
Blood Platelet Count	0.6	6.8	23.6	-4.9	-3.0	0.6	-2.0	-1.5	-1.2
Hypothyroidism (self reported)	0.6	1.4	3.1	1.5	1.4	0.1	0.7	0.8	1.8
Leg fat-free mass (left)	0.6	3.1	4.2	-1.8	-2.1	2.0	-1.1	-2.0	-1.2
Taking other prescription medications	0.6	0.9	1.6	-1.3	-1.0	0.6	-0.6	-1.2	-0.9
High blood pressure (mother)	0.6	0.8	2.7	1.0	0.4	-1.6	-0.1	0.0	1.0
Leg predicted mass (left)	0.6	3.0	4.4	-1.8	-2.1	2.1	-1.1	-1.9	-1.2
Trunk fat mass	0.6	2.5	5.7	-0.8	-2.4	0.7	-1.3	-2.1	-1.3
Had menopause	0.6	0.8	1.1	1.0	0.7	1.0	0.9	0.7	1.0
Trunk fat-free mass	0.6	3.5	8.8	-1.9	-1.4	3.0	-0.5	-2.1	-1.4
Hair/balding pattern: Pattern 3	0.6	0.8	2.8	0.4	1.1	0.2	0.7	0.4	1.7
Pulse rate	0.6	1.1	2.9	-1.7	0.5	-0.2	-1.7	0.2	-0.6
Trunk predicted mass	0.6	3.5	8.8	-1.8	-1.4	3.0	-0.5	-2.1	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.5	-0.1	1.1	0.5	0.7	1.9	0.4
Pulse rate, automated reading	0.6	1.9	5.2	-2.3	-0.5	-0.9	-1.9	-0.1	-1.3
Smoking status: Previous	0.6	0.9	2.4	-0.8	-0.9	0.2	-1.2	-0.6	-1.5
Whole body fat-free mass	0.6	3.5	7.5	-1.9	-1.7	2.7	-0.8	-2.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.6	-0.4	-0.7	0.8	0.3	-1.6	-0.5
Mineral and other dietary supplements	0.6	0.8	1.5	0.3	1.0	-1.2	-0.2	1.0	0.9
Breast cancer (self-reported)	0.6	0.7	1.5	-0.8	-0.0	-1.2	-1.0	-1.1	-0.3
Whole body water mass	0.6	3.7	8.0	-1.9	-1.8	2.8	-0.8	-2.2	-1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.8	0.8	0.0	1.3	1.3	0.1	0.5
Medication: Paracetamol	0.6	0.9	1.6	0.9	1.3	-1.0	0.3	0.6	1.2
Basal metabolic rate	0.6	3.3	6.7	-1.6	-1.9	2.6	-0.8	-2.1	-1.3
Arm fat-free mass (left)	0.6	3.1	9.8	-1.2	-1.4	3.1	-0.2	-2.0	-1.2
Ever depressed for a whole week	0.6	0.7	1.9	0.1	0.6	1.3	0.1	1.4	0.5
Unable to work because of sickness or disability	0.6	0.8	1.2	-1.1	-0.9	-0.6	-0.9	-1.0	-0.7
Impedance of whole body	0.6	3.2	13.5	-0.8	-0.8	-3.7	-1.6	0.1	-1.3
Alzheimer’s Disease (in father)	0.5	0.6	2.8	0.0	1.7	-0.1	-0.6	0.4	0.2
Fasting Glucose	0.5	0.6	1.6	-0.1	-1.3	-0.3	-0.4	0.7	-1.1
Height	0.5	9.1	17.1	-4.1	-2.5	1.3	-2.5	-3.1	-3.7
Systolic Blood Pressure	0.5	2.5	5.2	-1.1	-1.9	-2.3	-1.9	-0.5	-0.9
Lung FVC	0.5	2.7	4.6	1.0	2.1	2.0	1.4	1.2	1.6
Average weekly spirits intake	0.5	0.6	1.5	0.7	0.1	0.7	0.9	1.2	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	0.3	0.0	1.4	1.1	-0.5	0.1
Supplements: Glucosamine	0.5	0.7	1.4	-0.8	-1.2	0.5	-0.1	-0.8	-1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	0.8	0.8	-0.5	0.8	0.7	0.9	0.6
Past tobacco smoking	0.5	0.9	1.5	0.7	1.2	0.6	1.1	0.6	1.2
Medication: Ramipril	0.5	0.6	2.2	0.0	-0.9	0.5	0.5	-1.5	-0.3
Weight	0.5	2.4	4.3	-1.0	-1.9	2.1	-0.9	-1.9	-1.1
Father’s age at death	0.5	0.6	1.4	-0.8	-0.9	1.2	-0.3	0.4	-0.8
Happiness	0.5	0.6	1.1	1.1	0.5	-0.1	0.8	1.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.9	-0.7	-0.7	0.2	1.4	0.2
Lung cancer (father)	0.5	0.5	2.1	-0.6	-1.4	-0.6	-0.5	0.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.9	0.1	0.9	-0.0	0.5	1.4	0.8
Qualifications: College or University degree	0.5	1.6	3.4	-1.4	-0.8	0.5	-1.3	-1.8	-1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	-0.0	-1.0	-1.3	-0.9	0.3	-0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.7	0.0	1.1	-0.4	0.5	0.1	1.3
Knee pain experienced in last month	0.5	0.7	2.1	-1.5	-0.3	-0.3	-1.1	-0.2	-0.9
Leg fat-free mass (right)	0.5	2.5	4.7	-1.5	-1.6	2.2	-0.9	-1.9	-0.8
Medication: Gliclazide	0.5	0.6	2.4	0.5	-0.8	-1.5	-0.5	-0.1	-0.2
Leg predicted mass (right)	0.5	2.6	4.7	-1.6	-1.7	2.2	-0.9	-1.9	-0.9
Ever taken oral contraceptive pill	0.5	0.6	1.7	0.5	-0.0	-1.3	-0.1	0.8	1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	4.5	0.4	-0.5	-2.1	0.0	0.7	0.3
Prostate Cancer	0.4	0.6	2.2	-0.2	0.7	1.5	0.3	0.7	-0.2
Schizophrenia (2014)	0.4	0.9	4.0	0.4	-0.5	-2.0	0.0	0.8	0.4
Cardiovascular Disease	0.4	1.3	3.3	-1.0	-1.0	-0.7	-1.8	-1.3	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	2.1	-0.2	0.2	0.5	0.5	-1.5	0.5
Impedance of leg (right)	0.4	1.9	7.1	-0.6	-0.6	-2.7	-1.1	0.3	-1.5
Trunk fat percentage	0.4	1.8	4.5	-0.4	-2.1	-0.4	-1.4	-1.7	-1.1
Maternal smoking around birth	0.4	0.5	1.0	0.3	0.4	-1.0	0.7	0.8	1.0
Alcohol usually taken with meals	0.4	0.7	2.5	-0.1	0.1	1.6	0.6	0.8	-0.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.4	1.2	0.2	0.8	0.8	0.6	0.4
Qualifications: None of the above	0.4	0.8	1.6	0.9	1.2	0.0	0.6	1.1	1.0
Pain all over the body in last month	0.4	0.4	1.1	0.5	-0.2	0.5	0.9	0.3	1.0
Number of live births	0.4	0.5	1.2	-0.2	1.1	1.0	-0.6	-0.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	-0.2	0.2	-0.5	-1.0	-1.0	-0.2
Illnesses of mother	0.4	0.5	1.8	-0.5	0.4	1.3	0.4	0.3	0.7
Birth weight of first child	0.4	0.7	2.5	0.1	1.0	0.6	0.7	-1.6	-0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.5	0.1	0.5	0.2	1.4	0.5
Headache pain in last month	0.4	0.8	1.6	0.2	0.7	-1.2	-0.2	1.1	1.1
Glaucoma (self-reported)	0.4	0.5	1.4	0.9	-0.2	-0.6	0.4	0.6	1.2
Number of full brothers	0.4	0.5	1.1	0.5	1.1	0.1	0.1	0.7	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.9	0.5	-0.8	0.0	0.8	0.7
Shortness of breath walking on level ground	0.4	0.5	1.5	-0.6	0.7	-0.6	-0.3	1.2	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	3.7	-0.5	1.9	0.6	-0.3	0.2	0.0
Medication: Omeprazole	0.4	0.5	0.8	-0.7	-0.3	0.7	0.5	-0.9	-0.8
Whole body fat mass	0.4	1.6	3.7	-0.4	-1.9	1.2	-0.8	-1.7	-0.9
Leg fat mass (right)	0.4	1.5	2.9	-0.2	-1.6	1.7	-0.5	-1.5	-0.8
Leg pain on walking	0.4	0.5	1.1	0.8	0.4	-1.1	0.3	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.2	-0.1	0.2	1.5	0.7	-0.4	-0.3
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.2	-1.1	-0.2	-0.0	-0.9	-1.0
Guilty feelings	0.4	0.7	1.4	1.2	0.8	1.0	0.8	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.9	0.0	0.9	-0.4	-0.6	-0.7
Leg fat mass (left)	0.4	1.5	3.4	-0.1	-1.4	1.8	-0.5	-1.7	-0.6
Depressed Affect (Nagel 2018)	0.3	0.7	2.0	0.5	1.4	0.9	0.9	-0.1	0.8
Reaction Time	0.3	0.6	2.3	1.0	0.4	-1.5	-0.1	0.5	0.3
Coronary Artery Disease (CAD)	0.3	0.4	1.7	0.0	0.1	-0.1	0.0	1.3	0.8
Mean Putamen Volume	0.3	0.3	1.4	-0.1	0.1	1.2	0.5	0.5	0.1
Lupus	0.3	0.4	1.6	0.5	-1.3	0.6	0.5	0.3	-0.3
Blood Eosinophil Count	0.3	2.1	6.0	1.5	1.1	1.2	1.0	1.0	2.5
BMI	0.3	1.9	3.8	-0.7	-1.8	2.0	-0.8	-1.7	-0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.8	0.7	-0.3	-0.6	-0.9	0.4
Supplements: Zinc	0.3	0.3	0.6	0.7	-0.5	0.5	0.8	0.1	-0.1
Severe depression (siblings)	0.3	0.3	1.1	-0.5	-0.1	-1.1	-0.3	0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.7	0.8	0.3	-0.7	0.6	0.3	0.5
Relative age voice broke	0.3	0.5	1.4	-0.3	-1.2	-0.8	-0.1	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.3	0.2	-0.8	-1.8	-0.4	-0.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.9	-1.4	-0.1	-0.2	-0.4	-0.2	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.8	0.1	-1.0	-0.2	0.3	0.6
Waist circumference	0.3	1.0	2.7	-0.8	-1.0	1.6	-0.8	-0.9	-0.3
Had other major operations	0.3	0.4	1.0	-0.4	-1.0	-0.1	-0.2	-1.0	0.2
Hip circumference	0.3	1.4	4.6	-0.3	-1.2	2.1	-0.6	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.6	-1.2	-1.2	-0.2	-1.1	-0.8	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	-0.4	-1.0	-1.1	-1.1	-0.1	-0.2
Medication: Cholesterol lowering	0.3	0.4	0.8	0.7	-0.8	-0.6	-0.1	-0.9	-0.0
Length of working week for main job	0.3	0.4	0.9	-0.2	-0.7	-1.0	-0.8	-0.3	0.2
Hair/balding pattern: Pattern 4	0.3	0.7	2.3	-0.4	0.0	1.5	-0.1	-1.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.7	-0.3	-1.3	0.2	0.4	0.6
Blood clot in the leg (DVT)	0.3	0.3	0.9	0.1	-0.5	0.9	0.7	0.6	0.1
Neck or shoulder pain in last month	0.3	0.4	0.6	0.5	0.8	-0.1	0.7	0.7	0.6
Medication: Ibuprofen	0.3	0.4	0.6	0.8	-0.6	-0.8	0.1	0.7	0.4
Suffer from ‘nerves’	0.3	0.4	0.9	-0.7	-0.4	1.0	0.2	-0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	0.3	0.8	-0.5	0.6	0.5	1.0
Back pain experienced in last month	0.3	0.5	2.4	-1.6	0.2	-0.2	-0.5	-0.2	-0.1
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.1	-1.0	0.8	0.6	0.2	-0.2
Risk taking	0.3	0.4	1.6	0.4	-0.6	-1.3	-0.1	0.1	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	-0.3	0.5	0.6	0.6	-0.9	-0.1
Depression (Nagel 2018)	0.2	0.4	0.8	-0.1	-0.8	-0.9	-0.4	-0.1	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.3	-0.1	1.0	0.3	-0.1	0.6
Neuroticism (2016)	0.2	0.2	0.7	0.3	0.2	0.1	0.8	0.7	0.2
Blood Red Count	0.2	2.1	7.5	0.4	-0.8	-2.7	-1.7	-1.0	0.1
Neuroticism	0.2	0.5	1.1	-0.9	-0.9	0.0	-0.5	-0.4	-1.1
Chronotype (morning person)	0.2	0.5	1.3	0.8	0.6	1.1	0.6	-0.3	0.6
Hand grip strength (left)	0.2	0.5	1.5	-0.0	1.2	1.2	0.3	0.1	0.5
Number of treatments/medications taken	0.2	0.4	0.8	0.6	0.4	0.9	0.6	-0.3	0.6
Medication: Co-codamol	0.2	0.2	0.8	-0.3	0.5	-0.2	-0.0	-0.9	0.0
Diabetes (mother)	0.2	0.2	0.8	0.4	-0.6	0.9	0.0	-0.0	0.1
Current tobacco smoking	0.2	0.4	0.9	-0.7	-0.2	-1.0	-0.1	-0.8	-0.2
Multivitamins +/- minerals	0.2	0.2	0.9	0.1	-0.3	-0.3	-0.5	1.0	-0.1
Body mass index (BMI)	0.2	1.0	4.3	0.8	-0.7	2.1	0.4	-0.6	0.5
Impedance of leg (left)	0.2	1.2	5.4	-0.1	0.0	-2.3	-0.8	0.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.8	0.4	-0.3	-0.9	-0.5	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.3	-0.1	-0.4	0.1	-0.6	-1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.8	0.1	-0.5	-1.3	-0.1	-0.6	-0.6
Prospective memory result	0.2	0.2	0.8	0.2	-0.0	-0.9	-0.0	0.6	-0.6
Arm fat mass (right)	0.2	0.7	1.9	0.1	-1.4	1.1	-0.4	-0.9	-0.2
Breastfed as a baby	0.2	0.3	0.5	-0.6	-0.3	0.6	-0.2	-0.7	-0.4
Loud music exposure frequency	0.2	0.2	1.0	0.1	0.1	-0.7	0.0	0.1	-1.0
Medication: Paracetamol	0.2	0.3	1.0	0.3	0.3	-0.8	0.2	1.0	0.3
Medication: Amlodipine	0.2	0.3	1.6	0.2	-0.0	1.2	0.6	-0.0	-0.0
Body fat percentage	0.2	0.7	2.0	0.2	-1.4	0.4	-0.6	-1.2	-0.5
Leg fat percentage (right)	0.2	0.6	2.0	0.9	-0.6	1.4	0.4	-0.5	0.0
Worry too long after embarrassment	0.2	0.3	0.8	-0.9	0.0	0.8	-0.4	0.1	-0.6
Number of children fathered	0.2	0.2	0.6	0.7	-0.6	-0.2	-0.2	-0.8	-0.1
Health satisfaction	0.2	0.3	0.6	-0.0	0.7	0.8	0.4	0.2	0.7
Overall health rating	0.2	0.3	1.1	0.1	-0.5	-1.0	-0.4	-0.7	0.2
Family relationship satisfaction	0.2	0.2	0.8	-0.3	0.1	-0.3	0.1	-0.9	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.3	-0.4	0.8	-0.2	0.1	-0.7
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.7	-0.3	0.4	-0.7	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	-1.2	-0.1	-0.6	-0.9	-0.0	-0.4
Loneliness, isolation	0.2	0.3	1.1	-0.2	0.6	-0.1	0.7	-1.1	-0.1
Friendships satisfaction	0.2	0.3	0.8	0.4	0.7	0.1	0.9	-0.5	-0.0
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.4	-0.1	-0.2	0.7	-0.6	0.2
Medication for cholesterol	0.2	0.4	0.8	0.7	0.3	-0.9	0.3	0.9	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.8	0.4	0.1	-0.4	-0.1	0.5
Arm fat mass (left)	0.2	1.0	3.1	-0.1	-1.8	1.2	-0.4	-1.1	-0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	-0.2	0.9	0.6	-0.1	-0.4	0.7
Financial situation satisfaction	0.2	0.3	0.7	-0.5	0.7	0.0	0.2	0.9	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.0	-0.0	-1.0	-0.5	-0.4	-0.3	0.0
Commuting to job workplace: Public transport	0.2	0.3	1.1	-0.0	0.2	-0.6	0.1	0.4	1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	-0.8	0.2	0.6	-0.0	-0.8	-0.5
High cholesterol (Self-reported)	0.2	0.4	1.5	-0.2	-0.7	-0.4	-0.6	-1.2	0.1
Medication: Lisinopril	0.2	0.3	0.9	-0.1	-0.2	-0.7	-0.9	-0.5	-0.0
Alcohol drinker status: Never	0.2	0.2	0.4	0.2	0.3	0.6	0.4	-0.3	0.6
Leg fat percentage (left)	0.2	0.8	2.6	1.1	-0.3	1.6	0.5	-0.7	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.4	0.3	-0.5	-0.0	0.3	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.2	-0.9	0.7	0.5	0.0	-0.3
Bipolar Disorder (2018)	0.1	0.2	0.5	0.5	0.1	-0.0	0.7	0.6	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.2	-1.0	0.4	-0.5	-0.9	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.7	0.1	0.5	-0.3	-0.3	-0.3
HDL Cholesterol	0.1	0.2	0.3	0.6	-0.5	0.4	0.5	-0.1	0.2
LDL Cholesterol	0.1	0.1	0.5	0.2	0.7	0.3	0.0	0.3	0.1
Triglycerides	0.1	0.2	0.9	0.2	0.4	0.9	0.3	0.3	-0.2
Blood White Count	0.1	0.5	1.1	1.0	-1.0	-1.0	-0.2	0.1	0.2
Heel T-Score	0.1	1.1	3.7	0.7	-0.2	-1.9	-0.1	1.4	-0.3
Waist Hip Ratio (WHR)	0.1	0.2	0.6	-0.7	0.2	-0.4	-0.5	0.6	0.2
Smoking Status	0.1	0.3	0.8	-0.5	-0.7	-0.9	-0.4	0.1	-0.5
Respiratory disease	0.1	0.2	0.5	-0.1	0.3	0.4	-0.3	0.6	0.7
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.6	-0.3	-0.5	-0.4	0.2	-0.5
Systolic blood pressure, automated reading	0.1	0.4	0.8	0.7	0.3	-0.7	0.1	0.9	0.7
Vitamin and mineral supplements	0.1	0.2	0.6	0.1	0.2	0.2	0.8	0.3	0.5
Fed-up feelings	0.1	0.1	0.2	-0.4	0.5	-0.4	0.1	0.0	-0.2
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	-0.2	-0.4	-0.5	-0.1	-0.6
Forced vital capacity (FVC)	0.1	0.4	1.3	-1.1	-0.6	0.6	-0.4	-0.3	-0.4
Arm fat percentage (right)	0.1	0.3	1.1	0.4	-1.0	0.0	-0.3	-0.5	0.2
Worrier / anxious feelings	0.1	0.1	0.5	0.1	-0.0	0.7	-0.1	0.3	0.3
Asthma	0.1	0.2	0.5	-0.7	-0.2	0.4	-0.5	0.4	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.6	0.7	-0.2	-0.2	0.2	-0.0	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.7	-0.8	0.6	-0.2	-0.3	0.1
Gout (self-reported)	0.1	0.1	0.5	-0.4	0.0	0.0	-0.1	-0.7	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.7	-0.9	0.4	1.3	-0.2	-0.1	0.1
Pulse wave peak to peak time	0.1	0.1	0.7	-0.8	0.0	0.1	-0.2	-0.1	0.1
Eye problems/disorders: None of the above	0.1	0.2	0.6	-0.6	0.1	-0.1	-0.8	0.2	-0.1
Mean time to correctly identify matches	0.1	0.2	0.6	0.2	-0.1	-0.8	-0.2	-0.7	-0.2
Heart disease (mother)	0.1	0.1	0.4	-0.1	0.1	-0.6	0.2	0.3	-0.1
Chest pain or discomfort	0.1	0.1	0.3	-0.0	-0.4	-0.5	0.0	-0.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.1	0.5	0.1	0.2	-0.3	0.4
Arm fat percentage (left)	0.1	0.4	1.7	0.5	-1.3	0.4	-0.1	-0.4	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.5	-0.3	0.5	0.3	0.0	-0.7	-0.0
Asthma (self-reported)	0.1	0.3	0.9	-0.3	0.0	0.6	-0.2	0.9	0.6
Smoking status: Current	0.1	0.2	0.7	-0.4	-0.1	-0.8	0.2	-0.6	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.3	-0.7	0.0	0.4	0.0	0.3
Medication: Blood pressure	0.1	0.2	0.7	0.2	0.3	0.8	0.3	-0.4	0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.8	-0.1	0.2	-0.5	-0.2	0.9	0.4
Pain experienced in last month	0.1	0.2	0.6	0.5	0.1	0.8	-0.2	-0.3	-0.2
Supplements: Calcium	0.1	0.1	0.3	-0.1	-0.3	-0.1	-0.2	-0.5	-0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.5	1.4	0.6	0.6	0.1	0.4	-1.2	0.7
Tanning	0.0	0.4	1.2	0.6	0.7	-1.1	0.3	0.0	0.6
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.0	0.3	-0.1
Financial difficulties in last 2 years	0.0	0.0	0.1	0.2	-0.2	-0.1	0.3	0.3	-0.2
Neuroticism score	0.0	0.0	0.1	-0.2	0.2	0.0	-0.1	0.3	0.1
Depression (self-reported)	0.0	0.1	0.1	0.2	0.2	-0.3	0.3	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.3	-0.5	0.1	0.6	-0.4	0.1	0.4

Hub : Genes

PP14571

Models

Trait associations