Hub : Traits :

Ulcerative Colitis (UC)

583 significantly associated models · 156 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	1781220	3261925	7	2	1.9e-11	2.1e-11	6.7e-01	100	LOC115110 RP3-395M20.9
2	1	7314655	8738937	2	1	6.4e-10	3.4e-11	1.3e-02	86	ERRFI1
3	1	19515061	21114833	2	4	1.9e-31	3.0e-42	1.5e-01	99	OTUD3 PLA2G5
4	1	67357596	67972435	1	1	1.4e-09	2.0e-41	5.8e-38	9	IL23R
5	1	154473660	155862966	1	1	2.4e-07	1.7e-07	1.0e+00	100	THBS3
6	1	160851894	162630958	4	1	1.9e-19	2.2e-21	1.1e-06	74	FCGR2A
7	1	200014178	201528243	2	1	7.1e-12	4.3e-16	1.6e-07	58	CAMSAP1L1
8	2	60466491	62460013	8	2	2.4e-18	4.3e-23	1.6e-04	85	PEX13 PUS10
9	2	199443880	201021954	1	1	1.4e-12	9.8e-13	1.0e+00	100	SATB2
10	2	240827284	242265313	3	2	2.6e-16	4.0e-13	1.1e-01	95	GPR35 PP14571
11	3	47884239	50932324	37	2	8.8e-20	2.2e-21	1.0e+00	100	FAM212A PRKAR2A
12	4	74173715	75555721	1	1	1.8e-07	2.2e-07	1.0e+00	100	CXCL5
13	4	122842267	123530993	1	1	2.1e-08	1.5e-07	1.7e-02	79	KIAA1109
14	5	12225	1390349	5	1	4.8e-11	3.1e-09	1.7e-01	95	EXOC3
15	5	158501850	159005439	1	1	5.3e-17	1.1e-18	2.9e-03	89	IL12B
16	5	176043333	177426530	2	1	2.1e-08	4.5e-08	5.3e-01	99	RGS14
17	6	110883139	112621834	3	2	7.6e-09	4.5e-11	9.3e-03	84	C6orf3 KIAA1919
18	7	2032803	3581391	2	1	2.6e-10	3.9e-11	4.9e-02	91	AMZ1
19	7	72674074	73952169	3	1	5.2e-08	3.9e-07	8.7e-01	100	WBSCR26
20	7	106847492	108340749	4	1	6.0e-20	4.1e-21	3.6e-04	86	DLD
21	7	127878155	129393341	2	1	1.8e-10	3.2e-10	1.0e+00	100	IRF5
22	9	4287179	6472714	4	2	1.2e-13	6.8e-17	4.1e-03	88	CD274 IGHEP2
23	9	116849447	118266112	1	1	9.3e-12	5.9e-15	5.1e-05	73	TNFSF15
24	9	138558883	140142299	7	3	4.9e-16	1.4e-16	1.0e+00	100	CARD9 RP11-611D20.2
25	11	1613255	2161858	2	1	1.8e-08	1.4e-07	1.0e+00	100	LSP1
26	11	75678647	77069746	1	1	9.9e-08	5.3e-14	4.0e-08	47	LRRC32
27	12	67971319	69424500	1	1	4.5e-08	1.3e-31	1.2e-25	20	MDM1
28	15	41006523	42468786	1	1	2.1e-07	2.2e-07	1.0e+00	100	RTF1
29	16	23149956	24929475	1	1	4.2e-08	1.8e-08	6.8e-02	90	PRKCB
30	16	27691641	29595483	9	1	6.5e-08	4.2e-07	8.5e-01	100	SULT1A1
31	16	29790709	31224521	1	1	2.4e-07	6.9e-07	1.2e-01	90	ITGAL
32	16	67872251	69294770	1	1	1.5e-08	3.8e-08	1.0e+00	100	ZFP90
33	17	37083464	39502398	15	2	3.9e-17	7.2e-18	3.9e-02	94	RAPGEFL1 SMARCE1
34	17	39863901	41538783	5	2	1.0e-09	2.0e-11	4.3e-01	99	HSD17B1P1 PTRF
35	20	61576647	62912463	9	2	1.3e-12	3.0e-11	5.8e-01	99	RGS19 STMN3
36	21	45398656	45902320	1	1	3.4e-12	1.8e-13	4.8e-04	78	ICOSLG
37	22	34997079	36433816	2	1	2.5e-07	4.5e-07	1.0e+00	100	TOM1
38	22	39064209	40479448	1	1	1.2e-09	3.1e-10	1.5e-05	53	SYNGR1
39	22	49656585	51055900	1	1	3.1e-09	1.5e-10	1.0e+00	100	PIM3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Irritable Bowel Disease (IBD)	21.32	45	31	68.9	0.96	4.2e-26	AMZ1 C6orf3 CAMSAP1L1 CARD9 CD274 DLD ERRFI1 EXOC3 FAM212A FCGR2A GPR35 HSD17B1P1 ICOSLG IGHEP2 IL12B IL23R IRF5 ITGAL KIAA1109 KIAA1919 LOC115110 LRRC32 LSP1 MDM1 OTUD3 PEX13 PLA2G5 PP14571 PRKAR2A PRKCB PTRF RAPGEFL1 RGS14 RGS19 RP11-611D20.2 SATB2 SMARCE1 STMN3 SULT1A1 SYNGR1 THBS3 TNFSF15 TOM1 WBSCR26 ZFP90
Ulcerative Colitis	19.26	39	21	46.7	1.00	2.9e-42	AMZ1 CAMSAP1L1 CARD9 CD274 CXCL5 DLD ERRFI1 EXOC3 FAM212A FCGR2A GPR35 ICOSLG IGHEP2 IL12B IL23R IRF5 ITGAL KIAA1109 KIAA1919 LOC115110 LRRC32 MDM1 OTUD3 PEX13 PIM3 PLA2G5 PP14571 PRKAR2A PRKCB PTRF PUS10 RAPGEFL1 RP3-395M20.9 RTF1 SATB2 STMN3 SYNGR1 TNFSF15 ZFP90
Crohns Disease (2017)	12.32	21	16	35.6	0.94	6.4e-11	CAMSAP1L1 CARD9 ERRFI1 FAM212A GPR35 ICOSLG IGHEP2 IL12B IL23R KIAA1109 LRRC32 PEX13 PTRF RAPGEFL1 RGS14 RP11-611D20.2 STMN3 SULT1A1 SYNGR1 THBS3 TNFSF15
Crohns Disease (2012)	9.19	13	12	26.7	0.96	1.1e-07	CARD9 FAM212A ICOSLG IGHEP2 IL12B IL23R PEX13 PTRF RAPGEFL1 STMN3 SULT1A1 SYNGR1 TNFSF15
Allergy or Eczema	6.05	13	9	20.0	0.65	1.6e-02	AMZ1 GPR35 IGHEP2 KIAA1109 LOC115110 LRRC32 PEX13 RAPGEFL1 RGS14 RTF1 SMARCE1 STMN3 ZFP90
Blood White Count	6.03	9	8	17.8	-0.37	2.9e-01	AMZ1 CARD9 FAM212A ITGAL LSP1 PEX13 RAPGEFL1 RGS14 STMN3
Hayfever, allergic rhinitis or eczema	5.38	9	7	15.6	0.65	5.6e-02	IGHEP2 KIAA1109 LOC115110 LRRC32 PEX13 RAPGEFL1 RGS14 SMARCE1 STMN3
Allergy	5.35	11	5	11.1	-0.62	4.2e-02	AMZ1 IGHEP2 KIAA1109 LOC115110 LRRC32 PEX13 RAPGEFL1 RGS14 SMARCE1 STMN3 ZFP90
Respiratory disease	4.39	5	3	6.7	-0.89	4.2e-02	KIAA1109 LRRC32 RAPGEFL1 RGS14 SMARCE1
Asthma (self-reported)	4.27	4	3	6.7	-0.92	8.2e-02	KIAA1109 LRRC32 RAPGEFL1 SMARCE1
Asthma	4.22	4	3	6.7	-0.91	9.4e-02	KIAA1109 LRRC32 RAPGEFL1 SMARCE1
Rheumatoid Arthritis	3.55	5	1	2.2	0.78	1.2e-01	FCGR2A IRF5 LRRC32 PUS10 RP3-395M20.9
Primary Biliary Cirrhosis	3.43	3	3	6.7	0.00	1.0e+00	IRF5 RAPGEFL1 SYNGR1
Lupus	3.26	2	2	4.4	0.00	1.0e+00	FCGR2A IRF5
Hayfever/allergic rhinitis (self-reported)	2.81	4	1	2.2	0.54	4.6e-01	KIAA1109 LRRC32 RAPGEFL1 SMARCE1
Medication: Ventolin 100micrograms inhaler	2.60	2	2	4.4	0.00	1.0e+00	KIAA1109 RAPGEFL1
Blood Eosinophil Count	2.51	18	12	26.7	0.45	5.9e-02	AMZ1 CARD9 CD274 GPR35 HSD17B1P1 IGHEP2 IRF5 ITGAL KIAA1109 LOC115110 LRRC32 PRKAR2A RGS14 RP3-395M20.9 RTF1 SMARCE1 TNFSF15 ZFP90
Wheeze or whistling in the chest in last year	2.40	3	3	6.7	0.00	1.0e+00	FAM212A KIAA1109 RAPGEFL1
Trunk fat mass	2.36	6	3	6.7	0.26	6.1e-01	AMZ1 EXOC3 FAM212A ITGAL RTF1 SULT1A1
Hip circumference	2.33	6	4	8.9	0.35	5.0e-01	AMZ1 ERRFI1 FAM212A ITGAL SULT1A1 TOM1
Mouth/teeth dental problems: Mouth ulcers	2.30	3	2	4.4	0.00	1.0e+00	IL12B IRF5 RAPGEFL1
Whole body fat mass	2.29	5	3	6.7	0.16	8.0e-01	AMZ1 FAM212A ITGAL RTF1 SULT1A1
Hypothyroidism (self reported)	2.22	6	1	2.2	0.31	5.5e-01	CAMSAP1L1 CD274 IRF5 KIAA1109 PTRF RP3-395M20.9
Weight	2.20	5	3	6.7	0.23	7.1e-01	AMZ1 ERRFI1 FAM212A ITGAL SULT1A1
Age when periods started (menarche)	2.19	4	2	4.4	-0.01	9.9e-01	FAM212A LSP1 PUS10 SATB2
Hypothyroidism/myxoedema (self-reported)	2.19	4	0	0.0	-0.36	6.4e-01	CD274 KIAA1109 PTRF RP3-395M20.9
Arm fat mass (right)	2.15	7	4	8.9	-0.01	9.8e-01	AMZ1 FAM212A ITGAL LOC115110 RTF1 SULT1A1 THBS3
Taking other prescription medications	2.13	2	1	2.2	0.00	1.0e+00	FAM212A RAPGEFL1
Qualifications: College or University degree	2.13	6	2	4.4	0.29	5.8e-01	FAM212A ITGAL PEX13 PRKAR2A STMN3 SULT1A1
Arm fat mass (left)	2.11	7	4	8.9	-0.01	9.8e-01	AMZ1 FAM212A ITGAL LOC115110 RTF1 SULT1A1 THBS3
Trunk fat percentage	2.10	6	4	8.9	0.23	6.7e-01	AMZ1 EXOC3 FAM212A ITGAL RTF1 SULT1A1
Leg fat mass (left)	2.08	5	3	6.7	0.05	9.4e-01	AMZ1 FAM212A ITGAL RTF1 SULT1A1
Leg fat mass (right)	2.03	5	3	6.7	0.03	9.6e-01	AMZ1 FAM212A ITGAL RTF1 SULT1A1
Number of self-reported non-cancer illnesses	2.01	3	1	2.2	0.00	1.0e+00	RAPGEFL1 RGS19 STMN3
Body fat percentage	1.98	6	4	8.9	0.14	8.0e-01	AMZ1 EXOC3 FAM212A ITGAL RTF1 SULT1A1
Waist circumference	1.93	4	3	6.7	0.40	6.0e-01	AMZ1 FAM212A ITGAL SULT1A1
Arm fat percentage (left)	1.92	7	4	8.9	-0.04	9.3e-01	AMZ1 FAM212A ITGAL LOC115110 RTF1 SULT1A1 THBS3
Height	1.89	15	9	20.0	0.38	1.4e-01	AMZ1 C6orf3 CARD9 ERRFI1 FAM212A HSD17B1P1 IRF5 LRRC32 PP14571 PRKAR2A PTRF PUS10 RGS14 RTF1 TOM1
Arm fat percentage (right)	1.89	6	3	6.7	0.01	9.8e-01	AMZ1 FAM212A ITGAL RTF1 SULT1A1 THBS3
Cardiovascular Disease	1.86	4	3	6.7	0.01	9.9e-01	LSP1 RGS19 SMARCE1 STMN3
Mouth/teeth dental problems	1.83	2	0	0.0	0.00	1.0e+00	IRF5 THBS3
Diabetes (self-reported)	1.83	1	0	0.0	0.00	1.0e+00	STMN3
Standing height	1.83	10	4	8.9	0.59	5.6e-02	AMZ1 CARD9 ERRFI1 HSD17B1P1 PP14571 PRKAR2A PTRF RTF1 SULT1A1 TOM1
Leg fat-free mass (left)	1.82	5	3	6.7	0.14	8.2e-01	AMZ1 ERRFI1 FAM212A SULT1A1 THBS3
Leg predicted mass (left)	1.82	5	3	6.7	0.15	8.1e-01	AMZ1 ERRFI1 FAM212A SULT1A1 THBS3
Intelligence (Savage-Jansen 2018)	1.81	3	2	4.4	0.00	1.0e+00	FAM212A PRKAR2A SULT1A1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.80	4	1	2.2	-0.48	5.2e-01	AMZ1 ITGAL RAPGEFL1 STMN3
Medication: Levothyroxine sodium	1.78	2	0	0.0	0.00	1.0e+00	PTRF RP3-395M20.9
Leg fat percentage (left)	1.78	5	3	6.7	-0.29	6.3e-01	FAM212A ITGAL RTF1 SMARCE1 SULT1A1
Medication: Co-codamol	1.76	1	0	0.0	0.00	1.0e+00	FAM212A
Body mass index (BMI)	1.76	5	3	6.7	-0.23	7.1e-01	FAM212A ITGAL LOC115110 RTF1 SULT1A1
Mouth/teeth dental problems: Dentures	1.76	2	1	2.2	0.00	1.0e+00	FAM212A THBS3
Leg fat-free mass (right)	1.74	5	2	4.4	0.16	7.9e-01	AMZ1 ERRFI1 FAM212A SULT1A1 THBS3
Number of operations (self-reported)	1.74	2	1	2.2	0.00	1.0e+00	AMZ1 ERRFI1
Leg predicted mass (right)	1.73	5	2	4.4	0.16	8.0e-01	AMZ1 ERRFI1 FAM212A SULT1A1 THBS3
Lung FVC	1.72	8	6	13.3	-0.26	5.3e-01	CARD9 ERRFI1 FAM212A ITGAL SATB2 STMN3 SULT1A1 THBS3
Basal metabolic rate	1.72	5	4	8.9	0.24	6.9e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Number of treatments/medications taken	1.71	2	1	2.2	0.00	1.0e+00	FAM212A TNFSF15
Sitting height	1.71	7	3	6.7	0.52	2.3e-01	AMZ1 CARD9 ERRFI1 HSD17B1P1 PRKAR2A RGS14 TOM1
Leg fat percentage (right)	1.71	4	3	6.7	-0.63	3.7e-01	FAM212A RTF1 SMARCE1 SULT1A1
BMI	1.70	7	4	8.9	-0.29	5.3e-01	FAM212A ITGAL LOC115110 RTF1 SMARCE1 SULT1A1 THBS3
Prostate Cancer	1.64	1	0	0.0	0.00	1.0e+00	FAM212A
Comparative height size at age 10	1.64	4	3	6.7	0.84	7.4e-02	AMZ1 CARD9 EXOC3 SULT1A1
Qualifications: A levels/AS levels or equivalent	1.63	2	1	2.2	0.00	1.0e+00	FAM212A SULT1A1
Medication for cholesterol, blood pressure or diabetes	1.63	1	1	2.2	0.00	1.0e+00	RGS19
Fed-up feelings	1.61	1	1	2.2	0.00	1.0e+00	FAM212A
Medication: Aspirin	1.61	1	0	0.0	0.00	1.0e+00	RGS19
Medication: Aspirin	1.61	1	0	0.0	0.00	1.0e+00	RGS19
Emphysema/chronic bronchitis	1.59	1	0	0.0	0.00	1.0e+00	RAPGEFL1
Verbal and Numeric Reasoning (VNR)	1.57	2	2	4.4	0.00	1.0e+00	FAM212A SULT1A1
Alcohol intake frequency.	1.56	2	1	2.2	0.00	1.0e+00	FAM212A SULT1A1
Age at First Birth	1.55	1	1	2.2	0.00	1.0e+00	FAM212A
Waist Hip Ratio (WHR)	1.55	5	5	11.1	-0.18	7.7e-01	DLD HSD17B1P1 PRKAR2A RGS19 TOM1
Whole body fat-free mass	1.54	5	3	6.7	0.26	6.7e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Arm predicted mass (left)	1.54	5	4	8.9	0.16	8.0e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Breast Cancer	1.53	5	0	0.0	-0.06	9.2e-01	ERRFI1 FAM212A HSD17B1P1 RGS19 THBS3
Lung FEV1/FVC ratio	1.52	5	3	6.7	-0.15	8.1e-01	AMZ1 EXOC3 RAPGEFL1 RGS14 RTF1
Whole body water mass	1.51	5	3	6.7	0.26	6.7e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Miserableness	1.50	1	1	2.2	0.00	1.0e+00	FAM212A
Arm fat-free mass (left)	1.50	5	4	8.9	0.17	7.9e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Body Mass Index (BMI) (2010)	1.49	1	0	0.0	0.00	1.0e+00	SULT1A1
Arm predicted mass (right)	1.48	6	4	8.9	0.20	7.0e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1 SYNGR1
Overall health rating	1.47	2	1	2.2	0.00	1.0e+00	AMZ1 FAM212A
Forced expiratory volume in 1-second (FEV1), predicted	1.46	1	1	2.2	0.00	1.0e+00	AMZ1
Pack years adult smoking proportion	1.45	1	0	0.0	0.00	1.0e+00	PRKAR2A
Arm fat-free mass (right)	1.45	5	4	8.9	0.17	7.8e-01	AMZ1 CARD9 ERRFI1 FAM212A SULT1A1
Medication: Cholesterol lowering	1.44	1	0	0.0	0.00	1.0e+00	RGS19
Medication: Blood pressure	1.44	1	0	0.0	0.00	1.0e+00	LSP1
Loneliness, isolation	1.44	1	0	0.0	0.00	1.0e+00	FAM212A
Systolic blood pressure, automated reading	1.43	3	2	4.4	0.00	1.0e+00	FAM212A LSP1 RGS19
Age at last live birth	1.43	1	1	2.2	0.00	1.0e+00	FAM212A
Fluid intelligence score	1.42	2	2	4.4	0.00	1.0e+00	FAM212A SULT1A1
Chest pain or discomfort	1.42	1	0	0.0	0.00	1.0e+00	RAPGEFL1
Forced expiratory volume in 1-second (FEV1), Best measure	1.41	5	1	2.2	0.64	2.5e-01	FAM212A ICOSLG PRKAR2A SATB2 STMN3
Qualifications: O levels/GCSEs or equivalent	1.41	1	0	0.0	0.00	1.0e+00	FAM212A
Blood Platelet Count	1.40	12	9	20.0	-0.09	7.9e-01	AMZ1 ERRFI1 GPR35 IGHEP2 IRF5 PP14571 RP3-395M20.9 STMN3 SULT1A1 THBS3 TOM1 ZFP90
Blood Red Count	1.40	10	8	17.8	0.09	8.0e-01	C6orf3 EXOC3 FCGR2A IGHEP2 ITGAL KIAA1919 RGS14 STMN3 SULT1A1 THBS3
Qualifications: None of the above	1.38	2	2	4.4	0.00	1.0e+00	FAM212A SULT1A1
Comparative body size at age 10	1.38	3	1	2.2	0.00	1.0e+00	ITGAL PUS10 SULT1A1
High blood pressure	1.37	2	2	4.4	0.00	1.0e+00	LSP1 RGS19
Vascular/heart problems diagnosed by doctor	1.37	3	2	4.4	0.00	1.0e+00	LSP1 RGS19 RTF1
Father's age at death	1.36	1	0	0.0	0.00	1.0e+00	FAM212A
Gout (self-reported)	1.36	1	0	0.0	0.00	1.0e+00	THBS3
Depressed Affect (Nagel 2018)	1.35	1	1	2.2	0.00	1.0e+00	FAM212A
Type 2 Diabetes (T2D) (2018)	1.35	1	0	0.0	0.00	1.0e+00	STMN3
Trunk fat-free mass	1.35	4	4	8.9	0.53	4.7e-01	AMZ1 CARD9 ERRFI1 SULT1A1
Birth weight	1.35	2	1	2.2	0.00	1.0e+00	AMZ1 PIM3
Hypertension (Self-reported)	1.35	3	2	4.4	0.00	1.0e+00	LSP1 RGS19 SMARCE1
High cholesterol (Self-reported)	1.34	1	1	2.2	0.00	1.0e+00	RGS19
Diastolic blood pressure, automated reading	1.34	4	2	4.4	-0.09	9.1e-01	FAM212A LSP1 RTF1 STMN3
Trunk predicted mass	1.33	4	3	6.7	0.54	4.6e-01	AMZ1 CARD9 ERRFI1 SULT1A1
Medication: Bendroflumethiazide	1.31	1	1	2.2	0.00	1.0e+00	LSP1
Average weekly spirits intake	1.30	1	0	0.0	0.00	1.0e+00	FAM212A
Medication: Blood pressure	1.30	2	1	2.2	0.00	1.0e+00	LSP1 RGS19
Cholesterol lowering medication	1.30	1	0	0.0	0.00	1.0e+00	RGS19
Forced expiratory volume in 1-second (FEV1)	1.29	4	1	2.2	0.60	4.0e-01	EXOC3 FAM212A PRKAR2A STMN3
Smoking status: Previous	1.28	1	0	0.0	0.00	1.0e+00	THBS3
Systolic Blood Pressure	1.27	5	2	4.4	-0.12	8.5e-01	FAM212A IRF5 LSP1 RGS19 STMN3
Suffer from 'nerves'	1.27	2	1	2.2	0.00	1.0e+00	SATB2 SULT1A1
Age at first live birth	1.26	1	1	2.2	0.00	1.0e+00	FAM212A
Medication: Omeprazole (e.g. Zanprol)	1.26	1	0	0.0	0.00	1.0e+00	EXOC3
Chronotype (morning person)	1.25	2	0	0.0	0.00	1.0e+00	CARD9 KIAA1109
Hand grip strength (right)	1.25	3	0	0.0	0.00	1.0e+00	FCGR2A IRF5 SULT1A1
Forced vital capacity (FVC), Best measure	1.25	4	2	4.4	0.62	3.8e-01	AMZ1 FAM212A SATB2 STMN3
Hair/balding pattern: Pattern 4	1.24	2	0	0.0	0.00	1.0e+00	KIAA1919 THBS3
Medication: Simvastatin	1.23	1	0	0.0	0.00	1.0e+00	RGS19
Current tobacco smoking	1.22	1	1	2.2	0.00	1.0e+00	STMN3
Birth weight of first child	1.22	1	0	0.0	0.00	1.0e+00	RGS19
Alcohol intake versus 10 years previously	1.21	1	1	2.2	0.00	1.0e+00	FAM212A
Forced vital capacity (FVC)	1.20	4	2	4.4	0.60	4.0e-01	AMZ1 FAM212A SATB2 STMN3
Leg pain on walking	1.20	1	0	0.0	0.00	1.0e+00	FAM212A
Mood swings	1.19	1	1	2.2	0.00	1.0e+00	FAM212A
Angina	1.18	1	0	0.0	0.00	1.0e+00	RGS19
Medication: Paracetamol	1.18	3	0	0.0	0.00	1.0e+00	FAM212A PRKAR2A SULT1A1
Angina (self-reported)	1.13	1	0	0.0	0.00	1.0e+00	RGS19
Pulse rate, automated reading	1.13	2	1	2.2	0.00	1.0e+00	FAM212A PRKAR2A
Impedance of arm (left)	1.12	6	1	2.2	0.69	1.3e-01	AMZ1 FAM212A LRRC32 PRKAR2A RAPGEFL1 SATB2
Smoking status: Current	1.12	1	0	0.0	0.00	1.0e+00	STMN3
Pain experienced in last month	1.11	1	0	0.0	0.00	1.0e+00	FAM212A
HDL Cholesterol	1.10	1	1	2.2	0.00	1.0e+00	RAPGEFL1
Past tobacco smoking	1.09	1	0	0.0	0.00	1.0e+00	THBS3
Impedance of arm (right)	1.08	7	1	2.2	0.58	1.7e-01	AMZ1 FAM212A LRRC32 LSP1 PRKAR2A RAPGEFL1 SATB2
Worrier / anxious feelings	1.06	1	0	0.0	0.00	1.0e+00	SATB2
Medication for cholesterol	1.06	1	0	0.0	0.00	1.0e+00	RGS19
Medication: Allopurinol	1.02	1	0	0.0	0.00	1.0e+00	THBS3
Hearing difficulty/problems: Yes	1.01	1	0	0.0	0.00	1.0e+00	SATB2
Worry (Nagel 2018)	1.00	1	0	0.0	0.00	1.0e+00	SATB2
Hand grip strength (left)	0.99	1	0	0.0	0.00	1.0e+00	FCGR2A
Medication: Paracetamol	0.99	2	0	0.0	0.00	1.0e+00	FAM212A SULT1A1
Financial situation satisfaction	0.99	1	0	0.0	0.00	1.0e+00	FAM212A
Reaction Time	0.97	1	0	0.0	0.00	1.0e+00	EXOC3
Relative age of first facial hair	0.96	2	0	0.0	0.00	1.0e+00	LRRC32 SATB2
Nervous feelings	0.92	1	0	0.0	0.00	1.0e+00	SATB2
Qualifications: nursing, teaching	0.91	1	0	0.0	0.00	1.0e+00	FAM212A
Pulse rate	0.86	1	0	0.0	0.00	1.0e+00	PRKAR2A
Impedance of whole body	0.85	3	1	2.2	0.00	1.0e+00	FAM212A PRKAR2A SATB2
Heel bone mineral density (BMD) T-score, automated (left)	0.81	1	0	0.0	0.00	1.0e+00	THBS3
Schizophrenia (2014)	0.80	1	0	0.0	0.00	1.0e+00	FCGR2A
Impedance of leg (right)	0.78	3	1	2.2	0.00	1.0e+00	ITGAL SULT1A1 THBS3
Heel T-Score	0.76	5	3	6.7	-0.98	3.1e-03	AMZ1 FAM212A IRF5 SATB2 THBS3
Impedance of leg (left)	0.76	2	2	4.4	0.00	1.0e+00	SULT1A1 THBS3
Tanning	0.22	2	0	0.0	0.00	1.0e+00	PIM3 THBS3
Hair Pigment	0.17	4	3	6.7	-0.47	5.3e-01	RGS19 SYNGR1 THBS3 TOM1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Whole Blood	15	0.75	2.2
GTEx	Brain Frontal Cortex BA9	7	0.76	2.1
GTEx	Ovary	3	0.33	2.1
GTEx	Spleen	11	0.78	2.1
GTEx	Adipose Visceral Omentum	6	0.29	2.0
GTEx	Adrenal Gland	5	0.34	2.0
GTEx	Artery Coronary	5	0.42	2.0
GTEx	Brain Cerebellar Hemisphere	12	0.81	2.0
GTEx	Brain Hypothalamus	3	0.51	2.0
GTEx	Cells EBV-transformed lymphocytes	5	0.35	2.0
GTEx	Colon Sigmoid	8	0.55	2.0
GTEx	Esophagus Gastroesophageal Junction	5	0.35	2.0
GTEx	Esophagus Mucosa	15	0.45	2.0
GTEx	Esophagus Muscularis	18	0.56	2.0
GTEx	Heart Atrial Appendage	11	0.70	2.0
GTEx	Lung	11	0.38	2.0
GTEx	Pancreas	7	0.43	2.0
GTEx	Prostate	3	0.36	2.0
GTEx	Skin Not Sun Exposed Suprapubic	8	0.33	2.0
GTEx	Skin Sun Exposed Lower leg	16	0.44	2.0
GTEx	Stomach	8	0.55	2.0
GTEx	Uterus	4	0.71	2.0
GTEx	Vagina	1	0.16	2.0
NTR	Blood	14	0.58	2.0
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	9	0.54	2.0
The Cancer Genome Atlas	Rectum Adenocarcinoma	4	0.58	2.0
GTEx	Adipose Subcutaneous	7	0.20	1.9
GTEx	Artery Aorta	7	0.24	1.9
GTEx	Artery Tibial	15	0.40	1.9
GTEx	Brain Caudate basal ganglia	3	0.33	1.9
GTEx	Brain Cerebellum	9	0.45	1.9
GTEx	Brain Cortex	4	0.39	1.9
GTEx	Brain Nucleus accumbens basal ganglia	2	0.23	1.9
GTEx	Brain Putamen basal ganglia	2	0.32	1.9
GTEx	Breast Mammary Tissue	5	0.25	1.9
GTEx	Breast Mammary Tissue (Female)	3	0.18	1.9
GTEx	Cells Transformed fibroblasts	12	0.29	1.9
GTEx	Colon Transverse	6	0.29	1.9
GTEx	Heart Left Ventricle	5	0.33	1.9
GTEx	Muscle Skeletal	8	0.28	1.9
GTEx	Nerve Tibial	15	0.35	1.9
GTEx	Pituitary	4	0.36	1.9
GTEx	Testis	12	0.38	1.9
GTEx	Thyroid	12	0.30	1.9
METSIM	Adipose	14	0.30	1.9
ROSMAP	Brain Pre-frontal Cortex	17	0.39	1.9
YFS	Blood	24	0.52	1.9
The Cancer Genome Atlas	Colon Adenocarcinoma	6	0.29	1.9
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.20	1.9
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	9	0.33	1.9
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	9	0.44	1.9
The Cancer Genome Atlas	Lung Adenocarcinoma	12	0.41	1.9
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.19	1.9
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.00	1.9
GTEx	Brain Hippocampus	1	0.19	1.8
GTEx	Breast Mammary Tissue (Male)	3	0.25	1.8
GTEx	Liver	2	0.28	1.8
GTEx	Small Intestine Terminal Ileum	1	0.22	1.8
CommonMind	Brain Pre-frontal Cortex	14	0.26	1.8
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	7	0.42	1.8
The Cancer Genome Atlas	Breast Invasive Carcinoma	13	0.29	1.8
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.18	1.8
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	9	0.36	1.8
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	7	0.44	1.8
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	7	0.53	1.8
The Cancer Genome Atlas	Soft Tissue Sarcoma	2	0.19	1.8
The Cancer Genome Atlas	Stomach Adenocarcinoma	7	0.42	1.8
The Cancer Genome Atlas	Testicular Germ Cell Tumors	6	0.47	1.8
The Cancer Genome Atlas	Thyroid Carcinoma	21	0.41	1.8
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.15	1.7
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	9	0.22	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	13	0.30	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.27	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	16	0.35	1.7