Best TWAS P=3.69e-08 · Best GWAS P=2.96e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | DARS | 0.12 | 0.05 | lasso | 4 | 0.04 | 9.0e-04 | -5.1 | -5.2 | 2.2e-07 | 0.93 | 0.04 | 0.91 | FALSE |
| 2 | GTEx | Esophagus Muscularis | DARS | 0.12 | 0.11 | lasso | 3 | 0.09 | 3.5e-06 | -5.1 | -5.3 | 1.4e-07 | 0.94 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Lung | DARS | 0.07 | 0.05 | lasso | 4 | 0.05 | 5.8e-05 | -5.1 | -5.2 | 1.8e-07 | 0.94 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Nerve Tibial | DARS | 0.13 | 0.06 | lasso | 5 | 0.05 | 3.2e-04 | -5.4 | -5.3 | 1.1e-07 | 0.95 | 0.02 | 0.96 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | DARS | 0.15 | 0.11 | enet | 4 | 0.10 | 3.0e-06 | -5.1 | -5.3 | 1.0e-07 | 0.97 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Thyroid | DARS | 0.20 | 0.13 | lasso | 3 | 0.15 | 1.3e-11 | -5.1 | -5.3 | 9.9e-08 | 0.95 | 0.03 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LCT | 0.02 | 0.02 | enet | 3 | 0.03 | 7.6e-07 | -4.8 | 5.1 | 3.1e-07 | -0.82 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DARS | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.9e-03 | -5.2 | -5.3 | 1.2e-07 | 0.95 | 0.02 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DARS | 0.08 | 0.10 | lasso | 4 | 0.09 | 8.8e-05 | -5.4 | -5.4 | 8.1e-08 | 0.96 | 0.02 | 0.93 | FALSE |
| 10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DARS | 0.04 | 0.04 | blup | 40 | 0.04 | 1.6e-03 | -5.4 | -5.5 | 3.7e-08 | 0.95 | 0.02 | 0.93 | TRUE |