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chr7:134,650,544-136,074,356

Best TWAS P=9.13e-10 · Best GWAS P=7.79e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC13A4	0.46	0.24	lasso	3	0.24	2.4e-14	-5.7	-6.1	9.1e-10	0.95	0.00	1.00	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	C7orf73	0.49	0.28	enet	33	0.44	7.4e-16	-5.7	6.1	1.2e-09	-0.79	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	PL-5283	0.52	0.40	lasso	4	0.42	6.8e-26	-5.7	6.0	1.6e-09	-0.97	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	PL-5283	0.33	0.24	enet	14	0.24	1.5e-48	-5.7	6.0	1.7e-09	-0.95	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC13A4	0.14	0.05	lasso	5	0.07	1.5e-13	-5.7	-6.0	1.9e-09	0.84	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Rectum Adenocarcinoma	SLC13A4	0.55	0.21	lasso	3	0.17	7.1e-05	-5.7	-6.0	2.3e-09	0.98	0.00	0.98	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	PL-5283	0.59	0.38	lasso	6	0.42	1.5e-44	-5.7	6.0	2.4e-09	-0.94	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	C7orf73	0.44	0.49	lasso	8	0.53	5.3e-46	-5.7	5.9	3.1e-09	-0.96	0.00	1.00	FALSE
27	GTEx	Whole Blood	C7orf73	0.08	0.01	lasso	3	0.01	1.8e-02	-5.7	5.9	3.3e-09	-0.90	0.00	0.96	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC13A4	0.45	0.17	lasso	6	0.23	3.6e-24	-5.7	-5.9	3.7e-09	0.83	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	PL-5283	0.35	0.28	lasso	5	0.28	1.2e-31	-5.7	5.8	5.2e-09	-0.97	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PL-5283	0.22	0.16	lasso	3	0.15	5.6e-17	-5.7	5.8	5.3e-09	-0.98	0.00	1.00	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	C7orf73	0.38	0.33	lasso	5	0.37	2.3e-21	-5.7	5.8	5.6e-09	-0.94	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	PL-5283	0.40	0.24	lasso	5	0.26	4.2e-30	-5.7	5.8	6.0e-09	-0.96	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SLC13A4	0.33	0.16	lasso	3	0.16	5.5e-07	-5.7	-5.8	6.2e-09	0.97	0.00	1.00	FALSE
18	GTEx	Lung	C7orf73	0.26	0.21	lasso	10	0.22	1.5e-16	-5.7	5.8	7.0e-09	-0.94	0.00	1.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	C7orf73	0.23	0.16	enet	28	0.26	1.4e-33	-4.1	5.8	7.2e-09	-0.82	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	PL-5283	0.39	0.23	lasso	3	0.20	5.0e-07	-5.7	5.8	7.3e-09	-0.96	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PL-5283	0.26	0.22	lasso	6	0.20	2.5e-10	-5.7	5.8	7.5e-09	-0.97	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	PL-5283	0.20	0.12	lasso	2	0.11	5.1e-07	-5.7	5.8	8.2e-09	-0.97	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PL-5283	0.34	0.18	lasso	2	0.15	1.2e-07	-5.7	5.8	8.3e-09	-0.98	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	PL-5283	0.40	0.31	enet	7	0.33	3.8e-35	-5.7	5.8	8.8e-09	-0.95	0.00	1.00	FALSE
6	GTEx	Artery Tibial	C7orf73	0.18	0.18	lasso	5	0.18	2.5e-14	-5.7	5.7	9.5e-09	-0.97	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue (Female)	C7orf73	0.20	0.17	lasso	4	0.12	1.5e-04	-5.7	5.7	9.8e-09	-0.94	0.01	0.97	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PL-5283	0.50	0.34	enet	12	0.37	3.1e-16	-5.7	5.7	1.0e-08	-0.94	0.00	1.00	FALSE
20	GTEx	Pancreas	C7orf73	0.22	0.28	lasso	8	0.28	4.5e-12	-5.7	5.7	1.1e-08	-0.97	0.00	1.00	FALSE
14	GTEx	Esophagus Mucosa	C7orf73	0.42	0.31	lasso	6	0.38	1.3e-26	-5.7	5.7	1.2e-08	-0.93	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PL-5283	0.22	0.14	lasso	4	0.12	2.0e-07	-5.7	5.7	1.2e-08	-0.96	0.00	1.00	FALSE
12	GTEx	Colon Transverse	C7orf73	0.25	0.29	lasso	5	0.24	1.1e-11	-5.7	5.7	1.3e-08	-0.95	0.00	1.00	FALSE
23	GTEx	Stomach	C7orf73	0.29	0.17	lasso	6	0.13	6.3e-07	-5.7	5.7	1.4e-08	-0.94	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	PL-5283	0.28	0.20	lasso	5	0.19	1.5e-13	-5.7	5.7	1.4e-08	-0.97	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC13A4	0.31	0.17	lasso	5	0.24	3.4e-17	-5.7	-5.7	1.4e-08	0.81	0.00	1.00	FALSE
3	GTEx	Adrenal Gland	C7orf73	0.24	0.23	lasso	1	0.21	3.8e-08	-5.7	5.7	1.5e-08	-0.95	0.00	1.00	FALSE
4	GTEx	Artery Aorta	C7orf73	0.27	0.23	lasso	4	0.21	1.5e-11	-5.7	5.7	1.5e-08	-0.94	0.00	1.00	FALSE
24	GTEx	Testis	C7orf73	0.38	0.27	lasso	4	0.30	1.1e-13	-5.7	5.7	1.5e-08	-0.97	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PL-5283	0.28	0.22	lasso	4	0.24	1.4e-26	-5.7	5.7	1.5e-08	-0.94	0.00	1.00	FALSE
7	GTEx	Breast Mammary Tissue	C7orf73	0.15	0.11	lasso	6	0.15	4.3e-08	-5.7	5.7	1.6e-08	-0.91	0.00	1.00	FALSE
11	GTEx	Colon Sigmoid	C7orf73	0.25	0.22	lasso	2	0.21	6.1e-08	-5.7	5.7	1.6e-08	-0.93	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PL-5283	0.40	0.32	lasso	4	0.36	2.6e-42	-5.7	5.7	1.6e-08	-0.92	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PL-5283	0.40	0.26	enet	9	0.23	1.5e-08	-5.7	5.6	1.7e-08	-0.91	0.00	1.00	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	C7orf73	0.25	0.19	lasso	3	0.14	8.6e-06	-5.7	5.6	2.4e-08	-0.98	0.00	1.00	FALSE
15	GTEx	Esophagus Muscularis	C7orf73	0.22	0.31	lasso	2	0.29	8.8e-18	-5.7	5.6	2.7e-08	-0.95	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	C7orf73	0.23	0.14	lasso	7	0.18	9.5e-15	-5.1	5.5	3.0e-08	-0.85	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC13A4	0.20	0.11	enet	12	0.15	2.9e-17	-5.7	-5.5	3.0e-08	0.78	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PL-5283	0.40	0.15	lasso	7	0.18	1.2e-07	-5.7	5.5	3.0e-08	-0.89	0.00	1.00	FALSE
5	GTEx	Artery Coronary	C7orf73	0.40	0.29	enet	18	0.30	1.3e-10	-5.1	5.5	4.3e-08	-0.81	0.02	0.97	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PL-5283	0.24	0.10	lasso	4	0.17	2.2e-14	-4.0	5.5	4.3e-08	-0.84	0.00	1.00	FALSE
26	GTEx	Vagina	C7orf73	0.27	0.19	lasso	3	0.17	9.3e-05	-5.1	5.5	4.4e-08	-0.90	0.01	0.97	FALSE
22	GTEx	Skin Sun Exposed Lower leg	C7orf73	0.29	0.28	enet	21	0.32	3.2e-27	-5.7	5.5	4.6e-08	-0.93	0.00	1.00	FALSE
28	METSIM	Adipose	C7orf73	0.11	0.05	lasso	7	0.07	7.5e-11	-4.0	5.5	5.1e-08	-0.82	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC13A4	0.27	0.04	enet	10	0.15	4.8e-09	-5.7	-5.4	6.7e-08	0.67	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Soft Tissue Sarcoma	NUP205	0.07	0.05	lasso	4	0.04	2.7e-03	-5.8	5.4	7.0e-08	-0.98	0.00	0.83	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PL-5283	0.33	0.23	blup	49	0.24	1.3e-16	-5.7	5.4	8.4e-08	-0.89	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC13A4	0.35	0.08	blup	56	0.20	1.8e-22	-5.7	-5.4	8.5e-08	0.59	0.00	1.00	FALSE
16	GTEx	Heart Atrial Appendage	C7orf73	0.14	0.12	enet	10	0.09	7.4e-05	-5.2	5.3	1.1e-07	-0.72	0.03	0.95	FALSE
17	GTEx	Heart Left Ventricle	C7orf73	0.14	0.09	lasso	12	0.07	2.1e-04	-4.8	5.2	1.6e-07	-0.84	0.03	0.97	FALSE
25	GTEx	Thyroid	C7orf73	0.18	0.11	lasso	7	0.16	2.1e-12	-5.1	5.2	2.0e-07	-0.84	0.03	0.97	FALSE
2	GTEx	Adipose Visceral Omentum	C7orf73	0.18	0.11	lasso	4	0.09	2.8e-05	-5.1	5.2	2.5e-07	-0.78	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	SLC13A4	0.44	0.18	blup	56	0.24	2.0e-23	-5.7	-5.2	2.5e-07	0.79	0.00	1.00	FALSE
19	GTEx	Nerve Tibial	C7orf73	0.19	0.10	lasso	9	0.18	9.5e-13	-5.7	5.2	2.6e-07	-0.83	0.00	1.00	FALSE