Best TWAS P=9.13e-10 · Best GWAS P=7.79e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C7orf73 | 0.23 | 0.14 | lasso | 7 | 0.18 | 9.5e-15 | -5.1 | 5.5 | 3.0e-08 | -0.85 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C7orf73 | 0.18 | 0.11 | lasso | 4 | 0.09 | 2.8e-05 | -5.1 | 5.2 | 2.5e-07 | -0.78 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Adrenal Gland | C7orf73 | 0.24 | 0.23 | lasso | 1 | 0.21 | 3.8e-08 | -5.7 | 5.7 | 1.5e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Aorta | C7orf73 | 0.27 | 0.23 | lasso | 4 | 0.21 | 1.5e-11 | -5.7 | 5.7 | 1.5e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Coronary | C7orf73 | 0.40 | 0.29 | enet | 18 | 0.30 | 1.3e-10 | -5.1 | 5.5 | 4.3e-08 | -0.81 | 0.02 | 0.97 | FALSE |
| 6 | GTEx | Artery Tibial | C7orf73 | 0.18 | 0.18 | lasso | 5 | 0.18 | 2.5e-14 | -5.7 | 5.7 | 9.5e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | C7orf73 | 0.15 | 0.11 | lasso | 6 | 0.15 | 4.3e-08 | -5.7 | 5.7 | 1.6e-08 | -0.91 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | C7orf73 | 0.20 | 0.17 | lasso | 4 | 0.12 | 1.5e-04 | -5.7 | 5.7 | 9.8e-09 | -0.94 | 0.01 | 0.97 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | C7orf73 | 0.49 | 0.28 | enet | 33 | 0.44 | 7.4e-16 | -5.7 | 6.1 | 1.2e-09 | -0.79 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | C7orf73 | 0.44 | 0.49 | lasso | 8 | 0.53 | 5.3e-46 | -5.7 | 5.9 | 3.1e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Colon Sigmoid | C7orf73 | 0.25 | 0.22 | lasso | 2 | 0.21 | 6.1e-08 | -5.7 | 5.7 | 1.6e-08 | -0.93 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Colon Transverse | C7orf73 | 0.25 | 0.29 | lasso | 5 | 0.24 | 1.1e-11 | -5.7 | 5.7 | 1.3e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | C7orf73 | 0.25 | 0.19 | lasso | 3 | 0.14 | 8.6e-06 | -5.7 | 5.6 | 2.4e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Esophagus Mucosa | C7orf73 | 0.42 | 0.31 | lasso | 6 | 0.38 | 1.3e-26 | -5.7 | 5.7 | 1.2e-08 | -0.93 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Esophagus Muscularis | C7orf73 | 0.22 | 0.31 | lasso | 2 | 0.29 | 8.8e-18 | -5.7 | 5.6 | 2.7e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Heart Atrial Appendage | C7orf73 | 0.14 | 0.12 | enet | 10 | 0.09 | 7.4e-05 | -5.2 | 5.3 | 1.1e-07 | -0.72 | 0.03 | 0.95 | FALSE |
| 17 | GTEx | Heart Left Ventricle | C7orf73 | 0.14 | 0.09 | lasso | 12 | 0.07 | 2.1e-04 | -4.8 | 5.2 | 1.6e-07 | -0.84 | 0.03 | 0.97 | FALSE |
| 18 | GTEx | Lung | C7orf73 | 0.26 | 0.21 | lasso | 10 | 0.22 | 1.5e-16 | -5.7 | 5.8 | 7.0e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Nerve Tibial | C7orf73 | 0.19 | 0.10 | lasso | 9 | 0.18 | 9.5e-13 | -5.7 | 5.2 | 2.6e-07 | -0.83 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Pancreas | C7orf73 | 0.22 | 0.28 | lasso | 8 | 0.28 | 4.5e-12 | -5.7 | 5.7 | 1.1e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Skin Not Sun Exposed Suprapubic | C7orf73 | 0.38 | 0.33 | lasso | 5 | 0.37 | 2.3e-21 | -5.7 | 5.8 | 5.6e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | C7orf73 | 0.29 | 0.28 | enet | 21 | 0.32 | 3.2e-27 | -5.7 | 5.5 | 4.6e-08 | -0.93 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Stomach | C7orf73 | 0.29 | 0.17 | lasso | 6 | 0.13 | 6.3e-07 | -5.7 | 5.7 | 1.4e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Testis | C7orf73 | 0.38 | 0.27 | lasso | 4 | 0.30 | 1.1e-13 | -5.7 | 5.7 | 1.5e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Thyroid | C7orf73 | 0.18 | 0.11 | lasso | 7 | 0.16 | 2.1e-12 | -5.1 | 5.2 | 2.0e-07 | -0.84 | 0.03 | 0.97 | FALSE |
| 26 | GTEx | Vagina | C7orf73 | 0.27 | 0.19 | lasso | 3 | 0.17 | 9.3e-05 | -5.1 | 5.5 | 4.4e-08 | -0.90 | 0.01 | 0.97 | FALSE |
| 27 | GTEx | Whole Blood | C7orf73 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.8e-02 | -5.7 | 5.9 | 3.3e-09 | -0.90 | 0.00 | 0.96 | FALSE |
| 28 | METSIM | Adipose | C7orf73 | 0.11 | 0.05 | lasso | 7 | 0.07 | 7.5e-11 | -4.0 | 5.5 | 5.1e-08 | -0.82 | 0.01 | 0.99 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | C7orf73 | 0.23 | 0.16 | enet | 28 | 0.26 | 1.4e-33 | -4.1 | 5.8 | 7.2e-09 | -0.82 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PL-5283 | 0.24 | 0.10 | lasso | 4 | 0.17 | 2.2e-14 | -4.0 | 5.5 | 4.3e-08 | -0.84 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PL-5283 | 0.33 | 0.24 | enet | 14 | 0.24 | 1.5e-48 | -5.7 | 6.0 | 1.7e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC13A4 | 0.14 | 0.05 | lasso | 5 | 0.07 | 1.5e-13 | -5.7 | -6.0 | 1.9e-09 | 0.84 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PL-5283 | 0.26 | 0.22 | lasso | 6 | 0.20 | 2.5e-10 | -5.7 | 5.8 | 7.5e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 34 | The Cancer Genome Atlas | Colon Adenocarcinoma | PL-5283 | 0.52 | 0.40 | lasso | 4 | 0.42 | 6.8e-26 | -5.7 | 6.0 | 1.6e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC13A4 | 0.46 | 0.24 | lasso | 3 | 0.24 | 2.4e-14 | -5.7 | -6.1 | 9.1e-10 | 0.95 | 0.00 | 1.00 | TRUE |
| 36 | The Cancer Genome Atlas | Esophageal Carcinoma | PL-5283 | 0.39 | 0.23 | lasso | 3 | 0.20 | 5.0e-07 | -5.7 | 5.8 | 7.3e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PL-5283 | 0.28 | 0.22 | lasso | 4 | 0.24 | 1.4e-26 | -5.7 | 5.7 | 1.5e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PL-5283 | 0.40 | 0.32 | lasso | 4 | 0.36 | 2.6e-42 | -5.7 | 5.7 | 1.6e-08 | -0.92 | 0.00 | 1.00 | FALSE |
| 39 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC13A4 | 0.35 | 0.08 | blup | 56 | 0.20 | 1.8e-22 | -5.7 | -5.4 | 8.5e-08 | 0.59 | 0.00 | 1.00 | FALSE |
| 40 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PL-5283 | 0.22 | 0.14 | lasso | 4 | 0.12 | 2.0e-07 | -5.7 | 5.7 | 1.2e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 41 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC13A4 | 0.27 | 0.04 | enet | 10 | 0.15 | 4.8e-09 | -5.7 | -5.4 | 6.7e-08 | 0.67 | 0.00 | 1.00 | FALSE |
| 42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PL-5283 | 0.35 | 0.28 | lasso | 5 | 0.28 | 1.2e-31 | -5.7 | 5.8 | 5.2e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 43 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PL-5283 | 0.34 | 0.18 | lasso | 2 | 0.15 | 1.2e-07 | -5.7 | 5.8 | 8.3e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 44 | The Cancer Genome Atlas | Lung Adenocarcinoma | PL-5283 | 0.40 | 0.24 | lasso | 5 | 0.26 | 4.2e-30 | -5.7 | 5.8 | 6.0e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 45 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC13A4 | 0.20 | 0.11 | enet | 12 | 0.15 | 2.9e-17 | -5.7 | -5.5 | 3.0e-08 | 0.78 | 0.00 | 1.00 | FALSE |
| 46 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PL-5283 | 0.22 | 0.16 | lasso | 3 | 0.15 | 5.6e-17 | -5.7 | 5.8 | 5.3e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 47 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PL-5283 | 0.33 | 0.23 | blup | 49 | 0.24 | 1.3e-16 | -5.7 | 5.4 | 8.4e-08 | -0.89 | 0.00 | 1.00 | FALSE |
| 48 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PL-5283 | 0.50 | 0.34 | enet | 12 | 0.37 | 3.1e-16 | -5.7 | 5.7 | 1.0e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 49 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PL-5283 | 0.40 | 0.15 | lasso | 7 | 0.18 | 1.2e-07 | -5.7 | 5.5 | 3.0e-08 | -0.89 | 0.00 | 1.00 | FALSE |
| 50 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC13A4 | 0.33 | 0.16 | lasso | 3 | 0.16 | 5.5e-07 | -5.7 | -5.8 | 6.2e-09 | 0.97 | 0.00 | 1.00 | FALSE |
| 51 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PL-5283 | 0.40 | 0.31 | enet | 7 | 0.33 | 3.8e-35 | -5.7 | 5.8 | 8.8e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC13A4 | 0.45 | 0.17 | lasso | 6 | 0.23 | 3.6e-24 | -5.7 | -5.9 | 3.7e-09 | 0.83 | 0.00 | 1.00 | FALSE |
| 53 | The Cancer Genome Atlas | Rectum Adenocarcinoma | SLC13A4 | 0.55 | 0.21 | lasso | 3 | 0.17 | 7.1e-05 | -5.7 | -6.0 | 2.3e-09 | 0.98 | 0.00 | 0.98 | FALSE |
| 54 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUP205 | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-03 | -5.8 | 5.4 | 7.0e-08 | -0.98 | 0.00 | 0.83 | FALSE |
| 55 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PL-5283 | 0.20 | 0.12 | lasso | 2 | 0.11 | 5.1e-07 | -5.7 | 5.8 | 8.2e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 56 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PL-5283 | 0.28 | 0.20 | lasso | 5 | 0.19 | 1.5e-13 | -5.7 | 5.7 | 1.4e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 57 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SLC13A4 | 0.31 | 0.17 | lasso | 5 | 0.24 | 3.4e-17 | -5.7 | -5.7 | 1.4e-08 | 0.81 | 0.00 | 1.00 | FALSE |
| 58 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PL-5283 | 0.40 | 0.26 | enet | 9 | 0.23 | 1.5e-08 | -5.7 | 5.6 | 1.7e-08 | -0.91 | 0.00 | 1.00 | FALSE |
| 59 | The Cancer Genome Atlas | Thyroid Carcinoma | PL-5283 | 0.59 | 0.38 | lasso | 6 | 0.42 | 1.5e-44 | -5.7 | 6.0 | 2.4e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 60 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC13A4 | 0.44 | 0.18 | blup | 56 | 0.24 | 2.0e-23 | -5.7 | -5.2 | 2.5e-07 | 0.79 | 0.00 | 1.00 | FALSE |