Best TWAS P=9.12e-12 · Best GWAS P=9.72e-25 conditioned to 1.55e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | MKLN1-AS2 | 0.39 | 0.01 | enet | 9 | -0.01 | 6.5e-01 | 7.6 | 6.0 | 2.6e-09 | 0.45 | 0.06 | 0.42 | FALSE |
| 2 | GTEx | Artery Tibial | MKLN1-AS2 | 0.14 | 0.05 | enet | 22 | 0.04 | 2.4e-04 | 3.7 | 5.1 | 3.0e-07 | 0.54 | 0.69 | 0.10 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | MKLN1-AS2 | 0.20 | 0.05 | lasso | 6 | 0.02 | 7.8e-02 | 5.2 | 6.0 | 1.7e-09 | 0.64 | 0.18 | 0.28 | FALSE |
| 4 | GTEx | Nerve Tibial | MKLN1-AS2 | 0.20 | 0.16 | lasso | 7 | 0.16 | 1.3e-11 | 5.0 | 6.7 | 1.8e-11 | 0.66 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Thyroid | MKLN1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.7e-02 | 8.4 | 6.3 | 2.3e-10 | 0.64 | 0.14 | 0.14 | FALSE |
| 6 | GTEx | Thyroid | MKLN1-AS2 | 0.28 | 0.22 | lasso | 6 | 0.25 | 8.6e-19 | 5.0 | 6.8 | 9.1e-12 | 0.69 | 1.00 | 0.00 | TRUE |