Best TWAS P=2.93e-12 · Best GWAS P=9.1e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | SPON1 | 0.27 | 0.22 | enet | 16 | 0.24 | 5.6e-11 | 6.8 | 6.8 | 7.9e-12 | 0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Heart Left Ventricle | SPON1 | 0.18 | 0.12 | enet | 13 | 0.11 | 2.2e-06 | -6.8 | 6.6 | 4.0e-11 | 0.93 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Ovary | SPON1 | 0.31 | 0.16 | enet | 24 | 0.15 | 1.4e-04 | 6.8 | 6.0 | 1.5e-09 | 0.90 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Testis | SPON1 | 0.14 | 0.07 | enet | 13 | 0.04 | 6.0e-03 | 6.8 | 6.8 | 9.3e-12 | 0.93 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Thyroid | SPON1 | 0.12 | 0.10 | lasso | 3 | 0.08 | 1.2e-06 | 6.8 | 7.0 | 2.9e-12 | 1.00 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SPON1 | 0.15 | 0.03 | blup | 68 | 0.08 | 1.1e-04 | 5.8 | 5.3 | 1.3e-07 | 0.72 | 0.02 | 0.94 | FALSE |