TWAS hub - SPON1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0270	2.6e-03	0.018	0.017	0.026	0.020	0.022	2.4e-03	3.5e-03	3.3e-04	1.4e-03	1.0e-03
2	GTEx	Adrenal Gland	0.1790	0.0665	1.6e-03	-0.007	NA	0.000	NA	-0.006	6.9e-01	NA	3.2e-01	NA	5.8e-01
3	GTEx	Brain Cerebellar Hemisphere	0.3030	0.1040	5.8e-03	0.058	NA	0.033	NA	0.076	1.3e-02	NA	4.9e-02	NA	5.4e-03
4	GTEx	Brain Cerebellum	0.4610	0.0760	1.4e-07	0.473	NA	0.405	NA	0.447	8.7e-16	NA	4.1e-13	NA	9.6e-15
5	GTEx	Cells EBV-transformed lymphocytes	0.2520	0.0720	1.2e-05	0.298	NA	0.239	NA	0.276	2.5e-10	NA	2.4e-08	NA	1.3e-09
6	GTEx	Heart Atrial Appendage	0.2670	0.0610	9.1e-09	0.218	NA	0.236	NA	0.228	3.9e-10	NA	5.6e-11	NA	1.4e-10
7	GTEx	Heart Left Ventricle	0.1796	0.0485	3.0e-06	0.123	NA	0.109	NA	0.020	4.5e-07	NA	2.1e-06	NA	2.9e-02
8	GTEx	Ovary	0.3110	0.0840	1.6e-04	0.156	NA	0.152	NA	0.144	1.2e-04	NA	1.4e-04	NA	2.2e-04
9	GTEx	Testis	0.1440	0.0510	6.4e-04	0.070	NA	0.042	NA	0.001	5.0e-04	NA	6.0e-03	NA	3.0e-01
10	GTEx	Thyroid	0.1170	0.0370	8.1e-05	0.103	NA	0.063	NA	0.079	2.8e-08	NA	1.4e-05	NA	1.2e-06
11	NTR	Blood	0.0543	0.0142	4.9e-12	0.020	0.042	0.025	0.040	0.026	3.6e-07	2.4e-13	1.2e-08	6.0e-13	5.3e-09
12	ROSMAP	Brain Pre-frontal Cortex	0.1459	0.0448	1.1e-05	0.041	0.039	0.049	0.045	0.031	4.4e-06	8.3e-06	6.2e-07	1.7e-06	6.1e-05
13	TCGA	Liver Hepatocellular Carcinoma	0.1480	0.0570	4.5e-04	0.027	0.082	0.064	NA	0.071	2.0e-02	1.1e-04	5.7e-04	NA	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Pulse rate	6.8	11.4	27.9	-0.2	3.3	0.4	0.4	1.2	4.6	4.9	4.9	5.3	4.7	0.7	-1.5	3.6
Pulse rate, automated reading	6.6	21.3	48.7	-0.9	4.5	0.6	0.7	1.9	6.8	6.6	6.0	6.8	7.0	0.5	-0.7	5.3
Leg pain on walking	4.9	6.2	14.8	0.8	-2.3	-1.5	-1.4	-1.1	-3.6	-3.9	-3.4	-3.4	-3.5	0.2	0.1	-2.4
Pain type(s) experienced in last month: Hip pain	4.1	5.1	10.1	1.1	-2.4	-2.5	-2.6	0.0	-2.9	-3.2	-3.0	-2.9	-2.7	0.5	0.5	-1.9
Diastolic blood pressure, automated reading	3.9	12.2	25.6	-1.1	0.1	2.4	2.3	4.3	4.8	4.6	3.0	5.1	4.9	2.8	-2.9	3.0
HbA1C	3.4	3.7	9.9	0.8	1.9	0.1	0.0	0.1	3.0	2.9	2.4	3.0	3.1	1.0	-0.5	0.8
Number of full brothers	3.4	4.3	10.4	0.2	2.0	-0.3	-0.2	1.8	2.9	3.0	2.8	3.2	2.9	0.3	0.2	2.1
Rheumatoid Arthritis	3.1	4.3	7.9	0.8	1.5	1.9	1.9	0.6	2.7	2.6	2.7	2.2	2.8	-0.1	2.2	2.5
Pulse wave reflection index	2.8	3.4	8.0	1.9	-0.6	-0.2	-0.2	-0.7	-2.8	-2.7	-2.6	-2.7	-2.8	-0.7	0.7	-1.2
Chest pain or discomfort	2.8	4.0	9.5	2.0	-3.1	0.0	-0.1	0.1	-2.9	-2.7	-2.5	-1.7	-2.9	0.9	0.9	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	15.0	-0.2	1.0	-3.8	-3.9	-0.9	-1.7	-1.6	-1.3	-1.3	-1.6	-0.5	-1.5	-1.4
Mouth/teeth dental problems: Loose teeth	2.7	3.2	10.6	0.4	1.2	-1.2	-1.2	-3.3	-1.6	-2.0	-1.7	-1.7	-1.9	-3.2	1.0	-0.5
Forced vital capacity (FVC), Best measure	2.6	9.4	19.5	-1.0	-0.5	-2.6	-2.8	-2.1	-4.2	-3.9	-4.4	-4.2	-4.1	-3.2	0.4	-2.1
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	11.5	-0.2	0.1	-3.4	-3.4	0.2	-1.4	-1.4	-1.6	-1.7	-1.5	-0.9	-0.7	-1.7
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	7.0	0.5	-0.0	-2.5	-2.6	-0.9	-1.5	-1.5	-1.3	-1.9	-1.3	-0.4	-2.2	-1.1
Qualifications: CSEs or equivalent	2.3	3.1	7.7	1.9	2.4	-0.1	-0.1	1.3	2.3	2.5	1.7	2.8	2.5	-0.5	0.0	0.5
Blood clot in the leg (DVT)	2.3	2.9	8.1	-0.1	-1.4	-1.1	-1.1	-0.6	-2.1	-2.4	-2.8	-2.0	-1.9	-1.0	1.1	-2.3
Birth weight	2.3	5.0	16.2	-2.1	-0.2	-0.3	-0.4	-4.0	-2.9	-2.5	-2.5	-2.7	-2.9	-2.3	0.1	-1.1
Verbal and Numeric Reasoning (VNR)	2.2	5.3	14.7	0.8	2.4	0.1	-0.1	-2.8	1.8	2.4	2.2	1.7	1.6	-3.8	3.7	2.6
Guilty feelings	2.2	3.3	9.0	0.6	3.0	0.9	1.1	1.0	2.3	2.4	2.6	2.2	2.1	0.6	-1.2	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	4.6	1.3	-1.0	-1.5	-1.7	0.1	-1.9	-2.1	-2.0	-2.0	-1.8	-0.8	0.5	-1.8
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.3	-0.5	-1.7	-0.7	-0.7	-0.6	-2.0	-2.3	-2.7	-1.9	-1.8	-1.1	1.0	-2.3
Medication: Omeprazole	2.0	2.4	8.7	-0.5	-0.3	-2.9	-2.9	0.9	-1.2	-1.2	-1.4	-1.1	-1.2	-0.2	-1.3	-1.9
Average weekly beer plus cider intake	2.0	2.9	7.3	-0.3	0.6	-2.5	-2.3	-1.2	-1.8	-2.0	-2.7	-1.9	-1.6	-1.7	-0.1	-1.1
Crohns Disease (2012)	1.9	3.1	8.9	0.3	1.0	0.9	1.1	1.1	2.7	3.0	2.3	1.9	2.9	0.8	-1.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	14.4	-0.9	-0.3	-2.0	-2.1	-0.8	-3.4	-3.1	-3.8	-3.6	-3.4	-2.1	0.1	-1.4
Irritability	1.8	3.0	5.2	-0.1	1.5	-2.0	-2.1	-1.7	-2.2	-1.9	-0.8	-2.2	-2.3	-0.2	-1.5	-1.9
Fasting Glucose	1.7	2.0	4.8	0.2	1.6	-1.4	-1.3	-0.2	2.1	1.6	0.9	2.2	2.0	-1.3	0.2	1.0
Lupus	1.7	2.6	18.7	-0.5	-4.3	2.3	2.2	1.2	-0.8	-0.7	0.0	-0.4	-0.5	1.4	0.6	-0.6
Qualifications: A levels/AS levels or equivalent	1.7	3.8	10.1	-1.6	0.5	2.6	2.6	-2.3	1.7	1.4	1.6	0.9	1.5	-1.7	3.2	2.1
Knee pain experienced in last month	1.7	2.6	4.7	1.1	-2.1	-1.6	-1.6	0.7	-1.8	-2.2	-2.0	-1.6	-1.4	0.9	1.8	-1.5
Medication: Bendroflumethiazide	1.7	2.6	5.6	0.2	0.1	1.2	1.1	2.1	2.1	1.9	1.5	2.4	2.2	1.8	1.0	1.4
Reaction Time	1.6	3.0	8.0	1.8	0.3	-0.7	-0.5	0.0	-2.1	-2.2	-2.7	-2.8	-2.3	-0.5	-0.3	-2.3
Systolic Blood Pressure	1.6	7.8	32.3	-0.3	-3.3	2.6	2.6	4.9	1.2	0.9	-0.1	1.5	0.7	5.7	-3.8	1.2
Diabetes (father)	1.6	2.0	9.0	-1.2	2.3	-2.8	-3.0	-0.1	0.1	0.1	0.7	-0.3	0.1	-0.7	0.2	0.9
Happiness	1.6	1.9	6.2	-0.2	1.6	-2.1	-2.1	-2.2	-0.5	-0.9	0.1	-0.8	-0.4	-2.5	-0.4	-0.4
Heart disease (mother)	1.6	2.0	6.6	0.9	1.2	-0.8	-0.9	1.8	1.2	1.4	1.6	1.3	1.2	0.5	2.6	1.8
Handedness (chirality/laterality): Left-handed	1.6	1.9	7.3	-2.2	0.5	1.0	0.9	2.7	0.4	0.4	0.7	0.4	0.1	2.0	-1.4	1.8
Loneliness, isolation	1.6	2.2	9.4	-0.1	1.8	-3.1	-3.0	-1.8	-0.1	0.4	0.8	-0.1	-0.3	-1.2	-1.1	-0.8
Commuting to job workplace: Public transport	1.6	1.8	8.2	-0.7	-0.3	-0.9	-1.0	-2.7	-0.8	-1.2	-0.9	-1.0	-0.6	-2.9	0.2	-1.4
Waist Hip Ratio (WHR)	1.5	6.6	24.9	-2.7	-2.2	2.4	2.3	0.1	-1.9	-2.1	-2.0	-1.5	-2.3	3.7	-5.0	-1.7
Falls in the last year	1.5	2.0	5.2	0.2	0.3	-1.3	-1.2	-1.5	-1.6	-1.4	-2.3	-1.3	-1.5	-1.8	0.0	-1.9
Alcohol intake frequency.	1.5	3.6	8.6	2.9	2.7	0.6	0.9	-0.3	2.5	2.6	1.9	2.3	2.6	-0.8	0.4	0.2
Had major operations	1.5	1.7	6.3	0.8	-0.9	-2.5	-2.5	-1.7	-0.8	-1.2	-0.4	-0.6	-0.8	-0.5	-1.1	-1.0
Medication: Blood pressure	1.5	2.8	10.0	0.5	-1.0	0.9	0.8	2.5	1.6	1.6	1.2	1.4	1.4	3.2	-2.7	0.3
Pain experienced in last month	1.5	2.6	11.0	-2.8	-0.6	3.3	3.3	-1.0	0.1	0.5	0.9	0.4	-0.0	-0.4	-0.9	0.3
Intelligence (Savage-Jansen 2018)	1.4	4.2	8.6	1.3	2.6	1.1	1.1	-1.8	2.0	2.5	2.1	1.7	1.6	-2.7	2.9	2.1
Schizophrenia (2018)	1.4	3.0	7.0	-0.3	2.4	0.6	0.7	-0.7	1.9	1.9	2.0	2.2	2.0	-1.4	2.7	1.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.0	0.5	1.3	-0.8	-0.7	0.7	1.8	1.2	1.7	1.6	1.8	0.2	0.8	2.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.2	0.5	-0.8	1.6	1.6	-0.5	-1.3	-1.4	-1.8	-1.1	-1.5	0.2	1.4	-1.5
Worry too long after embarrassment	1.4	2.3	8.5	-0.0	2.9	1.0	0.9	-1.7	1.5	1.4	2.6	0.8	1.5	-1.7	0.2	0.5
Mother’s age at death	1.4	1.8	5.6	1.8	-0.5	-0.6	-0.9	0.2	-2.2	-1.6	-1.1	-1.1	-2.4	1.7	0.9	-0.1
Number of operations (self-reported)	1.4	2.0	9.2	0.4	-0.8	-3.0	-3.0	-0.5	-0.4	-0.8	-0.8	0.1	-0.1	0.1	-2.0	-1.3
Cholesterol lowering medication	1.4	2.0	10.0	1.7	-2.9	-0.1	0.0	1.9	0.1	-0.4	0.3	-0.3	0.1	3.2	-0.9	-0.0
Medication: Co-codamol	1.3	1.5	9.4	1.9	-1.0	0.1	0.1	3.1	0.2	-0.2	-0.7	0.6	0.6	1.8	0.2	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.3	0.5	-0.1	-1.2	-1.4	-1.9	-2.2	-1.8	-1.3	-1.6	-2.3	-0.2	0.1	-1.4
Impedance of arm (right)	1.3	6.1	12.1	-0.3	-1.1	-0.4	-0.4	-3.4	-3.5	-3.3	-2.4	-3.2	-3.4	-2.7	0.2	-2.9
Number of live births	1.3	1.8	4.3	-1.1	0.6	0.7	0.7	0.4	1.6	2.1	1.8	1.9	1.7	0.6	-1.8	0.4
Breastfed as a baby	1.3	1.6	5.0	-1.2	-0.4	1.9	2.0	0.8	1.0	0.8	0.9	0.6	0.6	1.4	-0.4	2.2
Family relationship satisfaction	1.3	1.5	3.6	0.2	0.5	-1.8	-1.9	-1.5	-0.9	-0.9	-0.1	-1.4	-0.8	-1.6	-1.1	-1.7
Back pain experienced in last month	1.3	1.9	9.0	3.0	0.2	-2.3	-2.2	1.7	0.3	-0.1	-0.9	0.4	0.2	0.8	0.6	0.2
Osteoporosis (self-reported)	1.3	1.7	3.4	-0.5	-1.8	-0.2	-0.2	-0.1	-1.8	-1.6	-1.8	-1.4	-1.7	0.5	-0.4	-1.8
Age started oral contraceptive pill	1.3	1.6	3.6	0.0	-1.5	1.1	0.9	-1.2	-1.9	-1.3	-1.1	-1.6	-1.9	-1.2	0.9	-0.3
Bipolar Disorder (2011)	1.2	1.1	3.2	-0.4	-1.8	1.4	1.3	-0.1	-0.8	-0.7	-0.9	-1.2	-1.1	1.4	-0.7	-1.0
Height	1.2	22.3	57.8	0.4	-0.6	-1.8	-1.8	-7.1	-5.9	-5.2	-6.2	-4.7	-5.7	-7.6	3.5	-2.8
Lung FVC	1.2	5.9	12.0	0.0	-2.3	-2.6	-2.7	1.2	-3.3	-3.3	-3.5	-3.1	-3.2	0.6	-0.1	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.6	7.3	0.5	-0.2	-2.7	-2.7	-0.5	-0.9	-0.6	-0.7	-0.3	-0.9	-0.1	-0.8	-1.5
Medication for hormone replacement therapy	1.2	1.4	5.9	-1.0	0.2	-2.3	-2.4	1.2	-1.0	-0.5	-0.5	-1.0	-1.1	0.3	-0.4	-0.5
Trunk fat percentage	1.2	4.6	15.8	-0.8	1.1	-2.6	-2.7	-2.3	-2.1	-1.2	-2.5	-1.5	-1.7	-4.0	1.0	-2.1
Hand grip strength (right)	1.2	3.4	9.2	1.5	1.1	-0.1	-0.2	0.0	2.4	2.4	2.0	3.0	2.7	-0.9	1.0	2.5
Trunk fat mass	1.2	5.2	18.8	-1.0	1.4	-2.7	-2.8	-2.5	-2.1	-1.3	-2.8	-1.5	-1.7	-4.3	1.5	-1.8
Forced vital capacity (FVC)	1.2	4.7	10.4	-1.7	0.9	-1.8	-1.9	-1.6	-2.9	-2.3	-2.7	-2.8	-2.9	-3.2	0.5	-0.5
Hip circumference	1.2	5.1	22.9	-0.4	1.8	-3.4	-3.4	-1.5	-1.0	-0.3	-1.7	-0.3	-0.6	-4.8	3.1	0.4
Number of children fathered	1.2	1.4	5.4	-0.8	1.2	-0.4	-0.4	-1.1	1.4	1.2	1.0	1.1	0.9	-1.4	0.8	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.9	1.8	1.5	-0.4	-0.5	-0.0	1.2	1.1	2.0	0.9	1.1	0.8	0.7	1.7
Comparative height size at age 10	1.2	6.8	15.2	0.4	-1.2	0.2	0.2	-3.2	-3.4	-3.0	-3.9	-2.9	-3.3	-3.9	2.0	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.7	0.6	-1.0	-1.5	-1.8	1.3	-1.4	-1.7	-1.0	-1.4	-1.4	2.2	-0.8	-1.3
Medication for cholesterol	1.2	1.8	8.8	-0.9	1.3	0.1	0.1	-2.4	-1.1	-1.0	-1.3	-0.7	-1.1	-3.0	0.5	-0.8
Depression (Nagel 2018)	1.1	1.6	7.7	0.2	0.8	-2.8	-2.8	-0.2	-0.9	-0.9	-0.5	-0.6	-0.9	0.6	-1.1	-0.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	8.3	0.3	0.7	0.3	0.4	1.4	1.1	0.8	0.2	1.1	1.1	1.3	-2.9	-0.1
Ever had hysterectomy (womb removed)	1.1	1.2	4.4	-0.7	-0.8	-1.1	-1.2	-0.7	-1.4	-1.0	-0.9	-0.9	-1.4	0.1	-0.8	-2.1
Systolic blood pressure, automated reading	1.1	3.2	12.2	-0.3	-1.5	0.6	0.5	3.2	1.0	0.8	0.2	1.3	0.7	3.4	-3.5	0.6
Fed-up feelings	1.1	2.0	8.1	0.8	2.9	-2.3	-2.0	-1.4	-0.7	-0.2	-0.0	-0.1	-0.6	-0.5	-0.6	-2.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.7	-0.8	0.6	-1.5	-1.4	-0.8	-1.0	-1.3	-1.3	-1.4	-1.0	-1.6	1.1	-1.3
Fluid intelligence score	1.1	2.4	8.2	-0.3	1.8	0.1	-0.1	-2.1	0.8	1.1	1.2	1.1	0.6	-2.4	2.9	2.0
Impedance of arm (left)	1.1	5.2	11.5	0.5	-1.0	-0.4	-0.5	-2.9	-3.4	-3.0	-2.2	-3.0	-3.3	-2.3	0.1	-2.6
Standing height	1.1	11.3	28.2	-1.2	-0.2	-1.1	-1.2	-5.1	-4.2	-3.8	-4.4	-3.7	-4.2	-5.3	1.7	-1.8
Tense / ‘highly strung’	1.1	1.8	5.2	0.4	-0.1	-0.8	-0.7	0.1	-2.1	-1.8	-1.3	-2.2	-2.3	0.8	-0.3	-1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	7.4	-0.2	0.4	1.7	1.5	-2.4	0.8	0.7	0.7	0.6	0.7	-0.9	2.7	0.0
Glaucoma (self-reported)	1.1	1.3	4.0	2.0	1.2	0.3	0.3	-0.4	0.8	0.6	1.1	0.8	0.6	-0.9	1.6	2.0
Medication: Seretide 50 evohaler	1.1	1.3	5.1	2.3	1.2	-0.3	-0.4	1.8	0.7	1.1	0.7	1.4	0.6	0.1	1.4	0.4
Mean time to correctly identify matches	1.1	2.2	6.4	1.7	0.4	-0.9	-0.8	-0.1	-1.7	-2.0	-1.8	-2.5	-2.0	0.3	-0.2	-1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	4.2	0.1	-1.1	1.9	2.1	0.1	-0.6	-0.3	-1.0	-1.2	-1.1	1.0	-1.2	-1.1
Financial situation satisfaction	1.1	1.3	4.0	1.0	1.4	-2.0	-1.9	-1.6	0.1	0.3	0.6	0.9	0.5	-1.1	0.8	-0.6
Heart disease (siblings)	1.1	1.4	2.6	-0.2	1.3	-1.3	-1.4	-1.6	0.9	0.9	1.3	1.3	0.8	-1.3	0.4	1.6
Depressed Affect (Nagel 2018)	1.0	2.0	7.6	1.1	2.5	-2.8	-2.5	-0.8	-0.1	0.4	1.0	0.4	-0.1	0.0	-1.2	-0.9
Schizophrenia vs Biploar Disorder	1.0	1.3	5.4	0.8	2.3	-0.7	-0.8	-1.1	-0.5	-0.3	0.0	0.0	-0.3	-1.8	2.3	-0.3
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	1.3	-1.6	-0.3	-0.1	0.5	-1.5	-1.4	-1.3	-0.9	-1.2	-0.0	0.2	-1.7
Number of incorrect matches in round	1.0	1.7	7.3	0.4	-0.9	2.7	2.5	1.1	-0.4	-0.4	-0.4	0.2	-0.7	2.1	-0.9	-0.2
Hearing difficulty/problems with background noise	1.0	1.7	5.2	1.4	2.3	-0.5	-0.7	-1.6	0.9	1.5	1.8	1.4	0.6	-0.1	1.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	6.5	1.4	1.7	-2.5	-2.6	-0.9	-0.9	-0.1	0.3	-0.3	-1.0	0.5	0.4	-0.0
Depression (self-reported)	1.0	1.2	5.8	0.6	-1.2	-0.9	-0.8	2.4	-0.0	-0.9	-0.5	0.4	0.1	2.2	-0.6	-0.2
Overall health rating	1.0	2.1	9.9	0.2	1.0	-3.1	-3.1	-0.8	-0.7	-0.4	-1.2	-0.1	-0.3	-1.0	0.2	-1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	5.8	-0.5	-0.6	-0.3	-0.3	2.4	-0.6	-0.4	-0.8	-0.3	-0.6	2.3	-0.5	-0.6
Medication: Aspirin	1.0	1.3	3.8	0.7	1.3	-0.3	-0.4	0.1	1.4	1.6	2.0	1.3	1.1	1.4	-0.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.4	0.1	-0.4	-1.4	-1.4	-0.0	-1.5	-1.4	-1.0	-1.1	-1.6	0.3	0.1	-1.4
Qualifications: nursing, teaching	1.0	1.6	4.1	-2.0	0.4	0.8	0.9	-1.0	1.2	1.4	1.6	1.5	1.1	0.1	0.6	1.9
Miserableness	1.0	1.7	7.4	0.8	2.7	-1.4	-1.2	-0.6	1.1	1.3	1.2	1.7	1.2	-0.6	-0.9	-0.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	5.7	-0.2	-0.7	2.4	2.3	-1.0	-0.6	-0.5	-0.4	-0.5	-0.9	-0.3	0.2	0.4
Impedance of whole body	1.0	5.2	11.7	0.5	-1.8	-0.1	-0.3	-1.7	-3.3	-3.3	-2.5	-3.1	-3.4	-0.8	-1.4	-3.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.7	-1.7	-0.2	-0.6	-0.5	0.5	-1.2	-1.2	-1.1	-1.6	-1.3	0.1	-1.2	-0.4
Alzheimer’s Disease (in father)	0.9	1.0	5.0	-1.2	0.9	-1.1	-1.4	-2.2	-0.1	-0.0	0.3	-0.3	-0.3	-1.2	0.4	0.8
Major Depression (MDD)	0.9	1.1	3.7	-1.1	0.7	-0.4	-0.5	0.1	1.1	1.4	1.4	1.9	1.1	0.2	-0.1	1.3
Respiratory disease	0.9	2.1	4.4	0.7	0.8	-1.4	-1.3	-0.4	1.8	1.8	1.4	2.1	2.1	-1.2	1.1	1.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	5.2	1.2	0.3	-2.3	-2.2	0.1	-0.9	-0.8	-0.6	-0.9	-1.0	0.9	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.2	0.5	-0.8	-0.4	-0.3	1.0	-1.4	-1.3	-1.3	-1.4	-1.5	0.9	0.2	-1.0
Impedance of leg (left)	0.9	4.2	9.5	-0.0	-2.0	0.0	-0.1	-0.4	-2.7	-2.8	-2.1	-2.6	-3.1	0.6	-2.9	-2.6
Weight	0.9	4.5	21.8	-1.4	1.9	-2.6	-2.7	-2.5	-1.2	-0.4	-1.9	-0.6	-0.8	-4.7	2.1	-0.2
Arm fat percentage (right)	0.9	3.7	17.2	-1.1	2.2	-2.6	-2.7	-2.0	-0.8	-0.0	-1.0	-0.3	-0.4	-4.2	2.0	-0.7
Time employed in main current job	0.9	1.1	2.6	0.0	-1.6	1.2	1.3	0.7	0.9	1.1	1.1	1.0	0.9	1.1	0.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.0	-1.5	0.5	-1.1	-1.3	-0.9	-2.4	-1.9	-2.5	-2.4	-2.4	-2.5	0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.5	0.3	0.1	-1.6	-1.6	-0.2	-0.8	-0.9	-0.6	-0.5	-0.9	1.4	-2.1	-2.0
Body fat percentage	0.9	3.7	13.2	-0.9	1.3	-2.7	-2.8	-1.9	-1.7	-0.8	-2.0	-1.1	-1.3	-3.6	0.8	-1.7
Age at first live birth	0.9	1.6	4.0	0.7	1.5	-0.5	-0.7	-2.0	-1.5	-1.0	-0.0	-1.3	-1.8	-1.3	2.0	0.5
Eye problems/disorders: None of the above	0.9	1.0	3.0	-1.6	-0.4	0.7	0.8	0.8	-0.5	-0.8	-0.7	-0.3	-0.2	1.7	-1.7	-1.2
Medication: Allopurinol	0.9	1.2	2.9	-0.3	-1.4	-0.9	-0.8	1.7	-0.7	-1.5	-1.4	-1.0	-0.7	1.2	-0.4	-1.0
Whole body fat mass	0.9	3.8	16.3	-1.2	1.5	-2.5	-2.6	-2.1	-1.5	-0.6	-2.2	-0.9	-1.2	-4.0	1.4	-1.1
Medication: Aspirin	0.9	1.1	3.2	0.6	0.8	-0.4	-0.5	0.5	1.2	1.3	1.5	1.1	0.8	1.8	-1.1	1.1
Wears glasses or contact lenses	0.9	1.0	3.6	1.0	0.1	0.8	0.5	-1.9	-0.6	-0.7	-0.3	-0.9	-0.8	-1.3	1.7	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	4.0	1.2	-1.1	1.6	1.5	-0.4	0.1	0.2	0.5	0.7	0.2	0.3	2.0	1.1
Myopia	0.9	1.4	9.9	-1.1	1.0	1.2	1.1	-1.3	-0.3	-0.2	0.1	-0.3	-0.3	-0.7	3.1	0.8
Bipolar Disorder (2018)	0.8	1.2	3.6	-1.4	-1.6	-0.5	-0.6	-0.8	-0.7	-1.0	-0.6	-1.3	-1.0	0.6	-1.9	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	3.9	-1.3	1.5	-0.2	-0.4	-2.0	-0.6	0.1	-0.2	-1.0	-0.8	-1.7	0.3	-1.4
Schizophrenia (2014)	0.8	1.9	3.8	-0.5	1.8	0.2	0.3	-1.1	1.5	1.4	2.0	1.6	1.7	-1.2	1.9	0.9
Average weekly spirits intake	0.8	0.9	2.2	0.1	-0.7	-0.4	-0.4	-1.1	-1.0	-1.3	-1.5	-1.2	-1.1	-0.9	-1.0	-0.7
Severe depression (siblings)	0.8	0.9	3.7	-1.8	1.9	-0.6	-0.4	-1.1	0.4	0.8	1.2	0.2	0.5	-0.1	-0.7	-0.6
Impedance of leg (right)	0.8	3.7	8.3	-0.2	-1.8	0.3	0.2	-0.3	-2.5	-2.6	-1.9	-2.5	-2.9	0.6	-2.7	-2.3
Relative age voice broke	0.8	1.2	4.2	2.0	0.2	-1.4	-1.0	-1.8	-1.0	-1.0	-0.6	-0.8	-1.0	0.1	0.7	-0.8
Multivitamins +/- minerals	0.8	1.1	3.9	0.8	1.0	-1.4	-1.4	0.3	0.9	0.6	0.9	0.5	1.0	-0.9	2.0	0.2
Supplements: Glucosamine	0.8	1.0	3.8	0.2	1.8	-0.9	-1.0	-0.2	0.5	0.5	0.7	0.1	0.6	-0.9	1.9	1.5
Sitting height	0.8	5.5	16.0	-1.2	0.4	-1.6	-1.6	-1.9	-3.0	-3.0	-4.0	-2.8	-2.9	-2.5	0.2	-2.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.3	0.4	1.1	-0.2	-0.3	-1.9	-0.3	-0.2	-0.1	-0.3	0.0	-2.1	0.6	-1.6
Medication: Simvastatin	0.8	1.1	5.2	0.5	-1.5	-0.5	-0.4	1.0	-0.4	-0.5	-0.4	-0.9	-0.7	2.3	-1.8	-0.7
Father’s age at death	0.8	1.1	2.5	-0.4	0.1	0.3	0.1	-1.5	-1.2	-1.5	-0.4	-1.2	-1.6	-1.3	0.9	0.8
Worrier / anxious feelings	0.8	1.5	3.4	0.4	-0.2	0.8	1.0	0.2	-1.4	-1.5	-0.4	-1.3	-1.7	1.8	-1.7	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	-0.0	0.9	-0.9	-1.1	-0.0	-0.6	-0.3	-0.1	-0.6	-0.6	-1.8	1.8	0.9
Medication: Lansoprazole	0.8	0.9	5.6	0.2	-0.1	-0.6	-0.7	2.4	0.3	0.8	0.5	0.5	0.4	2.0	0.1	-0.2
Arm fat mass (right)	0.8	3.4	15.5	-1.1	2.3	-2.6	-2.7	-1.7	-0.5	0.3	-1.1	0.1	-0.1	-3.9	1.9	-0.2
Length of working week for main job	0.8	0.9	2.5	0.1	0.5	1.5	1.5	-0.1	1.1	1.6	1.0	0.9	1.0	-0.2	-0.1	0.1
Gout (self-reported)	0.8	1.1	2.9	0.1	-1.0	-0.9	-0.9	0.6	-0.8	-1.2	-1.6	-0.8	-0.7	0.5	-1.7	-1.7
Smoking status: Previous	0.8	1.2	2.9	-1.7	0.9	0.3	0.2	0.6	1.1	1.3	1.5	1.1	1.1	0.2	-1.1	1.5
Arm fat percentage (left)	0.8	3.4	15.9	-0.8	2.2	-2.6	-2.7	-1.8	-0.7	0.1	-1.1	-0.3	-0.4	-4.0	1.8	-0.6
Breast cancer (self-reported)	0.8	1.0	2.7	0.2	-0.7	0.0	-0.1	0.4	-1.7	-1.3	-1.5	-1.2	-1.4	-0.4	0.1	-1.4
Arm fat mass (left)	0.8	3.3	16.6	-1.2	2.4	-2.4	-2.5	-1.7	-0.3	0.5	-1.0	0.1	0.0	-4.1	1.7	-0.2
Number of self-reported non-cancer illnesses	0.8	1.3	4.7	0.1	-1.5	-2.2	-2.1	1.2	-0.5	-0.5	-0.9	0.0	-0.3	1.0	-0.3	-1.3
Supplements: Calcium	0.8	0.8	4.0	1.3	0.5	-0.7	-0.7	-0.5	0.0	0.3	-0.0	0.4	0.2	-2.0	1.8	0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	3.0	-1.7	-0.2	-0.8	-0.7	-0.9	-1.2	-0.9	-0.6	-1.6	-1.4	-0.1	-1.0	0.0
Crohns Disease (2017)	0.7	1.5	4.3	0.7	-0.6	1.1	1.3	1.6	1.3	1.3	0.9	0.7	1.3	2.1	-1.8	-0.2
Chronotype (morning person)	0.7	1.7	6.4	0.1	-0.9	2.5	2.5	1.2	-0.7	-0.9	-0.7	-1.4	-0.7	1.3	-0.6	-1.0
Hearing difficulty/problems: Yes	0.7	1.1	4.4	2.1	0.6	0.4	0.4	-1.6	0.3	0.8	1.1	1.3	0.3	0.3	1.5	0.7
Townsend deprivation index at recruitment	0.7	1.0	4.1	0.1	1.2	-2.0	-1.8	-1.1	0.3	0.1	-0.2	0.1	0.5	-1.2	0.1	-0.9
Serious illness, injury or assault to yourself	0.7	0.9	4.1	-1.6	0.1	-1.2	-1.3	-0.7	-0.1	-0.3	-0.3	0.7	0.2	-2.0	0.2	-0.5
Stomach or abdominal pain in last month	0.7	0.8	3.8	0.2	0.9	-2.0	-1.9	0.3	-0.2	-0.4	-0.6	-0.7	-0.3	0.1	-0.6	-1.1
High blood pressure (mother)	0.7	1.0	6.5	-0.0	0.9	1.0	1.0	0.1	0.8	0.9	0.1	0.8	0.9	0.6	-2.6	-0.5
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	-1.4	-0.5	-0.6	-0.7	-1.4	-1.0	-1.0	-0.7	-0.9	-0.9	-0.8	-1.4	-1.1
Prospective memory result	0.7	0.9	2.1	0.7	-1.4	0.7	0.7	0.9	-0.9	-0.8	-0.7	-0.6	-1.0	1.4	-1.0	-0.5
Lung cancer (father)	0.7	0.9	2.8	0.1	0.6	-1.6	-1.7	-1.3	-0.9	-0.4	0.1	-0.1	-0.7	-1.0	1.0	-0.3
Wheeze or whistling in the chest in last year	0.7	1.3	4.1	0.2	-0.3	-2.0	-2.0	-0.1	-1.5	-1.2	-1.2	-0.6	-1.3	-0.1	-0.4	-0.8
Qualifications: College or University degree	0.7	2.3	7.0	-2.0	-0.7	2.7	2.5	-1.0	1.0	0.5	1.1	0.2	0.4	-0.6	1.3	2.5
Hypertension (Self-reported)	0.7	2.0	10.8	-0.8	-2.7	0.8	0.9	1.4	-0.0	-0.1	-0.5	0.1	-0.2	3.3	-1.7	-0.6
Illnesses of siblings: Diabetes	0.7	0.9	3.9	2.0	0.8	-0.8	-0.8	-0.1	-0.1	-0.4	-0.4	-0.3	-0.3	-0.9	2.0	0.5
Mood swings	0.7	1.3	4.5	0.9	1.1	-2.1	-2.0	-0.2	-0.9	-0.7	-0.1	-0.8	-0.9	0.4	-1.5	-1.3
Asthma (self-reported)	0.7	1.3	4.5	0.6	0.4	-2.1	-2.1	0.0	0.6	0.6	0.6	0.9	0.8	-1.4	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.5	0.3	0.5	-0.9	-1.1	1.2	-1.7	-1.3	-1.8	-1.8	-1.9	-0.5	0.4	-0.2
Eye problems/disorders: Glaucoma	0.7	0.8	4.8	2.2	0.7	-0.8	-0.8	0.0	0.3	0.2	0.5	0.7	0.1	-0.4	1.0	1.3
Illnesses of father: High blood pressure	0.7	0.9	4.4	-1.0	-1.6	-0.4	-0.4	1.4	0.0	-0.0	0.6	-0.4	0.2	2.1	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	9.9	0.1	1.9	-0.8	-0.8	-1.7	-0.9	-1.1	-0.5	-1.3	-0.7	-3.1	1.8	-0.0
Worry (Nagel 2018)	0.6	1.4	5.9	1.5	0.5	1.6	1.7	1.2	0.3	0.5	1.1	0.2	0.1	2.4	-0.8	-0.4
Age at First Birth	0.6	0.9	4.1	0.6	-0.3	2.0	2.0	0.3	0.4	0.2	0.6	0.1	0.4	0.7	1.4	-0.1
Coronary Artery Disease (CAD)	0.6	0.7	3.9	0.3	-2.0	0.8	0.6	-0.2	0.4	0.6	0.5	1.1	0.6	0.7	1.1	-0.3
HDL Cholesterol	0.6	0.9	4.1	0.1	1.0	-1.3	-1.3	-0.3	-0.9	-0.6	-1.0	-0.1	-0.6	-2.0	1.0	-0.4
Hypothyroidism (self reported)	0.6	1.5	3.5	0.5	1.4	1.4	1.4	-0.3	1.4	1.4	0.9	1.3	1.5	-1.9	0.3	0.7
Sensitivity / hurt feelings	0.6	1.0	3.8	1.5	0.8	-0.9	-1.0	0.0	-0.9	-0.6	0.3	-0.6	-1.0	1.9	0.6	-1.1
Leg fat-free mass (left)	0.6	3.2	16.9	-1.0	1.9	-1.4	-1.4	-2.2	-0.2	0.4	-1.3	0.3	0.2	-4.1	3.0	0.7
Maternal smoking around birth	0.6	0.9	1.7	0.9	0.1	1.0	1.2	1.2	0.7	1.2	0.8	1.0	0.9	1.3	-1.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	5.6	0.4	0.1	1.7	1.7	2.4	0.7	1.1	0.5	0.7	0.5	1.2	-1.1	0.0
High blood pressure	0.6	1.6	9.4	-0.7	-2.0	0.9	1.0	1.2	0.3	0.4	-0.2	0.5	0.1	3.1	-1.8	-0.4
Leg predicted mass (left)	0.6	3.1	16.7	-0.9	1.8	-1.4	-1.4	-2.2	-0.3	0.3	-1.3	0.2	0.2	-4.1	3.0	0.7
Alcohol usually taken with meals	0.6	1.0	3.7	-1.4	-1.9	0.8	0.5	1.7	-0.6	-0.5	-0.0	-0.4	-0.7	1.3	-0.5	0.9
Heart attack	0.6	0.8	4.2	1.2	0.1	-0.5	-0.5	1.7	-0.2	0.1	-0.1	-0.1	-0.1	2.1	0.8	-0.3
Allergy	0.6	1.3	4.4	-0.2	0.1	1.8	1.6	0.1	0.8	0.9	1.2	0.6	0.6	1.4	-2.1	1.1
Medication: Ramipril	0.6	0.8	3.3	-0.4	-1.0	0.7	0.8	0.7	-0.8	-0.8	-0.7	-0.4	-0.6	1.8	-0.5	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	3.0	1.5	1.3	-0.7	-0.6	-1.0	0.4	0.1	-0.1	0.1	0.6	-1.3	1.7	-0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.4	1.9	0.6	-0.3	-0.2	0.2	-1.5	-1.0	-1.1	-0.6	-1.6	0.2	1.1	-0.7
Asthma	0.6	1.2	4.2	0.6	0.1	-2.0	-2.1	-0.1	0.5	0.5	0.4	0.8	0.7	-1.6	1.4	0.6
Peak expiratory flow (PEF)	0.6	1.4	6.4	-1.2	1.8	-0.2	-0.5	-0.5	0.5	0.6	-0.2	0.4	0.5	-2.5	1.6	1.6
Health satisfaction	0.6	0.8	2.8	0.3	0.9	-1.3	-1.5	-1.3	-0.3	-0.3	-0.5	0.3	-0.1	-1.7	0.3	-0.4
Neck or shoulder pain in last month	0.6	0.8	2.4	1.5	-0.7	-0.9	-0.9	1.0	-0.1	-0.7	-1.3	0.1	0.0	1.4	0.3	-1.1
Leg fat mass (right)	0.6	2.5	9.9	-1.1	1.3	-2.5	-2.5	-1.1	-1.0	-0.2	-1.6	-0.4	-0.7	-3.1	1.2	-0.5
Leg fat-free mass (right)	0.6	3.2	16.6	-0.9	1.7	-1.5	-1.6	-2.4	-0.3	0.3	-1.3	0.2	0.2	-4.1	2.9	0.6
Average weekly red wine intake	0.6	0.8	3.2	-1.2	-0.6	0.7	0.6	1.0	1.1	0.7	0.8	0.3	0.8	0.9	0.7	1.8
Ever had bowel cancer screening	0.6	0.7	1.6	-0.7	-1.3	-1.0	-1.0	-0.1	-1.1	-1.2	-0.6	-0.6	-0.9	0.4	0.2	-0.4
Friendships satisfaction	0.6	0.8	3.7	0.4	1.0	-1.9	-1.9	-0.1	0.1	0.2	0.8	-0.1	0.4	0.4	-0.2	-0.9
Eye problems/disorders: Cataract	0.6	0.6	4.0	-0.5	-1.3	-0.3	-0.3	-1.4	-0.3	0.1	-0.3	-0.2	-0.4	-2.0	-0.2	-0.2
Leg predicted mass (right)	0.6	3.0	16.1	-1.0	1.6	-1.5	-1.6	-2.3	-0.2	0.3	-1.3	0.3	0.3	-4.0	2.8	0.6
Basal metabolic rate	0.6	3.2	17.6	-1.3	1.9	-1.5	-1.6	-2.1	-0.2	0.3	-1.3	0.2	0.1	-4.2	2.5	0.8
Fractured/broken bones in last 5 years	0.6	0.8	4.5	0.4	-0.5	-0.3	-0.4	-1.4	-0.5	-0.5	-0.9	0.4	-0.1	-2.1	1.3	-0.6
Ever depressed for a whole week	0.6	0.7	2.9	1.0	1.2	-1.0	-1.2	-0.4	-0.6	-0.4	-0.2	-0.6	-0.4	-0.2	0.7	-1.7
Commuting to job workplace: Cycle	0.6	0.7	2.0	1.1	-1.0	1.4	1.4	-0.7	0.3	-0.4	-0.1	0.1	0.1	0.3	1.3	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.5	1.4	0.0	-0.6	-0.6	1.5	-0.4	-0.1	-0.3	-0.3	-0.4	1.9	0.8	-0.4
Pack years of smoking	0.6	0.9	4.0	2.0	-0.1	-0.4	-0.3	1.0	0.5	0.7	0.8	0.7	0.5	1.6	-0.7	0.9
Leg fat mass (left)	0.6	2.4	10.0	-1.2	1.3	-2.3	-2.4	-1.1	-1.0	-0.3	-1.7	-0.5	-0.7	-3.2	1.0	-0.7
Primary Biliary Cirrhosis	0.5	0.8	2.3	1.2	0.3	-0.6	-0.6	1.1	0.4	0.6	0.5	1.0	0.4	1.3	1.5	0.7
Ulcerative Colitis	0.5	0.7	3.8	-1.9	0.6	0.3	0.5	0.8	0.5	1.1	0.7	0.7	0.7	1.0	-0.1	-0.1
Allergy or Eczema	0.5	1.2	3.8	0.3	-0.4	-2.0	-1.8	-0.8	-0.6	-0.6	-0.7	-0.2	-0.4	-1.6	1.7	-1.1
Cardiovascular Disease	0.5	1.6	5.7	-0.6	-2.1	1.2	1.3	1.6	0.7	0.4	-0.3	0.6	0.5	2.4	-1.8	-0.0
Hand grip strength (left)	0.5	1.2	3.0	1.0	0.3	-0.4	-0.5	1.7	1.2	1.3	0.7	1.6	1.2	0.6	-0.4	1.7
Vitamin and mineral supplements	0.5	0.7	5.0	-0.7	-0.6	0.8	0.8	-0.2	0.1	0.3	-0.2	0.4	-0.0	1.3	-2.2	0.2
Pack years adult smoking proportion	0.5	0.8	4.0	2.0	0.2	-0.5	-0.4	1.1	0.5	0.7	0.7	0.6	0.5	1.4	-0.7	0.7
Average weekly fortified wine intake	0.5	0.5	3.3	-0.2	-0.3	-0.7	-0.4	-1.2	0.2	0.6	0.7	-0.2	0.1	-0.5	0.6	1.8
Taking other prescription medications	0.5	0.8	3.6	1.9	-1.3	-0.8	-0.8	0.6	0.3	0.3	0.2	1.4	0.5	1.2	0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.2	0.3	0.2	-1.8	-1.6	-0.1	-0.7	-0.9	-1.1	-0.8	-0.6	-1.2	1.7	-1.2
Body mass index (BMI)	0.5	2.1	5.2	-1.0	2.2	-2.1	-2.1	-0.1	0.9	1.5	0.2	1.2	1.2	-2.3	1.3	0.6
Waist circumference	0.5	1.7	4.6	-1.8	1.0	-1.8	-1.9	-1.1	-1.2	-0.5	-1.6	-0.3	-0.9	-2.1	0.8	-0.0
Past tobacco smoking	0.5	1.0	4.0	2.0	-0.8	0.0	0.1	-0.8	-0.7	-0.6	-1.0	-1.0	-0.6	-0.5	1.6	-1.1
Had menopause	0.5	0.7	2.8	0.2	0.0	-0.8	-0.7	-0.3	-1.4	-0.9	-0.7	-0.8	-1.7	-0.8	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	5.1	0.4	-0.5	1.5	1.5	2.2	0.8	0.8	0.2	0.7	0.7	1.3	-0.8	0.3
Financial difficulties in last 2 years	0.5	0.7	3.4	1.1	0.1	-1.8	-1.8	0.1	0.3	0.2	-0.0	0.7	0.6	0.6	0.4	-0.6
Diabetes (self-reported)	0.5	0.7	1.6	-0.1	0.0	-1.1	-1.0	-0.0	-0.8	-1.0	-0.9	-1.2	-0.8	1.3	-0.6	-0.8
Neuroticism score	0.5	1.0	4.3	0.9	2.1	-0.8	-0.7	-0.5	-0.4	-0.3	0.5	-0.6	-0.6	0.6	-1.8	-1.4
Illnesses of mother	0.5	0.6	2.1	-0.6	-1.5	-0.4	-0.4	-0.7	-0.7	-0.9	-0.7	-0.9	-0.6	-1.1	-0.2	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	0.7	0.1	-0.8	-0.8	-0.4	-1.1	-0.9	-1.0	-0.4	-1.1	-1.2	-0.7	0.1
Exposure to tobacco smoke at home	0.5	0.6	2.0	1.4	0.1	0.9	1.0	-0.3	0.4	0.6	0.4	0.6	0.5	0.6	1.2	0.7
Loud music exposure frequency	0.5	0.5	1.5	-0.2	0.6	-0.4	-0.5	-0.6	-0.7	-0.5	-1.0	-1.2	-1.0	-0.3	-0.9	-0.8
Headache pain in last month	0.5	0.9	2.9	0.7	0.5	-0.9	-1.0	1.1	1.1	0.6	0.9	0.6	0.9	1.7	-0.8	0.9
Leg fat percentage (right)	0.5	1.9	6.2	-1.1	0.5	-2.5	-2.5	-0.4	-1.0	-0.4	-1.5	-0.5	-0.8	-2.2	0.3	-0.9
Exposure to tobacco smoke outside home	0.5	0.7	4.0	0.9	0.4	-0.8	-0.8	2.0	0.1	-0.0	-0.4	0.4	0.1	1.4	0.6	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	-0.8	-0.9	-0.8	-0.9	-0.7	-0.8	-1.4	-0.4	-1.0	-0.9	-0.6	-0.2	-0.1
Medication: Blood pressure	0.5	0.8	2.2	-0.1	-0.9	-0.4	-0.3	-0.2	-1.2	-1.0	-1.4	-1.0	-1.2	0.5	0.1	-1.5
Age at last live birth	0.5	0.8	5.1	-0.4	0.9	-0.6	-0.7	-2.3	-0.3	0.1	0.9	-0.2	-0.5	-1.0	0.3	0.9
Supplements: Vitamin C	0.5	0.6	3.5	1.9	-0.6	0.3	0.3	0.8	-0.4	-0.6	-0.5	-0.5	-0.3	0.0	1.5	-0.1
Whole body fat-free mass	0.5	2.6	14.7	-1.2	1.7	-0.9	-1.0	-2.0	-0.1	0.4	-1.1	0.4	0.2	-3.8	2.6	1.0
Mineral and other dietary supplements	0.5	0.7	1.7	-1.1	-0.4	0.8	0.9	-0.7	0.8	1.1	0.5	0.9	0.8	0.4	-1.3	-0.1
Whole body water mass	0.5	2.6	14.3	-1.3	1.8	-0.9	-1.0	-2.0	-0.1	0.4	-1.1	0.3	0.2	-3.8	2.5	1.0
Medication: Paracetamol	0.5	0.7	2.1	0.5	0.2	-1.2	-1.2	1.1	0.3	-0.0	0.5	0.3	0.5	1.4	-1.3	-0.8
Medication: Atorvastatin	0.5	0.6	1.4	-0.2	1.2	-0.5	-0.4	-0.2	1.0	1.2	1.0	0.8	1.0	-0.3	1.1	0.3
Alcohol drinker status: Never	0.5	0.6	1.4	0.4	0.8	-0.3	-0.4	-1.1	1.0	1.2	0.7	0.1	1.0	-0.5	-0.0	0.9
Leg fat percentage (left)	0.5	2.0	6.1	-1.1	0.5	-2.5	-2.5	-0.5	-1.1	-0.5	-1.6	-0.6	-0.9	-2.3	0.1	-1.1
Neuroticism (Nagel 2018)	0.4	0.9	4.2	1.2	2.0	-0.8	-0.6	-0.1	-0.1	0.5	1.4	0.3	-0.2	1.1	-1.1	-1.0
Triglycerides	0.4	0.7	3.6	-1.3	0.5	-0.2	-0.2	0.9	0.4	0.0	-0.0	0.0	0.3	0.9	-1.9	-0.9
Blood Platelet Count	0.4	5.2	11.6	-1.4	2.6	-1.0	-1.0	1.2	2.6	2.9	2.7	3.4	2.6	1.3	-2.8	2.0
Blood Red Count	0.4	3.8	8.6	-0.7	2.5	-0.3	-0.3	1.0	2.6	2.7	2.8	2.9	2.5	0.9	-0.7	1.8
Blood White Count	0.4	3.3	7.8	1.3	-0.0	0.7	0.8	1.7	2.2	2.0	2.1	2.8	2.2	1.9	0.8	2.5
Smoking Status	0.4	0.9	5.4	-0.4	0.7	0.0	0.2	1.2	0.4	-0.2	0.1	0.5	0.6	1.8	-2.3	-0.2
Number of treatments/medications taken	0.4	0.7	2.4	1.0	-0.7	-1.5	-1.6	1.0	-0.3	-0.0	-0.0	-0.1	-0.1	0.7	-0.2	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	0.9	-0.2	-0.6	-0.5	0.2	-0.5	-1.0	-0.9	-0.9	-0.3	-0.5	-0.0	-1.1
Medication: Atenolol	0.4	0.5	3.4	0.6	-0.8	0.3	0.2	0.4	-0.4	-0.1	-0.3	-0.4	-0.4	1.8	-0.7	-0.7
Nervous feelings	0.4	0.8	2.3	0.9	0.4	1.4	1.5	0.4	0.1	0.0	0.4	-0.2	0.0	1.4	-1.4	-1.0
Hair/balding pattern: Pattern 2	0.4	0.4	2.4	0.1	-0.8	-0.3	0.1	0.7	0.7	0.7	0.6	0.0	0.5	1.5	-0.6	0.4
Pain all over the body in last month	0.4	0.5	2.4	-0.3	0.1	0.2	0.3	-0.2	-0.3	-0.1	-0.6	-0.2	-0.2	-1.1	-1.6	-1.3
Trunk fat-free mass	0.4	2.1	11.7	-1.5	1.5	-0.4	-0.5	-1.9	-0.1	0.2	-1.0	0.2	0.0	-3.4	2.1	1.1
Noisy workplace	0.4	0.5	2.2	1.5	0.4	-0.7	-0.5	1.1	0.3	0.2	-0.8	0.9	0.5	0.3	-0.8	0.3
Trunk predicted mass	0.4	2.2	12.3	-1.5	1.6	-0.4	-0.4	-2.0	-0.0	0.3	-1.0	0.3	0.1	-3.5	2.2	1.1
Medication: Paracetamol	0.4	0.6	2.0	0.3	0.4	-1.4	-1.4	0.8	-0.1	-0.3	-0.0	0.2	0.1	1.2	-0.6	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	5.5	0.3	1.1	0.4	0.4	-0.8	0.4	0.8	0.5	0.9	0.6	-2.3	0.6	0.4
Medication: Amlodipine	0.4	0.6	2.0	0.1	-0.5	-0.5	-0.5	-0.8	-1.0	-0.7	-0.9	-0.9	-1.1	0.2	-0.4	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	4.6	-0.3	-0.1	0.4	0.3	2.1	-0.1	-0.3	-0.8	0.5	-0.1	-0.1	-0.5	-0.6
High blood pressure (siblings)	0.4	0.6	2.3	0.0	-1.5	-0.3	-0.3	0.4	0.6	0.4	0.4	0.7	0.6	1.5	-1.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.2	-0.8	1.2	1.1	0.0	-0.3	-0.7	-0.2	-0.3	-0.5	0.8	-0.6	-0.7
Pulse wave peak to peak time	0.4	0.4	0.8	-0.8	-0.2	0.8	0.7	-0.1	0.9	0.6	0.7	0.2	0.8	0.7	0.7	-0.3
Shortness of breath walking on level ground	0.4	0.4	1.4	1.2	0.0	0.5	0.4	0.9	0.5	0.4	0.3	1.0	0.6	0.5	0.9	0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	-0.7	-1.3	0.9	1.1	-1.2	-0.6	-0.3	-0.6	-0.3	-0.5	-1.4	0.6	-0.3
Medication: Ibuprofen	0.4	0.4	2.7	0.0	-0.1	-0.9	-1.1	-0.4	0.4	-0.0	0.6	0.0	0.6	0.3	0.0	1.6
Long-standing illness, disability or infirmity	0.4	0.6	2.0	0.3	-1.0	-0.2	-0.3	-0.2	-0.9	-0.8	-1.0	-0.3	-0.8	-0.5	-1.0	-1.4
Diabetes diagnosed by doctor	0.4	0.6	1.3	0.8	-0.0	-0.8	-0.8	-0.1	-0.6	-0.7	-0.9	-1.1	-0.8	0.8	-0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.1	-0.6	0.0	-0.0	-0.2	-1.4	-0.3	-0.1	0.2	-0.3	-0.4	0.5	-1.2	-0.7
Commuting to job workplace: Walk	0.4	0.4	1.2	0.6	-0.1	-0.6	-0.8	-1.1	0.6	0.1	0.4	0.6	0.9	-0.8	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.8	-0.5	0.9	0.9	-1.3	0.1	0.1	-0.8	-0.1	-0.1	-0.7	1.1	-0.2
Average weekly champagne plus white wine intake	0.4	0.5	1.7	-1.3	-0.8	-1.1	-1.2	-0.5	-0.6	-0.8	-0.1	-0.5	-0.9	-0.2	0.0	0.2
Ever taken oral contraceptive pill	0.4	0.5	2.2	0.2	0.5	0.5	0.4	1.5	-0.6	-0.4	-0.4	-0.4	-0.5	-0.0	0.8	1.2
Hearing aid user	0.4	0.5	1.4	-0.3	0.2	0.4	0.5	-0.3	0.8	0.9	1.1	1.2	0.8	0.7	0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	1.2	-0.8	-0.2	-0.3	1.0	-0.8	-1.2	-0.2	-0.5	-0.6	0.3	0.8	0.0
Ever smoked	0.4	0.7	3.9	-2.0	0.9	-0.7	-0.8	0.1	-0.1	-0.3	0.4	0.3	-0.2	-0.1	-1.6	0.6
Arm fat-free mass (left)	0.4	1.9	10.1	-1.6	1.6	-1.4	-1.5	-1.4	0.1	0.4	-1.1	0.4	0.3	-3.2	1.3	0.8
Unable to work because of sickness or disability	0.4	0.5	2.1	0.4	0.0	-0.8	-0.5	0.5	-0.7	-0.9	-1.5	-0.7	-0.6	0.2	-0.9	-0.6
Arm predicted mass (left)	0.4	2.2	11.4	-1.5	1.7	-1.7	-1.7	-1.6	0.1	0.3	-1.1	0.3	0.3	-3.4	1.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	-1.0	0.7	0.2	0.2	-1.0	1.0	0.9	1.1	0.9	0.9	-0.8	0.9	0.6
Breast Cancer	0.3	0.7	1.8	0.1	1.3	1.0	1.1	-0.8	1.1	0.5	0.5	0.5	0.8	-1.1	-0.0	0.4
Prostate Cancer	0.3	0.5	2.2	-0.1	1.5	0.2	0.2	-1.2	0.8	0.9	0.8	0.2	0.5	-0.2	-0.2	0.4
Mean Putamen Volume	0.3	0.3	0.8	0.3	-0.6	0.3	0.4	0.6	-0.5	-0.4	-0.9	0.0	-0.6	0.9	-0.6	-0.4
LDL Cholesterol	0.3	0.5	3.9	-0.2	0.5	-0.2	-0.3	-2.0	-0.1	-0.1	-0.3	0.1	0.1	-1.2	-1.0	-0.4
Neuroticism (2016)	0.3	0.4	1.8	1.1	0.8	-0.1	-0.2	-0.6	-0.3	-0.0	0.6	0.2	-0.3	0.8	-1.3	-0.1
Heel T-Score	0.3	2.2	9.2	0.6	-0.7	2.9	3.0	1.2	-0.7	-0.7	-0.9	-1.1	-0.8	2.1	-0.5	-0.9
BMI	0.3	1.8	4.8	-2.2	1.4	-2.2	-2.2	0.1	0.7	0.8	0.1	0.8	0.9	-1.5	1.2	1.1
Neuroticism	0.3	0.8	3.9	1.2	2.0	0.2	0.3	-0.9	0.1	0.2	1.2	-0.1	-0.1	0.4	-1.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.3	-0.3	0.8	0.6	-0.7	-0.1	0.2	0.3	0.8	0.1	-1.0	1.0	-0.1
Angina	0.3	0.4	2.9	1.7	-1.1	0.1	-0.0	-0.4	0.1	0.3	0.7	0.6	0.4	-0.5	-0.2	0.2
Supplements: Zinc	0.3	0.3	1.8	0.5	-0.2	0.9	1.0	-0.1	-0.4	-0.4	0.2	-0.0	-0.4	0.3	1.3	0.2
Medication: Metformin	0.3	0.4	1.4	-0.3	0.6	0.8	0.6	-1.2	0.4	0.3	-0.0	-0.1	0.3	-0.1	-1.1	-0.6
Diabetes (mother)	0.3	0.4	1.4	1.2	1.1	-0.9	-0.7	-0.0	0.2	0.3	0.2	0.2	0.4	0.2	0.4	-0.5
Current tobacco smoking	0.3	0.5	1.7	0.8	0.5	-0.9	-0.6	-0.4	-0.3	-0.6	-0.5	-0.2	-0.0	0.9	-1.3	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.4	-0.6	0.6	-0.3	-0.2	0.7	-0.2	0.4	0.6	0.4	-0.0	1.2	-0.5	-0.5
Qualifications: None of the above	0.3	0.7	2.5	1.2	0.6	-1.1	-0.8	1.6	0.1	0.2	-0.2	0.3	0.2	0.5	-1.2	0.2
Mouth/teeth dental problems	0.3	0.5	2.6	-1.6	-1.0	0.7	0.7	-0.0	0.3	0.6	-0.1	-0.1	0.3	-0.3	-1.1	-0.4
Illnesses of siblings	0.3	0.4	1.1	-0.7	-0.1	1.1	1.0	0.5	-0.4	-0.4	-0.6	-0.9	-0.4	-0.0	-0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.2	-0.2	0.3	0.1	-0.1	-0.1	0.9	0.2	0.6	0.3	1.0	0.1	0.2	1.5
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-1.0	0.4	0.7	0.8	-1.4	-0.8	-1.0	-0.7	-1.0	-0.5	-0.9	0.1	-1.5
Birth weight of first child	0.3	0.6	1.9	0.0	1.3	0.3	0.2	-1.4	-0.1	0.2	0.6	-0.5	0.0	-1.3	1.0	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.8	0.5	-0.5	-0.8	-0.9	-0.3	-0.2	-0.1	-0.5	-0.7	-0.2	0.4	-1.3	-0.5
Arm fat-free mass (right)	0.3	1.4	6.7	-1.1	1.1	-1.3	-1.4	-1.2	0.0	0.3	-1.2	0.3	0.2	-2.6	1.1	0.7
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.1	0.7	-0.9	-0.7	-0.6	-0.6	-0.6	-0.0	0.1	-0.4	-0.4	0.5	0.7
Angina (self-reported)	0.3	0.4	2.3	1.5	-1.0	-0.2	-0.2	-0.2	0.2	0.4	0.7	0.7	0.5	-0.5	-0.2	0.1
Arm predicted mass (right)	0.3	1.4	7.0	-1.1	1.2	-1.3	-1.4	-1.2	-0.2	0.2	-1.4	0.2	-0.0	-2.6	1.1	0.7
Suffer from ‘nerves’	0.3	0.4	2.2	1.5	-0.9	0.6	0.7	0.3	-0.2	-0.4	-0.1	0.0	-0.1	1.1	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	3.1	0.3	-1.8	-0.1	-0.1	0.2	0.0	-0.2	-0.6	0.3	0.2	-0.5	0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.8	0.1	0.5	0.6	0.7	-1.7	0.2	0.2	-0.3	0.3	0.6	-1.5	0.8	-0.5
Medication: Gliclazide	0.3	0.4	1.1	-0.2	-0.0	-0.6	-0.4	0.5	0.8	0.4	0.3	1.0	0.8	0.6	-1.0	0.5
Smoking status: Current	0.3	0.5	2.1	0.5	0.4	-1.0	-0.6	-0.1	-0.1	-0.4	-0.4	0.1	0.3	1.2	-1.4	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	2.3	1.5	0.2	-0.3	-0.3	-0.6	-0.0	-0.1	0.0	0.4	-0.1	0.4	0.4	1.3
Irritable Bowel Disease (IBD)	0.2	0.4	1.6	-0.1	-0.7	0.0	0.2	0.7	0.4	0.8	0.5	0.2	0.8	1.3	-1.1	-0.6
Ovarian Cancer	0.2	0.2	0.8	-0.1	0.6	-0.8	-0.7	-0.5	0.3	-0.2	-0.2	0.2	0.5	0.1	-0.9	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	0.9	0.3	-0.2	-0.2	0.7	-0.2	-0.0	-0.6	-0.4	-0.4	1.1	-0.5	-0.5
Age when periods started (menarche)	0.2	0.5	3.2	-0.2	0.6	-0.4	-0.4	1.0	0.6	0.4	0.3	-0.1	0.5	1.0	-1.8	-0.5
Had other major operations	0.2	0.3	1.3	-0.3	0.1	-1.1	-1.1	-0.4	0.4	0.5	-0.0	0.7	0.6	0.2	-0.3	-0.2
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.5	1.0	-0.5	-0.4	-0.6	0.2	0.6	0.0	-0.3	0.1	-0.5	-0.2	-0.7
Comparative body size at age 10	0.2	0.5	3.1	-0.3	0.0	-0.0	0.2	-0.7	0.1	-0.4	-0.4	-0.6	0.4	-1.8	1.5	-0.3
Migraine (self-reported)	0.2	0.2	1.2	-0.7	-1.1	0.2	0.1	-0.3	0.2	0.5	0.1	0.1	0.0	0.8	-0.5	-0.1
Osteoarthritis (self-reported)	0.2	0.3	1.7	0.8	0.3	0.2	0.2	1.3	0.4	0.1	-0.3	0.3	0.4	-0.0	-0.3	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.6	0.1	-0.6	-1.0	-0.9	0.3	0.2	0.1	0.2	-0.4	0.2	0.4	-1.2	-0.9
Medication: Lisinopril	0.2	0.3	1.5	-0.4	-0.7	0.3	0.2	1.1	0.3	0.1	-0.1	0.0	-0.1	1.2	-0.0	0.5
Alcohol drinker status: Previous	0.2	0.2	1.0	0.0	0.7	-0.1	-0.1	1.0	-0.2	-0.4	-0.0	0.1	-0.3	0.6	0.1	-0.2
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.9	-0.2	-0.9	-0.6	-0.0	-0.2	0.2	-0.1	0.1	-0.2	-0.1	-0.2	-0.4
Blood Eosinophil Count	0.1	1.0	5.7	1.0	-0.8	0.6	0.5	0.8	-0.6	-1.0	-1.2	-0.4	-0.5	1.0	2.4	-0.3
Lung FEV1/FVC ratio	0.1	0.3	1.7	-0.4	-1.3	0.4	0.2	0.4	0.3	-0.0	-0.1	-0.4	0.2	0.3	1.3	0.1
Hair Pigment	0.1	2.9	7.0	-1.3	-1.0	-1.3	-1.1	-0.4	-2.3	-2.6	-2.3	-2.1	-2.0	0.5	-1.1	-2.2
Tanning	0.1	1.3	4.2	0.1	0.6	-2.1	-2.0	0.1	-1.3	-0.9	-1.1	-1.4	-1.2	-0.4	0.3	-0.9
Relative age of first facial hair	0.1	0.1	0.6	0.2	0.3	-0.0	0.0	-0.3	0.2	0.3	0.4	0.4	-0.0	0.7	0.1	0.8
Medication: Levothyroxine sodium	0.1	0.1	0.8	0.5	-0.3	0.2	0.1	0.1	-0.3	-0.2	-0.0	-0.1	-0.1	-0.9	-0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.6	0.2	-0.2	0.7	0.5	0.3	-0.1	-0.4	-0.0	-0.1	0.0	-0.1	0.2	0.8
Number of full sisters	0.1	0.1	0.7	0.8	0.1	0.3	0.3	-0.1	-0.2	0.2	0.2	0.1	-0.2	0.2	0.2	-0.9
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.3	-0.5	0.4	0.3	0.2	-0.3	-0.3	0.5	0.0	-0.1	0.3	-0.4	-0.5
Risk taking	0.1	0.2	0.6	-0.3	-0.8	-0.5	-0.5	0.0	-0.3	-0.3	-0.4	-0.3	-0.4	0.1	-0.3	0.4

Hub : Genes

SPON1

Models

Trait associations