Hub : Genes

SPON1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0270	2.6e-03	0.018	0.017	0.026	0.020	0.022	2.4e-03	3.5e-03	3.3e-04	1.4e-03	1.0e-03
2	GTEx	Adrenal Gland	0.1790	0.0665	1.6e-03	-0.007	NA	0.000	NA	-0.006	6.9e-01	NA	3.2e-01	NA	5.8e-01
3	GTEx	Brain Cerebellar Hemisphere	0.3030	0.1040	5.8e-03	0.058	NA	0.033	NA	0.076	1.3e-02	NA	4.9e-02	NA	5.4e-03
4	GTEx	Brain Cerebellum	0.4610	0.0760	1.4e-07	0.473	NA	0.405	NA	0.447	8.7e-16	NA	4.1e-13	NA	9.6e-15
5	GTEx	Cells EBV-transformed lymphocytes	0.2520	0.0720	1.2e-05	0.298	NA	0.239	NA	0.276	2.5e-10	NA	2.4e-08	NA	1.3e-09
6	GTEx	Heart Atrial Appendage	0.2670	0.0610	9.1e-09	0.218	NA	0.236	NA	0.228	3.9e-10	NA	5.6e-11	NA	1.4e-10
7	GTEx	Heart Left Ventricle	0.1796	0.0485	3.0e-06	0.123	NA	0.109	NA	0.020	4.5e-07	NA	2.1e-06	NA	2.9e-02
8	GTEx	Ovary	0.3110	0.0840	1.6e-04	0.156	NA	0.152	NA	0.144	1.2e-04	NA	1.4e-04	NA	2.2e-04
9	GTEx	Testis	0.1440	0.0510	6.4e-04	0.070	NA	0.042	NA	0.001	5.0e-04	NA	6.0e-03	NA	3.0e-01
10	GTEx	Thyroid	0.1170	0.0370	8.1e-05	0.103	NA	0.063	NA	0.079	2.8e-08	NA	1.4e-05	NA	1.2e-06
11	NTR	Blood	0.0543	0.0142	4.9e-12	0.020	0.042	0.025	0.040	0.026	3.6e-07	2.4e-13	1.2e-08	6.0e-13	5.3e-09
12	ROSMAP	Brain Pre-frontal Cortex	0.1459	0.0448	1.1e-05	0.041	0.039	0.049	0.045	0.031	4.4e-06	8.3e-06	6.2e-07	1.7e-06	6.1e-05
13	TCGA	Liver Hepatocellular Carcinoma	0.1480	0.0570	4.5e-04	0.027	0.082	0.064	NA	0.071	2.0e-02	1.1e-04	5.7e-04	NA	3.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.8	1.2	3.6	-1.4	-1.6	-0.5	-0.6	-0.8	-0.7	-1.0	-0.6	-1.3	-1.0	0.6	-1.9	-1.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	-1.0	0.7	0.2	0.2	-1.0	1.0	0.9	1.1	0.9	0.9	-0.8	0.9	0.6
Depressed Affect (Nagel 2018)	1.0	2.0	7.6	1.1	2.5	-2.8	-2.5	-0.8	-0.1	0.4	1.0	0.4	-0.1	0.0	-1.2	-0.9
Depression (Nagel 2018)	1.1	1.6	7.7	0.2	0.8	-2.8	-2.8	-0.2	-0.9	-0.9	-0.5	-0.6	-0.9	0.6	-1.1	-0.7
Intelligence (Savage-Jansen 2018)	1.4	4.2	8.6	1.3	2.6	1.1	1.1	-1.8	2.0	2.5	2.1	1.7	1.6	-2.7	2.9	2.1
Neuroticism (Nagel 2018)	0.4	0.9	4.2	1.2	2.0	-0.8	-0.6	-0.1	-0.1	0.5	1.4	0.3	-0.2	1.1	-1.1	-1.0
Schizophrenia (2018)	1.4	3.0	7.0	-0.3	2.4	0.6	0.7	-0.7	1.9	1.9	2.0	2.2	2.0	-1.4	2.7	1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	5.4	0.8	2.3	-0.7	-0.8	-1.1	-0.5	-0.3	0.0	0.0	-0.3	-1.8	2.3	-0.3
Worry (Nagel 2018)	0.6	1.4	5.9	1.5	0.5	1.6	1.7	1.2	0.3	0.5	1.1	0.2	0.1	2.4	-0.8	-0.4
Alzheimer’s Disease (in mother)	0.9	1.0	2.7	-1.7	-0.2	-0.6	-0.5	0.5	-1.2	-1.2	-1.1	-1.6	-1.3	0.1	-1.2	-0.4
Alzheimer’s Disease (in father)	0.9	1.0	5.0	-1.2	0.9	-1.1	-1.4	-2.2	-0.1	-0.0	0.3	-0.3	-0.3	-1.2	0.4	0.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.0	-1.7	-0.2	-0.8	-0.7	-0.9	-1.2	-0.9	-0.6	-1.6	-1.4	-0.1	-1.0	0.0
Crohns Disease (2017)	0.7	1.5	4.3	0.7	-0.6	1.1	1.3	1.6	1.3	1.3	0.9	0.7	1.3	2.1	-1.8	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.6	-0.1	-0.7	0.0	0.2	0.7	0.4	0.8	0.5	0.2	0.8	1.3	-1.1	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.9	-0.2	-0.9	-0.6	-0.0	-0.2	0.2	-0.1	0.1	-0.2	-0.1	-0.2	-0.4
Major Depression (MDD)	0.9	1.1	3.7	-1.1	0.7	-0.4	-0.5	0.1	1.1	1.4	1.4	1.9	1.1	0.2	-0.1	1.3
Reaction Time	1.6	3.0	8.0	1.8	0.3	-0.7	-0.5	0.0	-2.1	-2.2	-2.7	-2.8	-2.3	-0.5	-0.3	-2.3
Verbal and Numeric Reasoning (VNR)	2.2	5.3	14.7	0.8	2.4	0.1	-0.1	-2.8	1.8	2.4	2.2	1.7	1.6	-3.8	3.7	2.6
Breast Cancer	0.3	0.7	1.8	0.1	1.3	1.0	1.1	-0.8	1.1	0.5	0.5	0.5	0.8	-1.1	-0.0	0.4
Ovarian Cancer	0.2	0.2	0.8	-0.1	0.6	-0.8	-0.7	-0.5	0.3	-0.2	-0.2	0.2	0.5	0.1	-0.9	-0.3
Prostate Cancer	0.3	0.5	2.2	-0.1	1.5	0.2	0.2	-1.2	0.8	0.9	0.8	0.2	0.5	-0.2	-0.2	0.4
Age at First Birth	0.6	0.9	4.1	0.6	-0.3	2.0	2.0	0.3	0.4	0.2	0.6	0.1	0.4	0.7	1.4	-0.1
Bipolar Disorder (2011)	1.2	1.1	3.2	-0.4	-1.8	1.4	1.3	-0.1	-0.8	-0.7	-0.9	-1.2	-1.1	1.4	-0.7	-1.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.9	-1.3	1.5	-0.2	-0.4	-2.0	-0.6	0.1	-0.2	-1.0	-0.8	-1.7	0.3	-1.4
Coronary Artery Disease (CAD)	0.6	0.7	3.9	0.3	-2.0	0.8	0.6	-0.2	0.4	0.6	0.5	1.1	0.6	0.7	1.1	-0.3
Crohns Disease (2012)	1.9	3.1	8.9	0.3	1.0	0.9	1.1	1.1	2.7	3.0	2.3	1.9	2.9	0.8	-1.2	0.5
Mean Putamen Volume	0.3	0.3	0.8	0.3	-0.6	0.3	0.4	0.6	-0.5	-0.4	-0.9	0.0	-0.6	0.9	-0.6	-0.4
Fasting Glucose	1.7	2.0	4.8	0.2	1.6	-1.4	-1.3	-0.2	2.1	1.6	0.9	2.2	2.0	-1.3	0.2	1.0
HbA1C	3.4	3.7	9.9	0.8	1.9	0.1	0.0	0.1	3.0	2.9	2.4	3.0	3.1	1.0	-0.5	0.8
HDL Cholesterol	0.6	0.9	4.1	0.1	1.0	-1.3	-1.3	-0.3	-0.9	-0.6	-1.0	-0.1	-0.6	-2.0	1.0	-0.4
LDL Cholesterol	0.3	0.5	3.9	-0.2	0.5	-0.2	-0.3	-2.0	-0.1	-0.1	-0.3	0.1	0.1	-1.2	-1.0	-0.4
Lupus	1.7	2.6	18.7	-0.5	-4.3	2.3	2.2	1.2	-0.8	-0.7	0.0	-0.4	-0.5	1.4	0.6	-0.6
Neuroticism (2016)	0.3	0.4	1.8	1.1	0.8	-0.1	-0.2	-0.6	-0.3	-0.0	0.6	0.2	-0.3	0.8	-1.3	-0.1
Primary Biliary Cirrhosis	0.5	0.8	2.3	1.2	0.3	-0.6	-0.6	1.1	0.4	0.6	0.5	1.0	0.4	1.3	1.5	0.7
Rheumatoid Arthritis	3.1	4.3	7.9	0.8	1.5	1.9	1.9	0.6	2.7	2.6	2.7	2.2	2.8	-0.1	2.2	2.5
Schizophrenia (2014)	0.8	1.9	3.8	-0.5	1.8	0.2	0.3	-1.1	1.5	1.4	2.0	1.6	1.7	-1.2	1.9	0.9
Triglycerides	0.4	0.7	3.6	-1.3	0.5	-0.2	-0.2	0.9	0.4	0.0	-0.0	0.0	0.3	0.9	-1.9	-0.9
Type 2 Diabetes (T2D) (2012)	1.1	1.3	8.3	0.3	0.7	0.3	0.4	1.4	1.1	0.8	0.2	1.1	1.1	1.3	-2.9	-0.1
Ulcerative Colitis	0.5	0.7	3.8	-1.9	0.6	0.3	0.5	0.8	0.5	1.1	0.7	0.7	0.7	1.0	-0.1	-0.1
Blood Eosinophil Count	0.1	1.0	5.7	1.0	-0.8	0.6	0.5	0.8	-0.6	-1.0	-1.2	-0.4	-0.5	1.0	2.4	-0.3
Blood Platelet Count	0.4	5.2	11.6	-1.4	2.6	-1.0	-1.0	1.2	2.6	2.9	2.7	3.4	2.6	1.3	-2.8	2.0
Blood Red Count	0.4	3.8	8.6	-0.7	2.5	-0.3	-0.3	1.0	2.6	2.7	2.8	2.9	2.5	0.9	-0.7	1.8
Blood White Count	0.4	3.3	7.8	1.3	-0.0	0.7	0.8	1.7	2.2	2.0	2.1	2.8	2.2	1.9	0.8	2.5
Heel T-Score	0.3	2.2	9.2	0.6	-0.7	2.9	3.0	1.2	-0.7	-0.7	-0.9	-1.1	-0.8	2.1	-0.5	-0.9
BMI	0.3	1.8	4.8	-2.2	1.4	-2.2	-2.2	0.1	0.7	0.8	0.1	0.8	0.9	-1.5	1.2	1.1
Height	1.2	22.3	57.8	0.4	-0.6	-1.8	-1.8	-7.1	-5.9	-5.2	-6.2	-4.7	-5.7	-7.6	3.5	-2.8
Waist Hip Ratio (WHR)	1.5	6.6	24.9	-2.7	-2.2	2.4	2.3	0.1	-1.9	-2.1	-2.0	-1.5	-2.3	3.7	-5.0	-1.7
Systolic Blood Pressure	1.6	7.8	32.3	-0.3	-3.3	2.6	2.6	4.9	1.2	0.9	-0.1	1.5	0.7	5.7	-3.8	1.2
Smoking Status	0.4	0.9	5.4	-0.4	0.7	0.0	0.2	1.2	0.4	-0.2	0.1	0.5	0.6	1.8	-2.3	-0.2
Allergy or Eczema	0.5	1.2	3.8	0.3	-0.4	-2.0	-1.8	-0.8	-0.6	-0.6	-0.7	-0.2	-0.4	-1.6	1.7	-1.1
Cardiovascular Disease	0.5	1.6	5.7	-0.6	-2.1	1.2	1.3	1.6	0.7	0.4	-0.3	0.6	0.5	2.4	-1.8	-0.0
Hypothyroidism (self reported)	0.6	1.5	3.5	0.5	1.4	1.4	1.4	-0.3	1.4	1.4	0.9	1.3	1.5	-1.9	0.3	0.7
Respiratory disease	0.9	2.1	4.4	0.7	0.8	-1.4	-1.3	-0.4	1.8	1.8	1.4	2.1	2.1	-1.2	1.1	1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	0.9	0.3	-0.2	-0.2	0.7	-0.2	-0.0	-0.6	-0.4	-0.4	1.1	-0.5	-0.5
Lung FEV1/FVC ratio	0.1	0.3	1.7	-0.4	-1.3	0.4	0.2	0.4	0.3	-0.0	-0.1	-0.4	0.2	0.3	1.3	0.1
Lung FVC	1.2	5.9	12.0	0.0	-2.3	-2.6	-2.7	1.2	-3.3	-3.3	-3.5	-3.1	-3.2	0.6	-0.1	-0.9
Neuroticism	0.3	0.8	3.9	1.2	2.0	0.2	0.3	-0.9	0.1	0.2	1.2	-0.1	-0.1	0.4	-1.2	-0.9
Chronotype (morning person)	0.7	1.7	6.4	0.1	-0.9	2.5	2.5	1.2	-0.7	-0.9	-0.7	-1.4	-0.7	1.3	-0.6	-1.0
Hair Pigment	0.1	2.9	7.0	-1.3	-1.0	-1.3	-1.1	-0.4	-2.3	-2.6	-2.3	-2.1	-2.0	0.5	-1.1	-2.2
Tanning	0.1	1.3	4.2	0.1	0.6	-2.1	-2.0	0.1	-1.3	-0.9	-1.1	-1.4	-1.2	-0.4	0.3	-0.9
Hand grip strength (left)	0.5	1.2	3.0	1.0	0.3	-0.4	-0.5	1.7	1.2	1.3	0.7	1.6	1.2	0.6	-0.4	1.7
Number of treatments/medications taken	0.4	0.7	2.4	1.0	-0.7	-1.5	-1.6	1.0	-0.3	-0.0	-0.0	-0.1	-0.1	0.7	-0.2	-1.2
Average weekly spirits intake	0.8	0.9	2.2	0.1	-0.7	-0.4	-0.4	-1.1	-1.0	-1.3	-1.5	-1.2	-1.1	-0.9	-1.0	-0.7
Sensitivity / hurt feelings	0.6	1.0	3.8	1.5	0.8	-0.9	-1.0	0.0	-0.9	-0.6	0.3	-0.6	-1.0	1.9	0.6	-1.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	5.2	1.2	0.3	-2.3	-2.2	0.1	-0.9	-0.8	-0.6	-0.9	-1.0	0.9	-0.9	-0.4
Hearing difficulty/problems: Yes	0.7	1.1	4.4	2.1	0.6	0.4	0.4	-1.6	0.3	0.8	1.1	1.3	0.3	0.3	1.5	0.7
Relative age of first facial hair	0.1	0.1	0.6	0.2	0.3	-0.0	0.0	-0.3	0.2	0.3	0.4	0.4	-0.0	0.7	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.3	-0.3	0.8	0.6	-0.7	-0.1	0.2	0.3	0.8	0.1	-1.0	1.0	-0.1
Ever used hormone-replacement therapy (HRT)	1.2	1.6	7.3	0.5	-0.2	-2.7	-2.7	-0.5	-0.9	-0.6	-0.7	-0.3	-0.9	-0.1	-0.8	-1.5
Ever had hysterectomy (womb removed)	1.1	1.2	4.4	-0.7	-0.8	-1.1	-1.2	-0.7	-1.4	-1.0	-0.9	-0.9	-1.4	0.1	-0.8	-2.1
Systolic blood pressure, automated reading	1.1	3.2	12.2	-0.3	-1.5	0.6	0.5	3.2	1.0	0.8	0.2	1.3	0.7	3.4	-3.5	0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	0.9	-0.2	-0.6	-0.5	0.2	-0.5	-1.0	-0.9	-0.9	-0.3	-0.5	-0.0	-1.1
Angina	0.3	0.4	2.9	1.7	-1.1	0.1	-0.0	-0.4	0.1	0.3	0.7	0.6	0.4	-0.5	-0.2	0.2
Medication for hormone replacement therapy	1.2	1.4	5.9	-1.0	0.2	-2.3	-2.4	1.2	-1.0	-0.5	-0.5	-1.0	-1.1	0.3	-0.4	-0.5
Vitamin and mineral supplements	0.5	0.7	5.0	-0.7	-0.6	0.8	0.8	-0.2	0.1	0.3	-0.2	0.4	-0.0	1.3	-2.2	0.2
Supplements: Zinc	0.3	0.3	1.8	0.5	-0.2	0.9	1.0	-0.1	-0.4	-0.4	0.2	-0.0	-0.4	0.3	1.3	0.2
Medication: Co-codamol	1.3	1.5	9.4	1.9	-1.0	0.1	0.1	3.1	0.2	-0.2	-0.7	0.6	0.6	1.8	0.2	-0.6
Medication: Metformin	0.3	0.4	1.4	-0.3	0.6	0.8	0.6	-1.2	0.4	0.3	-0.0	-0.1	0.3	-0.1	-1.1	-0.6
Diabetes (father)	1.6	2.0	9.0	-1.2	2.3	-2.8	-3.0	-0.1	0.1	0.1	0.7	-0.3	0.1	-0.7	0.2	0.9
Diabetes (mother)	0.3	0.4	1.4	1.2	1.1	-0.9	-0.7	-0.0	0.2	0.3	0.2	0.2	0.4	0.2	0.4	-0.5
Severe depression (siblings)	0.8	0.9	3.7	-1.8	1.9	-0.6	-0.4	-1.1	0.4	0.8	1.2	0.2	0.5	-0.1	-0.7	-0.6
Pack years adult smoking proportion	0.5	0.8	4.0	2.0	0.2	-0.5	-0.4	1.1	0.5	0.7	0.7	0.6	0.5	1.4	-0.7	0.7
Impedance of leg (right)	0.8	3.7	8.3	-0.2	-1.8	0.3	0.2	-0.3	-2.5	-2.6	-1.9	-2.5	-2.9	0.6	-2.7	-2.3
Leg fat-free mass (left)	0.6	3.2	16.9	-1.0	1.9	-1.4	-1.4	-2.2	-0.2	0.4	-1.3	0.3	0.2	-4.1	3.0	0.7
Trunk fat percentage	1.2	4.6	15.8	-0.8	1.1	-2.6	-2.7	-2.3	-2.1	-1.2	-2.5	-1.5	-1.7	-4.0	1.0	-2.1
Hand grip strength (right)	1.2	3.4	9.2	1.5	1.1	-0.1	-0.2	0.0	2.4	2.4	2.0	3.0	2.7	-0.9	1.0	2.5
Townsend deprivation index at recruitment	0.7	1.0	4.1	0.1	1.2	-2.0	-1.8	-1.1	0.3	0.1	-0.2	0.1	0.5	-1.2	0.1	-0.9
Current tobacco smoking	0.3	0.5	1.7	0.8	0.5	-0.9	-0.6	-0.4	-0.3	-0.6	-0.5	-0.2	-0.0	0.9	-1.3	-0.8
Average weekly fortified wine intake	0.5	0.5	3.3	-0.2	-0.3	-0.7	-0.4	-1.2	0.2	0.6	0.7	-0.2	0.1	-0.5	0.6	1.8
Maternal smoking around birth	0.6	0.9	1.7	0.9	0.1	1.0	1.2	1.2	0.7	1.2	0.8	1.0	0.9	1.3	-1.0	0.3
Fed-up feelings	1.1	2.0	8.1	0.8	2.9	-2.3	-2.0	-1.4	-0.7	-0.2	-0.0	-0.1	-0.6	-0.5	-0.6	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	15.0	-0.2	1.0	-3.8	-3.9	-0.9	-1.7	-1.6	-1.3	-1.3	-1.6	-0.5	-1.5	-1.4
Relative age voice broke	0.8	1.2	4.2	2.0	0.2	-1.4	-1.0	-1.8	-1.0	-1.0	-0.6	-0.8	-1.0	0.1	0.7	-0.8
Taking other prescription medications	0.5	0.8	3.6	1.9	-1.3	-0.8	-0.8	0.6	0.3	0.3	0.2	1.4	0.5	1.2	0.1	-0.1
Age when periods started (menarche)	0.2	0.5	3.2	-0.2	0.6	-0.4	-0.4	1.0	0.6	0.4	0.3	-0.1	0.5	1.0	-1.8	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.4	-0.6	0.6	-0.3	-0.2	0.7	-0.2	0.4	0.6	0.4	-0.0	1.2	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	5.6	0.4	0.1	1.7	1.7	2.4	0.7	1.1	0.5	0.7	0.5	1.2	-1.1	0.0
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	7.0	0.5	-0.0	-2.5	-2.6	-0.9	-1.5	-1.5	-1.3	-1.9	-1.3	-0.4	-2.2	-1.1
Qualifications: CSEs or equivalent	2.3	3.1	7.7	1.9	2.4	-0.1	-0.1	1.3	2.3	2.5	1.7	2.8	2.5	-0.5	0.0	0.5
Serious illness, injury or assault to yourself	0.7	0.9	4.1	-1.6	0.1	-1.2	-1.3	-0.7	-0.1	-0.3	-0.3	0.7	0.2	-2.0	0.2	-0.5
High blood pressure	0.6	1.6	9.4	-0.7	-2.0	0.9	1.0	1.2	0.3	0.4	-0.2	0.5	0.1	3.1	-1.8	-0.4
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.2	0.3	0.2	-1.8	-1.6	-0.1	-0.7	-0.9	-1.1	-0.8	-0.6	-1.2	1.7	-1.2
Multivitamins +/- minerals	0.8	1.1	3.9	0.8	1.0	-1.4	-1.4	0.3	0.9	0.6	0.9	0.5	1.0	-0.9	2.0	0.2
Stomach or abdominal pain in last month	0.7	0.8	3.8	0.2	0.9	-2.0	-1.9	0.3	-0.2	-0.4	-0.6	-0.7	-0.3	0.1	-0.6	-1.1
Supplements: Glucosamine	0.8	1.0	3.8	0.2	1.8	-0.9	-1.0	-0.2	0.5	0.5	0.7	0.1	0.6	-0.9	1.9	1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.2	0.5	-0.8	-0.4	-0.3	1.0	-1.4	-1.3	-1.3	-1.4	-1.5	0.9	0.2	-1.0
Medication: Atenolol	0.4	0.5	3.4	0.6	-0.8	0.3	0.2	0.4	-0.4	-0.1	-0.3	-0.4	-0.4	1.8	-0.7	-0.7
Medication: Levothyroxine sodium	0.1	0.1	0.8	0.5	-0.3	0.2	0.1	0.1	-0.3	-0.2	-0.0	-0.1	-0.1	-0.9	-0.0	-0.1
Sitting height	0.8	5.5	16.0	-1.2	0.4	-1.6	-1.6	-1.9	-3.0	-3.0	-4.0	-2.8	-2.9	-2.5	0.2	-2.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	1.3	-1.6	-0.3	-0.1	0.5	-1.5	-1.4	-1.3	-0.9	-1.2	-0.0	0.2	-1.7
High blood pressure (mother)	0.7	1.0	6.5	-0.0	0.9	1.0	1.0	0.1	0.8	0.9	0.1	0.8	0.9	0.6	-2.6	-0.5
Body mass index (BMI)	0.5	2.1	5.2	-1.0	2.2	-2.1	-2.1	-0.1	0.9	1.5	0.2	1.2	1.2	-2.3	1.3	0.6
Impedance of leg (left)	0.9	4.2	9.5	-0.0	-2.0	0.0	-0.1	-0.4	-2.7	-2.8	-2.1	-2.6	-3.1	0.6	-2.9	-2.6
Leg predicted mass (left)	0.6	3.1	16.7	-0.9	1.8	-1.4	-1.4	-2.2	-0.3	0.3	-1.3	0.2	0.2	-4.1	3.0	0.7
Trunk fat mass	1.2	5.2	18.8	-1.0	1.4	-2.7	-2.8	-2.5	-2.1	-1.3	-2.8	-1.5	-1.7	-4.3	1.5	-1.8
Waist circumference	0.5	1.7	4.6	-1.8	1.0	-1.8	-1.9	-1.1	-1.2	-0.5	-1.6	-0.3	-0.9	-2.1	0.8	-0.0
Number of incorrect matches in round	1.0	1.7	7.3	0.4	-0.9	2.7	2.5	1.1	-0.4	-0.4	-0.4	0.2	-0.7	2.1	-0.9	-0.2
Past tobacco smoking	0.5	1.0	4.0	2.0	-0.8	0.0	0.1	-0.8	-0.7	-0.6	-1.0	-1.0	-0.6	-0.5	1.6	-1.1
Alcohol usually taken with meals	0.6	1.0	3.7	-1.4	-1.9	0.8	0.5	1.7	-0.6	-0.5	-0.0	-0.4	-0.7	1.3	-0.5	0.9
Nervous feelings	0.4	0.8	2.3	0.9	0.4	1.4	1.5	0.4	0.1	0.0	0.4	-0.2	0.0	1.4	-1.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.3	0.5	-0.1	-1.2	-1.4	-1.9	-2.2	-1.8	-1.3	-1.6	-2.3	-0.2	0.1	-1.4
Hearing difficulty/problems with background noise	1.0	1.7	5.2	1.4	2.3	-0.5	-0.7	-1.6	0.9	1.5	1.8	1.4	0.6	-0.1	1.2	1.1
Hair/balding pattern: Pattern 2	0.4	0.4	2.4	0.1	-0.8	-0.3	0.1	0.7	0.7	0.7	0.6	0.0	0.5	1.5	-0.6	0.4
Had menopause	0.5	0.7	2.8	0.2	0.0	-0.8	-0.7	-0.3	-1.4	-0.9	-0.7	-0.8	-1.7	-0.8	-0.2	-0.5
Had other major operations	0.2	0.3	1.3	-0.3	0.1	-1.1	-1.1	-0.4	0.4	0.5	-0.0	0.7	0.6	0.2	-0.3	-0.2
Forced vital capacity (FVC)	1.2	4.7	10.4	-1.7	0.9	-1.8	-1.9	-1.6	-2.9	-2.3	-2.7	-2.8	-2.9	-3.2	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	5.1	0.4	-0.5	1.5	1.5	2.2	0.8	0.8	0.2	0.7	0.7	1.3	-0.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.3	0.4	1.1	-0.2	-0.3	-1.9	-0.3	-0.2	-0.1	-0.3	0.0	-2.1	0.6	-1.6
Qualifications: None of the above	0.3	0.7	2.5	1.2	0.6	-1.1	-0.8	1.6	0.1	0.2	-0.2	0.3	0.2	0.5	-1.2	0.2
Financial difficulties in last 2 years	0.5	0.7	3.4	1.1	0.1	-1.8	-1.8	0.1	0.3	0.2	-0.0	0.7	0.6	0.6	0.4	-0.6
Mouth/teeth dental problems	0.3	0.5	2.6	-1.6	-1.0	0.7	0.7	-0.0	0.3	0.6	-0.1	-0.1	0.3	-0.3	-1.1	-0.4
Heart attack	0.6	0.8	4.2	1.2	0.1	-0.5	-0.5	1.7	-0.2	0.1	-0.1	-0.1	-0.1	2.1	0.8	-0.3
Allergy	0.6	1.3	4.4	-0.2	0.1	1.8	1.6	0.1	0.8	0.9	1.2	0.6	0.6	1.4	-2.1	1.1
Pain all over the body in last month	0.4	0.5	2.4	-0.3	0.1	0.2	0.3	-0.2	-0.3	-0.1	-0.6	-0.2	-0.2	-1.1	-1.6	-1.3
Diabetes (self-reported)	0.5	0.7	1.6	-0.1	0.0	-1.1	-1.0	-0.0	-0.8	-1.0	-0.9	-1.2	-0.8	1.3	-0.6	-0.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.7	-0.8	0.6	-1.5	-1.4	-0.8	-1.0	-1.3	-1.3	-1.4	-1.0	-1.6	1.1	-1.3
Medication: Ramipril	0.6	0.8	3.3	-0.4	-1.0	0.7	0.8	0.7	-0.8	-0.8	-0.7	-0.4	-0.6	1.8	-0.5	-1.1
Medication: Simvastatin	0.8	1.1	5.2	0.5	-1.5	-0.5	-0.4	1.0	-0.4	-0.5	-0.4	-0.9	-0.7	2.3	-1.8	-0.7
Fluid intelligence score	1.1	2.4	8.2	-0.3	1.8	0.1	-0.1	-2.1	0.8	1.1	1.2	1.1	0.6	-2.4	2.9	2.0
Illnesses of siblings	0.3	0.4	1.1	-0.7	-0.1	1.1	1.0	0.5	-0.4	-0.4	-0.6	-0.9	-0.4	-0.0	-0.6	-0.8
Neuroticism score	0.5	1.0	4.3	0.9	2.1	-0.8	-0.7	-0.5	-0.4	-0.3	0.5	-0.6	-0.6	0.6	-1.8	-1.4
Weight	0.9	4.5	21.8	-1.4	1.9	-2.6	-2.7	-2.5	-1.2	-0.4	-1.9	-0.6	-0.8	-4.7	2.1	-0.2
Impedance of arm (right)	1.3	6.1	12.1	-0.3	-1.1	-0.4	-0.4	-3.4	-3.5	-3.3	-2.4	-3.2	-3.4	-2.7	0.2	-2.9
Arm fat percentage (right)	0.9	3.7	17.2	-1.1	2.2	-2.6	-2.7	-2.0	-0.8	-0.0	-1.0	-0.3	-0.4	-4.2	2.0	-0.7
Trunk fat-free mass	0.4	2.1	11.7	-1.5	1.5	-0.4	-0.5	-1.9	-0.1	0.2	-1.0	0.2	0.0	-3.4	2.1	1.1
Hip circumference	1.2	5.1	22.9	-0.4	1.8	-3.4	-3.4	-1.5	-1.0	-0.3	-1.7	-0.3	-0.6	-4.8	3.1	0.4
Time employed in main current job	0.9	1.1	2.6	0.0	-1.6	1.2	1.3	0.7	0.9	1.1	1.1	1.0	0.9	1.1	0.2	1.2
Alcohol intake versus 10 years previously	0.6	0.9	3.0	1.5	1.3	-0.7	-0.6	-1.0	0.4	0.1	-0.1	0.1	0.6	-1.3	1.7	-0.8
Father’s age at death	0.8	1.1	2.5	-0.4	0.1	0.3	0.1	-1.5	-1.2	-1.5	-0.4	-1.2	-1.6	-1.3	0.9	0.8
Worrier / anxious feelings	0.8	1.5	3.4	0.4	-0.2	0.8	1.0	0.2	-1.4	-1.5	-0.4	-1.3	-1.7	1.8	-1.7	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	6.5	1.4	1.7	-2.5	-2.6	-0.9	-0.9	-0.1	0.3	-0.3	-1.0	0.5	0.4	-0.0
Falls in the last year	1.5	2.0	5.2	0.2	0.3	-1.3	-1.2	-1.5	-1.6	-1.4	-2.3	-1.3	-1.5	-1.8	0.0	-1.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	-1.4	-0.5	-0.6	-0.7	-1.4	-1.0	-1.0	-0.7	-0.9	-0.9	-0.8	-1.4	-1.1
Number of live births	1.3	1.8	4.3	-1.1	0.6	0.7	0.7	0.4	1.6	2.1	1.8	1.9	1.7	0.6	-1.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.0	-1.5	0.5	-1.1	-1.3	-0.9	-2.4	-1.9	-2.5	-2.4	-2.4	-2.5	0.7	-0.3
Pulse rate	6.8	11.4	27.9	-0.2	3.3	0.4	0.4	1.2	4.6	4.9	4.9	5.3	4.7	0.7	-1.5	3.6
Happiness	1.6	1.9	6.2	-0.2	1.6	-2.1	-2.1	-2.2	-0.5	-0.9	0.1	-0.8	-0.4	-2.5	-0.4	-0.4
Noisy workplace	0.4	0.5	2.2	1.5	0.4	-0.7	-0.5	1.1	0.3	0.2	-0.8	0.9	0.5	0.3	-0.8	0.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	10.1	-1.6	0.5	2.6	2.6	-2.3	1.7	1.4	1.6	0.9	1.5	-1.7	3.2	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	-0.0	0.9	-0.9	-1.1	-0.0	-0.6	-0.3	-0.1	-0.6	-0.6	-1.8	1.8	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	3.4	1.9	0.6	-0.3	-0.2	0.2	-1.5	-1.0	-1.1	-0.6	-1.6	0.2	1.1	-0.7
Asthma	0.6	1.2	4.2	0.6	0.1	-2.0	-2.1	-0.1	0.5	0.5	0.4	0.8	0.7	-1.6	1.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.2	-0.2	0.3	0.1	-0.1	-0.1	0.9	0.2	0.6	0.3	1.0	0.1	0.2	1.5
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.5	1.0	-0.5	-0.4	-0.6	0.2	0.6	0.0	-0.3	0.1	-0.5	-0.2	-0.7
Depression (self-reported)	1.0	1.2	5.8	0.6	-1.2	-0.9	-0.8	2.4	-0.0	-0.9	-0.5	0.4	0.1	2.2	-0.6	-0.2
Medication: Lansoprazole	0.8	0.9	5.6	0.2	-0.1	-0.6	-0.7	2.4	0.3	0.8	0.5	0.5	0.4	2.0	0.1	-0.2
Prospective memory result	0.7	0.9	2.1	0.7	-1.4	0.7	0.7	0.9	-0.9	-0.8	-0.7	-0.6	-1.0	1.4	-1.0	-0.5
Lung cancer (father)	0.7	0.9	2.8	0.1	0.6	-1.6	-1.7	-1.3	-0.9	-0.4	0.1	-0.1	-0.7	-1.0	1.0	-0.3
Illnesses of mother	0.5	0.6	2.1	-0.6	-1.5	-0.4	-0.4	-0.7	-0.7	-0.9	-0.7	-0.9	-0.6	-1.1	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	14.4	-0.9	-0.3	-2.0	-2.1	-0.8	-3.4	-3.1	-3.8	-3.6	-3.4	-2.1	0.1	-1.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	0.7	0.1	-0.8	-0.8	-0.4	-1.1	-0.9	-1.0	-0.4	-1.1	-1.2	-0.7	0.1
Impedance of arm (left)	1.1	5.2	11.5	0.5	-1.0	-0.4	-0.5	-2.9	-3.4	-3.0	-2.2	-3.0	-3.3	-2.3	0.1	-2.6
Arm fat mass (right)	0.8	3.4	15.5	-1.1	2.3	-2.6	-2.7	-1.7	-0.5	0.3	-1.1	0.1	-0.1	-3.9	1.9	-0.2
Trunk predicted mass	0.4	2.2	12.3	-1.5	1.6	-0.4	-0.4	-2.0	-0.0	0.3	-1.0	0.3	0.1	-3.5	2.2	1.1
Standing height	1.1	11.3	28.2	-1.2	-0.2	-1.1	-1.2	-5.1	-4.2	-3.8	-4.4	-3.7	-4.2	-5.3	1.7	-1.8
Length of working week for main job	0.8	0.9	2.5	0.1	0.5	1.5	1.5	-0.1	1.1	1.6	1.0	0.9	1.0	-0.2	-0.1	0.1
Exposure to tobacco smoke at home	0.5	0.6	2.0	1.4	0.1	0.9	1.0	-0.3	0.4	0.6	0.4	0.6	0.5	0.6	1.2	0.7
Breastfed as a baby	1.3	1.6	5.0	-1.2	-0.4	1.9	2.0	0.8	1.0	0.8	0.9	0.6	0.6	1.4	-0.4	2.2
Tense / ‘highly strung’	1.1	1.8	5.2	0.4	-0.1	-0.8	-0.7	0.1	-2.1	-1.8	-1.3	-2.2	-2.3	0.8	-0.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.5	0.3	0.1	-1.6	-1.6	-0.2	-0.8	-0.9	-0.6	-0.5	-0.9	1.4	-2.1	-2.0
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-1.0	0.4	0.7	0.8	-1.4	-0.8	-1.0	-0.7	-1.0	-0.5	-0.9	0.1	-1.5
Birth weight of first child	0.3	0.6	1.9	0.0	1.3	0.3	0.2	-1.4	-0.1	0.2	0.6	-0.5	0.0	-1.3	1.0	0.4
Peak expiratory flow (PEF)	0.6	1.4	6.4	-1.2	1.8	-0.2	-0.5	-0.5	0.5	0.6	-0.2	0.4	0.5	-2.5	1.6	1.6
Pulse wave reflection index	2.8	3.4	8.0	1.9	-0.6	-0.2	-0.2	-0.7	-2.8	-2.7	-2.6	-2.7	-2.8	-0.7	0.7	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.8	0.5	-0.5	-0.8	-0.9	-0.3	-0.2	-0.1	-0.5	-0.7	-0.2	0.4	-1.3	-0.5
Loud music exposure frequency	0.5	0.5	1.5	-0.2	0.6	-0.4	-0.5	-0.6	-0.7	-0.5	-1.0	-1.2	-1.0	-0.3	-0.9	-0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	7.4	-0.2	0.4	1.7	1.5	-2.4	0.8	0.7	0.7	0.6	0.7	-0.9	2.7	0.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.0	0.5	1.3	-0.8	-0.7	0.7	1.8	1.2	1.7	1.6	1.8	0.2	0.8	2.4
Blood clot in the leg (DVT)	2.3	2.9	8.1	-0.1	-1.4	-1.1	-1.1	-0.6	-2.1	-2.4	-2.8	-2.0	-1.9	-1.0	1.1	-2.3
Medication: Paracetamol	0.4	0.6	2.0	0.3	0.4	-1.4	-1.4	0.8	-0.1	-0.3	-0.0	0.2	0.1	1.2	-0.6	-1.0
Headache pain in last month	0.5	0.9	2.9	0.7	0.5	-0.9	-1.0	1.1	1.1	0.6	0.9	0.6	0.9	1.7	-0.8	0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.6	0.2	-0.2	0.7	0.5	0.3	-0.1	-0.4	-0.0	-0.1	0.0	-0.1	0.2	0.8
Glaucoma (self-reported)	1.1	1.3	4.0	2.0	1.2	0.3	0.3	-0.4	0.8	0.6	1.1	0.8	0.6	-0.9	1.6	2.0
Gout (self-reported)	0.8	1.1	2.9	0.1	-1.0	-0.9	-0.9	0.6	-0.8	-1.2	-1.6	-0.8	-0.7	0.5	-1.7	-1.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	5.5	0.3	1.1	0.4	0.4	-0.8	0.4	0.8	0.5	0.9	0.6	-2.3	0.6	0.4
Medication: Amlodipine	0.4	0.6	2.0	0.1	-0.5	-0.5	-0.5	-0.8	-1.0	-0.7	-0.9	-0.9	-1.1	0.2	-0.4	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	4.6	-0.3	-0.1	0.4	0.3	2.1	-0.1	-0.3	-0.8	0.5	-0.1	-0.1	-0.5	-0.6
Birth weight	2.3	5.0	16.2	-2.1	-0.2	-0.3	-0.4	-4.0	-2.9	-2.5	-2.5	-2.7	-2.9	-2.3	0.1	-1.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.2	0.5	-0.8	1.6	1.6	-0.5	-1.3	-1.4	-1.8	-1.1	-1.5	0.2	1.4	-1.5
High blood pressure (siblings)	0.4	0.6	2.3	0.0	-1.5	-0.3	-0.3	0.4	0.6	0.4	0.4	0.7	0.6	1.5	-1.2	0.5
Forced vital capacity (FVC), Best measure	2.6	9.4	19.5	-1.0	-0.5	-2.6	-2.8	-2.1	-4.2	-3.9	-4.4	-4.2	-4.1	-3.2	0.4	-2.1
Body fat percentage	0.9	3.7	13.2	-0.9	1.3	-2.7	-2.8	-1.9	-1.7	-0.8	-2.0	-1.1	-1.3	-3.6	0.8	-1.7
Leg fat percentage (right)	0.5	1.9	6.2	-1.1	0.5	-2.5	-2.5	-0.4	-1.0	-0.4	-1.5	-0.5	-0.8	-2.2	0.3	-0.9
Arm fat-free mass (right)	0.3	1.4	6.7	-1.1	1.1	-1.3	-1.4	-1.2	0.0	0.3	-1.2	0.3	0.2	-2.6	1.1	0.7
Exposure to tobacco smoke outside home	0.5	0.7	4.0	0.9	0.4	-0.8	-0.8	2.0	0.1	-0.0	-0.4	0.4	0.1	1.4	0.6	0.0
Comparative body size at age 10	0.2	0.5	3.1	-0.3	0.0	-0.0	0.2	-0.7	0.1	-0.4	-0.4	-0.6	0.4	-1.8	1.5	-0.3
Number of full brothers	3.4	4.3	10.4	0.2	2.0	-0.3	-0.2	1.8	2.9	3.0	2.8	3.2	2.9	0.3	0.2	2.1
Worry too long after embarrassment	1.4	2.3	8.5	-0.0	2.9	1.0	0.9	-1.7	1.5	1.4	2.6	0.8	1.5	-1.7	0.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.2	-0.8	1.2	1.1	0.0	-0.3	-0.7	-0.2	-0.3	-0.5	0.8	-0.6	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	4.1	0.2	-0.3	-2.0	-2.0	-0.1	-1.5	-1.2	-1.2	-0.6	-1.3	-0.1	-0.4	-0.8
Number of children fathered	1.2	1.4	5.4	-0.8	1.2	-0.4	-0.4	-1.1	1.4	1.2	1.0	1.1	0.9	-1.4	0.8	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	-0.8	-0.9	-0.8	-0.9	-0.7	-0.8	-1.4	-0.4	-1.0	-0.9	-0.6	-0.2	-0.1
Age at first live birth	0.9	1.6	4.0	0.7	1.5	-0.5	-0.7	-2.0	-1.5	-1.0	-0.0	-1.3	-1.8	-1.3	2.0	0.5
Pulse wave peak to peak time	0.4	0.4	0.8	-0.8	-0.2	0.8	0.7	-0.1	0.9	0.6	0.7	0.2	0.8	0.7	0.7	-0.3
Health satisfaction	0.6	0.8	2.8	0.3	0.9	-1.3	-1.5	-1.3	-0.3	-0.3	-0.5	0.3	-0.1	-1.7	0.3	-0.4
Shortness of breath walking on level ground	0.4	0.4	1.4	1.2	0.0	0.5	0.4	0.9	0.5	0.4	0.3	1.0	0.6	0.5	0.9	0.2
Qualifications: College or University degree	0.7	2.3	7.0	-2.0	-0.7	2.7	2.5	-1.0	1.0	0.5	1.1	0.2	0.4	-0.6	1.3	2.5
Eye problems/disorders: None of the above	0.9	1.0	3.0	-1.6	-0.4	0.7	0.8	0.8	-0.5	-0.8	-0.7	-0.3	-0.2	1.7	-1.7	-1.2
Mouth/teeth dental problems: Loose teeth	2.7	3.2	10.6	0.4	1.2	-1.2	-1.2	-3.3	-1.6	-2.0	-1.7	-1.7	-1.9	-3.2	1.0	-0.5
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.1	0.7	-0.9	-0.7	-0.6	-0.6	-0.6	-0.0	0.1	-0.4	-0.4	0.5	0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	-0.7	-1.3	0.9	1.1	-1.2	-0.6	-0.3	-0.6	-0.3	-0.5	-1.4	0.6	-0.3
Neck or shoulder pain in last month	0.6	0.8	2.4	1.5	-0.7	-0.9	-0.9	1.0	-0.1	-0.7	-1.3	0.1	0.0	1.4	0.3	-1.1
Medication: Blood pressure	0.5	0.8	2.2	-0.1	-0.9	-0.4	-0.3	-0.2	-1.2	-1.0	-1.4	-1.0	-1.2	0.5	0.1	-1.5
Angina (self-reported)	0.3	0.4	2.3	1.5	-1.0	-0.2	-0.2	-0.2	0.2	0.4	0.7	0.7	0.5	-0.5	-0.2	0.1
Migraine (self-reported)	0.2	0.2	1.2	-0.7	-1.1	0.2	0.1	-0.3	0.2	0.5	0.1	0.1	0.0	0.8	-0.5	-0.1
Medication: Ibuprofen	0.4	0.4	2.7	0.0	-0.1	-0.9	-1.1	-0.4	0.4	-0.0	0.6	0.0	0.6	0.3	0.0	1.6
Medication: Allopurinol	0.9	1.2	2.9	-0.3	-1.4	-0.9	-0.8	1.7	-0.7	-1.5	-1.4	-1.0	-0.7	1.2	-0.4	-1.0
Medication: Omeprazole	2.0	2.4	8.7	-0.5	-0.3	-2.9	-2.9	0.9	-1.2	-1.2	-1.4	-1.1	-1.2	-0.2	-1.3	-1.9
Medication: Seretide 50 evohaler	1.1	1.3	5.1	2.3	1.2	-0.3	-0.4	1.8	0.7	1.1	0.7	1.4	0.6	0.1	1.4	0.4
Mean time to correctly identify matches	1.1	2.2	6.4	1.7	0.4	-0.9	-0.8	-0.1	-1.7	-2.0	-1.8	-2.5	-2.0	0.3	-0.2	-1.7
Heart disease (mother)	1.6	2.0	6.6	0.9	1.2	-0.8	-0.9	1.8	1.2	1.4	1.6	1.3	1.2	0.5	2.6	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.9	1.8	1.5	-0.4	-0.5	-0.0	1.2	1.1	2.0	0.9	1.1	0.8	0.7	1.7
Whole body fat mass	0.9	3.8	16.3	-1.2	1.5	-2.5	-2.6	-2.1	-1.5	-0.6	-2.2	-0.9	-1.2	-4.0	1.4	-1.1
Leg fat mass (right)	0.6	2.5	9.9	-1.1	1.3	-2.5	-2.5	-1.1	-1.0	-0.2	-1.6	-0.4	-0.7	-3.1	1.2	-0.5
Arm predicted mass (right)	0.3	1.4	7.0	-1.1	1.2	-1.3	-1.4	-1.2	-0.2	0.2	-1.4	0.2	-0.0	-2.6	1.1	0.7
Pulse rate, automated reading	6.6	21.3	48.7	-0.9	4.5	0.6	0.7	1.9	6.8	6.6	6.0	6.8	7.0	0.5	-0.7	5.3
Alcohol intake frequency.	1.5	3.6	8.6	2.9	2.7	0.6	0.9	-0.3	2.5	2.6	1.9	2.3	2.6	-0.8	0.4	0.2
Comparative height size at age 10	1.2	6.8	15.2	0.4	-1.2	0.2	0.2	-3.2	-3.4	-3.0	-3.9	-2.9	-3.3	-3.9	2.0	-1.5
Number of full sisters	0.1	0.1	0.7	0.8	0.1	0.3	0.3	-0.1	-0.2	0.2	0.2	0.1	-0.2	0.2	0.2	-0.9
Suffer from ‘nerves’	0.3	0.4	2.2	1.5	-0.9	0.6	0.7	0.3	-0.2	-0.4	-0.1	0.0	-0.1	1.1	-0.1	-0.6
Overall health rating	1.0	2.1	9.9	0.2	1.0	-3.1	-3.1	-0.8	-0.7	-0.4	-1.2	-0.1	-0.3	-1.0	0.2	-1.7
Chest pain or discomfort	2.8	4.0	9.5	2.0	-3.1	0.0	-0.1	0.1	-2.9	-2.7	-2.5	-1.7	-2.9	0.9	0.9	-1.9
Had major operations	1.5	1.7	6.3	0.8	-0.9	-2.5	-2.5	-1.7	-0.8	-1.2	-0.4	-0.6	-0.8	-0.5	-1.1	-1.0
Age at last live birth	0.5	0.8	5.1	-0.4	0.9	-0.6	-0.7	-2.3	-0.3	0.1	0.9	-0.2	-0.5	-1.0	0.3	0.9
Family relationship satisfaction	1.3	1.5	3.6	0.2	0.5	-1.8	-1.9	-1.5	-0.9	-0.9	-0.1	-1.4	-0.8	-1.6	-1.1	-1.7
Leg pain on walking	4.9	6.2	14.8	0.8	-2.3	-1.5	-1.4	-1.1	-3.6	-3.9	-3.4	-3.4	-3.5	0.2	0.1	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	3.1	0.3	-1.8	-0.1	-0.1	0.2	0.0	-0.2	-0.6	0.3	0.2	-0.5	0.7	-1.0
Commuting to job workplace: Car/motor vehicle	1.0	1.1	5.8	-0.5	-0.6	-0.3	-0.3	2.4	-0.6	-0.4	-0.8	-0.3	-0.6	2.3	-0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	4.2	0.1	-1.1	1.9	2.1	0.1	-0.6	-0.3	-1.0	-1.2	-1.1	1.0	-1.2	-1.1
Medication: Aspirin	1.0	1.3	3.8	0.7	1.3	-0.3	-0.4	0.1	1.4	1.6	2.0	1.3	1.1	1.4	-0.5	1.3
Supplements: Vitamin C	0.5	0.6	3.5	1.9	-0.6	0.3	0.3	0.8	-0.4	-0.6	-0.5	-0.5	-0.3	0.0	1.5	-0.1
Knee pain experienced in last month	1.7	2.6	4.7	1.1	-2.1	-1.6	-1.6	0.7	-1.8	-2.2	-2.0	-1.6	-1.4	0.9	1.8	-1.5
Hypertension (Self-reported)	0.7	2.0	10.8	-0.8	-2.7	0.8	0.9	1.4	-0.0	-0.1	-0.5	0.1	-0.2	3.3	-1.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.4	0.1	-0.4	-1.4	-1.4	-0.0	-1.5	-1.4	-1.0	-1.1	-1.6	0.3	0.1	-1.4
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.3	-0.5	0.4	0.3	0.2	-0.3	-0.3	0.5	0.0	-0.1	0.3	-0.4	-0.5
Illnesses of siblings: Diabetes	0.7	0.9	3.9	2.0	0.8	-0.8	-0.8	-0.1	-0.1	-0.4	-0.4	-0.3	-0.3	-0.9	2.0	0.5
Smoking status: Previous	0.8	1.2	2.9	-1.7	0.9	0.3	0.2	0.6	1.1	1.3	1.5	1.1	1.1	0.2	-1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.8	0.1	0.5	0.6	0.7	-1.7	0.2	0.2	-0.3	0.3	0.6	-1.5	0.8	-0.5
Whole body fat-free mass	0.5	2.6	14.7	-1.2	1.7	-0.9	-1.0	-2.0	-0.1	0.4	-1.1	0.4	0.2	-3.8	2.6	1.0
Leg fat-free mass (right)	0.6	3.2	16.6	-0.9	1.7	-1.5	-1.6	-2.4	-0.3	0.3	-1.3	0.2	0.2	-4.1	2.9	0.6
Arm fat percentage (left)	0.8	3.4	15.9	-0.8	2.2	-2.6	-2.7	-1.8	-0.7	0.1	-1.1	-0.3	-0.4	-4.0	1.8	-0.6
Average weekly red wine intake	0.6	0.8	3.2	-1.2	-0.6	0.7	0.6	1.0	1.1	0.7	0.8	0.3	0.8	0.9	0.7	1.8
Handedness (chirality/laterality): Left-handed	1.6	1.9	7.3	-2.2	0.5	1.0	0.9	2.7	0.4	0.4	0.7	0.4	0.1	2.0	-1.4	1.8
Mood swings	0.7	1.3	4.5	0.9	1.1	-2.1	-2.0	-0.2	-0.9	-0.7	-0.1	-0.8	-0.9	0.4	-1.5	-1.3
Loneliness, isolation	1.6	2.2	9.4	-0.1	1.8	-3.1	-3.0	-1.8	-0.1	0.4	0.8	-0.1	-0.3	-1.2	-1.1	-0.8
Long-standing illness, disability or infirmity	0.4	0.6	2.0	0.3	-1.0	-0.2	-0.3	-0.2	-0.9	-0.8	-1.0	-0.3	-0.8	-0.5	-1.0	-1.4
Ever had bowel cancer screening	0.6	0.7	1.6	-0.7	-1.3	-1.0	-1.0	-0.1	-1.1	-1.2	-0.6	-0.6	-0.9	0.4	0.2	-0.4
Diabetes diagnosed by doctor	0.4	0.6	1.3	0.8	-0.0	-0.8	-0.8	-0.1	-0.6	-0.7	-0.9	-1.1	-0.8	0.8	-0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.1	-0.6	0.0	-0.0	-0.2	-1.4	-0.3	-0.1	0.2	-0.3	-0.4	0.5	-1.2	-0.7
Friendships satisfaction	0.6	0.8	3.7	0.4	1.0	-1.9	-1.9	-0.1	0.1	0.2	0.8	-0.1	0.4	0.4	-0.2	-0.9
Qualifications: nursing, teaching	1.0	1.6	4.1	-2.0	0.4	0.8	0.9	-1.0	1.2	1.4	1.6	1.5	1.1	0.1	0.6	1.9
Commuting to job workplace: Walk	0.4	0.4	1.2	0.6	-0.1	-0.6	-0.8	-1.1	0.6	0.1	0.4	0.6	0.9	-0.8	-0.6	0.3
Eye problems/disorders: Cataract	0.6	0.6	4.0	-0.5	-1.3	-0.3	-0.3	-1.4	-0.3	0.1	-0.3	-0.2	-0.4	-2.0	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.7	0.6	-1.0	-1.5	-1.8	1.3	-1.4	-1.7	-1.0	-1.4	-1.4	2.2	-0.8	-1.3
Medication for cholesterol	1.2	1.8	8.8	-0.9	1.3	0.1	0.1	-2.4	-1.1	-1.0	-1.3	-0.7	-1.1	-3.0	0.5	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	4.6	1.3	-1.0	-1.5	-1.7	0.1	-1.9	-2.1	-2.0	-2.0	-1.8	-0.8	0.5	-1.8
Back pain experienced in last month	1.3	1.9	9.0	3.0	0.2	-2.3	-2.2	1.7	0.3	-0.1	-0.9	0.4	0.2	0.8	0.6	0.2
Mineral and other dietary supplements	0.5	0.7	1.7	-1.1	-0.4	0.8	0.9	-0.7	0.8	1.1	0.5	0.9	0.8	0.4	-1.3	-0.1
Breast cancer (self-reported)	0.8	1.0	2.7	0.2	-0.7	0.0	-0.1	0.4	-1.7	-1.3	-1.5	-1.2	-1.4	-0.4	0.1	-1.4
Asthma (self-reported)	0.7	1.3	4.5	0.6	0.4	-2.1	-2.1	0.0	0.6	0.6	0.6	0.9	0.8	-1.4	1.6	0.9
Osteoporosis (self-reported)	1.3	1.7	3.4	-0.5	-1.8	-0.2	-0.2	-0.1	-1.8	-1.6	-1.8	-1.4	-1.7	0.5	-0.4	-1.8
Osteoarthritis (self-reported)	0.2	0.3	1.7	0.8	0.3	0.2	0.2	1.3	0.4	0.1	-0.3	0.3	0.4	-0.0	-0.3	-0.4
Medication: Aspirin	0.9	1.1	3.2	0.6	0.8	-0.4	-0.5	0.5	1.2	1.3	1.5	1.1	0.8	1.8	-1.1	1.1
Medication: Gliclazide	0.3	0.4	1.1	-0.2	-0.0	-0.6	-0.4	0.5	0.8	0.4	0.3	1.0	0.8	0.6	-1.0	0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.8	-0.5	0.9	0.9	-1.3	0.1	0.1	-0.8	-0.1	-0.1	-0.7	1.1	-0.2
Smoking status: Current	0.3	0.5	2.1	0.5	0.4	-1.0	-0.6	-0.1	-0.1	-0.4	-0.4	0.1	0.3	1.2	-1.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.5	0.3	0.5	-0.9	-1.1	1.2	-1.7	-1.3	-1.8	-1.8	-1.9	-0.5	0.4	-0.2
Whole body water mass	0.5	2.6	14.3	-1.3	1.8	-0.9	-1.0	-2.0	-0.1	0.4	-1.1	0.3	0.2	-3.8	2.5	1.0
Leg predicted mass (right)	0.6	3.0	16.1	-1.0	1.6	-1.5	-1.6	-2.3	-0.2	0.3	-1.3	0.3	0.3	-4.0	2.8	0.6
Arm fat mass (left)	0.8	3.3	16.6	-1.2	2.4	-2.4	-2.5	-1.7	-0.3	0.5	-1.0	0.1	0.0	-4.1	1.7	-0.2
Number of self-reported non-cancer illnesses	0.8	1.3	4.7	0.1	-1.5	-2.2	-2.1	1.2	-0.5	-0.5	-0.9	0.0	-0.3	1.0	-0.3	-1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.7	-1.3	-0.8	-1.1	-1.2	-0.5	-0.6	-0.8	-0.1	-0.5	-0.9	-0.2	0.0	0.2
Miserableness	1.0	1.7	7.4	0.8	2.7	-1.4	-1.2	-0.6	1.1	1.3	1.2	1.7	1.2	-0.6	-0.9	-0.1
Guilty feelings	2.2	3.3	9.0	0.6	3.0	0.9	1.1	1.0	2.3	2.4	2.6	2.2	2.1	0.6	-1.2	1.2
Wears glasses or contact lenses	0.9	1.0	3.6	1.0	0.1	0.8	0.5	-1.9	-0.6	-0.7	-0.3	-0.9	-0.8	-1.3	1.7	-0.5
Ever taken oral contraceptive pill	0.4	0.5	2.2	0.2	0.5	0.5	0.4	1.5	-0.6	-0.4	-0.4	-0.4	-0.5	-0.0	0.8	1.2
Hearing aid user	0.4	0.5	1.4	-0.3	0.2	0.4	0.5	-0.3	0.8	0.9	1.1	1.2	0.8	0.7	0.1	0.4
Mother’s age at death	1.4	1.8	5.6	1.8	-0.5	-0.6	-0.9	0.2	-2.2	-1.6	-1.1	-1.1	-2.4	1.7	0.9	-0.1
Financial situation satisfaction	1.1	1.3	4.0	1.0	1.4	-2.0	-1.9	-1.6	0.1	0.3	0.6	0.9	0.5	-1.1	0.8	-0.6
Tinnitus: Yes, now most or all of the time	0.9	1.0	4.0	1.2	-1.1	1.6	1.5	-0.4	0.1	0.2	0.5	0.7	0.2	0.3	2.0	1.1
Commuting to job workplace: Public transport	1.6	1.8	8.2	-0.7	-0.3	-0.9	-1.0	-2.7	-0.8	-1.2	-0.9	-1.0	-0.6	-2.9	0.2	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	4.8	2.2	0.7	-0.8	-0.8	0.0	0.3	0.2	0.5	0.7	0.1	-0.4	1.0	1.3
Medication: Blood pressure	1.5	2.8	10.0	0.5	-1.0	0.9	0.8	2.5	1.6	1.6	1.2	1.4	1.4	3.2	-2.7	0.3
Pain type(s) experienced in last month: Hip pain	4.1	5.1	10.1	1.1	-2.4	-2.5	-2.6	0.0	-2.9	-3.2	-3.0	-2.9	-2.7	0.5	0.5	-1.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	1.2	-0.8	-0.2	-0.3	1.0	-0.8	-1.2	-0.2	-0.5	-0.6	0.3	0.8	0.0
High cholesterol (Self-reported)	0.2	0.4	1.6	0.1	-0.6	-1.0	-0.9	0.3	0.2	0.1	0.2	-0.4	0.2	0.4	-1.2	-0.9
Medication: Bendroflumethiazide	1.7	2.6	5.6	0.2	0.1	1.2	1.1	2.1	2.1	1.9	1.5	2.4	2.2	1.8	1.0	1.4
Medication: Paracetamol	0.5	0.7	2.1	0.5	0.2	-1.2	-1.2	1.1	0.3	-0.0	0.5	0.3	0.5	1.4	-1.3	-0.8
Medication: Lisinopril	0.2	0.3	1.5	-0.4	-0.7	0.3	0.2	1.1	0.3	0.1	-0.1	0.0	-0.1	1.2	-0.0	0.5
Medication: Atorvastatin	0.5	0.6	1.4	-0.2	1.2	-0.5	-0.4	-0.2	1.0	1.2	1.0	0.8	1.0	-0.3	1.1	0.3
Illnesses of father: High blood pressure	0.7	0.9	4.4	-1.0	-1.6	-0.4	-0.4	1.4	0.0	-0.0	0.6	-0.4	0.2	2.1	-0.1	0.5
Alcohol drinker status: Never	0.5	0.6	1.4	0.4	0.8	-0.3	-0.4	-1.1	1.0	1.2	0.7	0.1	1.0	-0.5	-0.0	0.9
Ever smoked	0.4	0.7	3.9	-2.0	0.9	-0.7	-0.8	0.1	-0.1	-0.3	0.4	0.3	-0.2	-0.1	-1.6	0.6
Basal metabolic rate	0.6	3.2	17.6	-1.3	1.9	-1.5	-1.6	-2.1	-0.2	0.3	-1.3	0.2	0.1	-4.2	2.5	0.8
Leg fat percentage (left)	0.5	2.0	6.1	-1.1	0.5	-2.5	-2.5	-0.5	-1.1	-0.5	-1.6	-0.6	-0.9	-2.3	0.1	-1.1
Arm fat-free mass (left)	0.4	1.9	10.1	-1.6	1.6	-1.4	-1.5	-1.4	0.1	0.4	-1.1	0.4	0.3	-3.2	1.3	0.8
Number of operations (self-reported)	1.4	2.0	9.2	0.4	-0.8	-3.0	-3.0	-0.5	-0.4	-0.8	-0.8	0.1	-0.1	0.1	-2.0	-1.3
Average weekly beer plus cider intake	2.0	2.9	7.3	-0.3	0.6	-2.5	-2.3	-1.2	-1.8	-2.0	-2.7	-1.9	-1.6	-1.7	-0.1	-1.1
Irritability	1.8	3.0	5.2	-0.1	1.5	-2.0	-2.1	-1.7	-2.2	-1.9	-0.8	-2.2	-2.3	-0.2	-1.5	-1.9
Risk taking	0.1	0.2	0.6	-0.3	-0.8	-0.5	-0.5	0.0	-0.3	-0.3	-0.4	-0.3	-0.4	0.1	-0.3	0.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	5.7	-0.2	-0.7	2.4	2.3	-1.0	-0.6	-0.5	-0.4	-0.5	-0.9	-0.3	0.2	0.4
Fractured/broken bones in last 5 years	0.6	0.8	4.5	0.4	-0.5	-0.3	-0.4	-1.4	-0.5	-0.5	-0.9	0.4	-0.1	-2.1	1.3	-0.6
Age started oral contraceptive pill	1.3	1.6	3.6	0.0	-1.5	1.1	0.9	-1.2	-1.9	-1.3	-1.1	-1.6	-1.9	-1.2	0.9	-0.3
Diastolic blood pressure, automated reading	3.9	12.2	25.6	-1.1	0.1	2.4	2.3	4.3	4.8	4.6	3.0	5.1	4.9	2.8	-2.9	3.0
Ever depressed for a whole week	0.6	0.7	2.9	1.0	1.2	-1.0	-1.2	-0.4	-0.6	-0.4	-0.2	-0.6	-0.4	-0.2	0.7	-1.7
Unable to work because of sickness or disability	0.4	0.5	2.1	0.4	0.0	-0.8	-0.5	0.5	-0.7	-0.9	-1.5	-0.7	-0.6	0.2	-0.9	-0.6
Commuting to job workplace: Cycle	0.6	0.7	2.0	1.1	-1.0	1.4	1.4	-0.7	0.3	-0.4	-0.1	0.1	0.1	0.3	1.3	1.0
Myopia	0.9	1.4	9.9	-1.1	1.0	1.2	1.1	-1.3	-0.3	-0.2	0.1	-0.3	-0.3	-0.7	3.1	0.8
Vascular/heart problems diagnosed by doctor	0.7	2.0	9.9	0.1	1.9	-0.8	-0.8	-1.7	-0.9	-1.1	-0.5	-1.3	-0.7	-3.1	1.8	-0.0
Cholesterol lowering medication	1.4	2.0	10.0	1.7	-2.9	-0.1	0.0	1.9	0.1	-0.4	0.3	-0.3	0.1	3.2	-0.9	-0.0
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	11.5	-0.2	0.1	-3.4	-3.4	0.2	-1.4	-1.4	-1.6	-1.7	-1.5	-0.9	-0.7	-1.7
Pain experienced in last month	1.5	2.6	11.0	-2.8	-0.6	3.3	3.3	-1.0	0.1	0.5	0.9	0.4	-0.0	-0.4	-0.9	0.3
Supplements: Calcium	0.8	0.8	4.0	1.3	0.5	-0.7	-0.7	-0.5	0.0	0.3	-0.0	0.4	0.2	-2.0	1.8	0.3
Basal cell carcinoma (self-reported)	0.3	0.4	2.3	1.5	0.2	-0.3	-0.3	-0.6	-0.0	-0.1	0.0	0.4	-0.1	0.4	0.4	1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.5	1.4	0.0	-0.6	-0.6	1.5	-0.4	-0.1	-0.3	-0.3	-0.4	1.9	0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.3	-0.5	-1.7	-0.7	-0.7	-0.6	-2.0	-2.3	-2.7	-1.9	-1.8	-1.1	1.0	-2.3
Heart disease (siblings)	1.1	1.4	2.6	-0.2	1.3	-1.3	-1.4	-1.6	0.9	0.9	1.3	1.3	0.8	-1.3	0.4	1.6
Alcohol drinker status: Previous	0.2	0.2	1.0	0.0	0.7	-0.1	-0.1	1.0	-0.2	-0.4	-0.0	0.1	-0.3	0.6	0.1	-0.2
Pack years of smoking	0.6	0.9	4.0	2.0	-0.1	-0.4	-0.3	1.0	0.5	0.7	0.8	0.7	0.5	1.6	-0.7	0.9
Impedance of whole body	1.0	5.2	11.7	0.5	-1.8	-0.1	-0.3	-1.7	-3.3	-3.3	-2.5	-3.1	-3.4	-0.8	-1.4	-3.1
Leg fat mass (left)	0.6	2.4	10.0	-1.2	1.3	-2.3	-2.4	-1.1	-1.0	-0.3	-1.7	-0.5	-0.7	-3.2	1.0	-0.7
Arm predicted mass (left)	0.4	2.2	11.4	-1.5	1.7	-1.7	-1.7	-1.6	0.1	0.3	-1.1	0.3	0.3	-3.4	1.5	0.7