TWAS
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Pulse rate, automated reading
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chr12:80,954,858-82,853,038
Best TWAS P=2.46e-12 · Best GWAS P=4.03e-12 conditioned to 1
81M
81.5M
82M
82.5M
0
2
4
6
8
10
12
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Lung
PPFIA2
0.13
0.10
lasso
3
0.09
2.9e-07
-6.9
-7.0
2.5e-12
0.96
0.01
0.99
TRUE
2
GTEx
Esophagus Muscularis
PPFIA2
0.12
0.14
lasso
3
0.14
1.1e-08
-6.9
-7.0
2.7e-12
0.99
0.01
0.99
FALSE
1
GTEx
Cells Transformed fibroblasts
PPFIA2
0.15
0.09
enet
19
0.07
3.4e-06
-6.9
-6.7
1.5e-11
0.91
0.01
0.99
FALSE
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
PPFIA2
0.11
0.08
enet
17
0.08
1.1e-09
-6.9
-6.6
4.9e-11
0.97
0.01
0.99
FALSE
4
GTEx
Nerve Tibial
PPFIA2
0.20
0.09
enet
36
0.08
2.1e-06
-6.6
-5.8
5.0e-09
0.78
0.03
0.97
FALSE