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chr12:109,591,369-111,699,146

Best TWAS P=8.18e-12 · Best GWAS P=1.36e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	-5.5	-5.4	7.1e-08	0.63	0.03	0.25	FALSE
2	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	-5.3	-6.0	1.6e-09	0.83	0.05	0.82	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	ARPC3	0.13	0.09	lasso	4	0.04	2.0e-02	-5.6	5.4	5.4e-08	-0.66	0.14	0.11	FALSE
4	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	-5.3	-5.4	5.9e-08	0.87	0.64	0.36	FALSE
5	GTEx	Esophagus Mucosa	VPS29	0.14	0.13	lasso	6	0.13	3.0e-09	-5.7	-6.0	2.5e-09	0.93	0.10	0.90	FALSE
6	GTEx	Esophagus Muscularis	VPS29	0.08	0.04	lasso	4	0.03	9.0e-03	-5.9	-6.1	9.9e-10	0.93	0.03	0.91	FALSE
7	GTEx	Esophagus Muscularis	IFT81	0.26	0.24	lasso	5	0.26	6.7e-16	-6.0	-6.0	2.5e-09	0.68	0.57	0.43	FALSE
8	GTEx	Esophagus Muscularis	ATP2A2	0.14	0.13	lasso	5	0.12	7.6e-08	-6.0	-5.4	5.4e-08	0.58	0.47	0.52	FALSE
9	GTEx	Lung	GPN3	0.08	0.08	enet	8	0.07	1.0e-05	-6.6	6.8	8.2e-12	-0.98	0.01	0.99	TRUE
10	GTEx	Muscle Skeletal	ARPC3	0.14	0.11	enet	23	0.10	2.2e-10	-5.6	5.6	1.6e-08	-0.78	0.74	0.26	FALSE
11	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	-5.3	-5.5	3.3e-08	0.86	0.45	0.53	FALSE
12	GTEx	Muscle Skeletal	IFT81	0.08	0.08	lasso	5	0.07	1.7e-07	-5.6	-5.2	1.7e-07	0.70	0.74	0.26	FALSE
13	GTEx	Muscle Skeletal	ANAPC7	0.08	0.01	lasso	3	0.00	1.1e-01	-5.8	-6.4	1.3e-10	0.92	0.02	0.83	FALSE
14	GTEx	Nerve Tibial	VPS29	0.05	0.01	lasso	4	0.00	2.5e-01	-5.7	-5.4	6.2e-08	0.88	0.05	0.56	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	-5.7	-6.3	3.9e-10	0.86	0.04	0.67	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ARPC3	0.13	0.15	lasso	3	0.15	1.9e-12	-5.6	5.6	1.7e-08	-0.69	0.79	0.21	FALSE
17	GTEx	Skin Sun Exposed Lower leg	VPS29	0.05	0.04	lasso	6	0.03	1.0e-03	-6.5	-6.3	3.1e-10	0.95	0.02	0.95	FALSE
18	GTEx	Spleen	VPS29	0.24	0.01	enet	14	0.04	2.9e-02	-6.1	-5.7	1.5e-08	0.83	0.04	0.52	FALSE
19	GTEx	Stomach	GLTP	0.25	0.19	lasso	5	0.18	4.2e-09	5.4	5.2	2.2e-07	-0.36	0.91	0.08	FALSE
20	GTEx	Testis	ARPC3	0.16	0.16	lasso	3	0.14	7.5e-07	-5.6	5.6	1.6e-08	-0.69	0.75	0.23	FALSE
21	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	-5.7	-5.9	4.2e-09	0.84	0.06	0.49	FALSE
22	GTEx	Whole Blood	GPN3	0.19	0.20	lasso	4	0.19	1.9e-17	-5.7	6.3	3.9e-10	-0.88	0.63	0.37	FALSE
23	METSIM	Adipose	GPN3	0.05	0.04	enet	17	0.04	1.1e-06	-5.7	6.0	2.1e-09	-0.83	0.11	0.89	FALSE
24	YFS	Blood	GLTP	0.05	0.01	enet	14	0.04	1.5e-13	-6.0	-6.3	3.5e-10	0.64	0.49	0.51	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	-5.7	-6.1	1.3e-09	0.90	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARPC3	0.03	0.01	blup	22	0.02	3.6e-03	-5.6	5.3	1.1e-07	-0.77	0.00	0.77	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VPS29	0.08	0.06	lasso	5	0.07	2.0e-08	-5.7	-5.6	2.5e-08	0.82	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLTP	0.07	0.06	lasso	5	0.05	2.8e-06	5.3	5.4	8.1e-08	-0.36	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	IFT81	0.05	0.01	blup	30	0.02	7.8e-04	-6.0	-5.5	3.9e-08	0.55	0.05	0.35	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAD9B	0.04	0.02	blup	29	0.03	4.9e-04	-5.6	-5.9	2.7e-09	0.88	0.02	0.77	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS29	0.06	0.06	enet	7	0.06	2.1e-07	-5.7	-5.5	5.0e-08	0.89	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	IFT81	0.02	0.02	blup	28	0.02	5.9e-03	-6.1	5.8	6.3e-09	-0.90	0.01	0.73	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	RAD9B	0.04	0.03	lasso	5	0.01	7.0e-03	-5.6	-5.9	4.4e-09	0.70	0.03	0.96	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP2A2	0.04	0.03	lasso	2	0.03	6.2e-04	-5.8	5.2	1.6e-07	-0.81	0.01	0.79	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	IFT81	0.06	0.09	lasso	1	0.09	3.8e-09	-6.1	6.1	9.8e-10	-0.91	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	RAD9B	0.10	0.06	enet	5	0.06	1.2e-06	-5.6	-5.6	1.7e-08	0.69	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	VPS29	0.10	0.10	enet	5	0.10	3.9e-10	-5.7	-5.3	1.2e-07	0.88	0.02	0.98	FALSE