Best TWAS P=4.49e-10 · Best GWAS P=4.61e-11 conditioned to 0.0271
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SDK1 | 0.18 | 0.12 | lasso | 8 | 0.14 | 9.4e-12 | 5.9 | -5.7 | 1.0e-08 | 0.90 | 0.11 | 0.89 | FALSE |
| 2 | GTEx | Esophagus Muscularis | SDK1 | 0.08 | 0.03 | lasso | 5 | 0.02 | 1.1e-02 | 6.4 | -6.2 | 4.5e-10 | 0.90 | 0.05 | 0.94 | TRUE |
| 3 | GTEx | Muscle Skeletal | SDK1 | 0.13 | 0.02 | lasso | 4 | 0.03 | 1.4e-03 | 5.9 | -5.7 | 9.7e-09 | 0.90 | 0.09 | 0.90 | FALSE |
| 4 | METSIM | Adipose | SDK1 | 0.09 | 0.07 | lasso | 15 | 0.11 | 3.9e-16 | -6.1 | -5.4 | 7.5e-08 | 0.75 | 0.08 | 0.92 | FALSE |