Hub : Traits :

Past tobacco smoking

150 significantly associated models · 49 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 44448632 45864710 1 1 4.3e-12 1.0e-11 1.0e+00 100 RP11-89K21.1
2 2 47224927 48727280 1 1 1.5e-07 8.6e-07 2.0e-02 78 MSH6
3 3 49634594 51032607 1 1 1.9e-07 9.2e-06 3.3e-01 95 NAT6
4 3 84317575 86808226 1 1 8.7e-17 2.1e-17 3.9e-02 94 CADM2
5 4 57080198 58531645 3 1 3.1e-08 2.3e-08 9.7e-02 91 REST
6 5 86867897 88427942 1 1 1.1e-07 5.0e-07 3.8e-01 97 TMEM161B-AS1
7 6 36751245 38162310 1 1 1.1e-07 1.3e-07 2.0e-02 80 CCDC167
8 6 110588546 112621834 5 3 1.3e-15 9.0e-18 3.4e-01 99 C6orf3 GTF3C6 RP5-1112D6.4
9 6 157013426 158435623 1 1 6.4e-08 6.8e-08 1.0e+00 100 TMEM242
10 7 1363454 1876081 1 1 1.4e-08 7.8e-09 2.4e-03 72 KIAA1908
11 7 2646223 5003373 1 1 4.5e-10 4.6e-11 2.7e-02 89 SDK1
12 7 98341025 99751521 1 1 9.3e-08 5.4e-07 7.1e-01 100 CPSF4
13 9 127218258 128824378 2 1 6.6e-08 2.2e-07 9.4e-03 75 PRPS1P2
14 10 103527782 105897979 14 2 1.4e-14 4.3e-13 5.9e-01 99 C10orf32 TMEM180
15 11 112135760 113846006 1 1 4.7e-09 5.1e-36 1.2e-28 21 NCAM1
16 12 111193499 113137832 3 1 3.2e-08 2.1e-11 1.7e-05 59 ATXN2
17 15 66850204 68789191 3 1 8.4e-09 2.6e-08 7.0e-02 89 MAP2K5
18 16 30347731 31720486 1 1 2.1e-07 7.6e-05 5.5e-03 51 STX1B
19 16 69062879 70473934 2 1 4.8e-10 2.7e-09 6.1e-01 99 NOB1
20 17 1517914 2918626 1 1 1.4e-07 5.2e-07 1.0e+00 100 SRR
21 18 20393480 21863589 1 1 2.4e-07 3.2e-07 1.4e-01 92 NPC1
22 20 30591354 32029439 1 1 2.9e-07 1.5e-06 1.9e-04 40 COMMD7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.43 2 0 0.0 0.00 1.0e+00 C10orf32 TMEM180
Depressed Affect (Nagel 2018) 1.45 2 0 0.0 0.00 1.0e+00 ATXN2 NCAM1
Intelligence (Savage-Jansen 2018) 1.28 1 0 0.0 0.00 1.0e+00 NAT6
Schizophrenia (2018) 1.66 2 0 0.0 0.00 1.0e+00 C10orf32 TMEM180
Worry (Nagel 2018) 3.96 5 1 2.2 0.79 1.1e-01 C10orf32 CADM2 PRPS1P2 STX1B TMEM180
Irritable Bowel Disease (IBD) 1.55 1 0 0.0 0.00 1.0e+00 C6orf3
Ulcerative Colitis (UC) 2.03 2 1 2.2 0.00 1.0e+00 C6orf3 NAT6
Reaction Time 2.67 2 1 2.2 0.00 1.0e+00 ATXN2 COMMD7
Age at First Birth 1.77 1 0 0.0 0.00 1.0e+00 NAT6
Body Mass Index (BMI) (2010) 2.90 2 1 2.2 0.00 1.0e+00 MAP2K5 NPC1
Coronary Artery Disease (CAD) 1.52 1 0 0.0 0.00 1.0e+00 ATXN2
HbA1C 1.55 1 0 0.0 0.00 1.0e+00 ATXN2
LDL Cholesterol 1.21 1 1 2.2 0.00 1.0e+00 ATXN2
Lupus 1.74 2 0 0.0 0.00 1.0e+00 ATXN2 STX1B
Primary Biliary Cirrhosis 1.57 1 0 0.0 0.00 1.0e+00 ATXN2
Schizophrenia (2014) 1.52 2 0 0.0 0.00 1.0e+00 C10orf32 TMEM161B-AS1
Ulcerative Colitis 2.12 2 0 0.0 0.00 1.0e+00 C6orf3 COMMD7
Blood Eosinophil Count 5.35 3 2 4.4 0.00 1.0e+00 ATXN2 NAT6 REST
Blood Platelet Count 0.99 11 3 6.7 -0.38 2.4e-01 ATXN2 C10orf32 COMMD7 CPSF4 MSH6 NOB1 REST STX1B TMEM161B-AS1 TMEM180 TMEM242
Blood Red Count 1.75 6 4 8.9 0.19 7.2e-01 ATXN2 COMMD7 GTF3C6 MAP2K5 NAT6 RP5-1112D6.4
Blood White Count 3.51 5 3 6.7 -0.93 2.2e-02 ATXN2 C10orf32 CPSF4 REST SRR
Heel T-Score 1.37 6 2 4.4 -0.53 2.8e-01 C10orf32 MSH6 NCAM1 NOB1 REST SRR
BMI 4.23 10 6 13.3 -0.45 1.9e-01 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Height 0.78 12 3 6.7 -0.17 6.0e-01 ATXN2 C10orf32 C6orf3 CCDC167 CPSF4 NAT6 NCAM1 NOB1 PRPS1P2 REST SRR TMEM180
Waist Hip Ratio (WHR) 1.16 3 0 0.0 0.00 1.0e+00 MSH6 NAT6 PRPS1P2
Systolic Blood Pressure 2.87 5 3 6.7 0.37 5.4e-01 ATXN2 CADM2 NCAM1 NOB1 SRR
Smoking Status 16.16 23 17 37.8 -0.99 7.3e-18 C10orf32 C6orf3 CADM2 CCDC167 COMMD7 CPSF4 GTF3C6 KIAA1908 MAP2K5 MSH6 NAT6 NCAM1 NOB1 PRPS1P2 REST RP11-89K21.1 RP5-1112D6.4 SDK1 SRR STX1B TMEM161B-AS1 TMEM180 TMEM242
Allergy or Eczema 1.92 5 0 0.0 0.69 1.9e-01 ATXN2 C10orf32 CPSF4 SRR TMEM180
Cardiovascular Disease 2.46 4 2 4.4 0.00 1.0e+00 ATXN2 MAP2K5 NPC1 TMEM161B-AS1
Hypothyroidism (self reported) 3.37 1 1 2.2 0.00 1.0e+00 ATXN2
Respiratory disease 1.29 1 0 0.0 0.00 1.0e+00 REST
Type 2 Diabetes (T2D) (2018) 1.80 2 0 0.0 0.00 1.0e+00 ATXN2 CPSF4
Lung FEV1/FVC ratio 0.87 3 0 0.0 0.00 1.0e+00 COMMD7 MSH6 REST
Lung FVC 1.85 7 4 8.9 0.04 9.3e-01 C6orf3 MAP2K5 MSH6 NOB1 PRPS1P2 REST STX1B
Neuroticism 2.10 3 0 0.0 0.00 1.0e+00 CADM2 MAP2K5 PRPS1P2
Chronotype (morning person) 2.20 4 0 0.0 -0.02 9.8e-01 ATXN2 CPSF4 NCAM1 TMEM161B-AS1
Hair Pigment 0.17 3 0 0.0 0.00 1.0e+00 ATXN2 MSH6 REST
Tanning 0.73 4 1 2.2 -0.95 4.6e-02 ATXN2 CADM2 COMMD7 KIAA1908
Hand grip strength (left) 3.09 5 2 4.4 -0.64 2.4e-01 C10orf32 CADM2 NOB1 PRPS1P2 TMEM180
Number of treatments/medications taken 2.02 2 1 2.2 0.00 1.0e+00 ATXN2 COMMD7
Sensitivity / hurt feelings 0.98 1 0 0.0 0.00 1.0e+00 PRPS1P2
Relative age of first facial hair 1.61 2 0 0.0 0.00 1.0e+00 NAT6 NPC1
Systolic blood pressure, automated reading 2.39 2 2 4.4 0.00 1.0e+00 ATXN2 SRR
Angina 1.38 1 0 0.0 0.00 1.0e+00 NOB1
Impedance of leg (right) 2.57 10 4 8.9 0.21 5.7e-01 CADM2 COMMD7 CPSF4 MAP2K5 NAT6 NCAM1 NOB1 PRPS1P2 SRR TMEM161B-AS1
Leg fat-free mass (left) 2.41 9 4 8.9 -0.34 3.7e-01 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 STX1B TMEM161B-AS1 TMEM180
Trunk fat percentage 2.56 8 2 4.4 -0.40 3.2e-01 C6orf3 CPSF4 GTF3C6 MAP2K5 NOB1 NPC1 STX1B TMEM161B-AS1
Hand grip strength (right) 2.34 4 1 2.2 0.12 8.8e-01 CADM2 NOB1 PRPS1P2 TMEM180
Townsend deprivation index at recruitment 2.62 2 0 0.0 0.00 1.0e+00 MAP2K5 PRPS1P2
Current tobacco smoking 4.95 5 2 4.4 -0.96 1.0e-02 C10orf32 GTF3C6 NCAM1 PRPS1P2 RP11-89K21.1
Maternal smoking around birth 4.30 3 1 2.2 0.00 1.0e+00 C10orf32 GTF3C6 RP5-1112D6.4
Fed-up feelings 1.16 1 0 0.0 0.00 1.0e+00 ATXN2
Taking other prescription medications 2.48 1 1 2.2 0.00 1.0e+00 ATXN2
Age when periods started (menarche) 2.81 5 1 2.2 0.29 6.4e-01 MAP2K5 MSH6 NAT6 NOB1 PRPS1P2
Heel bone mineral density (BMD) T-score, automated (left) 1.11 1 0 0.0 0.00 1.0e+00 REST
Qualifications: CSEs or equivalent 1.86 1 0 0.0 0.00 1.0e+00 COMMD7
High blood pressure 2.56 4 2 4.4 -0.79 2.1e-01 ATXN2 MAP2K5 SRR TMEM161B-AS1
Medication: Atenolol 1.98 1 1 2.2 0.00 1.0e+00 ATXN2
Medication: Levothyroxine sodium 3.07 1 1 2.2 0.00 1.0e+00 ATXN2
Sitting height 0.82 5 0 0.0 -0.52 3.7e-01 C10orf32 CPSF4 NCAM1 PRPS1P2 TMEM180
Chronic bronchitis/emphysema (father) 1.74 1 0 0.0 0.00 1.0e+00 MAP2K5
Body mass index (BMI) 4.19 11 6 13.3 -0.53 9.5e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Impedance of leg (left) 2.65 10 3 6.7 0.17 6.4e-01 CADM2 COMMD7 CPSF4 MAP2K5 NAT6 NOB1 PRPS1P2 SDK1 SRR TMEM161B-AS1
Leg predicted mass (left) 2.44 9 4 8.9 -0.34 3.8e-01 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 STX1B TMEM161B-AS1 TMEM180
Trunk fat mass 2.85 8 2 4.4 -0.38 3.5e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NPC1 STX1B TMEM161B-AS1
Waist circumference 3.57 9 4 8.9 -0.52 1.5e-01 C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NOB1 NPC1 STX1B TMEM161B-AS1
Number of incorrect matches in round 0.99 1 0 0.0 0.00 1.0e+00 C10orf32
Nervous feelings 4.08 5 1 2.2 0.82 9.1e-02 C10orf32 CADM2 PRPS1P2 SRR TMEM180
Hearing difficulty/problems with background noise 2.02 1 0 0.0 0.00 1.0e+00 NPC1
Had other major operations 1.89 1 0 0.0 0.00 1.0e+00 NPC1
Forced vital capacity (FVC) 1.74 4 1 2.2 -0.41 5.9e-01 C10orf32 NOB1 PRPS1P2 REST
Heel bone mineral density (BMD) T-score, automated (right) 1.22 2 0 0.0 0.00 1.0e+00 NCAM1 REST
Qualifications: None of the above 1.50 1 0 0.0 0.00 1.0e+00 NAT6
Mouth/teeth dental problems 1.38 1 0 0.0 0.00 1.0e+00 PRPS1P2
Heart attack 2.58 2 0 0.0 0.00 1.0e+00 ATXN2 NOB1
Allergy 1.34 1 0 0.0 0.00 1.0e+00 SRR
Medication: Ramipril 1.70 2 0 0.0 0.00 1.0e+00 ATXN2 NPC1
Illnesses of siblings 1.77 1 0 0.0 0.00 1.0e+00 ATXN2
Neuroticism score 1.76 1 0 0.0 0.00 1.0e+00 PRPS1P2
Weight 3.10 9 4 8.9 -0.53 1.4e-01 C10orf32 C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NPC1 STX1B TMEM161B-AS1
Impedance of arm (right) 2.85 5 2 4.4 0.93 2.2e-02 CADM2 CPSF4 MAP2K5 NAT6 STX1B
Arm fat percentage (right) 3.30 11 3 6.7 -0.41 2.1e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Trunk fat-free mass 2.05 9 4 8.9 -0.44 2.4e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST TMEM180
Hip circumference 3.12 10 5 11.1 -0.40 2.5e-01 ATXN2 C10orf32 C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NPC1 STX1B TMEM161B-AS1
Alcohol intake versus 10 years previously 2.26 2 0 0.0 0.00 1.0e+00 C10orf32 NPC1
Father's age at death 2.12 2 0 0.0 0.00 1.0e+00 ATXN2 CCDC167
Worrier / anxious feelings 4.57 5 1 2.2 0.99 2.0e-03 C10orf32 CADM2 GTF3C6 STX1B TMEM180
Number of live births 2.05 2 1 2.2 0.00 1.0e+00 CADM2 NAT6
Forced expiratory volume in 1-second (FEV1) 2.00 4 2 4.4 0.48 5.2e-01 NOB1 PRPS1P2 REST RP11-89K21.1
Pulse rate 2.09 1 0 0.0 0.00 1.0e+00 NAT6
Qualifications: A levels/AS levels or equivalent 1.71 2 0 0.0 0.00 1.0e+00 CADM2 NAT6
Mouth/teeth dental problems: Dentures 1.84 1 0 0.0 0.00 1.0e+00 NAT6
Forced expiratory volume in 1-second (FEV1), Best measure 1.60 3 0 0.0 0.00 1.0e+00 NOB1 PRPS1P2 REST
Impedance of arm (left) 2.93 7 2 4.4 0.94 1.5e-03 CADM2 CPSF4 MAP2K5 NAT6 REST STX1B TMEM180
Arm fat mass (right) 3.63 11 5 11.1 -0.47 1.5e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Trunk predicted mass 2.03 9 4 8.9 -0.43 2.5e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST TMEM180
Standing height 0.78 6 1 2.2 -0.15 7.8e-01 ATXN2 C10orf32 CPSF4 NCAM1 PRPS1P2 TMEM180
Tense / 'highly strung' 1.36 1 0 0.0 0.00 1.0e+00 CADM2
Hair/balding pattern: Pattern 4 1.77 3 1 2.2 0.00 1.0e+00 C6orf3 MSH6 SRR
Birth weight of first child 1.67 1 1 2.2 0.00 1.0e+00 ATXN2
Peak expiratory flow (PEF) 1.78 3 1 2.2 0.00 1.0e+00 C10orf32 PRPS1P2 REST
Pulse wave reflection index 2.46 1 0 0.0 0.00 1.0e+00 NAT6
Blood clot in the leg (DVT) 1.72 1 0 0.0 0.00 1.0e+00 ATXN2
Medication: Paracetamol 1.77 1 0 0.0 0.00 1.0e+00 COMMD7
Headache pain in last month 1.75 1 0 0.0 0.00 1.0e+00 MAP2K5
Medication for cholesterol, blood pressure or diabetes 2.11 1 0 0.0 0.00 1.0e+00 ATXN2
Gout (self-reported) 1.66 1 0 0.0 0.00 1.0e+00 ATXN2
Hypothyroidism/myxoedema (self-reported) 2.90 1 1 2.2 0.00 1.0e+00 ATXN2
Birth weight 1.80 2 1 2.2 0.00 1.0e+00 ATXN2 SRR
Forced vital capacity (FVC), Best measure 1.47 4 0 0.0 0.59 4.1e-01 MSH6 NOB1 PRPS1P2 REST
Body fat percentage 2.96 7 2 4.4 -0.37 4.1e-01 C6orf3 CPSF4 GTF3C6 MAP2K5 NPC1 STX1B TMEM161B-AS1
Leg fat percentage (right) 3.20 9 3 6.7 -0.67 4.7e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP5-1112D6.4 STX1B
Arm fat-free mass (right) 2.69 10 5 11.1 -0.47 1.7e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180
Exposure to tobacco smoke outside home 2.31 2 0 0.0 0.00 1.0e+00 C10orf32 NAT6
Comparative body size at age 10 4.32 6 5 11.1 0.03 9.6e-01 CADM2 MAP2K5 NAT6 NPC1 SRR TMEM161B-AS1
Number of full brothers 1.99 1 0 0.0 0.00 1.0e+00 CADM2
Worry too long after embarrassment 2.42 2 0 0.0 0.00 1.0e+00 CADM2 MAP2K5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.57 1 0 0.0 0.00 1.0e+00 PRPS1P2
Number of children fathered 2.57 1 1 2.2 0.00 1.0e+00 CADM2
Age at first live birth 1.68 1 0 0.0 0.00 1.0e+00 NAT6
Shortness of breath walking on level ground 2.00 1 0 0.0 0.00 1.0e+00 COMMD7
Qualifications: College or University degree 2.41 5 2 4.4 0.60 2.9e-01 C10orf32 CADM2 NAT6 NPC1 SDK1
Mouth/teeth dental problems: Loose teeth 1.52 1 0 0.0 0.00 1.0e+00 TMEM180
Medication for pain relief, constipation, heartburn 2.18 1 0 0.0 0.00 1.0e+00 COMMD7
Medication: Blood pressure 2.26 1 1 2.2 0.00 1.0e+00 ATXN2
Angina (self-reported) 1.33 1 0 0.0 0.00 1.0e+00 NOB1
Medication: Allopurinol 1.63 1 0 0.0 0.00 1.0e+00 ATXN2
Mean time to correctly identify matches 2.38 2 1 2.2 0.00 1.0e+00 ATXN2 COMMD7
Whole body fat mass 3.39 9 4 8.9 -0.47 2.0e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 STX1B TMEM161B-AS1
Leg fat mass (right) 3.93 8 5 11.1 -0.66 7.7e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 STX1B
Arm predicted mass (right) 2.67 10 4 8.9 -0.47 1.7e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180
Pulse rate, automated reading 2.07 4 1 2.2 0.57 4.3e-01 CPSF4 MSH6 NAT6 TMEM161B-AS1
Alcohol intake frequency. 3.29 4 2 4.4 0.90 9.5e-02 CADM2 NPC1 REST RP11-89K21.1
Comparative height size at age 10 0.83 3 0 0.0 0.00 1.0e+00 ATXN2 NAT6 TMEM180
Number of full sisters 2.25 1 1 2.2 0.00 1.0e+00 CADM2
Suffer from 'nerves' 2.65 1 1 2.2 0.00 1.0e+00 CADM2
Overall health rating 1.88 2 0 0.0 0.00 1.0e+00 NPC1 PRPS1P2
Age at last live birth 1.59 1 0 0.0 0.00 1.0e+00 NAT6
Qualifications: NVQ or HND or HNC or equivalent 2.38 2 0 0.0 0.00 1.0e+00 ATXN2 SDK1
Medication: Aspirin 1.72 1 0 0.0 0.00 1.0e+00 ATXN2
Hypertension (Self-reported) 2.34 3 1 2.2 0.00 1.0e+00 ATXN2 MAP2K5 SRR
Smoking status: Previous 15.57 23 6 13.3 -0.99 8.2e-21 ATXN2 C10orf32 C6orf3 CADM2 CCDC167 COMMD7 GTF3C6 KIAA1908 MAP2K5 MSH6 NAT6 NCAM1 NOB1 NPC1 REST RP11-89K21.1 RP5-1112D6.4 SDK1 SRR STX1B TMEM161B-AS1 TMEM180 TMEM242
Forced expiratory volume in 1-second (FEV1), predicted 0.93 1 0 0.0 0.00 1.0e+00 SDK1
Whole body fat-free mass 2.20 10 4 8.9 -0.44 2.0e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180
Leg fat-free mass (right) 2.23 9 3 6.7 -0.34 3.7e-01 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 STX1B TMEM161B-AS1 TMEM180
Arm fat percentage (left) 3.28 11 3 6.7 -0.41 2.1e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Average weekly red wine intake 3.09 1 1 2.2 0.00 1.0e+00 NPC1
Mood swings 1.00 1 0 0.0 0.00 1.0e+00 ATXN2
Loneliness, isolation 1.81 1 0 0.0 0.00 1.0e+00 KIAA1908
Long-standing illness, disability or infirmity 3.14 2 0 0.0 0.00 1.0e+00 GTF3C6 RP5-1112D6.4
Friendships satisfaction 1.52 1 0 0.0 0.00 1.0e+00 NPC1
Qualifications: nursing, teaching 1.67 2 0 0.0 0.00 1.0e+00 CADM2 SDK1
Medication for cholesterol 1.35 1 0 0.0 0.00 1.0e+00 ATXN2
Medication: Aspirin 1.61 1 0 0.0 0.00 1.0e+00 ATXN2
Illnesses of father: None of the above (group 1) 1.46 1 0 0.0 0.00 1.0e+00 ATXN2
Smoking status: Current 5.21 6 2 4.4 -0.97 1.8e-03 C10orf32 CADM2 GTF3C6 NCAM1 PRPS1P2 RP11-89K21.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.08 3 0 0.0 0.00 1.0e+00 PRPS1P2 REST STX1B
Whole body water mass 2.25 10 4 8.9 -0.43 2.1e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180
Leg predicted mass (right) 2.23 9 3 6.7 -0.34 3.7e-01 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 STX1B TMEM161B-AS1 TMEM180
Arm fat mass (left) 3.67 10 5 11.1 -0.55 1.0e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 STX1B TMEM161B-AS1
Number of self-reported non-cancer illnesses 2.34 2 1 2.2 0.00 1.0e+00 ATXN2 MAP2K5
Miserableness 1.22 1 0 0.0 0.00 1.0e+00 NCAM1
Wears glasses or contact lenses 2.22 2 0 0.0 0.00 1.0e+00 CADM2 NPC1
Commuting to job workplace: Public transport 1.62 1 0 0.0 0.00 1.0e+00 CADM2
Eye problems/disorders: Glaucoma 1.16 1 0 0.0 0.00 1.0e+00 MAP2K5
Medication: Blood pressure 1.65 1 1 2.2 0.00 1.0e+00 ATXN2
Supplements: Fish oil (including cod liver oil) 1.42 1 0 0.0 0.00 1.0e+00 CPSF4
Medication: Bendroflumethiazide 1.43 1 0 0.0 0.00 1.0e+00 ATXN2
Medication: Paracetamol 1.32 1 0 0.0 0.00 1.0e+00 COMMD7
Alcohol drinker status: Never 2.01 1 0 0.0 0.00 1.0e+00 CADM2
Ever smoked 16.05 25 11 24.4 -0.99 1.8e-24 ATXN2 C10orf32 C6orf3 CADM2 CCDC167 COMMD7 CPSF4 GTF3C6 KIAA1908 MAP2K5 MSH6 NAT6 NCAM1 NOB1 NPC1 PRPS1P2 REST RP11-89K21.1 RP5-1112D6.4 SDK1 SRR STX1B TMEM161B-AS1 TMEM180 TMEM242
Basal metabolic rate 2.43 9 5 11.1 -0.35 3.6e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 STX1B TMEM180
Leg fat percentage (left) 3.29 9 3 6.7 -0.67 4.7e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP5-1112D6.4 STX1B
Arm fat-free mass (left) 2.73 10 4 8.9 -0.46 1.9e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180
Number of operations (self-reported) 1.33 1 0 0.0 0.00 1.0e+00 NAT6
Average weekly beer plus cider intake 2.82 3 0 0.0 0.00 1.0e+00 CADM2 NAT6 RP11-89K21.1
Irritability 1.57 1 0 0.0 0.00 1.0e+00 C10orf32
Risk taking 4.59 4 1 2.2 -0.95 5.1e-02 C10orf32 CADM2 RP11-89K21.1 TMEM242
Age started oral contraceptive pill 2.82 2 0 0.0 0.00 1.0e+00 CADM2 NPC1
Diastolic blood pressure, automated reading 3.41 4 2 4.4 -0.74 2.6e-01 ATXN2 C10orf32 MAP2K5 SRR
Vascular/heart problems diagnosed by doctor 2.83 4 2 4.4 0.85 1.5e-01 ATXN2 MAP2K5 SRR TMEM161B-AS1
Pain experienced in last month 2.87 3 0 0.0 0.00 1.0e+00 ATXN2 COMMD7 PRPS1P2
Heart attack/myocardial infarction (self-reported) 2.47 2 0 0.0 0.00 1.0e+00 ATXN2 NOB1
Impedance of whole body 2.92 7 3 6.7 0.71 7.4e-02 CADM2 CPSF4 MAP2K5 NAT6 PRPS1P2 STX1B TMEM180
Leg fat mass (left) 3.93 9 5 11.1 -0.68 4.2e-02 C10orf32 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 STX1B
Arm predicted mass (left) 2.75 10 4 8.9 -0.45 1.9e-01 ATXN2 C10orf32 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST STX1B TMEM180

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.115 1.9
GTEx Adipose Visceral Omentum 2 0.098 2.0
GTEx Adrenal Gland 1 0.069 1.8
GTEx Artery Aorta 1 0.034 1.9
GTEx Artery Coronary 2 0.169 2.0
GTEx Artery Tibial 5 0.133 1.9
GTEx Brain Caudate basal ganglia 0 0.000 1.9
GTEx Brain Cerebellar Hemisphere 2 0.134 2.1
GTEx Brain Cerebellum 7 0.353 2.1
GTEx Brain Cortex 1 0.097 2.1
GTEx Brain Frontal Cortex BA9 0 0.000 2.0
GTEx Brain Hippocampus 1 0.191 2.1
GTEx Brain Hypothalamus 2 0.339 2.1
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.9
GTEx Brain Putamen basal ganglia 0 0.000 1.7
GTEx Breast Mammary Tissue 0 0.000 2.0
GTEx Breast Mammary Tissue (Male) 0 0.000 1.8
GTEx Breast Mammary Tissue (Female) 1 0.061 1.9
GTEx Cells EBV-transformed lymphocytes 2 0.141 2.0
GTEx Cells Transformed fibroblasts 1 0.024 1.9
GTEx Colon Sigmoid 0 0.000 1.9
GTEx Colon Transverse 1 0.048 2.0
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.9
GTEx Esophagus Mucosa 1 0.030 1.8
GTEx Esophagus Muscularis 3 0.093 1.9
GTEx Heart Atrial Appendage 1 0.063 1.9
GTEx Heart Left Ventricle 1 0.065 1.9
GTEx Liver 2 0.279 2.0
GTEx Lung 1 0.035 2.0
GTEx Muscle Skeletal 3 0.104 1.9
GTEx Nerve Tibial 3 0.069 1.9
GTEx Ovary 0 0.000 2.1
GTEx Pancreas 1 0.061 2.0
GTEx Pituitary 1 0.090 2.0
GTEx Prostate 1 0.120 2.0
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 2.0
GTEx Skin Sun Exposed Lower leg 4 0.110 1.9
GTEx Small Intestine Terminal Ileum 0 0.000 2.0
GTEx Spleen 1 0.071 2.0
GTEx Stomach 1 0.069 1.9
GTEx Testis 2 0.063 1.9
GTEx Thyroid 2 0.050 1.9
GTEx Uterus 1 0.176 2.0
GTEx Vagina 0 0.000 1.8
GTEx Whole Blood 0 0.000 2.0
METSIM Adipose 9 0.195 1.8
NTR Blood 5 0.208 1.7
ROSMAP Brain Pre-frontal Cortex 5 0.114 1.8
YFS Blood 1 0.022 1.7
CommonMind Brain Pre-frontal Cortex 11 0.205 1.8
The Cancer Genome Atlas Bladder Urothelial Carcinoma 3 0.181 1.7
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.7
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.8
The Cancer Genome Atlas Colon Adenocarcinoma 3 0.145 1.7
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 3 0.294 1.8
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.7
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.049 1.7
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.8
The Cancer Genome Atlas Brain Lower Grade Glioma 4 0.093 1.8
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.7
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.7
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 3 0.188 1.8
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.8
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 4 0.301 1.8
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.065 1.7
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.6
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.7
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.7
The Cancer Genome Atlas Thyroid Carcinoma 7 0.136 1.7
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4