Best TWAS P=8.7e-17 · Best GWAS P=2.12e-17 conditioned to 0.0393
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | -6.9 | -6.6 | 3.3e-11 | 0.67 | 0.95 | 0.05 | FALSE |
| 2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | 5.6 | 6.8 | 7.3e-12 | -0.46 | 0.07 | 0.06 | FALSE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | -8.1 | -8.3 | 8.7e-17 | 0.93 | 0.03 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | -8.1 | -8.0 | 1.7e-15 | 0.94 | 0.05 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | -8.3 | -6.2 | 6.0e-10 | 0.84 | 0.06 | 0.76 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CADM2 | 0.05 | 0.00 | blup | 339 | 0.02 | 3.2e-03 | -2.6 | -6.4 | 1.8e-10 | 0.67 | 0.04 | 0.51 | FALSE |