Best TWAS P=3.41e-09 · Best GWAS P=1.05e-06 conditioned to 0.482
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | STAG3L2 | 0.16 | 0.03 | enet | 11 | 0.09 | 1.0e-07 | 3.7 | -5.5 | 4.5e-08 | -0.70 | 0.05 | 0.90 | FALSE |
| 2 | GTEx | Brain Cerebellum | PMS2P5 | 0.62 | 0.08 | lasso | 6 | 0.22 | 3.3e-07 | 3.7 | -5.6 | 2.8e-08 | -0.69 | 0.02 | 0.74 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | PMS2P5 | 0.27 | 0.00 | enet | 20 | 0.03 | 6.6e-02 | 3.7 | -5.5 | 4.9e-08 | -0.62 | 0.01 | 0.26 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | PMS2P5 | 0.23 | 0.19 | lasso | 2 | 0.18 | 5.4e-07 | 4.8 | -5.3 | 9.8e-08 | -0.75 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Nerve Tibial | PMS2P5 | 0.16 | 0.04 | enet | 34 | 0.08 | 3.5e-06 | 3.7 | -5.6 | 2.3e-08 | -0.67 | 0.02 | 0.93 | FALSE |
| 6 | GTEx | Nerve Tibial | STAG3L2 | 0.36 | 0.09 | enet | 13 | 0.24 | 9.5e-17 | 3.7 | -5.9 | 3.4e-09 | -0.75 | 0.05 | 0.91 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | STAG3L2 | 0.15 | 0.05 | enet | 8 | 0.08 | 2.8e-07 | 3.7 | -5.7 | 9.4e-09 | -0.72 | 0.06 | 0.74 | FALSE |