Best TWAS P=1.48e-09 · Best GWAS P=8.58e-11 conditioned to 0.000524
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | HTT | 0.22 | 0.02 | lasso | 9 | 0.06 | 1.3e-06 | -5.3 | -5.4 | 8.0e-08 | -0.61 | 0.44 | 0.42 | FALSE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf44 | 0.03 | 0.02 | blup | 42 | 0.02 | 8.0e-04 | -4.6 | 6.0 | 1.5e-09 | 0.63 | 0.27 | 0.25 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf44 | 0.03 | 0.04 | lasso | 4 | 0.05 | 2.9e-06 | -4.6 | 5.6 | 2.1e-08 | 0.62 | 0.52 | 0.41 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C4orf44 | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.0e-04 | -5.2 | 5.2 | 2.5e-07 | 0.34 | 0.36 | 0.56 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | C4orf44 | 0.15 | 0.20 | lasso | 4 | 0.20 | 2.9e-19 | -5.1 | 5.2 | 1.9e-07 | 0.41 | 0.50 | 0.50 | FALSE |