Hub : Genes

HTT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2380 0.0840 2.4e-03 0.124 NA 0.072 NA 0.072 0.00008 NA 2.4e-03 NA 2.4e-03
2 GTEx Cells Transformed fibroblasts 0.0940 0.0360 1.5e-03 -0.001 NA 0.018 NA -0.002 0.43000 NA 1.6e-02 NA 5.3e-01
3 GTEx Lung 0.0632 0.0285 5.7e-03 0.003 NA -0.003 NA -0.003 0.19000 NA 6.4e-01 NA 5.8e-01
4 GTEx Muscle Skeletal 0.2184 0.0565 2.9e-07 0.024 NA 0.056 NA 0.061 0.00170 NA 3.1e-06 NA 1.3e-06
5 GTEx Whole Blood 0.1030 0.0330 1.7e-04 -0.003 NA 0.027 NA 0.004 0.99000 NA 1.4e-03 NA 1.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 3.1 0.7 -0.1 0.1 -1.8 -0.2
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 0.5 0.4 0.6 -0.8 0.9
Depressed Affect (Nagel 2018) 2.1 4.4 10.7 3.2 0.3 0.5 -3.3 1.0
Depression (Nagel 2018) 3.9 5.9 9.6 2.3 1.6 2.1 -3.1 2.8
Intelligence (Savage-Jansen 2018) 0.9 2.7 9.7 0.8 0.1 -3.1 0.3 -1.7
Neuroticism (Nagel 2018) 0.8 2.0 4.7 2.2 -0.9 -0.8 -1.9 -0.6
Schizophrenia (2018) 0.2 0.5 1.6 0.1 0.7 0.6 0.3 1.3
Schizophrenia vs Biploar Disorder 0.9 1.2 2.2 -0.5 -1.4 1.3 0.0 1.5
Worry (Nagel 2018) 0.7 1.4 4.0 1.3 -0.6 -0.5 -2.0 -0.8
Alzheimer’s Disease (in mother) 0.5 0.6 1.5 -0.9 -1.2 -0.6 -0.3 0.5
Alzheimer’s Disease (in father) 2.1 2.3 5.4 2.3 1.4 -0.4 -1.2 1.6
Alzheimer’s Disease (including proxy) 0.8 1.2 4.9 0.0 -0.5 -0.3 -1.0 2.2
Crohns Disease (2017) 1.6 3.4 6.2 1.2 1.5 1.6 -2.5 2.2
Irritable Bowel Disease (IBD) 1.9 4.5 6.8 1.5 2.2 2.5 -1.7 2.6
Ulcerative Colitis (UC) 1.4 2.7 5.0 0.9 1.8 2.1 -0.2 2.2
Major Depression (MDD) 1.5 1.8 5.6 -1.2 2.4 0.5 -0.9 1.0
Reaction Time 2.5 4.7 11.0 0.1 0.0 -2.1 3.3 -2.9
Verbal and Numeric Reasoning (VNR) 1.1 2.6 7.3 0.6 -0.2 -2.7 0.2 -2.2
Breast Cancer 0.7 1.7 6.6 -2.6 -1.4 -0.1 0.2 -0.1
Ovarian Cancer 0.7 1.0 1.9 0.0 1.2 1.4 -0.9 0.8
Prostate Cancer 1.2 1.6 3.1 -1.1 -1.3 -1.4 0.5 -1.7
Age at First Birth 2.2 3.2 5.6 -1.0 -0.2 -2.0 2.3 -2.4
Bipolar Disorder (2011) 0.2 0.2 0.5 0.7 0.3 -0.6 -0.2 -0.0
Body Mass Index (BMI) (2010) 0.3 0.5 1.1 -0.1 -1.0 -1.0 -0.3 -0.3
Coronary Artery Disease (CAD) 0.5 0.6 1.5 0.5 1.2 -0.1 -0.5 1.0
Crohns Disease (2012) 1.8 2.9 5.1 1.7 2.3 1.0 -2.2 0.9
Mean Putamen Volume 0.9 1.1 2.1 1.4 1.4 -0.7 -0.3 -0.8
Fasting Glucose 0.6 0.7 2.3 0.2 -1.5 -0.6 0.3 -0.7
HbA1C 0.3 0.3 0.6 -0.7 -0.1 -0.5 0.8 -0.5
HDL Cholesterol 1.1 1.8 5.2 -0.2 0.4 -0.9 1.6 -2.3
LDL Cholesterol 1.9 2.9 4.4 2.1 1.6 1.6 -2.0 1.1
Lupus 0.9 1.4 2.2 1.4 0.9 -0.7 -1.5 1.2
Neuroticism (2016) 0.1 0.2 0.4 0.3 -0.6 -0.5 0.0 0.2
Primary Biliary Cirrhosis 0.7 1.0 3.3 0.5 -0.6 -0.4 -1.8 0.9
Rheumatoid Arthritis 1.2 1.6 4.6 2.1 1.2 -0.6 -1.3 -0.2
Schizophrenia (2014) 0.4 0.9 2.4 -0.2 0.2 1.3 -0.3 1.6
Triglycerides 1.8 3.0 9.6 0.9 0.9 1.4 -3.1 1.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.6 0.6 0.3 0.4 -1.6 0.6
Ulcerative Colitis 0.9 1.3 2.7 0.7 1.5 1.6 -0.6 0.9
Blood Eosinophil Count 0.4 3.0 7.8 -2.8 -1.6 2.1 -0.1 0.3
Blood Platelet Count 1.6 18.4 41.7 1.3 4.5 5.0 -6.5 1.6
Blood Red Count 0.1 1.1 3.9 -0.3 -0.6 1.0 -2.0 -0.5
Blood White Count 4.5 33.6 53.1 2.7 6.5 7.3 -5.9 5.5
Heel T-Score 0.1 1.1 2.0 -0.5 -1.2 -1.4 0.8 1.0
BMI 2.1 12.4 23.9 -0.8 0.6 4.9 -3.9 4.7
Height 0.7 14.4 34.2 0.1 -1.4 -4.6 5.8 -3.9
Waist Hip Ratio (WHR) 2.2 10.1 24.4 2.7 4.9 3.0 -1.5 2.7
Systolic Blood Pressure 2.1 10.3 24.2 4.9 4.6 1.6 -1.9 -0.2
Smoking Status 1.9 4.4 13.4 -2.3 0.2 3.7 -1.3 1.4
Allergy or Eczema 0.8 2.1 3.3 1.4 1.6 1.2 -1.0 1.8
Cardiovascular Disease 4.7 15.5 18.9 4.2 4.4 3.3 -3.7 4.0
Hypothyroidism (self reported) 0.7 1.6 2.7 -0.7 0.6 1.4 -1.6 1.6
Respiratory disease 2.8 6.3 11.7 1.9 1.5 3.4 -2.4 2.9
Type 2 Diabetes (T2D) (2018) 4.3 8.1 13.7 1.8 2.8 2.2 -3.7 3.3
Lung FEV1/FVC ratio 0.5 2.5 5.2 -0.8 -0.7 -2.2 2.3 -1.2
Lung FVC 2.1 10.7 22.9 0.7 -2.8 -4.6 0.7 -4.8
Neuroticism 0.6 1.5 3.7 1.9 -0.3 0.3 -1.9 -0.3
Chronotype (morning person) 1.8 4.2 12.4 -0.7 0.4 3.5 0.1 2.8
Hair Pigment 0.1 4.1 12.4 2.6 3.5 1.2 0.1 -0.4
Tanning 0.3 3.1 7.2 -1.4 -0.2 2.7 -2.5 0.5
Hand grip strength (left) 0.3 0.7 1.7 -0.8 -0.7 -1.3 -0.7 0.3
Number of treatments/medications taken 2.1 3.7 7.1 1.2 1.9 2.1 -2.7 1.3
Average weekly spirits intake 0.6 0.8 1.6 -0.6 -0.7 0.4 -1.2 1.3
Sensitivity / hurt feelings 0.7 1.1 3.3 1.2 -0.7 0.6 0.1 1.8
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.2 2.1 0.8 0.9 -1.5 1.6
Hearing difficulty/problems: Yes 5.2 7.9 16.9 2.9 4.1 1.9 -1.4 2.9
Relative age of first facial hair 0.8 1.6 6.4 0.3 -0.1 -2.5 0.4 -1.2
Other serious medical condition/disability diagnosed by doctor 2.9 3.7 12.4 1.6 0.3 1.3 -3.5 1.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 -1.1 0.0 -0.8 0.3 -0.8
Ever had hysterectomy (womb removed) 1.8 2.0 6.3 1.3 1.1 0.8 -2.5 -0.1
Systolic blood pressure, automated reading 2.5 7.3 13.4 3.7 3.0 1.7 -3.4 0.5
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 2.7 1.0 1.4 1.1 -1.4 1.6
Angina 4.1 5.3 10.0 0.9 3.1 3.2 -2.0 1.6
Medication for hormone replacement therapy 0.3 0.3 1.0 0.5 0.5 0.3 -0.4 1.0
Vitamin and mineral supplements 1.4 1.9 5.6 0.9 1.5 2.4 -0.7 0.6
Supplements: Zinc 0.4 0.4 1.7 -0.0 0.4 -0.5 1.3 0.2
Medication: Co-codamol 1.5 1.8 3.9 0.5 0.3 1.3 -1.7 2.0
Medication: Metformin 2.1 3.0 5.8 2.3 2.4 1.0 -1.3 1.0
Diabetes (father) 0.4 0.5 1.5 -0.7 0.5 0.4 -0.5 1.2
Diabetes (mother) 1.9 2.4 5.5 -0.9 0.4 2.4 -1.0 2.1
Severe depression (siblings) 1.5 1.7 5.7 2.4 1.6 -0.1 -0.2 -0.5
Pack years adult smoking proportion 5.5 8.3 15.6 1.0 2.5 3.9 -4.0 1.9
Impedance of leg (right) 0.6 3.1 7.2 -1.0 0.2 -2.7 1.1 -2.5
Leg fat-free mass (left) 0.5 2.4 8.8 0.0 -1.1 1.3 -0.4 3.0
Trunk fat percentage 3.7 14.8 30.8 0.1 2.4 5.0 -3.6 5.5
Hand grip strength (right) 0.1 0.3 0.5 0.6 -0.6 -0.7 -0.5 0.2
Townsend deprivation index at recruitment 0.8 1.1 2.4 -0.0 0.9 1.5 -0.4 1.4
Current tobacco smoking 2.6 4.3 10.3 -0.2 1.0 3.2 -2.1 2.3
Average weekly fortified wine intake 0.8 0.9 2.7 0.8 1.6 1.0 0.4 -0.5
Maternal smoking around birth 1.4 2.0 5.0 1.2 0.6 1.4 -1.0 2.2
Fed-up feelings 0.9 1.7 5.0 2.2 -0.2 0.1 -1.5 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.6 6.6 1.6 1.8 2.4 -2.6 2.4
Relative age voice broke 1.8 2.8 10.7 -0.9 -0.9 -3.3 -0.1 -1.3
Taking other prescription medications 3.4 5.2 7.7 0.4 1.9 2.7 -2.7 2.8
Age when periods started (menarche) 1.8 4.4 9.2 -1.1 -0.8 -2.4 2.3 -3.0
Bilateral oophorectomy (both ovaries removed) 1.8 2.0 5.3 1.3 1.0 0.8 -2.3 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 5.0 -2.2 -1.3 0.5 0.0 1.2
Tinnitus: Yes, but not now, but have in the past 2.2 2.4 5.5 -1.9 -2.3 -1.2 -0.9 -0.8
Qualifications: CSEs or equivalent 2.4 3.1 4.6 1.6 -0.2 2.0 -2.1 2.2
Serious illness, injury or assault to yourself 1.6 1.9 3.8 0.9 1.2 1.9 -0.4 1.8
High blood pressure 3.1 8.8 18.2 4.3 3.1 2.3 -2.5 2.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.5 1.5 1.5 1.1 -0.8 1.9
Multivitamins +/- minerals 1.3 1.7 3.3 -0.7 -1.8 -1.7 -1.1 -0.6
Stomach or abdominal pain in last month 3.0 3.7 7.0 0.4 1.2 2.6 -2.1 2.3
Supplements: Glucosamine 2.8 3.7 7.5 -1.9 -2.2 -2.7 1.4 -0.7
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 3.8 0.6 1.9 1.9 -1.5 1.1
Medication: Atenolol 0.7 0.8 2.5 0.7 1.6 1.0 -0.1 0.1
Medication: Levothyroxine sodium 0.8 1.3 3.0 -0.8 0.5 0.9 -1.7 1.4
Sitting height 1.0 7.1 13.8 0.3 -3.1 -3.7 2.8 -2.1
Chronic bronchitis/emphysema (father) 1.7 2.0 6.5 -1.7 -2.5 0.8 -0.1 0.4
High blood pressure (mother) 3.2 4.5 11.3 2.9 3.4 -0.0 -0.6 1.4
Body mass index (BMI) 4.7 19.9 40.5 -0.4 1.2 6.0 -4.7 6.4
Impedance of leg (left) 0.4 2.1 4.8 -0.3 0.9 -2.2 0.4 -2.1
Leg predicted mass (left) 0.5 2.4 8.8 0.1 -1.1 1.4 -0.4 3.0
Trunk fat mass 2.8 11.8 27.7 -0.0 1.5 4.4 -3.2 5.3
Waist circumference 3.6 13.3 26.5 0.5 2.3 4.9 -3.2 5.1
Number of incorrect matches in round 1.8 2.9 9.1 0.1 -0.3 -3.0 1.4 -1.8
Past tobacco smoking 0.9 1.7 3.8 1.7 -0.9 -1.9 -0.8 -0.4
Alcohol usually taken with meals 2.7 4.4 9.5 -1.1 -1.6 -3.1 2.1 -2.0
Nervous feelings 0.3 0.5 0.8 0.7 0.5 -0.7 0.9 -0.8
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 10.5 2.1 1.1 2.0 -3.2 2.8
Hearing difficulty/problems with background noise 1.1 1.7 4.3 2.1 2.0 0.1 0.1 0.5
Hair/balding pattern: Pattern 2 0.6 0.8 2.6 1.6 0.2 0.8 -0.8 -0.1
Had menopause 1.1 1.3 2.6 -1.6 -0.4 -1.6 0.2 -1.2
Had other major operations 0.7 0.8 2.2 -0.0 0.8 -0.3 1.1 -1.5
Forced vital capacity (FVC) 2.5 9.6 19.6 1.2 -2.2 -4.4 2.6 -3.9
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 2.9 -1.0 -0.5 -0.1 0.3 1.7
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 6.5 1.3 1.5 1.4 -2.5 0.5
Qualifications: None of the above 3.5 7.4 19.5 1.0 2.0 4.4 -2.8 2.1
Financial difficulties in last 2 years 2.7 3.6 7.1 -0.4 0.6 2.7 -1.8 2.7
Mouth/teeth dental problems 2.1 3.3 6.7 -0.5 -1.8 -2.6 1.6 -2.0
Heart attack 2.8 3.5 8.2 0.5 2.9 2.3 -1.0 1.7
Allergy 1.5 3.4 7.7 -1.2 -1.3 -2.1 1.1 -2.8
Pain all over the body in last month 2.5 2.7 4.0 1.0 1.8 2.0 -2.0 1.1
Diabetes (self-reported) 3.7 5.7 6.8 2.1 2.3 2.3 -2.6 2.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.8 -0.9 0.4 0.6 0.5 -0.2
Medication: Ramipril 3.7 4.8 8.9 3.0 3.0 1.5 -0.8 1.8
Medication: Simvastatin 4.2 6.2 13.7 2.7 2.3 1.3 -3.7 1.7
Fluid intelligence score 0.8 1.6 5.4 0.8 -0.3 -1.2 -0.7 -2.3
Illnesses of siblings 8.2 11.5 29.5 -2.2 -3.5 -2.6 2.1 -5.4
Neuroticism score 1.0 2.1 5.1 2.3 0.3 1.2 -1.6 1.0
Weight 1.4 6.9 20.4 -0.5 -0.4 3.0 -2.1 4.5
Impedance of arm (right) 1.0 4.9 11.0 -0.9 0.1 -3.1 3.3 -1.8
Arm fat percentage (right) 4.3 17.1 38.7 -0.5 1.6 5.4 -3.8 6.2
Trunk fat-free mass 0.3 2.0 8.1 -0.4 -2.8 -1.1 0.7 0.2
Hip circumference 1.0 4.2 9.7 -1.2 -1.0 2.6 -1.6 3.1
Time employed in main current job 0.8 0.9 3.0 0.2 0.1 1.7 -1.3 -0.0
Alcohol intake versus 10 years previously 1.4 2.0 4.4 -0.4 2.1 1.1 -0.8 2.0
Father’s age at death 5.5 7.3 11.9 -1.1 -3.4 -3.3 2.6 -2.4
Worrier / anxious feelings 0.5 0.9 2.3 0.6 -0.2 -0.3 -1.5 1.3
Frequency of tiredness / lethargy in last 2 weeks 7.9 12.8 18.2 3.9 3.2 3.3 -4.3 3.1
Falls in the last year 2.6 3.5 7.7 0.5 0.9 2.4 -1.7 2.8
Hair/balding pattern: Pattern 3 0.4 0.7 1.6 1.3 0.7 -1.0 -0.2 0.4
Number of live births 0.4 0.6 1.2 0.3 -0.9 -1.1 0.8 0.2
Forced expiratory volume in 1-second (FEV1) 2.3 7.8 18.1 1.2 -1.5 -4.3 2.6 -3.2
Pulse rate 2.0 3.3 8.7 2.9 1.0 1.1 -2.3 0.3
Happiness 0.6 0.7 2.1 -0.3 -1.4 -0.5 -0.9 -0.6
Noisy workplace 3.5 4.3 13.6 0.6 1.5 3.7 -0.9 2.2
Qualifications: A levels/AS levels or equivalent 1.8 4.0 12.1 -0.9 -1.0 -3.5 1.8 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 4.4 -0.4 0.4 2.1 -0.5 0.7
Mouth/teeth dental problems: Dentures 5.0 8.5 10.2 3.1 2.3 3.2 -3.1 2.7
Asthma 2.8 5.6 9.2 1.7 0.9 2.9 -2.6 3.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.4 1.0 0.9 1.8 -0.2 0.0
Medication: Cholesterol lowering 6.2 9.7 14.8 2.9 3.9 3.0 -3.1 2.6
Depression (self-reported) 1.0 1.2 2.6 0.2 0.4 1.6 -1.3 1.1
Medication: Lansoprazole 1.0 1.1 2.8 -0.9 -1.3 0.6 -1.7 -0.0
Prospective memory result 0.5 0.6 2.8 0.0 0.3 -0.6 1.7 0.0
Lung cancer (father) 1.1 1.3 5.3 -0.3 -0.1 -0.5 0.9 -2.3
Illnesses of mother 1.0 1.3 3.4 -0.9 -1.9 -1.3 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 8.0 15.1 0.6 -1.9 -3.9 2.5 -3.9
Pulse wave Arterial Stiffness index 3.1 3.7 9.3 3.0 1.9 1.2 -1.8 0.7
Impedance of arm (left) 0.8 3.6 7.5 0.1 1.3 -2.4 2.7 -1.8
Arm fat mass (right) 3.5 14.5 33.2 -0.1 1.1 5.0 -3.6 5.8
Trunk predicted mass 0.3 1.9 7.6 -0.3 -2.8 -1.1 0.6 0.1
Standing height 1.7 16.5 33.8 -0.4 -3.3 -5.8 5.0 -3.6
Length of working week for main job 1.1 1.2 3.0 -1.2 -1.7 1.0 -0.5 0.5
Exposure to tobacco smoke at home 0.2 0.3 0.6 -0.1 -0.6 0.8 -0.2 0.7
Breastfed as a baby 1.8 2.2 8.5 -0.6 0.0 -2.9 1.5 -0.1
Tense / ‘highly strung’ 1.6 2.6 7.4 1.5 0.1 1.8 -2.7 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 3.7 5.6 15.2 2.2 1.5 1.5 -3.9 1.9
Hair/balding pattern: Pattern 4 0.2 0.6 1.6 -1.3 0.2 -0.7 -0.9 -0.3
Birth weight of first child 1.0 1.9 5.5 0.0 -1.9 -2.3 -0.4 -0.4
Peak expiratory flow (PEF) 1.7 3.9 7.5 0.1 -1.9 -2.7 1.7 -2.3
Pulse wave reflection index 0.1 0.1 0.4 -0.3 0.3 0.6 -0.3 0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.4 -0.8 -0.2 0.2 -1.9 1.2
Loud music exposure frequency 0.9 1.0 2.2 -1.5 -1.1 0.1 0.9 0.9
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 13.5 -0.2 -1.3 -3.7 1.1 -1.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 2.6 0.6 1.6 1.5 -1.0 1.6
Blood clot in the leg (DVT) 1.7 2.2 4.4 1.2 0.8 2.1 -2.1 0.4
Medication: Paracetamol 1.3 2.1 6.2 -1.1 0.2 2.5 -1.2 1.3
Headache pain in last month 1.0 1.7 3.4 0.6 0.5 1.6 -1.4 1.8
Medication for cholesterol, blood pressure or diabetes 4.7 7.8 8.9 -2.9 -3.0 -3.0 2.7 -2.4
Glaucoma (self-reported) 2.3 2.7 5.7 -1.8 -1.5 -2.4 -0.9 -1.3
Gout (self-reported) 1.0 1.4 2.8 0.5 1.0 1.0 -1.7 1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.6 -1.0 0.5 0.6 -0.8 1.3
Medication: Amlodipine 5.8 8.1 13.2 3.6 3.2 2.2 -3.1 1.7
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.9 -0.8 0.5 0.4 -0.4
Birth weight 0.4 0.8 2.6 0.3 0.3 -1.6 0.1 -1.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.7 0.1 -0.3 1.7 -0.5 -0.3
High blood pressure (siblings) 4.4 6.3 12.4 2.1 3.5 1.5 -0.3 3.5
Forced vital capacity (FVC), Best measure 2.9 10.4 20.4 0.4 -2.9 -4.1 2.5 -4.5
Body fat percentage 4.3 16.9 33.8 -0.2 2.4 5.4 -4.0 5.8
Leg fat percentage (right) 4.5 16.3 30.2 -0.7 1.7 4.8 -4.9 5.5
Arm fat-free mass (right) 0.2 1.2 3.2 0.2 -1.0 0.5 -1.2 1.8
Exposure to tobacco smoke outside home 2.9 3.8 7.3 0.7 0.1 2.5 -2.3 2.7
Comparative body size at age 10 1.5 4.3 15.0 0.7 0.4 0.9 -2.2 3.9
Number of full brothers 1.1 1.4 5.1 2.3 1.0 0.4 -0.8 0.1
Worry too long after embarrassment 3.0 5.1 7.8 0.1 -2.5 -2.6 2.1 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.8 3.7 5.4 2.0 2.2 1.3 -2.3 1.6
Wheeze or whistling in the chest in last year 2.8 5.1 10.8 -0.4 0.9 3.3 -2.4 2.8
Number of children fathered 0.2 0.2 0.4 0.0 -0.5 0.5 0.7 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 0.3 -0.8 0.0 -0.5 -0.9
Age at first live birth 5.1 9.1 17.4 -0.7 -2.2 -3.4 3.3 -4.2
Pulse wave peak to peak time 4.0 4.7 8.8 -3.0 -2.3 -1.8 2.2 -1.1
Health satisfaction 1.9 2.5 11.5 -0.7 -0.3 3.4 0.2 -0.5
Shortness of breath walking on level ground 2.3 2.8 6.8 -0.8 0.8 2.6 -0.4 2.4
Qualifications: College or University degree 5.1 16.2 41.3 -2.5 -3.7 -6.4 2.8 -3.4
Eye problems/disorders: None of the above 0.5 0.6 2.0 -0.7 -0.6 0.3 1.4 0.1
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.3 -1.5 -0.4 -0.3 1.3 0.1
Emphysema/chronic bronchitis 1.9 2.1 5.3 -2.3 -1.8 -0.2 1.3 0.4
Medication for pain relief, constipation, heartburn 1.6 2.7 6.7 0.1 -1.3 -2.6 1.7 -1.5
Neck or shoulder pain in last month 1.0 1.4 2.6 0.9 0.7 1.5 -1.6 1.0
Medication: Blood pressure 1.7 3.0 7.5 2.7 1.2 1.6 -1.5 1.2
Angina (self-reported) 3.6 4.7 8.3 0.6 2.9 2.9 -2.0 1.7
Migraine (self-reported) 1.0 1.2 2.7 1.1 0.6 1.0 -1.6 0.8
Medication: Ibuprofen 0.9 1.1 3.0 0.7 1.3 1.7 -0.7 0.0
Medication: Allopurinol 1.1 1.5 3.8 0.3 1.9 0.9 -0.5 1.5
Medication: Omeprazole 2.2 2.7 3.8 0.9 1.4 1.9 -1.8 1.9
Medication: Seretide 50 evohaler 0.1 0.2 0.4 -0.6 -0.5 0.2 -0.1 -0.3
Mean time to correctly identify matches 3.7 7.1 13.6 0.3 -0.7 -2.8 3.7 -3.7
Heart disease (mother) 0.1 0.1 0.4 -0.3 0.0 -0.2 0.4 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.5 0.7 0.5 0.8 -1.9 -0.3
Whole body fat mass 3.4 14.1 32.5 -0.1 1.5 4.9 -3.5 5.7
Leg fat mass (right) 3.9 15.1 33.6 -0.3 1.1 4.7 -4.2 5.8
Arm predicted mass (right) 0.3 1.4 3.6 0.2 -0.9 1.1 -1.1 1.9
Pulse rate, automated reading 3.6 11.7 20.0 1.9 3.4 3.1 -4.5 3.7
Alcohol intake frequency. 5.9 13.7 28.8 2.0 2.5 2.5 -5.4 4.8
Comparative height size at age 10 0.3 1.7 4.3 1.5 -0.1 -2.1 1.1 -0.8
Number of full sisters 1.0 1.2 3.3 -1.2 0.7 1.8 0.4 0.6
Suffer from ‘nerves’ 0.8 1.3 3.9 2.0 0.6 -0.0 -1.4 0.2
Overall health rating 6.7 14.5 41.3 1.5 2.6 6.4 -2.8 3.8
Chest pain or discomfort 6.8 9.7 16.8 1.3 2.5 3.9 -4.1 2.9
Had major operations 1.1 1.3 4.1 -2.0 -1.0 -1.0 0.2 -0.7
Age at last live birth 5.3 7.6 15.2 0.2 -1.2 -3.9 3.3 -3.2
Family relationship satisfaction 0.4 0.5 0.7 -0.9 -0.8 -0.8 0.6 0.2
Leg pain on walking 1.6 2.0 6.6 -0.2 0.6 1.4 -1.1 2.6
Qualifications: NVQ or HND or HNC or equivalent 5.0 6.0 11.1 1.3 2.6 3.3 -0.1 3.2
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.7 -0.7 -0.6 1.3 -1.3 0.8
Illness, injury, bereavement, stress in last 2 years 3.2 4.0 7.2 -1.4 -2.3 -2.7 1.1 -2.0
Medication: Aspirin 2.1 2.7 4.3 1.2 1.8 1.3 -2.1 1.7
Supplements: Vitamin C 1.9 2.2 4.1 -1.3 -1.1 -0.2 2.0 -2.0
Knee pain experienced in last month 2.2 3.5 7.9 -1.4 0.7 2.8 -0.4 2.6
Hypertension (Self-reported) 3.1 8.5 17.3 4.2 3.4 2.3 -2.2 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.8 -1.4 -0.8 0.5 0.4 0.0
Illnesses of father: Heart disease 2.8 3.9 7.0 1.7 2.6 2.0 -1.9 1.4
Illnesses of siblings: Diabetes 2.7 3.3 8.6 1.0 1.7 1.4 -1.3 2.9
Smoking status: Previous 0.7 1.0 2.2 -1.5 0.9 1.0 0.9 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.0 0.3 -1.4 -1.0 0.1 0.1
Whole body fat-free mass 0.2 1.3 4.3 -0.1 -2.1 0.1 0.0 1.4
Leg fat-free mass (right) 0.4 2.0 7.6 0.3 -1.0 1.1 -0.4 2.8
Arm fat percentage (left) 4.8 19.3 41.6 -0.0 2.3 5.7 -4.1 6.5
Average weekly red wine intake 1.4 2.0 6.3 -0.3 -0.6 -1.3 2.5 -1.2
Handedness (chirality/laterality): Left-handed 4.2 5.1 9.7 -1.9 -2.7 -3.1 0.8 -2.0
Mood swings 1.9 3.4 4.4 2.1 0.8 2.0 -1.9 2.1
Loneliness, isolation 3.8 5.2 8.3 2.5 2.0 2.2 -1.6 2.9
Long-standing illness, disability or infirmity 1.3 2.1 4.4 1.1 0.5 1.8 -2.1 1.1
Ever had bowel cancer screening 1.4 1.6 5.8 -2.4 -0.2 -1.4 0.0 -0.5
Diabetes diagnosed by doctor 3.3 5.4 7.7 2.1 2.3 2.3 -2.8 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.6 0.7 0.2 -0.4 1.3 -0.9
Friendships satisfaction 0.8 1.0 3.4 -1.3 -1.8 0.0 -0.0 0.2
Qualifications: nursing, teaching 0.9 1.4 4.4 0.3 -0.4 -2.1 -0.4 -1.4
Commuting to job workplace: Walk 1.0 1.1 4.3 2.1 0.5 -0.1 0.3 -0.8
Eye problems/disorders: Cataract 0.9 1.0 3.6 1.9 0.5 -0.3 -0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.4 -1.1 -0.0 -0.9 0.4 -1.9
Medication for cholesterol 1.7 2.5 3.9 -1.7 -2.0 -1.9 1.2 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.3 0.2 0.1 1.5 -0.8 1.4
Back pain experienced in last month 2.2 3.2 6.3 0.9 1.3 2.5 -1.3 2.4
Mineral and other dietary supplements 3.7 5.0 14.6 1.1 2.7 3.8 -1.3 0.7
Breast cancer (self-reported) 0.5 0.6 1.1 0.9 -0.6 -1.1 -0.3 -0.7
Asthma (self-reported) 2.7 5.5 9.3 1.7 0.8 3.0 -2.3 3.0
Osteoporosis (self-reported) 0.8 1.0 2.6 -1.6 -0.4 0.4 1.1 0.8
Osteoarthritis (self-reported) 2.2 2.9 6.5 0.4 2.1 2.6 -1.1 1.4
Medication: Aspirin 3.1 4.1 5.6 1.5 2.4 1.7 -2.3 2.1
Medication: Gliclazide 1.4 1.6 4.7 0.2 1.2 2.2 -0.7 1.2
Illnesses of father: None of the above (group 1) 1.3 1.6 3.3 -1.4 -0.8 -0.5 1.4 -1.8
Smoking status: Current 1.6 2.6 5.8 -0.3 0.2 2.4 -1.8 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.1 12.2 1.8 -0.9 -3.5 0.5 -2.0
Whole body water mass 0.2 1.2 3.8 -0.1 -1.9 0.2 0.1 1.4
Leg predicted mass (right) 0.4 2.1 8.1 0.4 -0.9 1.2 -0.4 2.8
Arm fat mass (left) 3.7 15.1 34.6 0.0 1.5 5.0 -3.7 5.9
Number of self-reported non-cancer illnesses 4.2 7.4 11.6 2.4 2.6 3.0 -3.4 2.0
Average weekly champagne plus white wine intake 4.6 6.3 12.4 -0.7 -2.6 -3.5 1.5 -3.1
Miserableness 2.1 3.6 8.8 3.0 1.8 0.3 -2.0 1.3
Guilty feelings 0.8 1.3 2.3 -0.6 -1.4 -1.5 0.8 -1.0
Wears glasses or contact lenses 1.9 2.2 4.7 1.1 0.7 -1.9 1.1 -2.2
Ever taken oral contraceptive pill 1.5 1.6 6.9 -0.2 -0.2 -0.8 2.6 0.8
Hearing aid user 2.5 2.8 7.8 1.7 1.3 1.2 -0.5 2.8
Mother’s age at death 3.4 4.3 6.3 -1.6 -1.6 -2.5 2.1 -2.4
Financial situation satisfaction 1.4 1.8 6.6 0.1 -0.4 2.6 -0.8 1.2
Tinnitus: Yes, now most or all of the time 2.3 2.7 4.7 1.4 2.1 0.5 -2.2 1.4
Commuting to job workplace: Public transport 0.3 0.3 0.8 -0.1 0.2 -0.8 0.9 -0.2
Eye problems/disorders: Glaucoma 0.9 1.1 3.1 -1.4 -0.5 -0.5 -1.8 -0.1
Medication: Blood pressure 2.5 4.8 10.4 2.3 3.2 1.9 -1.4 1.5
Pain type(s) experienced in last month: Hip pain 2.4 3.0 5.7 0.3 0.9 2.0 -2.4 2.1
Supplements: Fish oil (including cod liver oil) 4.0 5.2 14.5 -0.8 -2.0 -3.8 2.0 -1.6
High cholesterol (Self-reported) 4.7 8.4 15.1 3.4 2.9 2.0 -3.9 1.7
Medication: Bendroflumethiazide 0.3 0.5 1.3 -0.2 0.4 1.1 -0.9 0.4
Medication: Paracetamol 1.4 2.2 6.0 -1.8 0.1 2.4 -1.3 0.0
Medication: Lisinopril 1.6 2.1 3.8 0.9 1.6 1.5 -1.0 1.9
Medication: Atorvastatin 2.2 2.7 7.9 2.8 1.9 0.8 -0.6 -0.9
Illnesses of father: High blood pressure 0.5 0.6 1.5 1.2 -0.7 -0.6 0.0 -0.9
Alcohol drinker status: Never 0.9 1.0 2.4 -0.8 -0.4 0.8 -1.6 1.2
Ever smoked 0.7 1.3 3.4 -1.8 1.0 1.0 0.9 0.6
Basal metabolic rate 0.3 1.8 5.4 -0.2 -1.6 0.9 -0.5 2.3
Leg fat percentage (left) 5.2 18.8 33.4 -0.3 2.1 5.2 -5.3 5.8
Arm fat-free mass (left) 0.4 1.9 4.8 -0.0 -1.4 1.1 -1.3 2.2
Number of operations (self-reported) 0.3 0.5 0.9 -0.8 -0.9 -0.6 -0.5 -0.3
Average weekly beer plus cider intake 1.2 1.8 4.7 -0.8 0.6 1.1 2.2 -1.3
Irritability 0.3 0.5 1.6 -0.3 0.2 1.3 -0.7 0.7
Risk taking 0.3 0.5 1.4 0.0 0.5 0.5 -0.7 1.2
Ever had prostate specific antigen (PSA) test 2.8 3.2 7.0 0.1 -2.1 -2.6 0.4 -2.2
Fractured/broken bones in last 5 years 0.4 0.5 2.2 -0.4 0.4 0.1 -0.0 1.5
Age started oral contraceptive pill 0.6 0.7 1.1 -1.0 0.7 0.1 1.1 -1.0
Diastolic blood pressure, automated reading 1.4 4.4 8.7 0.7 0.7 2.6 -3.0 2.4
Ever depressed for a whole week 0.4 0.5 1.7 -0.3 1.3 0.1 -0.6 -0.3
Unable to work because of sickness or disability 4.4 5.7 12.5 0.3 0.8 3.5 -2.7 2.8
Commuting to job workplace: Cycle 2.5 3.0 6.4 -0.8 -2.5 -2.3 1.3 -1.1
Myopia 1.0 1.4 4.0 -0.7 -0.8 -2.0 1.0 -0.9
Vascular/heart problems diagnosed by doctor 3.9 10.7 15.8 -4.0 -3.7 -3.2 2.8 -2.5
Cholesterol lowering medication 0.3 0.4 1.0 1.0 0.4 0.7 -0.7 -0.1
Medication: Omeprazole (e.g. Zanprol) 3.8 4.7 7.7 1.4 2.0 2.3 -2.8 2.1
Pain experienced in last month 1.0 1.6 4.4 -0.4 -1.0 -2.1 0.9 -1.3
Supplements: Calcium 1.1 1.2 2.4 -0.5 -0.9 -1.5 1.2 -1.0
Basal cell carcinoma (self-reported) 1.3 1.5 4.2 2.0 -0.1 -1.3 0.3 1.2
Heart attack/myocardial infarction (self-reported) 2.9 3.8 9.7 0.9 3.1 2.3 -0.9 1.5
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 3.5 1.0 0.7 1.8 -1.9 0.0
Heart disease (siblings) 3.5 4.3 5.7 1.7 2.4 2.4 -1.3 2.3
Alcohol drinker status: Previous 6.4 7.3 8.8 2.4 2.9 2.3 -3.0 2.8
Pack years of smoking 5.1 7.5 14.8 1.2 2.2 3.7 -3.8 1.7
Impedance of whole body 0.7 3.3 6.8 0.1 1.4 -2.6 1.8 -2.1
Leg fat mass (left) 4.3 16.6 35.4 -0.1 1.3 5.0 -4.6 6.0
Arm predicted mass (left) 0.4 2.0 6.0 -0.4 -1.5 1.0 -0.9 2.4