Best TWAS P=1.43e-24 · Best GWAS P=1.76e-32 conditioned to 3.89e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIAS | 0.15 | 0.04 | bslmm | 387 | 0.10 | 2.0e-12 | -1.9 | -5.3 | 1.4e-07 | -0.32 | 0.55 | 0.07 | TRUE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RFC1 | 0.18 | 0.10 | lasso | 4 | 0.11 | 1.0e-03 | 11.9 | 10.2 | 1.4e-24 | 0.89 | 0.01 | 0.91 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | UGDH | 0.14 | 0.03 | lasso | 9 | 0.05 | 2.4e-04 | -4.5 | 5.4 | 8.6e-08 | 0.35 | 0.56 | 0.02 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | UGDH-AS1 | 0.17 | 0.09 | lasso | 4 | 0.06 | 1.7e-05 | 5.1 | 5.2 | 2.1e-07 | 0.32 | 0.96 | 0.00 | FALSE |
| 5 | GTEx | Lung | SMIM14 | 0.06 | 0.00 | enet | 5 | 0.00 | 3.7e-01 | -3.3 | -6.6 | 3.6e-11 | -0.54 | 0.04 | 0.68 | FALSE |
| 6 | GTEx | Muscle Skeletal | RFC1 | 0.10 | 0.10 | lasso | 5 | 0.07 | 4.2e-07 | 8.2 | 8.4 | 3.8e-17 | 0.71 | 0.73 | 0.26 | FALSE |
| 7 | GTEx | Small Intestine Terminal Ileum | UGDH-AS1 | 0.22 | 0.09 | enet | 11 | 0.17 | 1.3e-04 | -1.0 | 5.9 | 3.0e-09 | 0.60 | 0.04 | 0.68 | FALSE |
| 8 | GTEx | Testis | WDR19 | 0.28 | 0.29 | lasso | 5 | 0.27 | 1.6e-12 | -4.0 | 5.3 | 1.2e-07 | 0.47 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Thyroid | RP11-472B18.1 | 0.16 | 0.10 | lasso | 3 | 0.08 | 6.0e-07 | 5.5 | 5.3 | 1.2e-07 | 0.41 | 0.98 | 0.00 | FALSE |
| 10 | NTR | Blood | UGDH | 0.05 | 0.03 | bslmm | 369 | 0.04 | 2.7e-12 | -4.6 | 5.9 | 2.7e-09 | 0.43 | 1.00 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | WDR19 | 0.02 | 0.02 | enet | 9 | 0.02 | 2.8e-03 | 5.1 | 5.3 | 9.1e-08 | 0.54 | 0.37 | 0.07 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | RP11-472B18.1 | 0.22 | 0.17 | enet | 41 | 0.18 | 3.2e-22 | 5.5 | 5.8 | 6.4e-09 | 0.41 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | RPL9 | 0.06 | 0.02 | lasso | 7 | 0.02 | 8.2e-07 | 5.4 | 6.1 | 9.9e-10 | 0.46 | 0.99 | 0.01 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KLB | 0.03 | 0.00 | blup | 61 | 0.01 | 7.1e-02 | 8.5 | 6.3 | 4.0e-10 | 0.62 | 0.02 | 0.22 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KLB | 0.11 | 0.07 | blup | 60 | 0.05 | 9.8e-04 | 5.4 | 8.7 | 2.2e-18 | 0.67 | 0.03 | 0.70 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | UGDH | 0.06 | 0.02 | blup | 65 | 0.03 | 5.9e-03 | -4.5 | 5.5 | 3.4e-08 | 0.33 | 0.04 | 0.55 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UGDH | 0.11 | 0.00 | blup | 65 | 0.08 | 2.7e-05 | 4.7 | 5.2 | 1.8e-07 | 0.31 | 0.02 | 0.45 | FALSE |
| 18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UGDH | 0.05 | 0.02 | blup | 65 | 0.03 | 2.1e-03 | -4.9 | 5.6 | 2.4e-08 | 0.37 | 0.02 | 0.82 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | LIAS | 0.10 | 0.03 | blup | 66 | 0.05 | 8.1e-06 | 5.1 | -6.1 | 1.3e-09 | -0.41 | 0.48 | 0.09 | FALSE |