Best TWAS P=1.05e-09 · Best GWAS P=8.07e-09 conditioned to 0.0765
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | RP1-59D14.1 | 0.22 | 0.01 | lasso | 4 | 0.01 | 1.3e-01 | -3.5 | 5.2 | 2.0e-07 | -0.48 | 0.05 | 0.30 | FALSE |
| 2 | GTEx | Lung | MNT | 0.14 | 0.05 | lasso | 5 | 0.04 | 3.8e-04 | 5.5 | 5.8 | 6.2e-09 | -0.79 | 0.00 | 0.99 | FALSE |
| 3 | GTEx | Lung | RP1-59D14.1 | 0.08 | 0.03 | lasso | 2 | 0.01 | 8.6e-02 | 5.5 | 6.1 | 1.1e-09 | -0.76 | 0.01 | 0.94 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | MNT | 0.16 | 0.06 | lasso | 7 | 0.04 | 2.6e-03 | 5.5 | 5.4 | 7.1e-08 | -0.59 | 0.01 | 0.93 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | RP1-59D14.1 | 0.16 | 0.07 | lasso | 5 | 0.03 | 1.2e-02 | 5.5 | 5.7 | 9.5e-09 | -0.56 | 0.01 | 0.88 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MNT | 0.10 | 0.09 | enet | 16 | 0.08 | 5.1e-07 | 5.5 | 5.7 | 1.4e-08 | -0.57 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP1-59D14.1 | 0.11 | 0.07 | lasso | 4 | 0.06 | 1.8e-05 | 5.5 | 5.4 | 6.1e-08 | -0.58 | 0.01 | 0.99 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | MNT | 0.09 | 0.04 | lasso | 5 | 0.06 | 9.5e-09 | -5.5 | 5.7 | 1.6e-08 | -0.53 | 0.02 | 0.98 | FALSE |