Best TWAS P=1.54e-08 · Best GWAS P=4.21e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-54O7.17 | 0.28 | 0.28 | lasso | 3 | 0.30 | 3.8e-17 | -4.3 | 5.2 | 2.6e-07 | -0.83 | 0.11 | 0.88 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | UBE2J2 | 0.14 | 0.00 | lasso | 4 | 0.00 | 4.6e-01 | -5.5 | -5.5 | 5.1e-08 | 0.95 | 0.01 | 0.64 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | RP11-54O7.17 | 0.24 | 0.07 | enet | 10 | 0.06 | 4.0e-03 | -5.5 | 5.5 | 4.7e-08 | -0.93 | 0.00 | 0.97 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-54O7.17 | 0.23 | 0.10 | enet | 16 | 0.14 | 3.1e-08 | -5.5 | 5.3 | 9.8e-08 | -0.88 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | RP11-54O7.17 | 0.19 | 0.07 | lasso | 6 | 0.12 | 9.4e-10 | -4.3 | 5.3 | 1.5e-07 | -0.82 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Spleen | RP11-54O7.17 | 0.31 | 0.22 | enet | 6 | 0.20 | 6.8e-06 | -5.5 | 5.6 | 2.2e-08 | -0.94 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C1orf170 | 0.20 | 0.21 | lasso | 5 | 0.21 | 8.2e-24 | -5.5 | 5.6 | 2.1e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C1orf170 | 0.14 | 0.16 | enet | 5 | 0.14 | 3.9e-06 | -5.5 | 5.7 | 1.5e-08 | -0.98 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C1orf170 | 0.22 | 0.24 | lasso | 4 | 0.24 | 1.9e-25 | -5.5 | 5.6 | 1.9e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLEKHN1 | 0.04 | 0.01 | lasso | 5 | 0.02 | 4.7e-03 | -4.3 | 5.2 | 2.5e-07 | -0.79 | 0.00 | 0.76 | FALSE |