Hub : Traits :

Alcohol intake versus 10 years previously

136 significantly associated models · 25 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	752566	1907912	4	1	1.5e-08	4.2e-08	1.000	100	C1orf170
2	1	39328203	40737589	1	1	3.0e-07	3.1e-06	0.161	91	PABPC4
3	1	43699813	45157738	3	1	1.3e-07	4.9e-08	0.017	81	DPH2
4	2	26883355	28288392	2	1	1.1e-11	4.7e-11	1.000	100	FNDC4
5	3	49016056	50921261	10	1	4.2e-10	6.3e-09	0.049	88	RNF123
6	6	89108830	90520848	1	1	2.9e-07	2.7e-06	0.588	99	SRSF12
7	8	27099879	27720371	2	2	1.1e-08	4.5e-10	0.003	77	CLU EPHX2
8	19	48918157	49424381	1	1	5.4e-08	1.2e-06	0.637	99	NTN5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Triglycerides	49.91	3	1	2.2	0.00	1.000	FNDC4 NTN5 PABPC4
Alcohol intake frequency.	15.31	5	3	6.7	0.94	0.018	C1orf170 FNDC4 NTN5 PABPC4 RNF123
High cholesterol (Self-reported)	14.65	2	2	4.4	0.00	1.000	FNDC4 NTN5
Fasting Glucose	11.91	1	1	2.2	0.00	1.000	FNDC4
Gout (self-reported)	10.44	1	1	2.2	0.00	1.000	FNDC4
Medication: Allopurinol	8.85	1	1	2.2	0.00	1.000	FNDC4
Qualifications: A levels/AS levels or equivalent	7.96	2	2	4.4	0.00	1.000	DPH2 RNF123
Crohns Disease (2017)	7.84	3	2	4.4	0.00	1.000	FNDC4 NTN5 RNF123
Smoking Status	7.81	2	2	4.4	0.00	1.000	CLU EPHX2
Type 2 Diabetes (T2D) (2018)	7.71	3	3	6.7	0.00	1.000	FNDC4 PABPC4 RNF123
Medication: Cholesterol lowering	7.63	3	1	2.2	0.00	1.000	FNDC4 NTN5 RNF123
Qualifications: College or University degree	7.33	2	2	4.4	0.00	1.000	DPH2 RNF123
Mouth/teeth dental problems: Dentures	7.30	4	0	0.0	0.53	0.468	CLU EPHX2 NTN5 RNF123
Pulse rate, automated reading	7.30	3	3	6.7	0.00	1.000	FNDC4 PABPC4 RNF123
Cholesterol lowering medication	7.08	2	1	2.2	0.00	1.000	FNDC4 NTN5
Diabetes diagnosed by doctor	6.84	3	1	2.2	0.00	1.000	FNDC4 PABPC4 RNF123
Age at first live birth	6.82	2	1	2.2	0.00	1.000	DPH2 RNF123
Age at First Birth	6.81	1	1	2.2	0.00	1.000	RNF123
Medication: Atorvastatin	6.74	1	1	2.2	0.00	1.000	FNDC4
Arm predicted mass (right)	6.40	4	3	6.7	0.26	0.736	FNDC4 NTN5 PABPC4 RNF123
Arm predicted mass (left)	6.39	4	3	6.7	0.31	0.695	FNDC4 NTN5 PABPC4 RNF123
Diabetes (self-reported)	6.38	3	2	4.4	0.00	1.000	FNDC4 PABPC4 RNF123
Arm fat-free mass (right)	6.35	4	3	6.7	0.26	0.739	FNDC4 NTN5 PABPC4 RNF123
Arm fat-free mass (left)	6.32	4	3	6.7	0.30	0.702	FNDC4 NTN5 PABPC4 RNF123
Crohns Disease (2012)	6.21	2	1	2.2	0.00	1.000	FNDC4 RNF123
Schizophrenia vs Biploar Disorder	6.15	2	0	0.0	0.00	1.000	CLU FNDC4
Whole body water mass	6.03	4	3	6.7	0.19	0.809	FNDC4 NTN5 PABPC4 RNF123
Qualifications: None of the above	6.02	2	2	4.4	0.00	1.000	DPH2 RNF123
Blood Platelet Count	6.01	3	2	4.4	0.00	1.000	FNDC4 NTN5 PABPC4
Body mass index (BMI)	6.00	3	1	2.2	0.00	1.000	FNDC4 PABPC4 RNF123
Leg fat mass (left)	5.91	3	1	2.2	0.00	1.000	FNDC4 PABPC4 RNF123
Whole body fat-free mass	5.90	4	3	6.7	0.19	0.808	FNDC4 NTN5 PABPC4 RNF123
Basal metabolic rate	5.89	4	3	6.7	0.29	0.705	FNDC4 NTN5 PABPC4 RNF123
Trunk fat-free mass	5.83	4	3	6.7	0.11	0.894	FNDC4 NTN5 PABPC4 RNF123
Trunk predicted mass	5.83	4	3	6.7	0.10	0.899	FNDC4 NTN5 PABPC4 RNF123
Leg fat mass (right)	5.76	3	1	2.2	0.00	1.000	FNDC4 PABPC4 RNF123
Leg fat-free mass (left)	5.72	4	3	6.7	0.30	0.700	FNDC4 NTN5 PABPC4 RNF123
Leg predicted mass (left)	5.69	4	3	6.7	0.30	0.702	FNDC4 NTN5 PABPC4 RNF123
Weight	5.67	4	3	6.7	0.57	0.433	FNDC4 NTN5 PABPC4 RNF123
Impedance of arm (left)	5.63	2	2	4.4	0.00	1.000	FNDC4 RNF123
Irritable Bowel Disease (IBD)	5.59	2	2	4.4	0.00	1.000	FNDC4 RNF123
Impedance of arm (right)	5.59	3	2	4.4	0.00	1.000	FNDC4 NTN5 RNF123
Medication: Simvastatin	5.56	2	2	4.4	0.00	1.000	FNDC4 NTN5
BMI	5.53	3	3	6.7	0.00	1.000	FNDC4 PABPC4 RNF123
Leg fat-free mass (right)	5.52	4	3	6.7	0.26	0.735	FNDC4 NTN5 PABPC4 RNF123
Age at last live birth	5.51	1	1	2.2	0.00	1.000	RNF123
Arm fat mass (right)	5.49	3	2	4.4	0.00	1.000	FNDC4 PABPC4 RNF123
Leg predicted mass (right)	5.48	4	3	6.7	0.26	0.737	FNDC4 NTN5 PABPC4 RNF123
Smoking status: Current	5.44	2	2	4.4	0.00	1.000	CLU EPHX2
Arm fat mass (left)	5.41	3	2	4.4	0.00	1.000	FNDC4 PABPC4 RNF123
Intelligence (Savage-Jansen 2018)	5.27	1	1	2.2	0.00	1.000	RNF123
Waist circumference	5.24	3	2	4.4	0.00	1.000	FNDC4 PABPC4 RNF123
Blood White Count	5.16	2	2	4.4	0.00	1.000	FNDC4 RNF123
Impedance of whole body	5.16	3	2	4.4	0.00	1.000	FNDC4 PABPC4 RNF123
Fluid intelligence score	5.10	2	1	2.2	0.00	1.000	DPH2 RNF123
Overall health rating	5.07	2	1	2.2	0.00	1.000	PABPC4 RNF123
Current tobacco smoking	5.06	2	1	2.2	0.00	1.000	CLU EPHX2
Medication for cholesterol	5.06	2	1	2.2	0.00	1.000	FNDC4 NTN5
Whole body fat mass	5.02	2	1	2.2	0.00	1.000	PABPC4 RNF123
Leg fat percentage (left)	4.99	1	1	2.2	0.00	1.000	RNF123
Medication: Metformin	4.98	3	1	2.2	0.00	1.000	FNDC4 PABPC4 RNF123
Leg fat percentage (right)	4.95	2	1	2.2	0.00	1.000	DPH2 RNF123
Cardiovascular Disease	4.91	4	2	4.4	0.46	0.536	FNDC4 NTN5 PABPC4 RNF123
Number of treatments/medications taken	4.87	3	1	2.2	0.00	1.000	FNDC4 NTN5 RNF123
Medication for cholesterol, blood pressure or diabetes	4.87	3	0	0.0	0.00	1.000	FNDC4 NTN5 RNF123
Number of self-reported non-cancer illnesses	4.80	2	1	2.2	0.00	1.000	FNDC4 NTN5
Alcohol usually taken with meals	4.78	2	0	0.0	0.00	1.000	CLU DPH2
Maternal smoking around birth	4.73	2	0	0.0	0.00	1.000	DPH2 RNF123
Qualifications: nursing, teaching	4.52	2	1	2.2	0.00	1.000	DPH2 RNF123
Verbal and Numeric Reasoning (VNR)	4.50	1	1	2.2	0.00	1.000	RNF123
Ulcerative Colitis	4.48	1	1	2.2	0.00	1.000	RNF123
LDL Cholesterol	4.42	2	1	2.2	0.00	1.000	FNDC4 NTN5
Trunk fat mass	4.35	2	2	4.4	0.00	1.000	PABPC4 RNF123
Arm fat percentage (right)	4.31	2	2	4.4	0.00	1.000	PABPC4 RNF123
Arm fat percentage (left)	4.29	2	1	2.2	0.00	1.000	PABPC4 RNF123
Impedance of leg (left)	4.28	3	3	6.7	0.00	1.000	FNDC4 PABPC4 RNF123
Mouth/teeth dental problems	4.19	2	0	0.0	0.00	1.000	EPHX2 NTN5
HDL Cholesterol	4.17	1	1	2.2	0.00	1.000	PABPC4
Pulse rate	4.12	1	1	2.2	0.00	1.000	FNDC4
Body fat percentage	4.12	2	1	2.2	0.00	1.000	PABPC4 RNF123
Impedance of leg (right)	4.08	3	3	6.7	0.00	1.000	FNDC4 PABPC4 RNF123
Wheeze or whistling in the chest in last year	3.85	1	1	2.2	0.00	1.000	RNF123
Hip circumference	3.80	4	3	6.7	0.61	0.395	FNDC4 NTN5 PABPC4 RNF123
Diabetes (father)	3.73	1	0	0.0	0.00	1.000	FNDC4
Pain experienced in last month	3.61	2	0	0.0	0.00	1.000	PABPC4 RNF123
Long-standing illness, disability or infirmity	3.56	1	0	0.0	0.00	1.000	PABPC4
Trunk fat percentage	3.55	2	1	2.2	0.00	1.000	PABPC4 RNF123
Leg pain on walking	3.52	1	1	2.2	0.00	1.000	RNF123
Average weekly spirits intake	3.51	1	0	0.0	0.00	1.000	NTN5
Qualifications: O levels/GCSEs or equivalent	3.51	2	0	0.0	0.00	1.000	DPH2 RNF123
Qualifications: CSEs or equivalent	3.45	1	0	0.0	0.00	1.000	RNF123
Serious illness, injury or assault of a close relative in last 2 years	3.43	1	0	0.0	0.00	1.000	NTN5
Diabetes (mother)	3.41	1	0	0.0	0.00	1.000	FNDC4
Medication: Co-codamol	3.37	1	0	0.0	0.00	1.000	RNF123
Taking other prescription medications	3.37	1	1	2.2	0.00	1.000	RNF123
Father's age at death	3.33	2	0	0.0	0.00	1.000	CLU RNF123
Average weekly champagne plus white wine intake	3.32	1	0	0.0	0.00	1.000	RNF123
Schizophrenia (2014)	3.31	2	0	0.0	0.00	1.000	CLU EPHX2
Alzheimer’s Disease (including proxy)	3.27	2	0	0.0	0.00	1.000	CLU EPHX2
Diastolic blood pressure, automated reading	3.19	1	1	2.2	0.00	1.000	RNF123
Lung FEV1/FVC ratio	3.17	3	2	4.4	0.00	1.000	C1orf170 NTN5 PABPC4
Financial situation satisfaction	3.07	1	0	0.0	0.00	1.000	RNF123
Schizophrenia (2018)	3.05	1	0	0.0	0.00	1.000	EPHX2
Past tobacco smoking	3.02	2	0	0.0	0.00	1.000	CLU EPHX2
Ever had bowel cancer screening	2.98	1	0	0.0	0.00	1.000	RNF123
Sitting height	2.96	4	2	4.4	-0.36	0.637	C1orf170 FNDC4 NTN5 PABPC4
Heart attack	2.95	1	0	0.0	0.00	1.000	RNF123
Bipolar Disorder or Schizophrenia	2.93	1	0	0.0	0.00	1.000	NTN5
Health satisfaction	2.92	1	0	0.0	0.00	1.000	RNF123
Neck or shoulder pain in last month	2.92	1	0	0.0	0.00	1.000	PABPC4
Ulcerative Colitis (UC)	2.89	1	1	2.2	0.00	1.000	RNF123
Relative age of first facial hair	2.89	1	1	2.2	0.00	1.000	FNDC4
Comparative height size at age 10	2.87	2	2	4.4	0.00	1.000	FNDC4 NTN5
Average weekly beer plus cider intake	2.87	1	0	0.0	0.00	1.000	RNF123
Bipolar Disorder (2018)	2.84	1	0	0.0	0.00	1.000	FNDC4
Exposure to tobacco smoke outside home	2.80	1	0	0.0	0.00	1.000	RNF123
Age started oral contraceptive pill	2.77	1	0	0.0	0.00	1.000	RNF123
Qualifications: NVQ or HND or HNC or equivalent	2.74	1	0	0.0	0.00	1.000	RNF123
Coronary Artery Disease (CAD)	2.69	1	0	0.0	0.00	1.000	RNF123
Miserableness	2.68	1	1	2.2	0.00	1.000	RNF123
Mood swings	2.58	1	1	2.2	0.00	1.000	RNF123
High blood pressure (mother)	2.48	1	0	0.0	0.00	1.000	C1orf170
Peak expiratory flow (PEF)	2.48	1	0	0.0	0.00	1.000	NTN5
Knee pain experienced in last month	2.48	1	0	0.0	0.00	1.000	RNF123
Medication: Seretide 50 evohaler	2.45	1	0	0.0	0.00	1.000	RNF123
Heel bone mineral density (BMD) T-score, automated (left)	2.42	1	1	2.2	0.00	1.000	RNF123
Financial difficulties in last 2 years	2.41	1	0	0.0	0.00	1.000	PABPC4
Number of live births	2.41	1	0	0.0	0.00	1.000	RNF123
Exposure to tobacco smoke at home	2.39	1	0	0.0	0.00	1.000	RNF123
Medication: Bendroflumethiazide	2.39	1	0	0.0	0.00	1.000	C1orf170
Vascular/heart problems diagnosed by doctor	2.38	1	0	0.0	0.00	1.000	NTN5
Medication: Paracetamol	2.35	1	0	0.0	0.00	1.000	DPH2
Medication: Blood pressure	2.34	2	0	0.0	0.00	1.000	NTN5 RNF123
Breast Cancer	2.33	1	0	0.0	0.00	1.000	CLU
High blood pressure (siblings)	2.32	1	0	0.0	0.00	1.000	FNDC4
Systolic Blood Pressure	2.29	3	2	4.4	0.00	1.000	FNDC4 NTN5 RNF123
Comparative body size at age 10	2.28	2	0	0.0	0.00	1.000	FNDC4 NTN5
Heel bone mineral density (BMD) T-score, automated (right)	2.27	1	1	2.2	0.00	1.000	RNF123
Birth weight	2.23	1	0	0.0	0.00	1.000	NTN5
Smoking status: Previous	2.21	1	0	0.0	0.00	1.000	EPHX2
Hypothyroidism (self reported)	2.20	1	0	0.0	0.00	1.000	NTN5
Ever highly irritable/argumentative for 2 days	2.16	1	0	0.0	0.00	1.000	RNF123
Hypertension (Self-reported)	2.13	2	0	0.0	0.00	1.000	C1orf170 NTN5
Fed-up feelings	2.11	1	1	2.2	0.00	1.000	RNF123
Chronic bronchitis/emphysema (mother)	2.00	1	0	0.0	0.00	1.000	RNF123
Depressed Affect (Nagel 2018)	1.94	1	1	2.2	0.00	1.000	RNF123
Mean time to correctly identify matches	1.90	1	0	0.0	0.00	1.000	RNF123
Headache pain in last month	1.88	1	0	0.0	0.00	1.000	PABPC4
High blood pressure	1.83	1	0	0.0	0.00	1.000	NTN5
Number of operations (self-reported)	1.78	1	0	0.0	0.00	1.000	C1orf170
Heel T-Score	1.76	1	1	2.2	0.00	1.000	RNF123
Reaction Time	1.74	1	0	0.0	0.00	1.000	RNF123
Systolic blood pressure, automated reading	1.70	1	0	0.0	0.00	1.000	RNF123
Standing height	1.70	3	1	2.2	0.00	1.000	FNDC4 NTN5 PABPC4
Age when periods started (menarche)	1.68	1	0	0.0	0.00	1.000	NTN5
Waist Hip Ratio (WHR)	1.65	2	0	0.0	0.00	1.000	C1orf170 NTN5
Height	1.63	6	3	6.7	-0.29	0.575	C1orf170 CLU FNDC4 NTN5 PABPC4 RNF123
Blood Red Count	1.54	4	2	4.4	0.31	0.689	C1orf170 FNDC4 PABPC4 RNF123
Frequency of tiredness / lethargy in last 2 weeks	1.51	1	0	0.0	0.00	1.000	PABPC4
Forced expiratory volume in 1-second (FEV1), Best measure	1.47	1	0	0.0	0.00	1.000	RNF123
Forced expiratory volume in 1-second (FEV1)	1.44	2	0	0.0	0.00	1.000	EPHX2 RNF123
Neuroticism	1.42	1	0	0.0	0.00	1.000	RNF123
Hypothyroidism/myxoedema (self-reported)	1.41	1	0	0.0	0.00	1.000	NTN5
Neuroticism score	1.38	1	0	0.0	0.00	1.000	RNF123
Respiratory disease	1.34	1	0	0.0	0.00	1.000	PABPC4
Forced vital capacity (FVC), Best measure	1.22	1	0	0.0	0.00	1.000	RNF123
Lung FVC	1.21	2	0	0.0	0.00	1.000	FNDC4 PABPC4
Hand grip strength (right)	1.14	1	0	0.0	0.00	1.000	FNDC4
Hayfever, allergic rhinitis or eczema	1.10	1	0	0.0	0.00	1.000	FNDC4
Blood Eosinophil Count	1.00	2	0	0.0	0.00	1.000	DPH2 RNF123
Forced vital capacity (FVC)	0.93	1	0	0.0	0.00	1.000	RNF123
Allergy or Eczema	0.91	1	0	0.0	0.00	1.000	FNDC4
Tanning	0.65	1	1	2.2	0.00	1.000	FNDC4
Hair Pigment	0.22	2	0	0.0	0.00	1.000	FNDC4 PABPC4

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Ovary	0	0.000	1.7
GTEx	Small Intestine Terminal Ileum	0	0.000	1.7
GTEx	Vagina	1	0.157	1.7
GTEx	Adipose Visceral Omentum	2	0.098	1.6
GTEx	Adrenal Gland	1	0.069	1.6
GTEx	Artery Coronary	1	0.085	1.6
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cortex	3	0.290	1.6
GTEx	Brain Frontal Cortex BA9	1	0.108	1.6
GTEx	Brain Putamen basal ganglia	1	0.160	1.6
GTEx	Breast Mammary Tissue	2	0.101	1.6
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.6
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.6
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.6
GTEx	Heart Atrial Appendage	2	0.127	1.6
GTEx	Heart Left Ventricle	1	0.065	1.6
GTEx	Liver	1	0.139	1.6
GTEx	Lung	2	0.070	1.6
GTEx	Pancreas	1	0.061	1.6
GTEx	Prostate	1	0.120	1.6
GTEx	Skin Not Sun Exposed Suprapubic	4	0.163	1.6
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.6
GTEx	Spleen	4	0.283	1.6
GTEx	Stomach	1	0.069	1.6
ROSMAP	Brain Pre-frontal Cortex	3	0.068	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.6
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.6
GTEx	Adipose Subcutaneous	1	0.029	1.5
GTEx	Artery Aorta	5	0.168	1.5
GTEx	Artery Tibial	3	0.080	1.5
GTEx	Brain Cerebellar Hemisphere	4	0.269	1.5
GTEx	Brain Cerebellum	4	0.202	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	4	0.095	1.5
GTEx	Colon Sigmoid	1	0.068	1.5
GTEx	Colon Transverse	2	0.097	1.5
GTEx	Esophagus Mucosa	4	0.120	1.5
GTEx	Esophagus Muscularis	2	0.062	1.5
GTEx	Muscle Skeletal	2	0.069	1.5
GTEx	Nerve Tibial	2	0.046	1.5
GTEx	Pituitary	1	0.090	1.5
GTEx	Testis	3	0.095	1.5
GTEx	Thyroid	3	0.075	1.5
GTEx	Uterus	0	0.000	1.5
GTEx	Whole Blood	2	0.100	1.5
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	3	0.146	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	6	0.139	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	4	0.087	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.5
METSIM	Adipose	4	0.087	1.4
NTR	Blood	2	0.083	1.4
YFS	Blood	2	0.043	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	3	0.068	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3