Hub : Traits :

Alcohol intake versus 10 years previously

136 significantly associated models · 25 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1907912 4 1 1.5e-08 4.2e-08 1.000 100 C1orf170
2 1 39328203 40737589 1 1 3.0e-07 3.1e-06 0.161 91 PABPC4
3 1 43699813 45157738 3 1 1.3e-07 4.9e-08 0.017 81 DPH2
4 2 26883355 28288392 2 1 1.1e-11 4.7e-11 1.000 100 FNDC4
5 3 49016056 50921261 10 1 4.2e-10 6.3e-09 0.049 88 RNF123
6 6 89108830 90520848 1 1 2.9e-07 2.7e-06 0.588 99 SRSF12
7 8 27099879 27720371 2 2 1.1e-08 4.5e-10 0.003 77 CLU EPHX2
8 19 48918157 49424381 1 1 5.4e-08 1.2e-06 0.637 99 NTN5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.84 1 0 0.0 0.00 1.000 FNDC4
Bipolar Disorder or Schizophrenia 2.93 1 0 0.0 0.00 1.000 NTN5
Depressed Affect (Nagel 2018) 1.94 1 1 2.2 0.00 1.000 RNF123
Intelligence (Savage-Jansen 2018) 5.27 1 1 2.2 0.00 1.000 RNF123
Schizophrenia (2018) 3.05 1 0 0.0 0.00 1.000 EPHX2
Schizophrenia vs Biploar Disorder 6.15 2 0 0.0 0.00 1.000 CLU FNDC4
Alzheimer’s Disease (including proxy) 3.27 2 0 0.0 0.00 1.000 CLU EPHX2
Crohns Disease (2017) 7.84 3 2 4.4 0.00 1.000 FNDC4 NTN5 RNF123
Irritable Bowel Disease (IBD) 5.59 2 2 4.4 0.00 1.000 FNDC4 RNF123
Ulcerative Colitis (UC) 2.89 1 1 2.2 0.00 1.000 RNF123
Reaction Time 1.74 1 0 0.0 0.00 1.000 RNF123
Verbal and Numeric Reasoning (VNR) 4.50 1 1 2.2 0.00 1.000 RNF123
Breast Cancer 2.33 1 0 0.0 0.00 1.000 CLU
Age at First Birth 6.81 1 1 2.2 0.00 1.000 RNF123
Coronary Artery Disease (CAD) 2.69 1 0 0.0 0.00 1.000 RNF123
Crohns Disease (2012) 6.21 2 1 2.2 0.00 1.000 FNDC4 RNF123
Fasting Glucose 11.91 1 1 2.2 0.00 1.000 FNDC4
HDL Cholesterol 4.17 1 1 2.2 0.00 1.000 PABPC4
LDL Cholesterol 4.42 2 1 2.2 0.00 1.000 FNDC4 NTN5
Schizophrenia (2014) 3.31 2 0 0.0 0.00 1.000 CLU EPHX2
Triglycerides 49.91 3 1 2.2 0.00 1.000 FNDC4 NTN5 PABPC4
Ulcerative Colitis 4.48 1 1 2.2 0.00 1.000 RNF123
Blood Eosinophil Count 1.00 2 0 0.0 0.00 1.000 DPH2 RNF123
Blood Platelet Count 6.01 3 2 4.4 0.00 1.000 FNDC4 NTN5 PABPC4
Blood Red Count 1.54 4 2 4.4 0.31 0.689 C1orf170 FNDC4 PABPC4 RNF123
Blood White Count 5.16 2 2 4.4 0.00 1.000 FNDC4 RNF123
Heel T-Score 1.76 1 1 2.2 0.00 1.000 RNF123
BMI 5.53 3 3 6.7 0.00 1.000 FNDC4 PABPC4 RNF123
Height 1.63 6 3 6.7 -0.29 0.575 C1orf170 CLU FNDC4 NTN5 PABPC4 RNF123
Waist Hip Ratio (WHR) 1.65 2 0 0.0 0.00 1.000 C1orf170 NTN5
Systolic Blood Pressure 2.29 3 2 4.4 0.00 1.000 FNDC4 NTN5 RNF123
Smoking Status 7.81 2 2 4.4 0.00 1.000 CLU EPHX2
Allergy or Eczema 0.91 1 0 0.0 0.00 1.000 FNDC4
Cardiovascular Disease 4.91 4 2 4.4 0.46 0.536 FNDC4 NTN5 PABPC4 RNF123
Hypothyroidism (self reported) 2.20 1 0 0.0 0.00 1.000 NTN5
Respiratory disease 1.34 1 0 0.0 0.00 1.000 PABPC4
Type 2 Diabetes (T2D) (2018) 7.71 3 3 6.7 0.00 1.000 FNDC4 PABPC4 RNF123
Lung FEV1/FVC ratio 3.17 3 2 4.4 0.00 1.000 C1orf170 NTN5 PABPC4
Lung FVC 1.21 2 0 0.0 0.00 1.000 FNDC4 PABPC4
Neuroticism 1.42 1 0 0.0 0.00 1.000 RNF123
Hair Pigment 0.22 2 0 0.0 0.00 1.000 FNDC4 PABPC4
Tanning 0.65 1 1 2.2 0.00 1.000 FNDC4
Number of treatments/medications taken 4.87 3 1 2.2 0.00 1.000 FNDC4 NTN5 RNF123
Average weekly spirits intake 3.51 1 0 0.0 0.00 1.000 NTN5
Relative age of first facial hair 2.89 1 1 2.2 0.00 1.000 FNDC4
Systolic blood pressure, automated reading 1.70 1 0 0.0 0.00 1.000 RNF123
Medication: Co-codamol 3.37 1 0 0.0 0.00 1.000 RNF123
Medication: Metformin 4.98 3 1 2.2 0.00 1.000 FNDC4 PABPC4 RNF123
Diabetes (father) 3.73 1 0 0.0 0.00 1.000 FNDC4
Diabetes (mother) 3.41 1 0 0.0 0.00 1.000 FNDC4
Impedance of leg (right) 4.08 3 3 6.7 0.00 1.000 FNDC4 PABPC4 RNF123
Leg fat-free mass (left) 5.72 4 3 6.7 0.30 0.700 FNDC4 NTN5 PABPC4 RNF123
Trunk fat percentage 3.55 2 1 2.2 0.00 1.000 PABPC4 RNF123
Hand grip strength (right) 1.14 1 0 0.0 0.00 1.000 FNDC4
Current tobacco smoking 5.06 2 1 2.2 0.00 1.000 CLU EPHX2
Maternal smoking around birth 4.73 2 0 0.0 0.00 1.000 DPH2 RNF123
Fed-up feelings 2.11 1 1 2.2 0.00 1.000 RNF123
Taking other prescription medications 3.37 1 1 2.2 0.00 1.000 RNF123
Age when periods started (menarche) 1.68 1 0 0.0 0.00 1.000 NTN5
Heel bone mineral density (BMD) T-score, automated (left) 2.42 1 1 2.2 0.00 1.000 RNF123
Qualifications: CSEs or equivalent 3.45 1 0 0.0 0.00 1.000 RNF123
High blood pressure 1.83 1 0 0.0 0.00 1.000 NTN5
Hayfever, allergic rhinitis or eczema 1.10 1 0 0.0 0.00 1.000 FNDC4
Sitting height 2.96 4 2 4.4 -0.36 0.637 C1orf170 FNDC4 NTN5 PABPC4
High blood pressure (mother) 2.48 1 0 0.0 0.00 1.000 C1orf170
Body mass index (BMI) 6.00 3 1 2.2 0.00 1.000 FNDC4 PABPC4 RNF123
Impedance of leg (left) 4.28 3 3 6.7 0.00 1.000 FNDC4 PABPC4 RNF123
Leg predicted mass (left) 5.69 4 3 6.7 0.30 0.702 FNDC4 NTN5 PABPC4 RNF123
Trunk fat mass 4.35 2 2 4.4 0.00 1.000 PABPC4 RNF123
Waist circumference 5.24 3 2 4.4 0.00 1.000 FNDC4 PABPC4 RNF123
Past tobacco smoking 3.02 2 0 0.0 0.00 1.000 CLU EPHX2
Alcohol usually taken with meals 4.78 2 0 0.0 0.00 1.000 CLU DPH2
Forced vital capacity (FVC) 0.93 1 0 0.0 0.00 1.000 RNF123
Heel bone mineral density (BMD) T-score, automated (right) 2.27 1 1 2.2 0.00 1.000 RNF123
Qualifications: None of the above 6.02 2 2 4.4 0.00 1.000 DPH2 RNF123
Financial difficulties in last 2 years 2.41 1 0 0.0 0.00 1.000 PABPC4
Mouth/teeth dental problems 4.19 2 0 0.0 0.00 1.000 EPHX2 NTN5
Heart attack 2.95 1 0 0.0 0.00 1.000 RNF123
Diabetes (self-reported) 6.38 3 2 4.4 0.00 1.000 FNDC4 PABPC4 RNF123
Medication: Simvastatin 5.56 2 2 4.4 0.00 1.000 FNDC4 NTN5
Fluid intelligence score 5.10 2 1 2.2 0.00 1.000 DPH2 RNF123
Neuroticism score 1.38 1 0 0.0 0.00 1.000 RNF123
Weight 5.67 4 3 6.7 0.57 0.433 FNDC4 NTN5 PABPC4 RNF123
Impedance of arm (right) 5.59 3 2 4.4 0.00 1.000 FNDC4 NTN5 RNF123
Arm fat percentage (right) 4.31 2 2 4.4 0.00 1.000 PABPC4 RNF123
Trunk fat-free mass 5.83 4 3 6.7 0.11 0.894 FNDC4 NTN5 PABPC4 RNF123
Hip circumference 3.80 4 3 6.7 0.61 0.395 FNDC4 NTN5 PABPC4 RNF123
Father's age at death 3.33 2 0 0.0 0.00 1.000 CLU RNF123
Frequency of tiredness / lethargy in last 2 weeks 1.51 1 0 0.0 0.00 1.000 PABPC4
Number of live births 2.41 1 0 0.0 0.00 1.000 RNF123
Forced expiratory volume in 1-second (FEV1) 1.44 2 0 0.0 0.00 1.000 EPHX2 RNF123
Pulse rate 4.12 1 1 2.2 0.00 1.000 FNDC4
Qualifications: A levels/AS levels or equivalent 7.96 2 2 4.4 0.00 1.000 DPH2 RNF123
Serious illness, injury or assault of a close relative in last 2 years 3.43 1 0 0.0 0.00 1.000 NTN5
Mouth/teeth dental problems: Dentures 7.30 4 0 0.0 0.53 0.468 CLU EPHX2 NTN5 RNF123
Medication: Cholesterol lowering 7.63 3 1 2.2 0.00 1.000 FNDC4 NTN5 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 1.47 1 0 0.0 0.00 1.000 RNF123
Impedance of arm (left) 5.63 2 2 4.4 0.00 1.000 FNDC4 RNF123
Arm fat mass (right) 5.49 3 2 4.4 0.00 1.000 FNDC4 PABPC4 RNF123
Trunk predicted mass 5.83 4 3 6.7 0.10 0.899 FNDC4 NTN5 PABPC4 RNF123
Standing height 1.70 3 1 2.2 0.00 1.000 FNDC4 NTN5 PABPC4
Exposure to tobacco smoke at home 2.39 1 0 0.0 0.00 1.000 RNF123
Peak expiratory flow (PEF) 2.48 1 0 0.0 0.00 1.000 NTN5
Ever highly irritable/argumentative for 2 days 2.16 1 0 0.0 0.00 1.000 RNF123
Qualifications: O levels/GCSEs or equivalent 3.51 2 0 0.0 0.00 1.000 DPH2 RNF123
Headache pain in last month 1.88 1 0 0.0 0.00 1.000 PABPC4
Medication for cholesterol, blood pressure or diabetes 4.87 3 0 0.0 0.00 1.000 FNDC4 NTN5 RNF123
Gout (self-reported) 10.44 1 1 2.2 0.00 1.000 FNDC4
Hypothyroidism/myxoedema (self-reported) 1.41 1 0 0.0 0.00 1.000 NTN5
Birth weight 2.23 1 0 0.0 0.00 1.000 NTN5
Chronic bronchitis/emphysema (mother) 2.00 1 0 0.0 0.00 1.000 RNF123
High blood pressure (siblings) 2.32 1 0 0.0 0.00 1.000 FNDC4
Forced vital capacity (FVC), Best measure 1.22 1 0 0.0 0.00 1.000 RNF123
Body fat percentage 4.12 2 1 2.2 0.00 1.000 PABPC4 RNF123
Leg fat percentage (right) 4.95 2 1 2.2 0.00 1.000 DPH2 RNF123
Arm fat-free mass (right) 6.35 4 3 6.7 0.26 0.739 FNDC4 NTN5 PABPC4 RNF123
Exposure to tobacco smoke outside home 2.80 1 0 0.0 0.00 1.000 RNF123
Comparative body size at age 10 2.28 2 0 0.0 0.00 1.000 FNDC4 NTN5
Wheeze or whistling in the chest in last year 3.85 1 1 2.2 0.00 1.000 RNF123
Age at first live birth 6.82 2 1 2.2 0.00 1.000 DPH2 RNF123
Health satisfaction 2.92 1 0 0.0 0.00 1.000 RNF123
Qualifications: College or University degree 7.33 2 2 4.4 0.00 1.000 DPH2 RNF123
Neck or shoulder pain in last month 2.92 1 0 0.0 0.00 1.000 PABPC4
Medication: Blood pressure 2.34 2 0 0.0 0.00 1.000 NTN5 RNF123
Medication: Allopurinol 8.85 1 1 2.2 0.00 1.000 FNDC4
Medication: Seretide 50 evohaler 2.45 1 0 0.0 0.00 1.000 RNF123
Mean time to correctly identify matches 1.90 1 0 0.0 0.00 1.000 RNF123
Whole body fat mass 5.02 2 1 2.2 0.00 1.000 PABPC4 RNF123
Leg fat mass (right) 5.76 3 1 2.2 0.00 1.000 FNDC4 PABPC4 RNF123
Arm predicted mass (right) 6.40 4 3 6.7 0.26 0.736 FNDC4 NTN5 PABPC4 RNF123
Pulse rate, automated reading 7.30 3 3 6.7 0.00 1.000 FNDC4 PABPC4 RNF123
Alcohol intake frequency. 15.31 5 3 6.7 0.94 0.018 C1orf170 FNDC4 NTN5 PABPC4 RNF123
Comparative height size at age 10 2.87 2 2 4.4 0.00 1.000 FNDC4 NTN5
Overall health rating 5.07 2 1 2.2 0.00 1.000 PABPC4 RNF123
Age at last live birth 5.51 1 1 2.2 0.00 1.000 RNF123
Leg pain on walking 3.52 1 1 2.2 0.00 1.000 RNF123
Qualifications: NVQ or HND or HNC or equivalent 2.74 1 0 0.0 0.00 1.000 RNF123
Knee pain experienced in last month 2.48 1 0 0.0 0.00 1.000 RNF123
Hypertension (Self-reported) 2.13 2 0 0.0 0.00 1.000 C1orf170 NTN5
Smoking status: Previous 2.21 1 0 0.0 0.00 1.000 EPHX2
Whole body fat-free mass 5.90 4 3 6.7 0.19 0.808 FNDC4 NTN5 PABPC4 RNF123
Leg fat-free mass (right) 5.52 4 3 6.7 0.26 0.735 FNDC4 NTN5 PABPC4 RNF123
Arm fat percentage (left) 4.29 2 1 2.2 0.00 1.000 PABPC4 RNF123
Mood swings 2.58 1 1 2.2 0.00 1.000 RNF123
Long-standing illness, disability or infirmity 3.56 1 0 0.0 0.00 1.000 PABPC4
Ever had bowel cancer screening 2.98 1 0 0.0 0.00 1.000 RNF123
Diabetes diagnosed by doctor 6.84 3 1 2.2 0.00 1.000 FNDC4 PABPC4 RNF123
Qualifications: nursing, teaching 4.52 2 1 2.2 0.00 1.000 DPH2 RNF123
Medication for cholesterol 5.06 2 1 2.2 0.00 1.000 FNDC4 NTN5
Smoking status: Current 5.44 2 2 4.4 0.00 1.000 CLU EPHX2
Whole body water mass 6.03 4 3 6.7 0.19 0.809 FNDC4 NTN5 PABPC4 RNF123
Leg predicted mass (right) 5.48 4 3 6.7 0.26 0.737 FNDC4 NTN5 PABPC4 RNF123
Arm fat mass (left) 5.41 3 2 4.4 0.00 1.000 FNDC4 PABPC4 RNF123
Number of self-reported non-cancer illnesses 4.80 2 1 2.2 0.00 1.000 FNDC4 NTN5
Average weekly champagne plus white wine intake 3.32 1 0 0.0 0.00 1.000 RNF123
Miserableness 2.68 1 1 2.2 0.00 1.000 RNF123
Financial situation satisfaction 3.07 1 0 0.0 0.00 1.000 RNF123
High cholesterol (Self-reported) 14.65 2 2 4.4 0.00 1.000 FNDC4 NTN5
Medication: Bendroflumethiazide 2.39 1 0 0.0 0.00 1.000 C1orf170
Medication: Paracetamol 2.35 1 0 0.0 0.00 1.000 DPH2
Medication: Atorvastatin 6.74 1 1 2.2 0.00 1.000 FNDC4
Basal metabolic rate 5.89 4 3 6.7 0.29 0.705 FNDC4 NTN5 PABPC4 RNF123
Leg fat percentage (left) 4.99 1 1 2.2 0.00 1.000 RNF123
Arm fat-free mass (left) 6.32 4 3 6.7 0.30 0.702 FNDC4 NTN5 PABPC4 RNF123
Number of operations (self-reported) 1.78 1 0 0.0 0.00 1.000 C1orf170
Average weekly beer plus cider intake 2.87 1 0 0.0 0.00 1.000 RNF123
Age started oral contraceptive pill 2.77 1 0 0.0 0.00 1.000 RNF123
Diastolic blood pressure, automated reading 3.19 1 1 2.2 0.00 1.000 RNF123
Vascular/heart problems diagnosed by doctor 2.38 1 0 0.0 0.00 1.000 NTN5
Cholesterol lowering medication 7.08 2 1 2.2 0.00 1.000 FNDC4 NTN5
Pain experienced in last month 3.61 2 0 0.0 0.00 1.000 PABPC4 RNF123
Impedance of whole body 5.16 3 2 4.4 0.00 1.000 FNDC4 PABPC4 RNF123
Leg fat mass (left) 5.91 3 1 2.2 0.00 1.000 FNDC4 PABPC4 RNF123
Arm predicted mass (left) 6.39 4 3 6.7 0.31 0.695 FNDC4 NTN5 PABPC4 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.5
GTEx Adipose Visceral Omentum 2 0.098 1.6
GTEx Adrenal Gland 1 0.069 1.6
GTEx Artery Aorta 5 0.168 1.5
GTEx Artery Coronary 1 0.085 1.6
GTEx Artery Tibial 3 0.080 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.6
GTEx Brain Cerebellar Hemisphere 4 0.269 1.5
GTEx Brain Cerebellum 4 0.202 1.5
GTEx Brain Cortex 3 0.290 1.6
GTEx Brain Frontal Cortex BA9 1 0.108 1.6
GTEx Brain Hippocampus 0 0.000 1.5
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.5
GTEx Brain Putamen basal ganglia 1 0.160 1.6
GTEx Breast Mammary Tissue 2 0.101 1.6
GTEx Breast Mammary Tissue (Male) 0 0.000 1.5
GTEx Breast Mammary Tissue (Female) 2 0.122 1.6
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.6
GTEx Cells Transformed fibroblasts 4 0.095 1.5
GTEx Colon Sigmoid 1 0.068 1.5
GTEx Colon Transverse 2 0.097 1.5
GTEx Esophagus Gastroesophageal Junction 2 0.138 1.6
GTEx Esophagus Mucosa 4 0.120 1.5
GTEx Esophagus Muscularis 2 0.062 1.5
GTEx Heart Atrial Appendage 2 0.127 1.6
GTEx Heart Left Ventricle 1 0.065 1.6
GTEx Liver 1 0.139 1.6
GTEx Lung 2 0.070 1.6
GTEx Muscle Skeletal 2 0.069 1.5
GTEx Nerve Tibial 2 0.046 1.5
GTEx Ovary 0 0.000 1.7
GTEx Pancreas 1 0.061 1.6
GTEx Pituitary 1 0.090 1.5
GTEx Prostate 1 0.120 1.6
GTEx Skin Not Sun Exposed Suprapubic 4 0.163 1.6
GTEx Skin Sun Exposed Lower leg 4 0.110 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.7
GTEx Spleen 4 0.283 1.6
GTEx Stomach 1 0.069 1.6
GTEx Testis 3 0.095 1.5
GTEx Thyroid 3 0.075 1.5
GTEx Uterus 0 0.000 1.5
GTEx Vagina 1 0.157 1.7
GTEx Whole Blood 2 0.100 1.5
METSIM Adipose 4 0.087 1.4
NTR Blood 2 0.083 1.4
ROSMAP Brain Pre-frontal Cortex 3 0.068 1.6
YFS Blood 2 0.043 1.4
CommonMind Brain Pre-frontal Cortex 2 0.037 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 3 0.068 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.146 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 6 0.139 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 4 0.087 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.4
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3