Best TWAS P=1.23e-07 · Best GWAS P=1.33e-06 conditioned to 0.0666
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cortex | ST7L | 0.29 | 0.18 | lasso | 5 | 0.20 | 3.1e-06 | 4.6 | 5.2 | 1.6e-07 | 0.72 | 0.03 | 0.88 | FALSE |
2 | GTEx | Colon Transverse | ST7L | 0.22 | 0.19 | enet | 9 | 0.16 | 3.4e-08 | 4.6 | 5.3 | 1.2e-07 | 0.65 | 0.03 | 0.94 | TRUE |
3 | METSIM | Adipose | ST7L | 0.22 | 0.25 | enet | 11 | 0.25 | 1.0e-37 | 4.4 | 5.1 | 2.8e-07 | 0.65 | 0.04 | 0.92 | FALSE |
4 | NTR | Blood | ST7L | 0.02 | 0.01 | enet | 18 | 0.01 | 5.1e-03 | 4.6 | 5.1 | 3.1e-07 | 0.47 | 0.04 | 0.91 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | 4.8 | 5.1 | 2.9e-07 | 0.92 | 0.01 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | ST7L | 0.33 | 0.19 | lasso | 3 | 0.21 | 1.7e-12 | 4.6 | 5.2 | 1.5e-07 | 0.75 | 0.03 | 0.94 | FALSE |