Best TWAS P=3.53e-10 · Best GWAS P=1.39e-08 conditioned to 0.472
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SYPL2 | 0.35 | 0.23 | lasso | 4 | 0.27 | 2.6e-15 | -4.6 | 5.4 | 6.9e-08 | -0.45 | 0.23 | 0.75 | FALSE |
| 2 | GTEx | Artery Tibial | ATXN7L2 | 0.23 | 0.03 | enet | 12 | 0.11 | 9.1e-09 | -4.6 | 6.3 | 3.5e-10 | -0.49 | 0.20 | 0.70 | TRUE |
| 3 | GTEx | Esophagus Muscularis | SYPL2 | 0.32 | 0.23 | lasso | 10 | 0.37 | 6.8e-24 | 4.0 | 5.3 | 9.0e-08 | -0.57 | 0.59 | 0.36 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | SYPL2 | 0.37 | 0.13 | lasso | 7 | 0.27 | 1.8e-12 | -4.6 | 5.3 | 8.6e-08 | -0.48 | 0.24 | 0.74 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | AMIGO1 | 0.24 | 0.08 | blup | 46 | 0.18 | 3.0e-06 | 2.9 | 5.5 | 4.5e-08 | -0.71 | 0.06 | 0.55 | TRUE |