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chr3:87,495,550-88,911,119

Best TWAS P=3.55e-09 · Best GWAS P=7.17e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Esophagus Mucosa	C3orf38	0.11	0.06	lasso	7	0.07	1.5e-05	-5.6	5.9	3.5e-09	-0.97	0.04	0.96	TRUE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C3orf38	0.02	0.01	blup	24	0.02	2.0e-03	-5.5	5.8	5.8e-09	-0.98	0.02	0.78	FALSE
5	GTEx	Nerve Tibial	C3orf38	0.09	0.05	lasso	4	0.04	6.3e-04	-5.8	5.8	8.4e-09	-1.00	0.03	0.96	FALSE
2	GTEx	Artery Aorta	C3orf38	0.06	0.06	lasso	7	0.05	6.0e-04	-5.8	5.8	9.0e-09	-1.00	0.04	0.94	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	C3orf38	0.09	0.07	lasso	6	0.04	2.8e-03	-5.5	5.7	1.4e-08	-0.97	0.04	0.91	FALSE
8	GTEx	Thyroid	C3orf38	0.12	0.08	lasso	18	0.07	1.0e-05	-5.5	5.6	2.4e-08	-0.99	0.04	0.95	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF654	0.03	0.04	lasso	3	0.03	4.6e-04	-5.4	-5.6	2.7e-08	0.98	0.02	0.94	FALSE
3	GTEx	Cells Transformed fibroblasts	ZNF654	0.08	0.09	enet	6	0.10	3.1e-08	-5.6	-5.5	2.8e-08	0.81	0.05	0.95	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf38	0.05	0.05	blup	24	0.05	1.1e-05	-5.7	5.5	3.2e-08	-0.97	0.02	0.97	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf38	0.01	0.01	lasso	3	0.01	1.2e-03	-5.5	5.5	3.6e-08	-0.99	0.01	0.71	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	ZNF654	0.09	0.01	lasso	7	0.06	2.7e-04	-5.7	-5.5	4.7e-08	0.91	0.04	0.72	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf38	0.02	0.03	lasso	1	0.03	1.9e-04	-5.4	5.4	6.3e-08	-0.97	0.02	0.76	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	C3orf38	0.03	0.05	lasso	1	0.05	8.1e-06	-5.4	5.4	6.3e-08	-0.97	0.02	0.97	FALSE
9	GTEx	Uterus	ZNF654	0.29	-0.01	lasso	4	0.01	1.7e-01	-5.7	-5.3	9.3e-08	0.97	0.03	0.68	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C3orf38	0.08	0.00	enet	14	0.04	2.3e-05	-5.4	-5.2	2.4e-07	0.68	0.05	0.91	FALSE
13	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C3orf38	0.04	0.01	blup	24	0.03	5.7e-03	-5.7	5.2	2.7e-07	-0.95	0.01	0.65	FALSE