Best TWAS P=3.7e-16 · Best GWAS P=5.33e-18 conditioned to 2.17e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | 6.2 | 6.9 | 4.8e-12 | 0.76 | 0.92 | 0.08 | FALSE |
2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | -3.8 | -6.4 | 1.3e-10 | -0.29 | 0.06 | 0.08 | FALSE |
3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | 7.8 | 7.2 | 6.6e-13 | 0.50 | 0.79 | 0.20 | FALSE |
4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | 7.8 | 8.2 | 3.7e-16 | 0.59 | 0.43 | 0.54 | TRUE |
5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | 7.3 | 7.4 | 1.8e-13 | 0.53 | 0.18 | 0.26 | FALSE |
6 | The Cancer Genome Atlas | Thyroid Carcinoma | CADM2 | 0.05 | 0.00 | blup | 339 | 0.02 | 3.2e-03 | 3.4 | 6.4 | 1.4e-10 | 0.29 | 0.06 | 0.35 | FALSE |