Best TWAS P=2.8e-26 · Best GWAS P=9e-31 conditioned to 6.46e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | CCDC126 | 0.52 | 0.39 | enet | 26 | 0.40 | 3.0e-14 | -5.6 | -5.2 | 2.1e-07 | 0.23 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CCDC126 | 0.12 | 0.03 | lasso | 7 | 0.01 | 4.3e-02 | -7.6 | 7.8 | 5.7e-15 | -0.51 | 0.18 | 0.10 | FALSE |
| 3 | GTEx | Prostate | NUPL2 | 0.21 | 0.12 | enet | 15 | 0.17 | 4.7e-05 | -1.1 | -6.4 | 1.2e-10 | 0.39 | 0.06 | 0.46 | FALSE |
| 4 | YFS | Blood | TRA2A | 0.07 | 0.04 | lasso | 9 | 0.05 | 3.9e-16 | -10.2 | 7.1 | 1.2e-12 | -0.77 | 0.65 | 0.35 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | TRA2A | 0.18 | 0.02 | blup | 40 | 0.05 | 1.2e-02 | -9.3 | -10.6 | 2.8e-26 | 0.82 | 0.01 | 0.40 | TRUE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS2P32 | 0.08 | 0.02 | blup | 27 | 0.02 | 3.1e-02 | -4.6 | 5.6 | 2.6e-08 | -0.45 | 0.03 | 0.11 | FALSE |