TWAS hub - TRA2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0447	0.0172	1.5e-03	0.008	0.014	0.013	0.015	0.010	1.1e-03	2.1e-05	3.8e-05	1.0e-05	1.8e-04
2	YFS	Blood	0.0699	0.0169	1.9e-13	0.039	0.042	0.047	0.045	0.050	7.2e-13	1.3e-13	3.4e-15	1.1e-14	3.9e-16
3	TCGA	Esophageal Carcinoma	0.1840	0.1180	9.9e-03	0.023	0.049	0.032	NA	0.036	6.0e-02	1.2e-02	3.4e-02	NA	2.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative height size at age 10	10.4	57.4	112.4	3.1	7.1	-10.6
Standing height	7.9	78.8	193.2	0.3	6.6	-13.9
Sitting height	7.2	51.4	121.0	0.7	5.7	-11.0
Birth weight	7.2	15.6	43.8	-1.4	1.1	-6.6
Forced expiratory volume in 1-second (FEV1), predicted	6.6	13.8	32.5	-0.5	2.9	-5.7
Height	6.5	125.5	295.8	3.6	8.2	-17.2
Trunk fat-free mass	6.5	37.2	86.1	-0.1	5.0	-9.3
Trunk predicted mass	6.4	36.7	85.2	-0.2	5.0	-9.2
Whole body fat-free mass	5.7	32.4	74.1	-0.2	4.8	-8.6
Arm fat-free mass (right)	5.6	28.9	63.4	0.4	4.8	-8.0
Whole body water mass	5.6	32.1	73.4	-0.2	4.8	-8.6
Forced vital capacity (FVC), Best measure	5.5	20.0	53.6	-2.5	0.4	-7.3
Forced vital capacity (FVC)	5.3	20.2	48.2	-3.4	-0.8	-6.9
Arm predicted mass (right)	5.2	26.4	57.9	0.3	4.6	-7.6
Arm fat-free mass (left)	5.2	26.5	57.6	0.6	4.7	-7.6
Arm predicted mass (left)	5.0	25.2	56.6	0.3	4.4	-7.5
Basal metabolic rate	4.9	27.3	60.8	0.0	4.6	-7.8
Exposure to tobacco smoke at home	4.5	5.1	12.1	3.5	1.2	-1.3
Forced expiratory volume in 1-second (FEV1)	4.3	14.4	32.1	-2.9	-1.6	-5.7
Leg fat-free mass (left)	4.2	22.0	48.7	-0.6	4.1	-7.0
Leg fat-free mass (right)	4.2	22.4	49.3	-0.4	4.2	-7.0
Leg predicted mass (right)	4.2	22.4	49.7	-0.4	4.2	-7.0
Leg predicted mass (left)	4.1	22.0	48.3	-0.5	4.2	-7.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.2	32.1	-2.1	-0.4	-5.7
Loud music exposure frequency	3.3	3.6	7.4	1.8	2.7	-0.5
Lung FVC	3.2	16.2	23.2	-3.2	-4.8	-3.9
Birth weight of first child	3.0	5.5	9.1	-3.0	-0.7	-2.6
Peak expiratory flow (PEF)	3.0	7.0	7.3	-2.6	-2.7	-2.5
Ever had prostate specific antigen (PSA) test	2.9	3.3	4.8	-1.2	-1.9	2.2
Type 2 Diabetes (T2D) (2018)	2.8	5.2	7.1	-2.4	-1.6	2.7
Commuting to job workplace: Walk	2.8	3.0	6.2	-1.4	-2.5	1.0
Medication: Cholesterol lowering	2.7	4.2	5.9	-1.4	-2.2	2.4
Hand grip strength (right)	2.6	7.2	19.5	-1.2	-0.7	-4.4
Weight	2.6	12.9	22.6	0.8	3.9	-4.8
Overall health rating	2.6	5.6	15.6	1.0	-0.5	3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	9.3	-3.0	-2.2	-1.5
Hand grip strength (left)	2.5	6.5	18.8	-0.4	0.8	-4.3
Schizophrenia (2014)	2.4	5.2	12.2	-0.1	-1.8	3.5
Medication: Lansoprazole	2.3	2.6	4.7	2.2	0.6	1.7
Medication: Amlodipine	2.3	3.3	3.5	1.7	1.9	-1.8
Diabetes diagnosed by doctor	2.3	3.8	7.1	-2.7	-1.2	1.7
Number of operations (self-reported)	2.3	3.4	7.7	1.3	-0.9	2.8
Chronotype (morning person)	2.1	4.8	13.9	-3.7	-0.6	0.4
Stomach or abdominal pain in last month	2.1	2.6	6.4	-1.0	-0.7	2.5
Had other major operations	2.1	2.6	4.2	2.0	0.2	1.9
Diabetes (self-reported)	2.1	3.3	4.5	-1.8	-1.5	2.1
Medication: Simvastatin	2.1	3.1	8.3	-0.6	-0.9	2.9
Exposure to tobacco smoke outside home	2.1	2.8	7.3	-0.1	-1.1	2.7
Diabetes (mother)	2.0	2.5	4.6	-1.2	-1.2	2.1
Tense / ‘highly strung’	2.0	3.3	7.1	0.1	-1.6	2.7
Breast cancer (self-reported)	2.0	2.4	6.2	0.3	-1.0	2.5
Bipolar Disorder or Schizophrenia	1.9	4.7	9.3	-0.6	-2.1	3.0
Schizophrenia vs Biploar Disorder	1.9	2.4	2.6	1.6	-1.5	1.6
HDL Cholesterol	1.9	3.1	5.5	-0.9	-1.8	2.3
Hip circumference	1.9	8.2	14.6	1.2	3.8	-2.9
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.7	-0.1	-1.4	2.2
Illnesses of father: Heart disease	1.9	2.7	4.3	2.1	1.1	-1.6
Schizophrenia (2018)	1.8	3.7	7.8	-0.1	-1.8	2.8
Age when periods started (menarche)	1.8	4.3	8.5	-1.9	-2.9	0.9
Illnesses of siblings	1.8	2.5	4.8	-2.2	-1.0	-1.4
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.1	0.5	1.6	-2.0
Systolic blood pressure, automated reading	1.7	4.8	7.6	2.6	2.8	-0.1
Diabetes (father)	1.7	2.1	5.9	-0.4	0.4	2.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	4.3	1.3	2.1	-0.0
Diastolic blood pressure, automated reading	1.7	5.2	8.7	3.0	2.5	-0.6
Had menopause	1.6	2.0	4.1	1.4	2.0	0.3
Age at first live birth	1.6	2.9	5.8	-1.4	-2.4	0.9
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.5	1.4	1.6	-1.1
Depression (Nagel 2018)	1.5	2.3	5.2	0.1	2.3	1.3
Coronary Artery Disease (CAD)	1.5	1.8	4.5	0.9	2.1	0.3
Allergy or Eczema	1.5	3.9	6.7	-1.9	-2.6	1.1
Pain all over the body in last month	1.5	1.6	2.6	0.7	1.6	-1.3
Had major operations	1.5	1.7	2.9	1.3	-0.9	1.7
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.4	-1.4	0.7	1.8
Ovarian Cancer	1.4	1.9	5.2	-2.3	0.0	0.7
Bipolar Disorder (2011)	1.4	1.3	2.2	-0.7	-1.5	1.1
Qualifications: CSEs or equivalent	1.4	1.9	3.8	-1.2	-1.9	0.7
Serious illness, injury or assault to yourself	1.4	1.6	3.6	0.0	-1.2	1.9
Hair/balding pattern: Pattern 2	1.4	1.8	3.9	-1.0	-2.0	0.5
Number of live births	1.4	2.0	3.4	1.0	1.9	-1.2
Depression (self-reported)	1.4	1.6	3.7	-1.1	-0.3	1.9
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.4	-0.8	-1.5	1.4
Qualifications: nursing, teaching	1.4	2.2	5.1	-2.3	-1.2	0.4
Tinnitus: Yes, now most or all of the time	1.4	1.7	3.5	0.1	1.2	-1.9
Pack years of smoking	1.4	2.1	5.4	0.8	-0.5	2.3
Breast Cancer	1.3	3.2	6.0	-2.4	0.8	-1.7
Townsend deprivation index at recruitment	1.3	1.9	5.3	-0.3	-0.4	2.3
High blood pressure (siblings)	1.3	1.9	5.4	2.3	0.4	0.5
Number of full brothers	1.3	1.7	2.6	1.6	1.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.5	0.5	-1.6	1.3
Chest pain or discomfort	1.3	1.9	3.0	1.4	1.7	-0.9
Alcohol drinker status: Never	1.3	1.6	4.2	-0.0	-0.7	2.1
Alzheimer’s Disease (in father)	1.2	1.3	2.2	-0.0	1.5	-1.3
Blood White Count	1.2	9.0	25.4	1.1	-0.6	5.0
Neuroticism	1.2	2.8	5.1	2.3	0.5	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.3	1.8	0.3	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.7	-0.9	-1.6	0.8
Blood clot in the leg (DVT)	1.2	1.6	2.7	-1.2	0.8	1.6
Medication: Allopurinol	1.2	1.6	3.3	-1.1	-1.8	0.7
Leg pain on walking	1.2	1.5	3.8	-0.2	-0.7	1.9
Age started oral contraceptive pill	1.2	1.5	2.2	0.6	1.5	-1.3
Supplements: Calcium	1.2	1.3	3.0	1.7	0.7	0.7
Chronic bronchitis/emphysema (father)	1.1	1.2	2.1	0.3	-1.5	1.2
Average weekly red wine intake	1.1	1.6	3.0	-1.3	-1.7	0.3
Ever had bowel cancer screening	1.1	1.3	2.0	-0.8	-1.1	1.4
Medication: Levothyroxine sodium	1.0	1.7	2.8	-1.5	-1.7	0.2
Qualifications: None of the above	1.0	2.2	5.2	1.2	2.3	0.1
Financial difficulties in last 2 years	1.0	1.4	2.3	0.7	-1.5	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.9	0.2	0.9	-2.0
Age at last live birth	1.0	1.5	3.0	-1.1	-1.7	0.5
Knee pain experienced in last month	1.0	1.6	2.4	0.8	-1.4	1.6
Back pain experienced in last month	1.0	1.4	4.0	0.1	2.0	-0.6
Fractured/broken bones in last 5 years	1.0	1.3	2.7	1.6	0.7	-0.9
Heart disease (siblings)	1.0	1.2	1.8	-0.5	-1.3	1.3
Hearing difficulty/problems: Yes	0.9	1.3	3.7	1.9	0.5	-0.3
Relative age of first facial hair	0.9	1.9	3.1	-1.6	-0.2	-1.8
Angina	0.9	1.2	2.9	1.7	0.6	-0.5
Pack years adult smoking proportion	0.9	1.4	3.5	0.9	-0.1	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.9	0.3	1.7	0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	2.3	1.5	1.5	0.3
Heart disease (mother)	0.9	1.1	2.6	1.6	0.4	0.6
Illnesses of father: High blood pressure	0.9	1.1	1.6	-1.0	-0.9	1.2
Bipolar Disorder (2018)	0.8	1.3	2.0	-0.8	-1.1	1.4
Systolic Blood Pressure	0.8	4.1	6.3	2.4	2.5	0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.4	-0.6	1.2	-0.9
Medication: Atenolol	0.8	1.0	2.0	1.4	1.0	0.3
Trunk fat mass	0.8	3.5	6.0	0.3	2.5	-2.1
Waist circumference	0.8	3.0	6.4	1.1	2.5	-1.1
Lung cancer (father)	0.8	0.9	2.2	0.5	-1.5	0.6
Illnesses of mother	0.8	1.0	1.8	0.1	1.3	-1.1
Gout (self-reported)	0.8	1.1	1.6	-0.5	-1.3	1.1
Qualifications: College or University degree	0.8	2.4	5.6	-2.4	-1.3	0.0
Neck or shoulder pain in last month	0.8	1.1	1.7	1.2	0.4	1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.6	-0.2	0.6	1.6
Asthma (self-reported)	0.8	1.6	2.6	-1.6	-1.2	0.9
Medication: Lisinopril	0.8	1.1	1.9	0.0	-1.4	1.2
Risk taking	0.8	1.1	3.3	0.2	-1.8	-0.2
Neuroticism (2016)	0.7	1.0	1.7	1.1	-1.3	0.3
Hypothyroidism (self reported)	0.7	1.5	2.8	-1.7	0.4	-1.2
Respiratory disease	0.7	1.5	3.3	-1.8	-0.4	1.0
High blood pressure	0.7	2.0	3.0	1.7	1.7	0.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.2	-1.0	-1.8	0.5
Pulse wave reflection index	0.7	0.8	1.3	0.7	-1.1	0.8
Shortness of breath walking on level ground	0.7	0.9	2.6	0.0	0.1	1.6
Medication: Omeprazole	0.7	0.9	1.7	-0.6	-1.3	0.7
Medication: Seretide 50 evohaler	0.7	0.8	1.1	-1.0	1.0	0.4
Medication: Aspirin	0.7	0.9	1.8	0.6	-0.7	1.4
Number of self-reported non-cancer illnesses	0.7	1.3	2.8	0.6	-0.7	1.7
Financial situation satisfaction	0.7	0.8	2.0	1.4	-0.1	0.7
Leg fat percentage (left)	0.7	2.6	5.5	1.3	0.8	2.3
Irritability	0.7	1.1	2.7	0.7	-0.5	1.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.0	1.0	-0.3	0.9
Crohns Disease (2017)	0.6	1.4	1.8	-1.4	1.0	-1.1
Sensitivity / hurt feelings	0.6	1.0	2.3	0.2	-0.9	1.5
Severe depression (siblings)	0.6	0.7	1.4	-0.5	-1.2	0.7
Hearing difficulty/problems with background noise	0.6	0.9	2.1	1.4	0.3	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.9	-0.6	-1.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.0	1.0	1.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-1.6	-0.0	-0.8
Leg fat percentage (right)	0.6	2.2	5.4	0.9	0.7	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	0.8	-0.9	-0.9	0.9
Angina (self-reported)	0.6	0.8	1.6	1.3	0.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.9	-0.9	-0.9	0.7
Whole body fat mass	0.6	2.3	4.2	0.5	2.1	-1.6
Medication: Aspirin	0.6	0.8	2.1	0.2	-0.5	1.4
Hypertension (Self-reported)	0.6	1.7	3.0	1.7	1.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	1.0	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.0	1.0	-1.0	0.3
Friendships satisfaction	0.6	0.7	1.2	1.1	0.4	-1.0
Osteoarthritis (self-reported)	0.6	0.8	1.4	1.2	0.2	-0.9
Average weekly champagne plus white wine intake	0.6	0.8	2.2	0.1	0.5	-1.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	0.4	-1.1	0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.1	1.0	-0.6	1.0
Medication: Atorvastatin	0.6	0.7	1.8	1.4	-0.4	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.6	-1.3	-0.7	-0.3
Myopia	0.6	0.9	2.0	-0.6	-1.4	0.6
Pain experienced in last month	0.6	1.0	1.6	-1.2	0.4	-1.2
Alcohol drinker status: Previous	0.6	0.7	1.2	-0.5	-0.9	1.1
Irritable Bowel Disease (IBD)	0.5	1.3	1.5	-1.2	1.1	-1.0
Blood Eosinophil Count	0.5	4.2	11.8	-0.4	-0.7	3.4
Number of treatments/medications taken	0.5	0.9	1.8	0.3	-0.9	1.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	1.0	0.7	0.3
Medication: Co-codamol	0.5	0.6	1.6	-0.2	-0.4	1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	-1.1	-0.3	0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	-1.2	-0.6	0.3
Impedance of leg (left)	0.5	2.6	3.0	1.7	-1.5	1.7
Number of incorrect matches in round	0.5	0.8	1.2	0.6	0.9	1.1
Mouth/teeth dental problems	0.5	0.8	1.8	-0.7	-1.4	0.2
Heart attack	0.5	0.7	1.1	0.8	-0.4	1.1
Worrier / anxious feelings	0.5	1.0	1.7	1.3	-0.2	1.1
Happiness	0.5	0.7	1.5	-1.2	-0.2	-0.6
Asthma	0.5	1.0	1.8	-1.4	-0.9	0.5
Pulse wave Arterial Stiffness index	0.5	0.5	0.9	0.3	1.0	-0.7
Arm fat mass (right)	0.5	2.0	4.6	0.2	2.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	0.2	-1.5	0.6
Glaucoma (self-reported)	0.5	0.6	1.1	0.5	-1.0	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-1.2	0.1	-0.7
Number of full sisters	0.5	0.6	0.8	0.8	-0.6	0.9
Osteoporosis (self-reported)	0.5	0.6	1.4	-1.2	-0.4	-0.5
Ever taken oral contraceptive pill	0.5	0.5	1.3	1.2	0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	1.1	-0.5	0.7
Leg fat mass (left)	0.5	1.9	3.8	1.1	2.0	-0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.1	1.0	1.1	0.7
Neuroticism (Nagel 2018)	0.4	1.0	1.8	1.1	0.1	1.3
Prostate Cancer	0.4	0.6	1.2	1.1	-0.5	0.7
Age at First Birth	0.4	0.6	1.0	-1.0	-0.8	0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	-1.2	-0.0	0.4
HbA1C	0.4	0.5	1.0	0.4	0.4	-1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	0.3	0.2	1.1
Average weekly spirits intake	0.4	0.5	0.6	0.8	0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	-0.9	0.5	0.7
Impedance of leg (right)	0.4	1.7	2.3	1.0	-1.5	1.3
Maternal smoking around birth	0.4	0.7	1.3	1.1	0.7	0.4
Fed-up feelings	0.4	0.8	1.3	1.1	1.0	0.4
Supplements: Glucosamine	0.4	0.5	1.0	0.1	0.6	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	-0.0	-0.8	0.9
Neuroticism score	0.4	0.8	1.8	1.3	0.1	0.7
Time employed in main current job	0.4	0.5	0.9	0.1	-0.8	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.5	-0.2	-0.6	-1.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	1.1	0.3	0.3
Comparative body size at age 10	0.4	1.0	1.8	-1.4	-1.0	0.1
Medication: Blood pressure	0.4	0.8	1.8	1.3	0.6	0.4
Leg fat mass (right)	0.4	1.6	3.6	0.9	1.9	-0.7
Alcohol intake frequency.	0.4	0.8	2.2	0.0	-0.5	1.5
Family relationship satisfaction	0.4	0.5	0.8	-0.8	-0.9	0.3
Loneliness, isolation	0.4	0.6	1.6	0.3	-0.3	1.3
Mineral and other dietary supplements	0.4	0.6	1.1	-1.0	-0.3	-0.7
Arm fat mass (left)	0.4	1.8	4.2	-0.1	2.0	-1.0
Guilty feelings	0.4	0.5	0.9	0.9	0.8	0.2
Hearing aid user	0.4	0.5	0.9	0.3	-1.0	0.6
Mother’s age at death	0.4	0.5	1.4	-1.2	-0.0	0.3
Ever depressed for a whole week	0.4	0.5	1.5	0.0	-1.2	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	-1.3	-1.1	-0.6
Impedance of whole body	0.4	2.2	3.5	0.3	-1.9	1.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.0	-1.0	-0.9	-0.9
Ulcerative Colitis (UC)	0.3	0.5	0.8	-0.6	0.9	-0.5
Crohns Disease (2012)	0.3	0.5	1.0	-0.3	0.7	-1.0
Mean Putamen Volume	0.3	0.4	0.5	0.3	-0.7	0.7
Rheumatoid Arthritis	0.3	0.4	1.0	1.0	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	0.4	0.7	0.5
Supplements: Zinc	0.3	0.3	0.8	-0.3	0.9	-0.3
Body mass index (BMI)	0.3	1.2	1.9	0.7	1.2	1.4
Medication: Ramipril	0.3	0.4	0.8	-0.1	0.6	-0.9
Arm fat percentage (right)	0.3	1.1	2.7	0.0	0.8	1.6
Father’s age at death	0.3	0.4	1.0	-0.5	1.0	0.2
Prospective memory result	0.3	0.4	0.5	-0.6	0.7	0.6
Impedance of arm (left)	0.3	1.2	1.9	-0.8	-1.4	1.0
Length of working week for main job	0.3	0.3	0.4	0.6	0.7	-0.3
Breastfed as a baby	0.3	0.3	1.0	-1.0	-0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	0.5	1.1	-0.4
Headache pain in last month	0.3	0.5	1.1	-0.4	-0.5	1.1
Number of children fathered	0.3	0.3	0.4	-0.6	0.6	-0.4
Suffer from ‘nerves’	0.3	0.4	0.6	0.6	0.8	-0.6
Smoking status: Previous	0.3	0.4	1.0	-0.1	0.6	-1.0
Arm fat percentage (left)	0.3	1.1	2.9	-0.3	0.6	1.7
Long-standing illness, disability or infirmity	0.3	0.4	1.1	1.1	-0.1	-0.1
Medication for cholesterol	0.3	0.4	1.1	-0.2	1.0	-0.3
Medication: Gliclazide	0.3	0.3	0.5	0.5	0.4	0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	-0.3	0.9	-0.4
Commuting to job workplace: Public transport	0.3	0.4	0.9	-0.9	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.0	0.3	-1.0	0.6
High cholesterol (Self-reported)	0.3	0.6	0.9	0.1	-0.9	1.0
Average weekly beer plus cider intake	0.3	0.5	1.3	0.3	-0.3	1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.0	-0.9	0.6
Worry (Nagel 2018)	0.2	0.5	0.8	0.9	-0.2	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.0	-0.7	0.8
Lupus	0.2	0.3	0.6	0.6	0.1	-0.8
Blood Platelet Count	0.2	2.3	6.4	0.7	-0.2	2.5
Smoking Status	0.2	0.4	0.8	0.6	-0.1	-0.9
Cardiovascular Disease	0.2	0.5	0.8	0.1	0.9	0.9
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.3	-0.6	0.2
Medication: Metformin	0.2	0.3	0.6	-0.7	0.1	0.5
Current tobacco smoking	0.2	0.3	0.4	0.2	-0.6	0.6
Average weekly fortified wine intake	0.2	0.3	0.3	0.6	-0.5	0.5
Taking other prescription medications	0.2	0.2	0.4	0.5	0.6	-0.1
Past tobacco smoking	0.2	0.3	0.9	0.1	-0.2	0.9
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.1	-0.6	0.8
Allergy	0.2	0.4	0.7	0.6	0.8	-0.5
Fluid intelligence score	0.2	0.4	0.5	-0.2	-0.7	-0.7
Impedance of arm (right)	0.2	0.9	1.9	-0.6	-1.4	0.7
Hair/balding pattern: Pattern 3	0.2	0.4	0.8	0.2	-0.4	0.9
Noisy workplace	0.2	0.2	0.5	-0.0	-0.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.3	-0.2	0.9
Medication: Paracetamol	0.2	0.3	0.8	-0.9	-0.3	0.3
Body fat percentage	0.2	0.9	1.3	0.7	1.0	1.1
Worry too long after embarrassment	0.2	0.3	0.4	-0.3	-0.5	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.0	-0.8	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.8	0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.3	0.7	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.1	-0.2	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.0	0.7	-0.7
Pulse rate, automated reading	0.2	0.5	1.2	0.0	1.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.8	-0.4	0.0
Mood swings	0.2	0.4	1.2	-0.0	0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.5	-0.1	-0.7
Wears glasses or contact lenses	0.2	0.3	0.5	-0.5	-0.1	-0.7
Ever smoked	0.2	0.3	0.8	0.0	0.3	-0.9
Cholesterol lowering medication	0.2	0.3	0.9	0.9	0.3	0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	-0.9	-0.1	0.1
Major Depression (MDD)	0.1	0.2	0.4	0.1	-0.3	0.7
Reaction Time	0.1	0.3	0.6	0.0	-0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	-0.2	0.1	-1.0
Fasting Glucose	0.1	0.1	0.4	-0.2	0.0	0.6
LDL Cholesterol	0.1	0.1	0.3	-0.3	0.0	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.0	-0.4	-0.4
Triglycerides	0.1	0.1	0.3	-0.5	0.1	-0.4
Ulcerative Colitis	0.1	0.2	0.4	0.0	0.3	-0.6
Blood Red Count	0.1	1.3	1.9	1.4	1.4	0.5
Heel T-Score	0.1	0.9	1.4	0.5	1.2	1.1
BMI	0.1	0.5	1.0	-0.2	1.0	0.8
Lung FEV1/FVC ratio	0.1	0.6	0.9	-0.6	-1.0	0.6
Tanning	0.1	1.2	2.0	0.8	1.0	-1.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.3	0.6	-0.1
Vitamin and mineral supplements	0.1	0.2	0.5	0.1	0.1	-0.7
Trunk fat percentage	0.1	0.6	1.5	0.4	1.2	0.3
Relative age voice broke	0.1	0.1	0.2	-0.4	0.0	-0.3
Multivitamins +/- minerals	0.1	0.2	0.3	0.5	0.4	-0.2
High blood pressure (mother)	0.1	0.2	0.2	-0.5	-0.5	-0.1
Nervous feelings	0.1	0.1	0.4	0.7	0.0	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.1	-0.0	0.7
Alcohol intake versus 10 years previously	0.1	0.1	0.4	0.1	0.6	-0.2
Falls in the last year	0.1	0.1	0.1	-0.4	0.1	0.4
Pulse rate	0.1	0.2	0.6	0.4	0.8	0.1
Pulse wave peak to peak time	0.1	0.2	0.3	-0.3	-0.5	-0.3
Health satisfaction	0.1	0.1	0.1	0.3	-0.1	0.4
Mean time to correctly identify matches	0.1	0.3	0.7	-0.2	-0.8	0.2
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	0.1	0.3
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.6	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.3	0.2	0.6
Smoking status: Current	0.1	0.1	0.3	0.2	-0.6	0.1
Miserableness	0.1	0.1	0.3	0.6	0.1	0.3
Medication: Blood pressure	0.1	0.2	0.6	0.8	0.1	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.5	0.4	-0.1
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.2	0.2
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.0	0.2	0.5
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.1	-0.3	0.2
Hair Pigment	0.0	1.4	2.3	0.2	-1.3	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.2	0.3	0.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	-0.0	0.5	0.1
Migraine (self-reported)	0.0	0.0	0.1	0.3	-0.1	0.1
Medication: Ibuprofen	0.0	0.1	0.1	-0.1	0.3	0.2

Hub : Genes

TRA2A

Models

Trait associations