Hub : Genes

CCDC126

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.019	5.1e-03	0.015	0.007	0.013	0.01	0.016	4.8e-03	3.7e-02	9.1e-03	0.021	4.4e-03
2	GTEx	Artery Aorta	0.0780	0.038	7.5e-03	0.013	NA	0.000	NA	0.001	6.2e-02	NA	3.2e-01	NA	2.8e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.5180	0.088	5.6e-07	0.388	NA	0.402	NA	0.374	1.0e-13	NA	2.9e-14	NA	3.6e-13
4	GTEx	Esophagus Mucosa	0.1220	0.048	1.2e-03	0.032	NA	0.010	NA	0.013	3.3e-03	NA	6.7e-02	NA	4.3e-02
5	YFS	Blood	0.0548	0.016	6.4e-10	0.042	0.035	0.048	NA	0.048	1.2e-13	1.0e-11	1.6e-15	NA	2.3e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.6	3.5	-1.0	0.5	-1.9	0.8	-1.7
Bipolar Disorder or Schizophrenia	1.3	3.2	6.5	-2.1	-1.0	-1.6	1.3	-2.5
Depressed Affect (Nagel 2018)	0.8	1.6	3.0	-1.5	1.7	1.2	-0.7	1.1
Depression (Nagel 2018)	1.8	2.7	4.5	-1.3	0.1	2.0	-1.9	2.1
Intelligence (Savage-Jansen 2018)	1.2	3.7	7.2	-1.6	1.0	-0.9	2.7	-2.7
Neuroticism (Nagel 2018)	0.9	2.1	6.2	-2.5	1.7	1.2	-0.3	0.5
Schizophrenia (2018)	1.1	2.3	3.9	-2.0	-1.7	-0.2	1.1	-1.9
Schizophrenia vs Biploar Disorder	1.5	2.0	6.2	-2.5	-1.0	1.2	0.8	-0.8
Worry (Nagel 2018)	0.6	1.3	3.4	-1.9	1.5	0.7	-0.4	0.1
Alzheimer’s Disease (in mother)	1.0	1.1	4.4	-2.1	-0.6	0.9	-0.1	-0.3
Alzheimer’s Disease (in father)	0.6	0.6	1.9	1.4	-0.2	0.8	-0.1	0.8
Alzheimer’s Disease (including proxy)	0.7	0.9	2.2	-1.4	0.5	1.5	-0.4	0.4
Crohns Disease (2017)	0.5	1.1	3.8	-0.9	-0.8	0.4	2.0	-0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.6	-0.7	-0.4	0.7	1.3	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.5	-0.0	-0.1	0.7	0.4
Major Depression (MDD)	1.5	1.8	4.9	-2.2	0.8	1.3	-0.8	1.1
Reaction Time	2.4	4.6	9.4	-1.0	2.7	-1.6	3.1	-1.6
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.2	-0.5	0.8	-0.7	2.3	-2.3
Breast Cancer	0.2	0.5	1.5	-0.3	-1.2	-0.3	0.9	0.1
Ovarian Cancer	0.9	1.2	4.6	-1.0	-0.5	2.1	0.4	0.2
Prostate Cancer	1.7	2.4	4.7	1.7	0.4	-2.0	0.3	-2.2
Age at First Birth	0.5	0.7	1.5	-0.4	-1.2	1.2	-0.1	0.4
Bipolar Disorder (2011)	1.0	1.0	2.4	0.2	-0.7	-1.2	0.6	-1.6
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-1.2	0.2	0.7	0.1	0.4
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.6	0.1	0.9	-0.8	0.8
Crohns Disease (2012)	1.1	1.7	5.9	-0.8	-2.4	1.0	1.1	0.1
Mean Putamen Volume	0.2	0.2	0.8	0.9	0.0	0.3	0.1	-0.3
Fasting Glucose	1.4	1.6	3.0	-1.1	-0.8	1.3	-1.3	1.7
HbA1C	1.3	1.4	3.1	-0.2	-1.2	-1.1	1.8	-1.1
HDL Cholesterol	0.3	0.5	1.3	-0.6	-0.2	-0.9	-0.3	-1.2
LDL Cholesterol	0.1	0.2	0.7	0.1	0.4	-0.2	0.4	-0.8
Lupus	1.5	2.3	5.9	2.4	-1.2	-1.5	0.3	-1.2
Neuroticism (2016)	0.6	0.8	2.2	-1.5	-0.5	-0.1	0.8	-0.9
Primary Biliary Cirrhosis	0.4	0.5	1.4	-0.9	1.2	-0.2	0.5	-0.4
Rheumatoid Arthritis	2.1	2.9	5.3	0.0	2.3	-2.3	0.8	-1.9
Schizophrenia (2014)	1.5	3.3	6.6	-2.6	-1.9	-0.3	1.2	-2.2
Triglycerides	1.7	2.7	7.9	-0.4	-2.8	1.9	-0.5	1.3
Type 2 Diabetes (T2D) (2012)	0.7	0.9	3.3	0.4	0.0	0.1	-1.8	0.9
Ulcerative Colitis	0.2	0.2	0.8	0.7	0.1	-0.0	-0.1	0.9
Blood Eosinophil Count	1.4	10.6	16.5	-3.6	-0.1	4.1	-3.2	3.6
Blood Platelet Count	0.1	1.6	6.9	0.3	0.0	1.0	-2.6	-0.1
Blood Red Count	0.1	0.6	1.7	0.6	-0.7	0.7	-1.3	0.4
Blood White Count	2.2	16.0	29.3	-2.8	0.6	4.6	-5.4	4.6
Heel T-Score	0.6	5.0	8.9	0.5	-1.8	2.5	-3.0	2.5
BMI	0.3	1.6	3.1	-1.7	0.7	1.8	-0.1	1.1
Height	4.7	90.7	201.6	6.2	0.9	-10.3	14.2	-10.3
Waist Hip Ratio (WHR)	0.6	2.6	5.0	0.5	-2.2	1.3	-1.6	1.9
Systolic Blood Pressure	0.6	3.0	14.1	-0.1	-3.8	0.7	0.2	-0.7
Smoking Status	0.7	1.6	2.9	-0.1	1.5	1.7	0.2	1.7
Allergy or Eczema	0.5	1.4	5.4	0.7	2.3	-0.9	-0.4	-0.2
Cardiovascular Disease	0.2	0.7	2.9	-0.5	-1.7	-0.5	0.3	-0.2
Hypothyroidism (self reported)	0.6	1.3	2.8	1.1	-0.2	-1.3	1.7	-0.8
Respiratory disease	0.3	0.6	2.5	-1.6	0.1	0.5	-0.2	0.5
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.8	-2.6	-1.4	1.9	-0.9	1.1
Lung FEV1/FVC ratio	0.4	2.1	3.7	1.9	1.2	0.2	-1.6	1.6
Lung FVC	4.2	21.3	31.7	4.2	2.2	-5.6	4.6	-5.6
Neuroticism	1.0	2.4	4.5	-2.1	1.4	1.8	-1.1	1.1
Chronotype (morning person)	1.1	2.4	5.5	-2.3	-0.4	1.7	-0.4	1.8
Hair Pigment	0.1	2.2	10.1	-0.8	3.2	-0.2	-0.6	0.2
Tanning	0.1	1.7	6.3	2.5	-0.1	-0.7	-0.9	1.0
Hand grip strength (left)	0.9	2.3	5.8	2.4	-1.5	-0.2	1.6	0.8
Number of treatments/medications taken	0.3	0.5	2.2	-1.5	-0.3	0.3	-0.1	0.2
Average weekly spirits intake	0.9	1.1	2.7	-0.5	1.4	1.6	0.1	0.7
Sensitivity / hurt feelings	0.3	0.5	1.8	-0.8	1.4	0.3	0.0	-0.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.2	-0.6	0.6	-0.5	0.2
Hearing difficulty/problems: Yes	0.6	0.9	3.6	-1.9	0.2	-0.3	0.7	-0.3
Relative age of first facial hair	0.3	0.7	1.3	0.9	-0.4	-0.8	1.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.6	-0.4	-0.3	-0.1	-0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.8	-1.1	-0.6	1.5	-0.8	1.7
Ever had hysterectomy (womb removed)	1.5	1.7	2.6	0.7	-1.6	1.0	-1.6	1.5
Systolic blood pressure, automated reading	0.5	1.4	5.7	0.6	-2.4	0.7	-0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.8	-0.3	0.7	0.4	0.3
Angina	0.8	1.1	4.8	-2.2	-0.1	-0.2	0.6	-0.2
Medication for hormone replacement therapy	0.8	0.9	1.7	-0.5	0.4	-1.3	0.9	-1.1
Vitamin and mineral supplements	1.1	1.5	3.8	1.6	-1.9	-0.3	-0.8	0.6
Supplements: Zinc	0.3	0.3	0.8	0.7	0.9	0.0	0.4	-0.1
Medication: Co-codamol	1.8	2.1	5.7	0.5	2.4	0.5	-1.7	1.2
Medication: Metformin	0.3	0.5	0.9	-1.0	-0.7	0.8	0.1	0.5
Diabetes (father)	3.8	4.7	6.8	-2.1	-1.3	2.6	-2.3	2.4
Diabetes (mother)	2.0	2.5	4.2	0.3	-1.4	1.6	-2.1	1.9
Severe depression (siblings)	1.5	1.7	4.2	-0.7	2.0	0.8	-1.1	1.4
Pack years adult smoking proportion	3.4	5.2	9.2	0.0	-0.2	3.0	-2.8	3.0
Impedance of leg (right)	0.7	3.3	10.3	0.8	-1.3	0.4	-3.2	2.0
Leg fat-free mass (left)	2.1	11.2	37.0	1.2	0.6	-2.4	6.1	-3.4
Trunk fat percentage	0.2	0.8	1.7	-1.3	0.3	0.9	-0.5	1.1
Hand grip strength (right)	1.5	4.0	7.7	2.5	-1.5	-1.6	2.8	-1.1
Townsend deprivation index at recruitment	2.2	3.1	4.9	-2.1	0.2	2.2	-1.7	1.8
Current tobacco smoking	1.4	2.2	5.0	0.2	2.2	1.0	-1.5	1.7
Average weekly fortified wine intake	1.1	1.3	2.5	-1.2	-0.1	-1.6	1.0	-1.1
Maternal smoking around birth	2.0	2.9	7.9	1.1	-0.6	1.5	-2.8	1.7
Fed-up feelings	0.5	1.0	1.7	0.1	-1.3	0.7	-1.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	7.5	-0.5	-0.5	2.0	-2.6	2.7
Relative age voice broke	0.4	0.6	1.3	0.7	-0.5	0.7	-0.6	1.1
Taking other prescription medications	0.3	0.5	1.8	0.7	-1.3	-0.3	-0.1	-0.0
Age when periods started (menarche)	0.6	1.5	5.3	0.8	2.3	-1.1	0.1	0.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.4	3.5	1.6	-1.9	1.0	-1.3	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.0	-1.3	0.1	1.7	-0.6	1.1
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	4.1	0.8	2.0	1.3	-1.4	2.0
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.2	0.1	0.7	-0.1	-0.0
Serious illness, injury or assault to yourself	0.3	0.3	0.9	-0.2	-0.9	0.1	-0.8	-0.1
High blood pressure	0.7	1.9	2.8	-1.1	-1.7	-1.3	1.1	-1.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	0.8	1.1	-0.5	-0.5	-0.0
Multivitamins +/- minerals	0.7	0.9	2.0	-1.4	0.3	0.2	1.2	-0.9
Stomach or abdominal pain in last month	1.8	2.3	8.3	-2.9	0.8	0.7	0.8	-1.1
Supplements: Glucosamine	1.6	2.1	4.1	0.8	1.2	-1.5	2.0	-1.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.2	0.5	-0.4	0.4	-0.4
Medication: Atenolol	0.4	0.4	1.4	-1.2	-0.8	-0.1	0.2	-0.1
Medication: Levothyroxine sodium	0.8	1.4	2.1	-0.3	-1.1	-1.5	1.4	-1.2
Sitting height	3.7	26.3	65.0	3.7	0.4	-5.0	8.1	-5.3
Chronic bronchitis/emphysema (father)	1.0	1.2	3.1	0.1	-1.4	-0.8	-0.3	-1.8
High blood pressure (mother)	0.2	0.3	0.8	-0.5	0.3	0.6	-0.1	0.9
Body mass index (BMI)	0.4	1.9	3.8	-1.9	-0.0	2.0	-0.8	1.2
Impedance of leg (left)	0.7	3.5	11.3	1.2	-1.4	0.1	-3.4	1.7
Leg predicted mass (left)	2.0	10.8	36.6	1.2	0.6	-2.2	6.0	-3.3
Trunk fat mass	0.2	0.7	2.5	-0.8	0.4	-0.0	1.6	-0.1
Waist circumference	0.3	1.0	1.8	-1.2	-1.3	0.3	1.3	-0.3
Number of incorrect matches in round	0.8	1.2	5.5	-0.7	-2.3	0.5	-0.1	0.2
Past tobacco smoking	0.2	0.3	0.8	-0.3	-0.0	-0.9	-0.7	-0.5
Alcohol usually taken with meals	1.0	1.6	3.6	-1.1	-0.5	-1.9	1.3	-1.2
Nervous feelings	0.1	0.1	0.3	-0.3	0.2	0.5	0.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-0.9	-0.2	1.0	-0.1	0.3
Hearing difficulty/problems with background noise	1.7	2.7	10.6	-3.3	0.6	1.3	0.8	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.2	1.0	0.1	-0.9	0.6
Had menopause	0.8	1.0	2.1	0.2	0.2	0.9	-1.3	1.4
Had other major operations	2.6	3.2	7.6	1.4	0.7	1.1	-2.8	2.1
Forced vital capacity (FVC)	7.5	28.9	44.7	4.5	2.9	-6.0	6.7	-6.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.2	-1.5	0.1	1.5	-1.0	1.0
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.5	-1.6	-0.3	1.9	-1.3	1.5
Qualifications: None of the above	1.7	3.6	7.3	1.9	0.2	1.1	-2.7	2.4
Financial difficulties in last 2 years	0.5	0.7	1.8	-1.4	-0.7	0.3	-1.0	0.2
Mouth/teeth dental problems	0.5	0.7	1.5	1.2	-0.3	-0.7	-0.6	-1.1
Heart attack	0.2	0.2	0.5	-0.7	-0.4	-0.1	-0.4	0.6
Allergy	0.1	0.3	0.5	-0.6	-0.5	0.2	0.7	-0.6
Pain all over the body in last month	0.5	0.5	0.7	0.8	0.3	-0.8	-0.8	0.8
Diabetes (self-reported)	1.6	2.5	4.6	-1.5	-0.9	2.1	-1.4	1.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.5	0.9	-0.4	0.2	-0.2
Medication: Ramipril	0.2	0.3	0.6	0.6	0.2	-0.8	0.4	-0.5
Medication: Simvastatin	2.0	2.9	5.0	-1.1	-0.9	1.7	-2.2	2.2
Fluid intelligence score	0.5	1.0	2.6	-0.4	0.6	0.2	1.3	-1.6
Illnesses of siblings	1.2	1.7	7.3	2.7	-0.2	-0.9	0.3	-0.6
Neuroticism score	0.4	0.8	1.8	-1.4	1.2	0.7	-0.4	0.0
Weight	0.9	4.6	17.1	0.1	0.2	-1.3	4.1	-2.0
Impedance of arm (right)	0.2	0.8	2.5	0.6	-0.8	-0.3	-1.6	0.7
Arm fat percentage (right)	0.7	2.8	4.8	-2.2	0.0	2.0	-1.5	1.7
Trunk fat-free mass	3.1	17.9	53.4	2.4	0.4	-3.6	7.3	-4.1
Hip circumference	0.4	1.5	5.6	-0.7	-0.2	-0.6	2.4	-1.0
Time employed in main current job	2.1	2.4	4.7	-0.5	0.2	-1.9	1.9	-2.2
Alcohol intake versus 10 years previously	0.3	0.5	1.0	1.0	-0.5	0.2	-0.6	0.8
Father’s age at death	1.4	1.9	3.9	-1.3	-1.0	2.0	-0.5	1.7
Worrier / anxious feelings	0.4	0.8	1.9	-0.8	0.6	1.4	-1.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.1	-1.6	-2.0	1.0	-1.0	1.1
Falls in the last year	0.5	0.7	1.3	-0.7	-0.4	-0.8	-0.8	1.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.4	-1.0	-0.7	-0.7	0.5
Number of live births	0.5	0.7	1.9	-0.4	1.4	-0.6	1.0	-0.5
Forced expiratory volume in 1-second (FEV1)	7.6	25.8	36.1	4.6	2.3	-6.0	5.9	-5.7
Pulse rate	0.1	0.2	0.3	-0.5	-0.5	0.5	0.0	0.3
Happiness	1.5	1.8	3.9	-0.2	0.3	-2.0	1.4	-1.8
Noisy workplace	0.3	0.4	1.1	0.1	1.1	0.4	-0.4	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.8	-0.7	0.8	0.1	2.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	-0.8	-0.9	-1.8	-0.1	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.9	-0.4	0.8	-0.4	0.9
Asthma	0.2	0.3	0.8	-0.6	-0.4	0.3	-0.5	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.5	-2.1	-0.4	1.7	0.2	0.9
Medication: Cholesterol lowering	0.8	1.3	2.4	-1.1	-0.1	1.2	-1.5	1.2
Depression (self-reported)	1.0	1.2	2.0	-0.8	0.3	1.1	-1.4	1.4
Medication: Lansoprazole	2.5	2.8	5.3	-2.3	-2.0	1.2	-1.3	1.3
Prospective memory result	0.8	1.0	1.9	-1.2	-0.4	1.4	-0.6	1.1
Lung cancer (father)	0.6	0.7	1.4	1.1	1.2	-0.6	-0.7	-0.1
Illnesses of mother	0.3	0.3	1.1	0.5	-1.1	0.6	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.5	20.0	4.5	1.2	-4.4	4.4	-4.2
Pulse wave Arterial Stiffness index	1.4	1.7	3.1	0.7	1.1	-1.3	1.3	-1.8
Impedance of arm (left)	0.1	0.4	1.4	0.2	-0.4	-0.1	-1.2	0.6
Arm fat mass (right)	0.1	0.5	1.4	-1.2	0.3	0.6	0.9	0.1
Trunk predicted mass	3.1	17.6	52.7	2.4	0.4	-3.6	7.3	-4.1
Standing height	4.8	47.3	116.6	4.5	0.9	-7.2	10.8	-6.9
Length of working week for main job	0.2	0.2	0.8	0.1	0.3	-0.9	-0.4	-0.2
Exposure to tobacco smoke at home	1.6	1.8	4.9	-0.5	-2.2	-1.0	1.3	-1.1
Breastfed as a baby	0.2	0.2	0.4	0.2	0.6	-0.5	0.6	-0.4
Tense / ‘highly strung’	1.3	2.1	5.3	-1.3	0.7	1.5	-2.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.9	-1.2	0.3	1.6	-1.3	2.2
Hair/balding pattern: Pattern 4	0.4	0.9	3.3	-1.8	-0.5	0.8	0.5	-0.3
Birth weight of first child	2.9	5.3	9.3	1.7	1.3	-2.9	3.0	-2.1
Peak expiratory flow (PEF)	3.2	7.5	11.2	2.6	2.4	-3.3	2.6	-2.6
Pulse wave reflection index	1.7	2.1	3.6	1.4	1.2	-1.8	0.4	-1.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.2	-1.8	-0.9	0.9	-0.5	0.9
Loud music exposure frequency	4.0	4.4	7.7	1.1	1.3	2.0	-2.8	2.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.0	-0.6	-2.0	0.5	0.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.1	-1.8	0.5	-0.1	1.4	0.0
Blood clot in the leg (DVT)	3.1	4.1	7.3	0.2	-0.2	2.5	-2.6	2.7
Medication: Paracetamol	0.5	0.8	1.2	-0.9	-0.2	1.1	-0.8	1.1
Headache pain in last month	0.5	0.9	3.0	-0.5	-0.2	-0.5	1.0	-1.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.5	0.8	-0.3	-1.0	1.6	-1.1
Glaucoma (self-reported)	1.5	1.8	3.5	1.9	1.3	-0.7	-1.8	0.2
Gout (self-reported)	0.9	1.2	2.6	-1.6	0.7	-0.8	0.8	-1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.6	0.5	-0.5	-1.0	1.9	-0.9
Medication: Amlodipine	1.9	2.7	6.8	-1.5	0.4	-1.0	2.6	-1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.3	1.3	2.3	-0.8	0.2	-0.5
Birth weight	6.8	14.6	44.5	1.8	0.3	-3.3	6.7	-3.9
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.7	-1.0	0.5	-0.9	0.8	-1.6
High blood pressure (siblings)	0.4	0.5	0.8	-0.9	0.6	0.1	-0.9	0.8
Forced vital capacity (FVC), Best measure	6.2	22.5	35.1	4.8	1.4	-5.1	5.9	-5.2
Body fat percentage	0.4	1.7	2.7	-1.7	-0.1	1.5	-1.1	1.5
Leg fat percentage (right)	1.2	4.2	5.5	-2.0	-0.9	2.3	-2.3	2.3
Arm fat-free mass (right)	2.4	12.4	38.6	2.1	0.7	-2.8	6.2	-3.3
Exposure to tobacco smoke outside home	1.5	1.9	7.0	-2.6	-0.2	1.2	-0.8	0.7
Comparative body size at age 10	1.1	3.0	6.7	-1.4	-0.6	0.1	2.4	-2.6
Number of full brothers	0.3	0.4	0.8	-0.5	0.9	0.6	-0.2	0.8
Worry too long after embarrassment	0.5	0.8	1.4	-1.1	0.8	0.6	0.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.6	-0.0	1.5	0.5	-1.6	1.3
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-1.2	0.6	0.1	-1.2	1.4
Number of children fathered	0.2	0.2	0.5	0.2	-0.7	0.7	0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.3	-0.1	1.8	-1.2	-1.5	-0.4
Age at first live birth	1.0	1.9	2.7	-1.6	-1.4	-0.2	1.5	-1.5
Pulse wave peak to peak time	0.7	0.9	2.0	-0.6	-0.9	0.9	-0.6	1.4
Health satisfaction	0.5	0.7	1.7	-1.3	-0.7	-0.4	0.8	-0.7
Shortness of breath walking on level ground	2.2	2.6	5.2	-1.4	-2.3	1.4	-1.4	1.3
Qualifications: College or University degree	1.1	3.4	7.0	-2.6	2.0	-0.8	1.9	-1.5
Eye problems/disorders: None of the above	0.3	0.4	0.8	0.8	-0.9	-0.3	0.6	-0.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.0	-1.7	1.2	1.7	-0.5	1.4
Emphysema/chronic bronchitis	0.2	0.3	0.9	-0.9	0.6	-0.2	0.1	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.8	2.9	1.7	0.2	-0.8	-0.5	-0.5
Neck or shoulder pain in last month	1.0	1.5	3.4	1.0	-1.2	0.5	-1.9	1.2
Medication: Blood pressure	0.1	0.1	0.2	-0.5	0.1	-0.1	-0.2	-0.4
Angina (self-reported)	1.0	1.3	5.6	-2.4	0.1	-0.2	0.8	-0.2
Migraine (self-reported)	0.6	0.8	3.1	0.2	-1.8	0.8	-0.0	0.2
Medication: Ibuprofen	1.2	1.4	3.3	-1.5	0.5	1.8	0.2	1.2
Medication: Allopurinol	1.1	1.5	2.6	-0.8	-1.0	-1.3	1.2	-1.6
Medication: Omeprazole	0.4	0.5	0.9	-0.6	-0.2	0.8	-0.7	1.0
Medication: Seretide 50 evohaler	0.4	0.4	1.8	0.1	1.4	-0.0	0.6	0.0
Mean time to correctly identify matches	2.8	5.3	11.1	-1.4	3.3	-2.1	2.5	-1.7
Heart disease (mother)	0.7	0.8	1.6	0.6	-0.6	-1.2	-1.3	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	1.2	-0.4	-1.0	-0.6	-0.6
Whole body fat mass	0.1	0.5	1.8	-0.9	0.1	0.2	1.3	-0.2
Leg fat mass (right)	0.2	0.8	1.9	-1.4	-0.6	1.0	0.3	0.7
Arm predicted mass (right)	2.4	12.0	36.1	2.0	0.6	-2.9	6.0	-3.3
Pulse rate, automated reading	0.5	1.6	3.9	-0.5	-2.0	1.9	-0.2	0.5
Alcohol intake frequency.	0.5	1.1	4.4	-2.1	0.8	0.6	0.1	-0.2
Comparative height size at age 10	4.5	24.6	61.0	3.7	-0.1	-5.2	7.8	-4.6
Number of full sisters	0.7	0.8	1.7	0.8	-1.2	0.2	-1.3	0.5
Suffer from ‘nerves’	0.0	0.1	0.1	0.0	0.1	-0.3	-0.4	-0.1
Overall health rating	0.9	2.0	3.6	-1.9	-1.1	1.1	-1.9	0.7
Chest pain or discomfort	0.2	0.3	1.4	0.0	-0.1	-1.2	-0.2	-0.3
Had major operations	3.7	4.4	9.9	0.0	2.0	1.5	-3.1	2.4
Age at last live birth	1.2	1.7	3.0	-1.2	-1.1	-0.8	1.7	-1.5
Family relationship satisfaction	0.3	0.3	0.5	-0.3	0.3	0.7	-0.7	0.6
Leg pain on walking	1.3	1.7	4.5	-0.0	-0.4	2.1	-1.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.6	0.3	-1.1	0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	0.8	0.7	1.0	-0.6	1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	1.7	1.6	0.6	-0.0	0.6
Medication: Aspirin	0.4	0.6	1.5	-1.1	-1.2	0.4	-0.3	0.1
Supplements: Vitamin C	1.3	1.5	7.6	0.3	2.8	0.2	0.1	-0.1
Knee pain experienced in last month	0.5	0.8	2.0	-1.4	-0.7	-0.3	0.5	-1.0
Hypertension (Self-reported)	0.8	2.3	3.5	-1.4	-1.2	-1.4	1.7	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.3	-0.1	-1.5	0.5	0.2	0.1
Illnesses of father: Heart disease	1.1	1.6	5.5	2.4	1.0	-0.8	-0.5	0.7
Illnesses of siblings: Diabetes	1.5	1.9	2.6	-1.6	-1.3	1.4	-1.0	1.4
Smoking status: Previous	0.4	0.6	1.2	-0.1	-1.1	0.7	1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	11.1	2.2	0.1	-0.9	3.3	-1.9
Whole body fat-free mass	2.8	15.9	49.1	2.1	0.6	-3.2	7.0	-3.9
Leg fat-free mass (right)	2.3	12.6	40.3	1.4	0.6	-2.6	6.3	-3.6
Arm fat percentage (left)	0.7	2.6	5.4	-2.3	0.1	2.0	-1.1	1.6
Average weekly red wine intake	0.1	0.1	0.3	0.6	-0.3	0.5	0.2	0.1
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.3	-0.6	0.0	1.8	-1.2	1.6
Mood swings	1.1	2.0	5.0	-2.2	1.2	1.7	0.4	0.5
Loneliness, isolation	1.9	2.6	8.8	0.5	1.3	0.5	-3.0	1.3
Long-standing illness, disability or infirmity	0.6	0.9	2.6	-0.1	-0.9	-1.6	0.4	-0.9
Ever had bowel cancer screening	0.4	0.5	1.6	-0.1	0.1	-1.3	0.2	-1.0
Diabetes diagnosed by doctor	1.5	2.5	4.2	-1.8	-1.7	2.0	-0.7	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.1	-1.5	-1.8	0.9	-0.3	-0.1
Friendships satisfaction	1.2	1.4	2.2	-1.3	-0.9	-0.6	1.5	-1.4
Qualifications: nursing, teaching	0.7	1.0	2.0	1.1	0.7	-1.0	0.6	-1.4
Commuting to job workplace: Walk	1.6	1.7	4.6	-2.1	0.6	-0.9	1.1	-1.4
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.5	0.1	0.3	0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.6	0.1	-0.0	1.6	-1.2	1.6
Medication for cholesterol	2.3	3.5	7.9	-0.1	1.7	2.8	-1.7	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.2	0.5	0.1	0.9	-0.4
Back pain experienced in last month	0.8	1.2	5.7	0.0	-2.4	-0.4	0.2	0.0
Mineral and other dietary supplements	1.1	1.5	5.2	0.8	-2.3	-0.1	-0.7	1.0
Breast cancer (self-reported)	3.4	4.0	11.7	-0.3	-3.4	1.6	-2.2	1.0
Asthma (self-reported)	0.2	0.4	1.0	-1.0	-0.2	0.3	-0.4	0.7
Osteoporosis (self-reported)	0.6	0.8	2.0	0.0	1.4	1.1	0.5	0.6
Osteoarthritis (self-reported)	0.6	0.8	1.6	1.2	0.7	-0.6	1.1	-0.7
Medication: Aspirin	0.5	0.7	2.8	-0.7	-1.7	0.1	-0.6	0.1
Medication: Gliclazide	1.0	1.2	2.3	-0.5	-0.3	1.0	-1.5	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	0.3	0.8	1.2	0.2	0.8
Smoking status: Current	1.3	2.1	4.7	0.3	2.2	1.2	-1.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	7.2	1.9	0.7	-2.2	2.5	-2.7
Whole body water mass	2.8	15.9	49.0	2.1	0.7	-3.2	7.0	-3.9
Leg predicted mass (right)	2.3	12.4	39.7	1.5	0.6	-2.6	6.3	-3.6
Arm fat mass (left)	0.2	0.9	2.1	-1.5	0.3	1.0	1.0	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.2	-0.4	-0.6	-0.6	0.2
Average weekly champagne plus white wine intake	1.2	1.6	2.8	0.0	0.1	-1.6	1.6	-1.7
Miserableness	0.3	0.4	1.2	-0.7	1.1	0.5	-0.2	0.4
Guilty feelings	1.7	2.6	10.6	-3.3	0.4	1.4	0.5	0.3
Wears glasses or contact lenses	2.9	3.4	8.3	-0.7	2.9	-2.0	1.3	-1.6
Ever taken oral contraceptive pill	2.2	2.5	7.0	-1.7	-0.5	2.7	0.0	1.5
Hearing aid user	0.5	0.6	1.5	-1.1	0.1	-0.2	-1.2	0.6
Mother’s age at death	0.1	0.1	0.2	0.0	0.3	-0.1	0.4	-0.4
Financial situation satisfaction	2.0	2.5	4.5	-2.0	-0.5	2.1	-1.1	1.6
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	0.9	0.3	-1.1	0.5	0.4
Commuting to job workplace: Public transport	1.1	1.4	3.3	-1.1	1.8	-0.3	1.0	-1.0
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	1.2	0.7	-0.4	-1.4	0.3
Medication: Blood pressure	1.3	2.6	4.4	-0.1	-1.6	-2.1	1.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-0.2	-1.1	-0.8	0.4	-1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.2	-0.6	2.3	0.4	0.4	-0.6
High cholesterol (Self-reported)	0.4	0.7	2.3	-0.0	-1.5	-0.3	-0.8	0.6
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.4	-0.2	-0.5	0.6	-0.8
Medication: Paracetamol	1.0	1.6	3.4	-0.3	-0.1	1.5	-1.5	1.8
Medication: Lisinopril	0.3	0.4	1.7	-1.3	-0.3	0.2	-0.0	0.0
Medication: Atorvastatin	0.2	0.2	0.7	0.0	-0.8	-0.3	-0.2	-0.4
Illnesses of father: High blood pressure	0.9	1.1	3.0	-1.7	-0.9	0.0	-0.6	1.2
Alcohol drinker status: Never	1.6	1.9	3.3	-1.8	1.6	1.4	-1.1	0.6
Ever smoked	0.6	1.0	2.2	0.8	1.5	1.1	0.1	1.0
Basal metabolic rate	2.4	13.0	41.5	1.6	0.5	-2.8	6.4	-3.6
Leg fat percentage (left)	0.9	3.4	5.0	-1.8	-0.8	2.0	-2.2	2.0
Arm fat-free mass (left)	2.2	11.2	32.6	2.2	0.7	-2.8	5.7	-3.2
Number of operations (self-reported)	6.4	9.5	22.3	0.4	1.9	2.9	-4.7	3.6
Average weekly beer plus cider intake	3.8	5.5	11.4	-0.3	0.9	3.4	-2.5	3.0
Irritability	2.0	3.4	8.6	-2.2	-0.6	2.9	-0.8	1.6
Risk taking	0.6	0.8	3.2	-0.6	1.8	-0.3	0.2	0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	-0.1	1.2	-0.4	-1.6	0.2
Fractured/broken bones in last 5 years	1.4	1.8	4.5	1.6	-0.9	-2.1	0.2	-1.1
Age started oral contraceptive pill	0.1	0.2	0.4	0.3	-0.7	0.2	0.4	-0.3
Diastolic blood pressure, automated reading	0.2	0.5	1.6	1.3	-0.9	0.2	0.0	-0.2
Ever depressed for a whole week	0.3	0.3	0.5	-0.6	0.7	-0.7	0.5	-0.4
Unable to work because of sickness or disability	0.4	0.6	0.8	-0.9	-0.9	0.8	-0.7	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.4	0.5	0.3	0.5	-0.2
Myopia	0.8	1.1	2.0	-1.0	0.3	-1.4	0.8	-1.4
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.6	2.1	1.7	1.0	-1.4	1.4
Cholesterol lowering medication	0.9	1.3	5.2	0.3	-2.3	-0.9	0.0	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-0.2	0.1	0.5	-0.8	1.0
Pain experienced in last month	0.1	0.2	0.5	-0.0	0.4	0.7	-0.0	0.6
Supplements: Calcium	0.6	0.7	1.4	-0.6	1.0	-1.2	0.3	-0.7
Basal cell carcinoma (self-reported)	0.6	0.8	2.3	0.2	-1.5	-0.6	0.6	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.9	-0.4	-0.3	0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	6.0	0.0	-0.2	2.2	-2.5	2.4
Heart disease (siblings)	1.6	2.0	5.4	-2.3	-0.8	-0.8	1.2	-1.5
Alcohol drinker status: Previous	0.5	0.6	1.6	-1.3	-0.9	-0.2	0.4	-0.7
Pack years of smoking	3.7	5.5	9.6	0.3	-0.5	2.8	-3.1	3.1
Impedance of whole body	0.3	1.7	6.1	0.6	-0.8	0.2	-2.5	1.2
Leg fat mass (left)	0.1	0.5	1.3	-1.1	-0.5	0.8	0.3	0.5
Arm predicted mass (left)	2.2	11.4	32.7	2.1	0.5	-3.0	5.7	-3.2