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chr11:73,825,503-75,359,175

Best TWAS P=1.44e-08 · Best GWAS P=4.82e-21 conditioned to 5.25e-20

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	XRRA1	0.37	0.36	blup	73	0.36	5.7e-18	5.2	5.7	1.4e-08	0.05	0.01	0.99	TRUE
10	GTEx	Brain Nucleus accumbens basal ganglia	XRRA1	0.70	0.50	lasso	8	0.51	1.0e-15	5.3	5.6	2.7e-08	0.03	0.04	0.95	FALSE
26	GTEx	Pancreas	RP11-147I3.1	0.28	0.18	lasso	7	0.20	1.2e-08	5.3	-5.4	6.0e-08	-0.04	0.06	0.94	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-147I3.1	0.36	0.12	lasso	7	0.13	2.6e-04	5.4	-5.4	6.5e-08	-0.04	0.06	0.91	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	XRRA1	0.56	0.72	bslmm	505	0.72	6.2e-136	5.3	5.4	7.8e-08	0.04	0.04	0.96	FALSE
27	GTEx	Pituitary	XRRA1	0.67	0.68	lasso	3	0.68	6.4e-23	5.4	5.4	8.4e-08	0.04	0.04	0.96	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	RP11-147I3.1	0.23	0.20	lasso	1	0.17	2.9e-05	5.4	-5.4	8.5e-08	-0.04	0.06	0.84	FALSE
9	GTEx	Brain Cerebellum	XRRA1	0.67	0.65	lasso	9	0.69	2.7e-27	5.3	5.3	8.9e-08	0.04	0.04	0.96	FALSE
48	The Cancer Genome Atlas	Rectum Adenocarcinoma	XRRA1	0.65	0.69	lasso	3	0.69	1.6e-21	5.3	5.3	9.3e-08	0.04	0.01	0.99	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	XRRA1	0.64	0.72	lasso	4	0.71	6.1e-32	5.3	5.3	1.0e-07	0.04	0.04	0.96	FALSE
25	GTEx	Pancreas	XRRA1	0.56	0.64	lasso	5	0.64	1.4e-34	5.3	5.3	1.0e-07	0.04	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XRRA1	0.40	0.54	lasso	7	0.54	1.2e-35	5.3	5.3	1.0e-07	0.04	0.01	0.99	FALSE
7	GTEx	Brain Cerebellar Hemisphere	XRRA1	0.79	0.74	lasso	8	0.74	2.5e-27	5.4	5.3	1.1e-07	0.04	0.04	0.96	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XRRA1	0.34	0.30	lasso	3	0.29	1.0e-14	5.3	5.3	1.1e-07	0.05	0.01	0.99	FALSE
12	GTEx	Brain Putamen basal ganglia	XRRA1	0.55	0.50	lasso	3	0.50	9.3e-14	5.3	5.3	1.2e-07	0.05	0.05	0.95	FALSE
13	GTEx	Brain Putamen basal ganglia	RP11-147I3.1	0.19	0.20	lasso	2	0.20	2.0e-05	5.3	-5.3	1.2e-07	-0.05	0.06	0.87	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	RP11-147I3.1	0.28	0.41	lasso	4	0.41	6.9e-57	5.2	-5.3	1.2e-07	-0.04	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	XRRA1	0.27	0.34	lasso	4	0.34	7.5e-21	5.4	5.3	1.2e-07	0.04	0.01	0.99	FALSE
34	GTEx	Uterus	XRRA1	0.59	0.59	lasso	7	0.59	6.9e-15	5.3	5.3	1.3e-07	0.04	0.06	0.94	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XRRA1	0.45	0.53	lasso	3	0.53	4.2e-42	5.3	5.3	1.3e-07	0.05	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	XRRA1	0.59	0.79	lasso	3	0.78	5.8e-152	5.2	5.3	1.4e-07	0.05	0.05	0.95	FALSE
18	GTEx	Esophagus Mucosa	RP11-147I3.1	0.20	0.12	lasso	4	0.12	1.2e-08	5.2	-5.3	1.4e-07	-0.04	0.05	0.95	FALSE
19	GTEx	Esophagus Muscularis	XRRA1	0.59	0.70	lasso	5	0.70	1.2e-58	5.3	5.3	1.4e-07	0.04	0.04	0.96	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	XRRA1	0.51	0.59	enet	12	0.60	5.3e-41	5.2	5.3	1.4e-07	0.04	0.04	0.95	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	XRRA1	0.39	0.54	lasso	4	0.53	5.7e-73	5.2	5.3	1.4e-07	0.04	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Skin Cutaneous Melanoma	XRRA1	0.37	0.40	lasso	8	0.37	5.7e-11	5.2	5.3	1.4e-07	0.04	0.01	0.99	FALSE
6	GTEx	Brain Caudate basal ganglia	XRRA1	0.72	0.61	lasso	5	0.60	2.6e-21	5.3	5.2	1.5e-07	0.04	0.04	0.96	FALSE
17	GTEx	Esophagus Mucosa	XRRA1	0.64	0.76	lasso	7	0.76	5.9e-75	5.2	5.2	1.5e-07	0.04	0.04	0.96	FALSE
20	GTEx	Heart Left Ventricle	XRRA1	0.58	0.69	lasso	6	0.69	1.0e-49	5.2	5.2	1.5e-07	0.04	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XRRA1	0.28	0.38	lasso	4	0.38	1.3e-44	5.4	5.3	1.5e-07	0.04	0.01	0.99	FALSE
28	GTEx	Prostate	XRRA1	0.80	0.63	lasso	12	0.69	1.5e-23	5.3	5.2	1.6e-07	0.03	0.05	0.95	FALSE
33	GTEx	Thyroid	XRRA1	0.66	0.76	lasso	4	0.76	1.1e-88	5.2	5.2	1.6e-07	0.05	0.05	0.95	FALSE
36	NTR	Blood	XRRA1	0.09	0.16	lasso	3	0.16	3.2e-49	5.3	5.2	1.6e-07	0.04	0.04	0.95	FALSE
22	GTEx	Lung	XRRA1	0.66	0.70	enet	35	0.72	1.1e-78	5.2	5.2	1.7e-07	0.04	0.04	0.96	FALSE
24	GTEx	Nerve Tibial	XRRA1	0.52	0.67	lasso	5	0.68	3.6e-64	5.3	5.2	1.7e-07	0.04	0.04	0.96	FALSE
14	GTEx	Breast Mammary Tissue	XRRA1	0.48	0.57	lasso	1	0.57	8.3e-35	5.2	5.2	1.8e-07	0.04	0.05	0.95	FALSE
32	GTEx	Stomach	XRRA1	0.57	0.64	lasso	6	0.66	7.9e-41	5.3	5.2	1.8e-07	0.03	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	XRRA1	0.29	0.43	lasso	4	0.43	2.7e-97	5.2	5.2	1.8e-07	0.04	0.01	0.99	FALSE
31	GTEx	Small Intestine Terminal Ileum	RP11-147I3.1	0.32	0.08	lasso	6	0.06	2.1e-02	5.2	-5.2	1.9e-07	-0.04	0.10	0.63	FALSE
2	GTEx	Adipose Subcutaneous	XRRA1	0.49	0.62	enet	27	0.64	6.1e-67	5.3	5.2	2.0e-07	0.04	0.04	0.96	FALSE
3	GTEx	Artery Aorta	XRRA1	0.57	0.65	lasso	7	0.68	1.1e-50	5.2	5.2	2.0e-07	0.04	0.05	0.95	FALSE
5	GTEx	Artery Tibial	XRRA1	0.63	0.72	lasso	10	0.74	1.9e-83	5.2	5.2	2.0e-07	0.04	0.04	0.96	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRRA1	0.52	0.69	lasso	6	0.70	2.8e-111	5.3	5.2	2.0e-07	0.04	0.01	0.99	FALSE
21	GTEx	Heart Left Ventricle	RP11-147I3.1	0.21	0.14	lasso	3	0.14	4.6e-08	5.0	-5.2	2.2e-07	-0.03	0.06	0.94	FALSE
23	GTEx	Muscle Skeletal	XRRA1	0.53	0.68	enet	16	0.72	8.9e-100	5.2	5.2	2.3e-07	0.03	0.04	0.96	FALSE
4	GTEx	Artery Coronary	XRRA1	0.72	0.71	enet	24	0.73	4.8e-35	5.2	5.2	2.4e-07	0.04	0.06	0.94	FALSE
30	GTEx	Skin Sun Exposed Lower leg	XRRA1	0.50	0.65	lasso	6	0.66	7.4e-72	5.2	5.2	2.4e-07	0.04	0.05	0.95	FALSE
35	GTEx	Vagina	XRRA1	0.72	0.75	lasso	4	0.76	2.5e-25	5.3	5.2	2.5e-07	0.04	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	XRRA1	0.41	0.32	lasso	8	0.30	3.4e-09	5.2	5.2	2.5e-07	0.05	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XRRA1	0.34	0.39	enet	10	0.39	5.6e-35	5.2	5.1	2.8e-07	0.04	0.02	0.98	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	XRRA1	0.55	0.68	enet	17	0.68	5.2e-33	5.2	5.1	3.0e-07	0.04	0.05	0.95	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	XRRA1	0.49	0.58	lasso	9	0.57	6.3e-50	5.2	5.1	3.1e-07	0.04	0.01	0.99	FALSE